Real 2D Galvanostatic Model: Encoding Physicochemical Heterogeneity into a Full Battery.

The propagation of physicochemical heterogeneity from particles to electrodes under galvanostatic cycling conditions largely determines battery performance but is often computationally unreachable. We formulate a Real 2D (R2D) full-battery model via an electrode-adaptive mathematical framework that addresses the electrochemically correlated nonlinear current-potential responses of the electrodes. This allows us to quantify the impact of multiphysics coupling on cycling performance in emerging solid-state batteries.

Eight new amide alkaloids from Piper Longum and their anti-inflammatory activities.

Eight new amide alkaloids (1-5) along with four new natural products (6-8) were isolated from the fruit of piper longum L. Their structures were determined by extensive spectroscopic data analysis, electronic circular dichroism (ECD) calculations, and X-ray crystallographic analysis. The data and configurations of 6-7 were reported for the first time.

A multitask framework based on CA-EfficientNetV2 for the prediction of glioma molecular biomarkers.

Introduction: Glioma is the most common primary malignant tumor of the central nervous system. The mutation status of isocitrate dehydrogenase (IDH) and the methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) promoter are key biomarkers for glioma diagnosis and prognosis. Accurate, non-invasive prediction of these biomarkers using MRI is of significant clinical value.

Phase sensitivity for an SU(1,1) interferometer via multiphoton subtraction at the output port.

In the field of quantum precision measurement, enhancing phase sensitivity is crucial for various applications, including quantum metrology and quantum sensing technologies. We theoretically investigate the improvement in phase sensitivity and quantum Fisher information achieved through multiphoton subtraction operations at the output port of an SU(1,1) interferometer under conditions of photon loss. We use vacuum and coherent states as the inputs and detect the outputs by intensity detection.

Defective hierarchical porous Ce-UiO-66 excites phosphotungstic acid for superior low-temperature oxidative desulfurization.

Metal-organic frameworks (MOFs) as host-guest catalyst in oxidative desulfurization (ODS) face challenges due to limited access to active sites through their microporosity. Herein, hierarchical porous Ce-UiO-66 (HCU) was synthesized through a templating method in an aqueous environment to enhance host accessibility; phosphotungstic acid (PW) was uniformly loaded within the mesopores of HCU via post-impregnation; Ce sites were exposed by selective removing the coordinated acetate from the HCU with the acid post-treatment, these synergistically optimized the catalytic potential of the composite. The resulting HCU@5PW-H demonstrates outstanding desulfurization performance (1000 ppm sulfur removal) within 16 minutes under mild conditions (40 °C, O/S molar ratio = 5) and maintains high efficiency over at least eight cycles.

Differences in human skin volatiles between populations with high and low attraction to mosquitoes.

Background: The attractiveness of mosquitoes to humans varies among individuals, with human volatile organic compounds (VOCs) playing a pivotal role in the mosquitoes' host-seeking behavior. Differences between human volatiles detected by GC-MS can effectively modulate mosquito host selection.

Methods: Participants were enrolled and then assessed for mosquito attraction via an olfactometer.

Semisupervised adaptive learning models for IDH1 mutation status prediction.

The mutation status of isocitrate dehydrogenase1 (IDH1) in glioma is critical information for the diagnosis, treatment, and prognosis. Accurately determining such information from MRI data has emerged as a significant research challenge in recent years. Existing techniques for this problem often suffer from various limitations, such as the data waste and instability issues.

Development of Attractive Toxic Sugar Baits (ATSBs) System and Its Effectiveness in Mosquito Control.

Background: Attractive Toxic Sugar Baits (ATSBs) are an innovative vector control strategy based on the "attract-and-kill" principle. The core of ATSBs lies in the preparation of attractive and toxic baits through the mixing and proportioning of luring and active ingredients. Although previous studies have investigated the effects of ATSBs on mosquitoes, significant challenges remain for broader field application.

