Large-scale fate tendency of lufenuron during cabbage cultivation: new insights into dietary risk and models comparison.

Elucidating the environmental fate and exposure risk of lufenuron is crucial to ensure food safety and protect human health. In this study, we developed a rapid and sensitive analytical method for tracing lufenuron in cabbages using ultra-high-performance liquid chromatography-tandem mass spectrometry. The occurrence, pharmacokinetic dissipation, and concentration variation of lufenuron were characterized by primary concentrations (0.

Integrating processing factors and large-scale cabbage cultivation to understand the fate tendency and health risks of tolfenpyrad using deterministic and probabilistic models.

Understanding the negative effects of agrochemicals on the environment and human health is indispensable for achieving green agriculture. In this study, the optimized UHPLC-MS/MS method achieved a highly sensitive quantification of tolfenpyrad in cabbage within 4.04 min.

Sensitive and portable intelligent detection platform construction and dietary risk assessment of procymidone in Chinese leek, cowpea and celery.

Procymidone (PRM), a widely used amide-type fungicide in vegetables, poses potential health risks due to its high detection rate. This study introduces a pretreatment device and an intelligent quantification method for PRM in Chinese leek, cowpea, and celery using a lateral flow immunoassay (LFIA) integrated with a smartphone. The whole pretreatment and detection process can be achieved within 21 min.

Quantitative tracing of typical herbicides and their metabolites in sorghum agrosystems for fate tendency and cumulative risk.

Elucidating the combined exposure of agrochemicals is essential for safeguarding human health and agroecosystem safety. A rapid and high-sensitivity UHPLC-MS/MS method was developed for simultaneous quantification of nine compounds in sorghum by an assembly-line optimization process with a limit of quantitation of 0.001 mg/kg.

Insights into the occurrence, distribution and dissipation of widespread agrochemicals in celery agrosystems for joint risk assessment.

Elucidating exposure risks associated with the most widely used agrochemicals and their metabolites in celery agrosystems are vital for food safety and human health. The occurrence, distribution, dissipation and metabolism of imidacloprid (IMI), acetamiprid (ACE), thiamethoxam (THM) and difenoconazole (DIF) in celery tissues reflected by initial depositions, uptake characteristics, half-lives, concentration variations. DIF exhibited unacceptable ecological risk to soil organisms under multi-risk evaluation models, including toxicity exposure ratio, risk quotient, and BITSSD model.

Oxidative stress, DNA damage, and gene expression in earthworms (Eisenia fetida) exposure to ethiprole.

To evaluate the potential ecotoxicity of ethiprole and early warning to earthworms (Eisenia fetida), different concentrations (0 mg·kg, 416 mg·kg, 625 mg·kg, and 1000 mg·kg) of ethiprole were added to artificial soil. The key bioindicators were measured and screened at 3 days, 7 days, 14 days, 21 days, and 28 days. The results show that the activity of catalase (CAT) was inhibited for all treatments during the whole exposure period.

A systemic study of cyenopyrafen in strawberry cultivation system: Efficacy, residue behavior, and impact on honeybees (Apis mellifera L.).

The pesticide application method is one of the important factors affecting its effectiveness and residues, and the risk of pesticides to non-target organisms. To elucidate the effect of application methods on the efficacy and residue of cyenopyrafen, and the toxic effects on pollinators honeybees in strawberry cultivation, the efficacy and residual behavior of cyenopyrafen were investigated using foliar spray and backward leaf spray in field trials. The results showed that the initial deposition of cyenopyrafen using backward leaf spray on target leaves reached 5.

Residue analysis and dietary risk assessment of picoxystrobin in potato (), citrus fruit ( Blanco), and Kimura et Migo.

Picoxystrobin is a systemic fungicide widely used on potato, citrus fruit, and . To provide information for the risk assessment of potato, citrus, and , field experiments combined with QuEChERS and HPLC-MS/MS were performed to detect picoxystrobin. Picoxystrobin had good linearity ( > 0.

Residue Analysis and Dietary Risk Assessment of Pymetrozine in Potato ( L.) and (Ramat).

Pymetrozine is used on potato () and () to obtain greater yield and quality. However, pesticide use carries the potential for residues to remain and be detected on harvested crops. Therefore, the aim of this study was to estimate pesticide residues in and products that are commercially available for human consumption and to assess the associated dietary risks.

Large-scale fate profiling of butralin between cultivated and processed garlics for multi-risk estimations.

Elaborating on the fate profiling and risk magnitude of butralin during large-scale applications was conducive to agroecosystems sustainability and dietary rationality. Occurrence, dissipation and concentration variation of butralin were elucidated from garlic cultivation to household processing by tracing UHPLC-MS/MS within 2 min, with regard to original depositions, half-lives, and terminal magnitude in typical origins of garlic. The processing factors (Pfs) of butralin were further clarified among washing, stir-frying and pickling of garlic crops, and pickling was the most effective way for butralin removal with a Pf of 0.

