Exploring the epigenetic mechanisms of recurrent pregnancy loss: from genetic predisposition to environmental influences.

Recurrent pregnancy loss (RPL) is a complex and emotionally distressing condition defined by the occurrence of two or more consecutive miscarriages before 20 weeks of gestation. The exact causes of RPL remain unclear, despite extensive research into its genetic, immune, and environmental underpinnings. Recent advances in epigenetics have revealed that alterations in DNA methylation, histone modifications, and non-coding RNA expression play crucial roles in regulating pregnancy-related processes such as immune tolerance, placental development, and embryo implantation.

Short-chain fatty acids regulate T cell heterogeneity to alleviate recurrent spontaneous abortion.

Background And Purpose: The aetiology of recurrent spontaneous abortion (RSA) is multifactorial, with immune factors playing a critical role. Gut microbiota and its metabolites have been found to participate in host immune regulation. This study explores the role of gut microbiota-derived short-chain fatty acids (SCFAs) in immune tolerance in RSA.

The Indoor Distribution Patterns and Exposure Risks of Meperfluthrin in Different Mosquito-Repellent Incenses.

Mosquito-repellent incenses are extensively employed in households; nevertheless, the potential hazards associated with exposure to their active ingredients have not garnered widespread attention. This study systematically evaluates airborne distribution dynamics, surface deposition patterns, and human exposure risks associated with meperfluthrin-based mosquito-repellent incenses (disc, electric liquid, and electric mat) under the conditions of open and closed windows. The highest concentration of meperfluthrin derived from disc incense in the respiratory zone (0.

A nano-pesticide with low toxicity for earthworms obtained by immobilizing avermectin onto Mg/Al layered double hydroxides.

Nanopesticides offer significant advantages, such as enhancing pesticide bioactivity, increasing efficacy, and reducing overall usage. However, knowledge gaps regarding their environmental risks to non-target organisms hinder the industrial adoption of nanopesticides. In this study, abamectin was selected as a model pesticide, and earthworms (Eisenia foetida) were employed as representative non-target organisms to evaluate the environmental behavior and ecotoxicity mechanisms of abamectin-loaded layered double hydroxides nanopesticide (Mg/Al LDHs-AVM) in soil systems.

Extracellular matrix dysregulation in PCOS: pathogenesis, therapeutic strategies, and innovative technologies.

Polycystic ovary syndrome (PCOS), the most common endocrine disease in women of reproductive age, severely impacts female fertility due to chronic anovulation and currently lacks effective clinical treatment strategies. The extracellular matrix (ECM) is a three-dimensional, non-cellular framework comprising molecules such as collagens, elastin, and laminin, which support the ovarian structure and provide extracellular signals to cells. Changes in ECM localization and composition can disturb local biochemical pathways, impair folliculogenesis, and reduce the fertility of women.

Deciphering pollinator exposure hazards: Systemic translocation and accumulation of seed-coating pesticides in maize and their synergistic exposure risk to bees.

Seed coating agents, especially neonicotinoid-fungicide combinations, is widely used for crop pest and disease control, their distribution behavior and potential ecological risks are largely overlooked. This study aimed to reveal the translocation pattern of 7 seed-coating pesticides in maize tissues and leaf guttation, and the exposure risk to bees. Hydrophilic pesticides including thiamethoxam, imidacloprid, clothianidin, and metalaxyl-M (log K = -0.

Dissipation and metabolism of fluxapyroxad, oxathiapiprolin and penthiopyrad in grapes: A comprehensive risk assessment from field to raisins.

Understanding the residue fate of new pesticides in crops is essential to ensure their safe use and to safeguard human health. The present study examined the dissipation, metabolism, processing factors (PFs) and risk assessment of fluxapyroxad, oxathiapiprolin and penthiopyrad in grapes from field to raisins. The half-lives of the three pesticides in grapes ranged from 9.

Insight into abiotic and biotic transformations of fenaminstrobin in water and soil: Kinetics, transformation mechanism and ecotoxicity.

In 2009, fenaminstrobin was officially registered in China as a strobilurin pesticide, particularly developed for effectively controlling fungal diseases. Despite its widespread use, limited information is available regarding its environmental persistence and eco-toxicological profile. Herein, we comprehensively assess the abiotic and biotic transformations of fenaminstrobin, along with the associated ecological risks.

Revolutionizing anticoagulation: Nanoengineered therapies and precision medicine approaches.

