Comparative Multi-Omics Analysis and Antitumor Activity of and .

Wood-decay fungi, particularly those within the genus, have attracted considerable interest due to their diverse bioactivities, including antitumor, immune-modulatory, anti-inflammatory, antiviral, antioxidant, and antibacterial effects. This study conducted a comparative analysis of the antitumor activities and underlying molecular mechanisms of two species, and , from Shandong Province. assays demonstrated that ethanol extract from the two species exhibited significant, time- and concentration-dependent inhibition of breast cancer (MCF-7), esophageal cancer (Eca-109), and human non-small cell lung cancer (A549).

Electro-switchable cellulose nanocrystal films with chiroptical properties.

A series of stable electro-switchable cellulose nanocrystal (CNC) films is fabricated by the covalent functionalization of preassembled chiral nematic CNC substrates with electro-active molecules. Through this approach, we anchor siloxy-group-containing viologens (SV) to the surface of CNCs in a preformed film. Unlike conventional premixing strategies that typically disrupt chiral self-assembly of CNCs, this method produces films that retain the structural color and chiroptical properties of the chiral nematic CNC substrate, while exhibiting stable electrochromic performance.

Dosimetry study of 3D-printed noncoplanar template-assisted CT-guided 125I seed implantation for the treatment of recurrent and metastatic tumors in the head and neck.

Objective: Recurrent and metastatic tumors of the head and neck pose significant treatment challenges due to their proximity to critical structures and prior radiation exposure. This study aimed to evaluate the consistency between preoperative and postoperative dosimetric parameters in CT-guided 3D-printed noncoplanar template (3DPNCT)-assisted radioactive iodine-125 seed implantation (RISI).

Methods: Twenty-six patients with recurrent or metastatic head and neck cancer were retrospectively analyzed.

Machine-Learning-Enhanced Intelligent Recognition of Integrated Neuromorphic Vision Sensors Based on Copolyurethane.

Artificial photoreceptors utilizing piezoelectric polymers and semiconductors can convert external mechanical deformations, forces, or changes in light into electrical signals, making them essential for advanced optoelectronic sensors and smart wearable devices. However, this approach faces several challenges, including slow response time, weak signal, and high power consumption. This study synthesizes a series of polyurethanes containing azobenzene-based photoisomer units and ionic-liquid-based dipole units (comprising loose cation-anion pairs) based on the nanophotoelectric effect, wherein ultraviolet light induces isomerization of photoisomer segments and generates dynamic dipoles, creating equal amounts of charges with opposite signs at the electrodes.

A retrospective study of automatic progressive optimization for lung cancer radiotherapy plans on the Halcyon and RayStation systems.

This study aims to evaluate the feasibility of using RayStation's scripting function to generate automated radiotherapy plans for non-small cell lung cancer (NSCLC) patients on a Varian Halcyon accelerator and to compare their dosimetric characteristics with those of retrospectively collected manual clinical plans. A total of 63 conventional fractionation plans for NSCLC, previously designed using RayStation 4.5 for a variety of linear accelerators-including Trilogy, TrueBeam, Halcyon, and Elekta Infinity-were compared with automated plans generated using RayStation 9.

Cancer therapy resistance from a spatial-omics perspective.

Cancer therapy resistance (CTR) remains a significant challenge in oncology. Traditional methods like imaging, liquid biopsies and conventional omics analyses provide valuable insights, but lack the spatial resolution to fully characterise heterogeneity of tumour and the tumour microenvironment (TME). Recent advancements in spatial omics technologies offer unprecedented insights into the spatial organisation of tumours and TME.

Comprehensive Understanding of Closed Pores in Hard Carbon Anode for High-Energy Sodium-Ion Batteries.

Hard carbon (HC) is considered the most promising anode material for sodium-ion batteries (SIBs) due to its high cost-effectiveness and outstanding overall performance. However, the amorphous and intricate microstructure of HC poses significant challenges in elucidating the structure-performance relationship, which has led to persistent misinterpretations regarding the intrinsic characteristics of closed pores. An irrational construction methodology of closed pores inevitably results in diminished plateau capacity, which severely restricts the practical application of HC in high-energy-density scenarios.