Oxidative stress, DNA damage, and gene expression induced by flufiprole enantiomers in the earthworms (Eisenia fetida).

To evaluate flufiprole enantiomers ecotoxicology and early warning to earthworms in the soil, the effect of flufiprole enantiomers on the activity of antioxidative enzymes (superoxide dismutase, SOD; catalase, CAT; peroxidase, POD), malondialdehyde (MDA) content, DNA damage and expression level of target genes (SOD, TCTP, l-rRNA, and HSP90) have been investigated. Compared to the controls, the activities of SOD, CAT, POD, and MDA content were first inhibited and then stimulated by all concentrations of flufiprole enantiomers in 28 days. The olive tail moment (OTM) value was maximum on the 14th day, then decreased gradually, and the higher the concentration, the slower the decrease.

Enantiomeric profiling of mefentrifluconazole in watermelon across China: Enantiochemistry, environmental fate, storage stability, and comparative dietary risk assessment.

Elucidating the enantiomeric chemistry and enantioselective fate of the novel chiral triazole fungicide mefentrifluconazole is of vital importance for agroecosystem safety and human health. The absolute configuration of mefentrifluconazole was identified firstly as S-(+)-mefentrifluconazole and R-(-)-mefentrifluconazole on a cellulose tris(3-chloro-4-methylphenylcarbamate) chiral phase. A baseline resolution (Rs, 2.

Stereoselective bioactivity, acute toxicity and dissipation in typical paddy soils of the chiral fungicide propiconazole.

Propiconazole is a widely used systemic agricultural triazole fungicide with two chiral centers. In the present study, systemic assessments of propiconazole stereoisomers are reported for the first time, including absolute configuration, stereoselective bioactivity toward pathogens (Ustilaginoidea virens, Magnaporthe oryzae, Fusarium moniliforme, Thanatephorus cucumeris, and Rhizoctonia solani), and stereoselective acute toxicity toward aquatic organisms (Scenedesmus obliquus, and Daphnia magna). Moreover, the stereoselective dissipation of propiconazole in three types of paddy soil under laboratory-controlled conditions (aerobic, anaerobic and sterile) was investigated.

The fate and enantioselective behavior of zoxamide during wine-making process.

The fate of zoxamide and its enantiomers were evaluated in detail during wine-making process. The enantiomers of zoxamide were separated and determined by ultra-high-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS) after each processing procedure including washing, peeling, fermentation and clarification. Significant enantioselectivity was observed in all three treatments with the half-lives of R-zoxamide and S-zoxamide estimated to be 45.

Stereoselective Analysis and Dissipation of Propiconazole in Wheat, Grapes, and Soil by Supercritical Fluid Chromatography-Tandem Mass Spectrometry.

An efficient and sensitive chiral analytical method was established for the determination of propiconazole stereoisomers by supercritical fluid chromatography-tandem mass spectrometry (SFC-MS/MS). Stereoisomeric separation was performed on a Chiralpak AD-3 column with CO/ethanol (93:7) as the mobile phase. The four propiconazole stereoisomers were well separated in 4.

Simultaneous enantioselective determination of phenylpyrazole insecticide flufiprole and its chiral metabolite in paddy field ecosystem by ultra-high performance liquid chromatography/tandem mass spectrometry.

A novel and sensitive ultra-high performance liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) method was developed and validated for simultaneous enantioselective determination of flufiprole and its hydrolysis metabolite in paddy field ecosystem. The separation and determination were performed using reversed-phase chromatography on a novel cellulose chiral stationary phase, a Lux Cellulose-4 (150 mm × 2.0 mm) column, under isocratic conditions at 0.

Green and sensitive supercritical fluid chromatographic-tandem mass spectrometric method for the separation and determination of flutriafol enantiomers in vegetables, fruits, and soil.

A green and sensitive chiral analytical method was developed to determine flutriafol enantiomers in vegetables (tomato, cucumber), fruits (apple, grape), and soil by supercritical fluid chromatography-tandem mass spectrometry. The enantioseparation was performed within 3.50 min using Chiralpak IA-3 column with CO2/methanol (88:12, v/v) as the mobile phase at a 2.

Comparison of different cleanup procedures for oil crops based on the development of a trace analytical method for the determination of pyraclostrobin and epoxiconazole.

The effects of different cleanup procedures in removing high-molecular-mass lipids and natural colorants from oil-crop extracts, including dispersive solid-phase extraction, low-temperature precipitation and gel permeation chromatography, were studied. The pigment removal, lipid quantity, and matrix effects of the three cleanup methods were evaluated. Results indicated that the gel permeation chromatography method is the most effective way to compare the dispersive solid-phase extraction and low-temperature precipitation.

