Color-neutral and reversible tissue transparency enables longitudinal deep-tissue imaging in live mice.

Light scattering in biological tissue presents a significant challenge for deep in vivo imaging. Our previous work demonstrated the ability to achieve optical transparency in live mice using intensely absorbing dye molecules, which created transparency in the red spectrum while blocking shorter-wavelength photons. In this paper, we extend this capability to achieve optical transparency across the entire visible spectrum by employing molecules with strong absorption in the ultraviolet spectrum and sharp absorption edges that rapidly decline upon entering the visible spectrum.

Preoperative halo traction for rigid spinal deformity in contractures, pterygia, and spondylocarpotarsal fusion syndrome 1B: a case report and literature review.

Purpose: This study reports a surgical case for spinal deformity in a patient with contractures, pterygia, and spondylocarpotarsal fusion syndrome 1B (CPSFSIB), a rare autosomal recessive musculoskeletal disorder caused by biallelic mutations in MYH3.

Methods: A female patient with congenital joint contractures was admitted due to severe thoracic scoliosis and lordosis. The patient was diagnosed with CPSFSIB following whole exome sequencing (WES).

Molecular Dynamics Study on Characterization of CO/Oil Miscibility in Nanopores.

CO enhanced oil recovery (CO-EOR) has received significant attention in the field of energy and environment due to its ability to increase oil production and reduce greenhouse gases. Minimum miscibility pressure (MMP) has become a research hotspot as a key parameter in the implementation process of this technology. In this paper, based on molecular dynamics simulation, the MMP of the established complex oil and gas system in the confined state is calculated by applying the diminishing interface method, which quantitatively analyzes the response rules of two-phase miscibility to the external conditions.

MAFF mitigates oxidative stress and pyroptosis in cardiopulmonary bypass-induced myocardium injury.

Background: Cardiopulmonary bypass (CPB) remains an indispensable technique for open-heart surgery; however, it induces systemic inflammation and oxidative stress, leading to myocardial cell damage and compromised prognosis. Optimizing myocardial protection during CPB remains a critical objective. This study aimed to identify potential therapeutic targets for myocardial protection during CPB.

Carbonation and Corrosion Durability Assessment of Reinforced Concrete Beam in Heavy-Haul Railways by Multi-Physics Coupling-Based Analytical Method.

The operation of heavy-haul railway trains with large loads results in significant cracking issues in reinforced concrete beams. Atmospheric carbon dioxide, oxygen, and moisture from the atmosphere penetrate into the beam interior through these cracks, accelerating the carbonation of the concrete and the corrosion of the steel bars. The rust-induced expansion of steel bars further exacerbates the cracking of the beam.

Machine-Learning-Enhanced Intelligent Recognition of Integrated Neuromorphic Vision Sensors Based on Copolyurethane.

Artificial photoreceptors utilizing piezoelectric polymers and semiconductors can convert external mechanical deformations, forces, or changes in light into electrical signals, making them essential for advanced optoelectronic sensors and smart wearable devices. However, this approach faces several challenges, including slow response time, weak signal, and high power consumption. This study synthesizes a series of polyurethanes containing azobenzene-based photoisomer units and ionic-liquid-based dipole units (comprising loose cation-anion pairs) based on the nanophotoelectric effect, wherein ultraviolet light induces isomerization of photoisomer segments and generates dynamic dipoles, creating equal amounts of charges with opposite signs at the electrodes.

Ciliated cell-derived IL-17D restrains allergic asthma through controlling monocyte recruitment.

The airway epithelium plays a crucial role in maintaining lung homeostasis, and its dysregulation is often linked to various lung diseases, including asthma. Ciliated cells, abundantly present in the mammalian airway epithelium, have a critical function in clearing inhaled particles and pathogens. We show here that ciliated cells constitutively express IL-17D, which functions as an immune brake in limiting allergic inflammation in murine models of asthma.

Adverse childhood experiences contribute to increased risk of health in middle and late life: The longitudinal mediating effect of activities of daily living and chronic diseases.

