Eco-friendly diflufenican nanosuspension improved foliar dispersion, penetration, and contact herbicidal activity against broadleaf weeds by uniform deposition.

Background: Herbicides play an irreplaceable role in ensuring global food production and security. The low dispersion, non-uniform deposition, and negligible translocation of low water-soluble contact herbicides restrict the bioactivity. Therefore, there is an urgent need to develop novel, promising, and eco-friendly pesticide formulations to improve bioactivity and reduce the environmental input of herbicides.

Geometrically and Micromechanically Optimized Sprayable Short Fibers for Precision Pesticide Delivery.

Pesticides are crucial for global food security, but improving their efficient use to reduce environmental losses remains a key challenge for sustainable agriculture. One promising solution is enhancing pesticide adhesion to hydrophobic waxy leaf surface. Inspired by the dynamics of pinball machines, it is developed sprayable short-fiber carriers composed of biodegradable poly(3-hydroxybutyrate-4-hydroxybutyrate) using electrospinning technique and aminolysis.

'Disappeared balloon': the trap of transseptal puncture for a large closure device of atrial septal defect-a case report.

Background: Several studies have demonstrated a notable increase in the incidence of atrial arrhythmias among individuals with atrial septal defect (ASD) occluder. Although the sequential dilation technique has been proposed as the mainstream technique for transseptal puncture with ASD occluder, it is associated with substantial risks and technical difficulties.

Case Summary: We report a patient who underwent catheter ablation for atrial fibrillation and had a large ASD occluder.

Tebuconazole residue in wheat and food risks: Comparison among nano and conventional formulations.

Nanopesticides exhibit different residue patterns in crops after application compared to conventional formulations, thus affecting human dietary exposure. Residue, dissipation, and dietary exposure to tebuconazole nanoformulations (nanoemulsion and nano-capsules) and conventional formulations (suspension concentrate and micro-capsules) on wheat were investigated and compared. Nano-capsules (1950 μg/kg) and micro-capsules (1771 μg/kg) had significantly lower initial deposition on wheat-leaf than suspension concentrate (2666 μg/kg).

Size Effects of Nanoenabled Agrochemicals in Sustainable Crop Production: Advances, Challenges, and Perspectives.

Nanoenabled agrochemicals mainly including nanopesticides and nanofertilizers based on nanotechnology play a crucial role in plant protection and food security. These agrochemicals exhibit high dose delivery efficiency and biological activity due to their unique nanoscale properties. However, nanoscale properties can also be a double-edged sword, posing potential risks to both humans and the environment.

Efficient delivery of the herbicide quinclorac by nanosuspension for enhancing deposition, uptake and herbicidal activity.

Background: The presence of barnyardgrass poses a threat to global food security by reducing rice yields. Currently, herbicides are primarily applied for weed management. However, the effectiveness of herbicide deposition and uptake on barnyardgrass is limited as a consequence of the high wax content on leaves, low water solubility and extreme lipophilicity of herbicides.

Making the Complicated Simple: A Minimizing Carrier Strategy on Innovative Nanopesticides.

The flourishing progress in nanotechnology offers boundless opportunities for agriculture, particularly in the realm of nanopesticides research and development. However, concerns have been raised regarding the human and environmental safety issues stemming from the unrestrained use of non-therapeutic nanomaterials in nanopesticides. It is also important to consider whether the current development strategy of nanopesticides based on nanocarriers can strike a balance between investment and return, and if the complex material composition genuinely improves the efficiency, safety, and circularity of nanopesticides.

Safety and efficacy of the second-generation cryoballoon for left atrial appendage electrical isolation in canines.

Aims: Left atrial appendage electrical isolation (LAAEI) has demonstrated a significant enhancement in the success rate of atrial fibrillation (AF) ablation. Nevertheless, concerns persist about the safety of LAAEI, particularly regarding alterations in left atrial appendage (LAA) flow velocity and the potential risks of thrombus. This study aimed to assess the efficacy and safety of LAAEI, investigating changes in LAA flow velocity in canines.

Zero x-rays radiofrequency catheter ablation for ventricular premature contraction originating from the left coronary cusp during pregnancy: a case report.

Pregnancy predisposes to arrhythmias in females due to physiological changes in the cardiovascular system, enhanced activity of the sympathetic nervous system (SNS), and changes in the endocrine system, regardless of whether there exist cardiovascular diseases before the pregnancy. Tachyarrhythmias may present for the first time or worsen persistently during pregnancy, potentially leading to maternal heart failure and sudden death, as well as some adverse fetal outcomes such as growth restriction, distress, premature birth, and stillbirth. Radiofrequency ablation (RFA) is one of the most important therapeutic methods for tachyarrhythmias.

Effect of sodium alginate-gelatin-polyvinyl pyrrolidone microspheres on cucumber plants, soil, and microbial communities under lead stress.

Lead is highly persistent and toxic in soil, hindering plant growth. Microspheres are a novel, functional, and slow-release preparation commonly used for controlled release of agricultural chemicals. However, their application in the remediation of Pb-contaminated soil has not been studied; furthermore, the remediation mechanism involved has not been systematically assessed.