With the advancement of therapeutic concepts, early intervention with antithrombotic therapy for patients at potential thrombotic risk is becoming more proactive. Anticoagulant therapy, a critical component of antithrombotic treatment, thus plays a key role in the prevention and treatment of cardiovascular diseases. Unfortunately, existing anticoagulation treatments still face many challenges, including abnormal bleeding, allergic reactions, and drug resistance.

Occurrence and risk assessment of mycotoxins and their modified forms in maize from typical planting regions of China.

Mycotoxin contamination in maize has been a longstanding public concern. This study developed a high-performance liquid chromatography tandem mass spectrometry method for the analysis of 17 mycotoxins and investigated the contamination characteristics of maize grains from three planting regions in China. The results revealed that a total of 12 mycotoxins were detected, with co-occurrence rates of at least 2, 5, and 10 mycotoxins in maize being 69.

Elucidating the Molecular Mechanisms of Hederagenin-Regulated Mitophagy in Cervical Cancer SiHa Cells through an Integrative Approach Combining Proteomics and Advanced Network Association Algorithm.

Hederagenin (Hed), a natural triterpenoid, exhibits antitumor potential in cervical cancer. The present study was designed to explore Hed's regulatory mechanisms on mitophagy in SiHa cervical cancer cells, employing tandem mass tag (TMT) proteomics and an advanced network association algorithm (NAA). Our findings revealed that Hed decreased SiHa cell viability, induced apoptosis, and altered mitochondrial membrane potential.

Unraveling shared diagnostic genes and cellular microenvironmental changes in endometriosis and recurrent implantation failure through multi-omics analysis.

Endometriosis and Recurrent Implantation Failure (RIF) are both pivotal clinical issues within the realm of reproductive medicine, sharing significant overlap in their pathophysiological mechanisms. However, research exploring the commonalities between these two conditions remains relatively scarce, and reliable shared diagnostic biomarkers have yet to be identified. In this study, we integrated transcriptomic and single-cell sequencing data from the Gene Expression Omnibus (GEO) database to identify shared diagnostic genes and alterations in the cellular microenvironment between EMs and RIF.

Insights on persistent herbicides in cropland soils in northern China: Occurrence, ecological risks, and phytotoxicity to subsequent crops.

Herbicides are essential inputs in agriculture, but their long-term persistence creates underappreciated risks in intensive cropping systems. While previous studies focused on single-herbicide persistence, the cumulative ecological and agronomic impacts of multi-herbicide residues remain poorly understood, particularly in phytotoxicity to subsequent crops. This study investigated the occurrence, ecological risk, and phytotoxicity of six persistent herbicides in cropland soils in northern China.

From field to table: Reducing residual toxicity and risk of four pesticides via washing and blanching of cowpea (Vigna unguiculata (L.) Walp.).

The presence of acetamiprid, chlorantraniliprole, thiamethoxam, and cyromazine residues in cowpea raises significant health concerns. This study evaluated pesticide residues through field tests and examined the effects of washing, blanching, and frying on residue removal. Washing for 20-60 s reduced residues by 17.

Tebuconazole residue in wheat and food risks: Comparison among nano and conventional formulations.

Nanopesticides exhibit different residue patterns in crops after application compared to conventional formulations, thus affecting human dietary exposure. Residue, dissipation, and dietary exposure to tebuconazole nanoformulations (nanoemulsion and nano-capsules) and conventional formulations (suspension concentrate and micro-capsules) on wheat were investigated and compared. Nano-capsules (1950 μg/kg) and micro-capsules (1771 μg/kg) had significantly lower initial deposition on wheat-leaf than suspension concentrate (2666 μg/kg).

Prediction of Potential Risk for Ten Azole and Benzimidazole Fungicides with the Aryl Hydrocarbon Receptor Agonistic Activity to Aquatic Ecosystems.

Azole and benzimidazole fungicides are widely used agrochemicals to prevent and treat fungal growth and are frequently detected in aquatic environments. Here, we aimed to assess the aquatic ecological risks of ten currently used azole and benzimidazole fungicides, which with the aryl hydrocarbon receptor (AhR) agonistic activity, and their transformation products (TPs). We obtained over 400 types of aerobic TPs for ten fungicides.

Efficient Control of Head Blight and Reduction of Deoxynivalenol Accumulation by a Novel Nanopartner-Based Strategy.