Background: Adverse Childhood Experiences (ACEs) have long-term effects on health, but the mechanisms remain unclear.

Objective: To investigate the association between ACEs and health status, exploring the potential mediating roles of activities of daily living (ADL) and chronic diseases.

Participants And Setting: 9575 middle-aged and older adults from the China Health and Retirement Longitudinal Study (CHARLS).

Development and validation of a visual nomogram for predicting clinically significant prostate cancer in negative mpMRI using Ga-PSMA PET/CT.

Multi-parametric magnetic resonance imaging (mpMRI) is a valuable medical technology for detecting clinically significant prostate cancer (csPCa). The diagnostic accuracy of mpMRI for csPCa in negative mpMRI (PI-RADS 1-2) remains suboptimal, underscoring the need for improvements for csPCa. This study aimed to build a visual predictive nomogram for early detection of csPCa in negative mpMRI.

Virtual reality force feedback spine surgery simulator training for pedicle screw placement: assessing the impact of seniority and spinal region.

Objective: To evaluate the efficacy of Virtual Reality Force Feedback Spine Surgery Training Simulators (VRFF-SSTS) in enhancing the skills of spinal pedicle screw placement (PSP) among orthopedic fellows in continuing medical education, and whether influenced by seniority and spinal location.

Methods: A multi-centered, cross-sectional study enrolled fellows from three tertiary care referral hospitals. Participants were categorized into three groups (A, B, and C) based on their post-graduation year (PGY), reflecting their hierarchical order of spine-surgical training: A (PGY1-5), B (PGY6-10), and C (> 10).

Divergent and Selective Synthesis of Functionalized Fluoroalkenes through Switchable Photocatalytic Dialkylation/Cyclization of Alkenes.

A switchable photocatalytic dialkylation/cyclization of alkenes with α-CF alkenes and protic C(sp)-H feedstocks was readily achieved by simply switching the commercially available base and/or its stoichiometry. This mild strategy enabled the divergent one-pot synthesis of diverse functionalized fluoroalkenes including gem-difluoroalkenes, monofluorocyclohexenes, and 2-fluoropyrrolines in a single operational step.

Modified Frailty Index-11-A New Predictor of Postoperative Complications in the Aging Thoracic Spinal Stenosis Patients.

Objective: Operation for thoracic spinal stenosis (TSS) is considered a high-risk surgery. Because of the frailty of elderly patients, the prediction for postoperative complications is crucial. This study investigated the relationship between frailty, as measured by the modified frailty index-11 (mFI-11), and postoperative complications in elderly patients with thoracic myelopathy secondary to TSS.

Risk Factors for Poor Matching of Intervertebral Fusion Devices After Posterior Vertebral Column Resection in Patients With Kyphosis or Kyphoscoliosis.

Objectives: Numerous studies have reported the manifestations and influencing factors of poor matching of intervertebral fusion devices (IFDs) in patients with cervical and lumbar degenerative diseases. However, there is currently no research addressing the use of IFDs matching in posterior vertebral column resection (PVCR) procedures. The purpose of this retrospective radiographic study was to analyze the risk factors associated with poor matching of IFDs following PVCR.

Sub-inhibitory concentrations of fosfomycin enhance biofilm formation by a -dependent mechanism.

readily forms biofilms, which contribute to antimicrobial resistance and the persistence of chronic infections. This study investigates the effects of sub-inhibitory concentrations of fosfomycin on biofilm formation and elucidates the underlying molecular mechanisms. Using crystal violet staining and confocal laser scanning microscopy, we demonstrated that fosfomycin at 1 µg/mL significantly enhanced biofilm biomass by 1.

Stillbirth increase long-term health risks of diabetes, CVD, CVD mortality, and all-cause mortality.

Background: Fewer studies on association of single stillbirth exposure with long-term health outcomes in women. In this study of cohort data from UK Biobank, we aim to explore the association of stillbirth with the risk of diabetes, cardiovascular disease (CVD), all-cause mortality, CVD mortality, ischemic heart disease (IHD), myocardial infarction (MI), heart failure (HF), and stroke.