Stereoselective separation and pharmacokinetic dissipation of the chiral neonicotinoid sulfoxaflor in soil by ultraperformance convergence chromatography/tandem mass spectrometry.

Ultraperformance convergence chromatography/tandem triple quadrupole mass spectrometry (UPC(2)-MS/MS) is a novel tool in separation science that combines the advantages of supercritical fluid chromatography with ultraperformance liquid chromatography/MS/MS technology. The use of nontoxic CO2 fluid and a postcolumn additive to complement MS/MS allows better control of analyte retention for chiral separation and high-sensitivity determination with different chiral stationary phases. This paper reports the stereoselective separation and determination of the chiral neonicotinoid sulfoxaflor in vegetables and soil by UPC(2)-MS/MS.

A quick, easy, cheap, effective, rugged, and safe method for the simultaneous detection of four triazolone herbicides in cereals combined with ultrahigh performance liquid chromatography with tandem mass spectrometry.

This paper describes a novel, rapid, and sensitive analytical method for monitoring four triazolone herbicides in cereals (wheat, rice, corn, and soybean), using a quick, easy, cheap, effective, rugged, and safe sample extraction procedure followed by ultrahigh performance liquid chromatography coupled with tandem mass spectrometry. The four triazolone herbicides (amicarbazone, carfentrazone-ethyl, sulfentrazone, and thiencarbazone-methyl) were extracted using acidified acetonitrile (containing 1% v/v formic acid) and subsequently purified with octadecylsilane (C18 ) prior to sample analysis. Ultrahigh performance liquid chromatography coupled with tandem mass spectrometry was operated in positive and negative ionization switching mode.

Stereoselective determination of a novel chiral insecticide, sulfoxaflor, in brown rice, cucumber and apple by normal-phase high-performance liquid chromatography.

An effective high-performance liquid chromatography method was developed for the stereoselective determination of a new sulfoximines insecticide, sulfoxaflor, in brown rice, cucumber and apple. Target compounds were extracted with acetonitrile and an aliquot cleaned with Cleanert PestiCarb/PSA (primary and secondary amine) cartridge. Five polysaccharide-based columns were investigated on the separation of sulfoxaflor stereoisomers and the best was achieved on a ChromegaChiral CCA column with n-hexane/ethanol/methanol (90:2:8, v/v/v) as mobile phase by UV detection at 220 nm at 20ºC.

Enantioselective separation and transformation of metalaxyl and its major metabolite metalaxyl acid in tomato and cucumber.

Many studies have shown the enantioselective transformation of metalaxyl in soil and animals, but little is known about the enantioselective biotransformation of metalaxyl in plants. In this study, a sensitive and convenient chiral liquid chromatography-tandem mass spectrometry method was developed for simultaneous measurement of the enantiomers of metalaxyl and its major metabolite, metalaxyl acid, in tomato and cucumber. Separation was by reversed-phase chromatography on a Chiralcel OD-RH column under isocratic conditions using acetonitrile-water (60/40, v/v) as mobile phase.

Enantioselective determination of the insecticide indoxacarb in cucumber and tomato by chiral liquid chromatography-tandem mass spectrometry.

A convenient and precise chiral method was developed and validated for measuring indoxacarb enantiomers in cucumber and tomato using liquid chromatography-tandem mass spectrometry (LC-MS/MS) with a reversed-phase Chiralpak AD-RH column. The target analytes were extracted by acetonitrile and then purified by solid phase extraction (SPE) using NH2 /Carb combined-cartridge. Parameters including the matrix effect, linearity, precision, accuracy, and stability were used.

Simultaneous enantioselective determination of triazole fungicide difenoconazole and its main chiral metabolite in vegetables and soil by normal-phase high-performance liquid chromatography.

Herein is reported, for the first time, a simple and highly sensitive chiral high-performance liquid chromatography (HPLC) method for the simultaneous quantitative determination of difenoconazole stereoisomers and their hydroxylated metabolite difenoconazole alcohol (CGA-205375) enantiomers in vegetables and soil matrix. The separation of difenoconazole and CGA-205375 including their simultaneous enantioseparation was studied using four different polysaccharide-type chiral stationary phases (CSPs) in combination with n-hexane-polar organic alcohols mobile phase. Chiralcel OJ consisting of 25 % of cellulose tris(4-methylbenzoate) coated on wide-pore polysaccharide silica gel exhibited higher resolving ability compared to cellulose tris(3,5-dimethylphenylcarbamate) (Chiralcel OD) as well as to its similar amylose derivative (Chiralpak AD) CSPs for this particular set of chiral analytes.