Not for nothing, microplastics can (potentially) reduce the risk of mosquito-to-human transmission of arboviruses.

The impact of microplastic pollution has emerged as a significant global ecological concern. Various organisms have exhibited alterations in behavior or metabolic activities following exposure to microplastics (MPs). Mosquitoes, as crucial disease vectors, are particularly susceptible MPs exposure in the environment.

Transcriptome analysis of midgut and salivary gland post-Zika virus infection.

This study aimed to investigate the transcriptomic changes in the midgut and salivary glands of mosquitoes infected with Zika virus (ZIKV), in order to explore the molecular mechanisms underlying the interaction between the virus and the mosquito vector. from Jiegao (JG) and Mengding (MD) in China were experimentally infected with ZIKV, and the midgut and salivary gland tissues were collected at 2-, 4- and 6 days post-infection (dpi). High-throughput sequencing was performed to analyze the transcriptomic changes between ZIKV-infected and non-infected .

Accounting for the gross ecosystem product (GEP) of forests in nature reserves-taking the Taishan Scenic and Historic Spot as an example.

How to measure the economic value of forest ecosystems is an important research topic for sustainable development. Existing quantitative systems for ecosystem values were compared and analyzed on the basis of characteristics of forest ecosystems in the Taishan Scenic and Historic Spot with reference to the Technical Guidelines for Accounting for the Gross Value of Ecological Products in Shandong Province. Two new indicators, namely, forest protection and scientific research and education, were added to the accounting system, forming a "forest sample" applicable to the accounting of GEP in nature reserves to better understand the synergistic effect between conservation and development.

Brain tumor intelligent diagnosis based on Auto-Encoder and U-Net feature extraction.

Preoperative classification of brain tumors is critical to developing personalized treatment plans, however existing classification methods rely on manual intervention and often have problems with efficiency and accuracy, which may lead to misdiagnosis or delayed diagnosis in clinical practice and affect the therapeutic effect. We propose a fully automated approach to brain tumor magnetic resonance imaging (MRI) classification, consisted by a feature extractor based on the improved U-Net and a classifier based on convolutional recurrent neural network (CRNN). The encoder of the feature extractor based on dense block, is used to enhance feature propagation and reduce the number of parameters.

Fatigue, sleep quality, depression symptoms, and antiseizure medication resistance in patients with newly diagnosed epilepsy.

Background: Complaints of fatigue and poor sleep quality are common in patients with epilepsy. Fatigue may precipitate seizures, and patients with poor sleep quality have higher frequency of seizures and are more likely to have symptoms of depression.

Objectives: This study aims to determine the association of baseline fatigue and sleep quality with antiseizure medication (ASM) resistance in patients with newly diagnosed epilepsy (PWNDE).

Functional Verification of Differentially Expressed Genes Following DENV2 Infection in .

The dengue virus (DENV) is primarily transmitted by . Investigating genes associated with mosquito susceptibility to DENV2 offers a theoretical foundation for targeted interventions to regulate or block viral replication and transmission within mosquitoes. Based on the transcriptomic analyses of the midgut and salivary glands from infected with DENV2, alongside analyses of Aag2 cell infections, 24 genes potentially related to the regulation of infection with DENV2 were selected.

Amino-Acid-Induced Circularly Polarized Luminescence of Octahedral Lanthanide Cage.

Chiral metal organic cage compounds with excellent circularly polarized luminescent performance have broad application prospects in many fields. Herein, two lanthanide complexes with luminescent properties in the form of racemic hexagonal octahedral cages were synthesized using a tri (β-diketone) ligand. Eu(CHFO)(HO) exhibited red light emission with high quantum yields of 61 %.

Dual-mode colorimetric and chemiluminescence aptasensor for organophosphorus pesticides detection using aptamer-regulated peroxidase-like activity of TA-Cu.