Methods: We initially included 502,366 participants aged 40-69 years.

In situ vascularization and epithelialization of segmental bioengineered trachea based on marrow-derived stem/progenitor cells.

The success of tracheal transplantation depends on the rapid establishment of vascularization and epithelialization to support functional tissue formation. This study presents an innovative approach for in situ transplantation of a biomimetic tracheal graft, integrating microvascularization and epithelialization. First, endothelial progenitor cells (EPCs) and mesenchymal stem cells (MSCs) were isolated and purified from bone marrow, serving as seed cells for graft vascularization and epithelialization.

The Influence of Different Kidney Replacement Modalities on Health-Related Quality of Life in ESKD Patients.

Background: Health-related quality of life (HRQOL) has gained increasing emphasis on the long-term outcome of patients taking sustained kidney replacement therapy (KRT). However, the influence of KRT modalities on patients' quality of life and their comparison needs further investigation.

Methods: This study included 267 patients: 101 under hemodialysis (HD), 87 under peritoneal dialysis (PD) and 79 received kidney transplantation (KT).

EGFRvIII-positive glioblastoma contributes to immune escape and malignant progression via the c-Fos-MDK-LRP1 axis.

Epidermal growth factor receptor variant III (EGFRvIII) confers growth advantage to glioblastoma multiforme (GBM) and is associated with significantly shorter survival in GBM patients. The interaction between tumor cells and macrophages plays a crucial role in tumor development, supporting angiogenesis, nurturing tumor stem cells, and promoting immune-suppressive TME. Therefore, elucidating the potential mechanisms by which EGFRvIII mutation in GBM cells regulates surrounding immune cells to drive tumor progression may provide new targets for precise immune therapy for specific GBM subtypes or genotypes.

Deep learning and inflammatory markers predict early response to immunotherapy in unresectable NSCLC: A multicenter study.

Immune checkpoint inhibitors (ICIs) demonstrate substantial interpatient variability in clinical efficacy for unresectable non-small cell lung cancer (NSCLC), underscoring the unmet need for noninvasive biomarkers to predict early therapeutic responses and improve survival outcomes. To address this, we developed a CT-based deep learning model integrated with the systemic immune-inflammatory-nutritional index (SIINI) for early prediction of ICI response. In a retrospective multicenter study of 265 patients treated with ICIs (incorporating chest CT and laboratory data), the cohort was divided into training (70%), internal validation (30%), and external validation sets.

Midterm Outcomes of Castor Stent Graft in Treatment of Type B Aortic Dissection Involving Left Subclavian Artery: A Retrospective Single-Center Study.

Objective: For type B aortic dissection (TBAD) involving the left subclavian artery (LSA), to secure sufficient proximal landing zones, the LSA can be intentionally covered during thoracic endovascular aortic repair (TEVAR). This study aimed to evaluate the midterm clinical outcomes of endovascular treatment for TBAD involving the LSA using the Castor single-branched stent graft.

Aims: The aim of this study was to evaluate the midterm efficacy and safety of Cator stent graft in the treatment of type B aortic dissection involving left subclavian artery.

Predicting infarct outcomes after extended time window thrombectomy in large vessel occlusion using knowledge guided deep learning.

Background: Predicting the final infarct after an extended time window mechanical thrombectomy (MT) is beneficial for treatment planning in acute ischemic stroke (AIS). By introducing guidance from prior knowledge, this study aims to improve the accuracy of the deep learning model for post-MT infarct prediction using pre-MT brain perfusion data.

Methods: This retrospective study collected CT perfusion data at admission for AIS patients receiving MT over 6 hours after symptom onset, from January 2020 to December 2024, across three centers.

A Novel Germline Mutation (p.W156∗) in High-Grade Astrocytoma, Mutant.

Germline mutations in the DNA repair gene () are established predisposing factors for colorectal polyposis, colorectal carcinoma, and various extracolonic malignancies. Nevertheless, the association between mutations and central nervous system (CNS) tumorigenesis remains poorly characterized. In this study, we reported the first identification of a novel c.