Active Ingredient Paeonol of Jijiu Huiyang Decoction Alleviates Isoproterenol-Induced Chronic Heart Failure via the GSK3A/PPAR Pathway.

Background: The pharmacological mechanism of the traditional Chinese medicine formula-Jijiu Huiyang decoction (JJHYD), which contains several herbal medicines for the treatment of chronic heart failure (CHF), is yet unknown. . The main active components of JJHYD were analyzed by ultrahigh-performance liquid chromatography-mass spectrometry (UHPLC-MS/MS).

Sodium alginate-based composite microspheres for controlled release of pesticides and reduction of adverse effects of copper in agricultural soils.

Excessive copper (Cu) concentrations pose significant health risks to both plants and humans. In this study, sodium alginate (SA)-gelatin (GEL)-polyvinyl pyrrolidone (PVP)- embedded dinotefuran (DIN) microspheres were prepared using spray-drying technology. The loading content and encapsulation efficiency of optimal microspheres determined by physical modifications were 19.

Therapeutic overexpression of miR-92a-2-5p ameliorated cardiomyocyte oxidative stress injury in the development of diabetic cardiomyopathy.

Background: Diabetic cardiomyopathy (DCM) results from pathological changes in cardiac structure and function caused by diabetes. Excessive oxidative stress is an important feature of DCM pathogenesis. MicroRNAs (miRNAs) are key regulators of oxidative stress in the cardiovascular system.

KLF4 prevented angiotensin II-induced smooth muscle cell senescence by enhancing autophagic activity.

Background: Vascular aging is an important risk factor for various cardiovascular diseases. Transcription factor krüppel-like factor 4 (KLF4) could regulate the phenotypic transformation of the vascular smooth muscle cell (VSMC) in the pathogenesis of aortic diseases. The present study aimed to explore the role and mechanism of KLF4 in angiotensin II (Ang II)-induced VSMC senescence.

Controlled release of dinotefuran with temperature/pH-responsive chitosan-gelatin microspheres to reduce leaching risk during application.

Neonicotinoid-based pesticides are extensively used owing to their broad insecticidal spectrum and activity. We developed neonicotinoid dinotefuran (DIN)-loaded chitosan-gelatin microspheres using a spray-drying technology, resulting in a pH- and temperature-responsive controlled-release system. Upon introducing chitosan into the triple-helix structure of gelatin, the physically modified gelatin microspheres became smooth, round, and solid, improving their thermal storage stability.

Di-2-ethylhexyl phthalate induces heart looping disorders during zebrafish development.

Di-2-ethylhexyl phthalate (DEHP) is a type of plasticizer widely used in industry. It is well-known for its toxic effects to endocrine and reproductive systems and has been detected in amniotic fluid and placenta. In the present study, we explored the effects of DEHP on heart development by using zebrafish as a model organism.

Electrocardiographic and electrophysiological characteristics of idiopathic ventricular arrhythmias originating from the vicinity of tricuspid annulus.

Electrocardiographic and electrophysiological characteristics of VAs originating from the vicinity of the TA are not fully understood. Hence, 104 patients (mean age 52.6 ± 17.

Development of leaf-adhesive pesticide nanocapsules with pH-responsive release to enhance retention time on crop leaves and improve utilization efficiency.

Pesticides play a very important role in pest control and plant protection. However, they can be limited by a tendency to cause ecological system damage due to significant losses into the environment. To increase pesticide utilization efficiency, we developed highly leaf-adhesive avermectin nanocapsules (Av-pH-cat@CS) with pH-responsive controlled release properties.

Dysregulation of HULC promotes contrast-induced nephropathy (CIN) via regulating signaling pathway of miRNA-512 and prostaglandin E1 (PGE).

It has been shown that contrast-induced nephropathy (CIN) can be attenuated by the administration of PGE1. As an enzyme responsible for the production of PGE1, PTGS1 was confirmed in this study as a miR-512 target. Meanwhile, HULC has been identified as a competing endogenous RNA of miR-512.

Biocidal activity of polylactic acid-based nano-formulated abamectin on Acyrthosiphon pisum (Hemiptera: Aphididae) and the aphid predator Adalia bipunctata (Coleoptera: Coccinellidae).

Abamectin is a common biocide used to control agricultural insect pests. However, the water insolubility of abamectin may result in extra organic solvent introduced in the environment. To solve this issue, it is desirable to develop nanoformulations to encapsulate abamectin with environment-friendly polymers.

Tannic acid-based nanopesticides coating with highly improved foliage adhesion to enhance foliar retention.

Poor utilization efficiency of conventional pesticide formulation has resulted in overuse, which could increase costs, toxicity to other non-target organisms, concerns about human health and safety, groundwater contamination, causing ecosystem destruction and food pollution. The folia-adhesive formulation is supposed to enhance foliar retention time and utilization efficiency. According to the microstructure of the foliage, the nanopesticides surfaces were modified by affinity groups to improve folia adhesion and decrease the loss from crop foliage.