The residues of organophosphorus pesticides (OPs) in food pose a huge threat to human health. Therefore, the development of detection methods with simple design and high sensitivity is urgently needed. Here, a colorimetric/chemiluminescence (CL) dual-mode aptasensor strategy with high selectivity and sensitivity for detecting Parathion-methyl (PM) was designed based on aptamer-regulated nanozyme activity.

Phase estimation via coherent and photon-catalyzed squeezed vacuum states.

The research focused on enhancing the measurement accuracy through the use of non-Gaussian states has garnered increasing attention. In this study, we propose a scheme to input the coherent state mixed with a photon-catalyzed squeezed vacuum state into the Mach-Zender interferometer to enhance phase measurement accuracy. The findings demonstrate that photon catalysis, particularly multi-photon catalysis, can effectively improve the phase sensitivity of parity detection and the quantum Fisher information.

Optimal preservation condition for the extraction of cell-free DNA from bile of patients with biliary tract cancer.

Background: Patients with biliary tract cancer (BTC) often have dismal outcomes due to the poor performance of traditional methods for early diagnosis. Recently, bile cell-free DNA (cfDNA) has been reported as a potential liquid biopsy material for BTC diagnosis. However, bile is a complex alkaline aqueous medium, and the proper storage conditions for bile remain to be explored.

The shifts in microbial interactions and gene expression caused by temperature and nutrient loading influence Raphidiopsis raciborskii blooms.

Climate change and the trophic status of water bodies are important factors in global occurrence of cyanobacterial blooms. The aim of this study was to explore the cyanobacteria‒bacterial interactions that occur during Raphidiopsis raciborskii (R. raciborskii) blooms by conducting microcosm simulation experiments at different temperatures (20 °C and 30 °C) and with different phosphorus concentrations (0.

[Characteristics of Phytoplankton Community Structure in Lakes of Wetlands Dominated by Different Aquatic Plants and Its Driving Factors].

In wetland ecosystems, small shallow lakes are critical transition zones of land and water, which are usually dominated by aquatic plants with different growth forms. However, the differences and key influencing factors of phytoplankton communities in shallow lakes dominated by different aquatic plants are unclear. On this basis, nine surveys were conducted at five sampling sites of three lakes in Zhangye National Wetland Park from June to November in 2022, which were respectively dominated by the emergent （LL）, the submerged （CL）, and the floating-leaved （SL）.

Evaluation of Double Self-Immolative Linker-Based Antibody-Drug Conjugate FDA022-BB05 with Enhanced Therapeutic Potential.

Typical antibody-drug conjugates (ADCs) with valine-alanine linkage, often conjugated with the amino group in payloads, face challenges when interacting with hydroxyl group-containing payloads. Herein, we introduced a transformative Val-Ala-based double self-immolative linker-payload platform, reshaping ADCs by optimizing hydroxyl group-containing payload integration. Utilizing this platform, was successfully conjugated with the hydroxyl group-containing payload DXd using trastuzumab (FDA022) as the monoclonal antibody (mAb).

Dendrite-Free Lithium Batteries Enabled by an Artificial High-Dielectric Biopolymer Interface Layer.

Lithium (Li) metal batteries face challenges, such as dendrite growth and electrolyte interface instability. Artificial interface layers alleviate these issues. Here, cellulose nanocrystal (CNC) nanomembranes, with excellent mechanical properties and high specific surface areas, combine with polyvinylidene-hexafluoropropylene (PVDF-HFP) porous membranes to form an artificial solid electrolyte interphase (SEI) layer.

Effects of Multi-Sensory Stimulation on Apathy Symptoms in Elderly Patients with Alzheimer's Disease.

Background: We aimed to explore the effect of multi-sensory stimulation on apathy symptoms in elderly patients with Alzheimer's disease (AD).

Methods: Eighty elderly patients with AD admitted to the Third Affiliated Hospital of Qiqihar Medical University, China from January 2022 to February 2023 were selected as the research objects by convenient sampling method. According to the random number table, they were divided into intervention group and control group, with 40 cases in each group.