Chemical control of head blight (FHB) in wheat plants is often challenged by the resistance outbreak and deoxynivalenol (DON) accumulation. Developing green partners for fungicides is crucial for reducing fungal growth, mycotoxin contamination, and agricultural fungicides input. Herein, we investigated the mechanism of MgO nanoparticles (NPs) in controlling FHB.

Thiophanate-methyl and its major metabolite carbendazim weaken rhizobacteria-mediated defense responses in cucumbers against Fusarium wilt.

Unlabelled: The effect of fungicides on the plant-rhizosphere microbiome is a subject of ongoing debate, but whether any alteration in the rhizosphere microbiome could affect plant health is an issue that has not been thoroughly investigated. To address this deficiency, we analyzed the rhizosphere microbiome of wilt disease-resistant and disease-susceptible cucumber cultivars to determine whether (and which) plant-associated microorganisms have a role in disease resistance. We further assessed whether the fungicides thiophanate-methyl and carbendazim affect the rhizosphere microbiome, which may contribute to the plant's immune response.

Acid-modified corn straw biochar immobilized Pseudomonas hibiscus CN-1 facilitated the bioremediation of carbendazim-contaminated soil.

Carbendazim application in agroecosystems has posed potential threats to ecosystems and human health. The utilization of biochar-based materials for immobilizing microorganisms offers a sustainable strategy for effective bioremediation. In this study, a novel highly efficient carbendazim-degrading bacterium Pseudomonas hibiscus CN-1 was isolated and immobilized using corn straw-based biochar as a carrier.

Enantioselective Metabolism of Mefentrifluconazole by Human Liver Microsomes.

A better understanding of the metabolic differences between chiral pesticide enantiomers in organisms is crucial for accurately assessing their risk. The enantioselective metabolism of mefentrifluconazole was investigated by the human liver microsome reaction system. The metabolic rate of -mefentrifluconazole was found to be 4 times that of -mefentrifluconazole.

Sensitive and portable intelligent detection platform construction and dietary risk assessment of procymidone in Chinese leek, cowpea and celery.

Procymidone (PRM), a widely used amide-type fungicide in vegetables, poses potential health risks due to its high detection rate. This study introduces a pretreatment device and an intelligent quantification method for PRM in Chinese leek, cowpea, and celery using a lateral flow immunoassay (LFIA) integrated with a smartphone. The whole pretreatment and detection process can be achieved within 21 min.

A systematic workflow of data mining confirms widespread ecological risks of SDHIs fungicides contamination in aquatic environment.

Succinate dehydrogenase inhibitors (SDHIs) are widely utilized fungicides that have been detected in various environments, raising significant concerns regarding their toxicity to aquatic organisms. A comprehensive analysis of SDHIs contamination and associated ecological risks has been challenging due to scattered data and varying scale. This study consolidated residue data from 194 aquatic environments across six regions, up to June 2024, providing an overview of SDHIs distribution and conducting a global-scale aquatic ecological risk assessment.

Degradation of a novel herbicide fluchloraminopyr in soil: Dissipation kinetics, degradation pathways, transformation products identification and ecotoxicity assessment.

With the continuous application of new agricultural chemicals in agricultural systems, it is imperative to study the environmental fate and potential transformation products (TPs) of these chemicals to better assess their ecological and health risks, as well as guide scientific application. The dissipation of fluchloraminopyr was firstly evaluated under aerobic/anaerobic condition in four representative soils, with Dissipation Time 50 (DT) values ranging from 0.107 to 4.

Transfer of pesticides and metabolites in corn: Production, processing, and livestock dietary burden.

Corn stover is widely used in livestock feed but has received limited attention regarding its potential risks. In this study, pesticide residues were monitored across 12 provinces in China, and terminal residues of four pesticides, chlorantraniliprole, thiamethoxam, epoxiconazole, and pyraclostrobin, were tested. In addition, the silage processing experiment was conducted.

The role of non-coding RNAs in fibroblast-like synoviocytes in rheumatoid arthritis.

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by synovial hyperplasia, and fibroblast-like synoviocytes (FLSs) constitute the majority of cells in the synovial tissue, playing a crucial role in the onset of RA. Dysregulation of FLSs function is a critical strategy in treating joint damage associated with RA. Non-coding RNAs, a class of RNA molecules that do not encode proteins, participate in the development of various diseases.