Interfacial Structure Design for High-Voltage and Safe Polymer Solid-State Lithium Batteries.

Solid polymer electrolytes (SPEs) have garnered significant attention as key enablers for next-generation lithium metal batteries (LMBs), offering the potential for enhanced safety and higher energy density. However, critical challenges persist at the interfaces between SPEs and both lithium metal anodes and high-voltage cathodes, where electrochemical, mechanical, and chemical instabilities severely limit long-term performance. This review focuses on the fundamental origins and manifestations of these interfacial issues and summarizes recent progress in addressing them through materials design and interface engineering.

WRN as a Novel Target of Synthetic Lethality: Current Advances and Future Perspectives.

Werner syndrome (WS) is an autosomal recessive disorder caused by mutations in the Werner syndrome protein (WRN, also known as RecQ3) gene. As a pivotal member of the RecQ DNA helicase family, WRN facilitates essential processes in DNA replication, recombination, and repair, thus safeguarding genomic stability. In this perspective, we provide a critical analysis of WRN's structural and biological features as well as its regulatory networks.

Regulating the structure of hard carbon derived from industrial waste to boost sodium storage performance.

Biomass-derived hard carbon materials stand out in the research of anode materials for sodium-ion batteries (SIBs) due to their low cost, high performance, and broad range of raw materials. However, the low carbonization yields of biomass-derived hard carbons and the waste produced during industrial production processes contribute to the high production cost of these hard carbons. Furthermore, it is essential to discuss the use of various electrolytes aimed at enhancing the ion storage capacity within SIBs.

Ultrafast Thermal Engineering in Energy Materials: Design, Recycling, and Future Directions.

Energy materials are essential for addressing global energy challenges, and their design, recycling, and performance optimization are critical for sustainable development. To efficiently rise to this occasion, advanced technology should be explored to address these challenges. This review focuses on the potential of ultrafast thermal engineering as an innovative approach to the design and recycling of energy materials and systematically examines ultrahigh temperature shock's origins, mechanisms, and developmental progress, clarifying fundamental differences between the Joule heating and carbothermal shock modes.

Synergistic Regulation of Multi-Interface Chemistry by Functional Carbon Dots for High-Performance Composite Solid Electrolytes.

Low ionic conductivity, poor mechanical strength, and unstable interface structure are still the main factors hindering the practical application of polymer solid-state lithium metal batteries (SSLMBs). In this work, we have developed a unique composite filler (LLZTOCDs) for solid polymer electrolytes to address these challenges through synergistic regulation of multi-interface chemistry. The LLZTOCDs is prepared via thermal treatment of N,S,F-codoped carbon dots (NSFCDs) and LiLaZrTaO (LLZTO) inorganic electrolyte.

Preliminary findings on psychometric properties of the adolescent story stem profile.

Introduction: The Adolescent Story Stem Assessment Profile (ASSP) is a newly developed narrative measure aimed at assessing the psychological wellbeing of adolescents. This study investigates the psychometric properties of the ASSP within the British population, with the goal of elucidating its unique strengths and limitations.

Methods: We conducted an exploratory factor analysis on the responses of a community sample of adolescents in the UK ( = 182) to identify the underlying factors that reflect adolescents' internal representations as measured by the ASSP.

Improving the Long-Term Cycling Stability of Sodium Metal Anodes with LiBF Additives.

The lower redox potential and higher theoretical specific capacity of the sodium metal anode make sodium metal batteries highly promising. However, the uneven plating/stripping behavior of sodium resulted in the growth of sodium dendrites and the decrease in Coulombic efficiency (CE). In this study, LiBF was used as an additive in an ether-based electrolyte.

Toward quantitative cognitive-behavioral modeling of psychopathology: An active inference account of social anxiety disorder.

Understanding psychopathological mechanisms is a central goal in clinical science. While existing theories have demonstrated high research and clinical utility, they have provided limited quantitative explanations of mechanisms. Previous computational modeling studies have primarily focused on isolated factors, posing challenges for advancing clinical theories holistically.

Modality-Aware Distillation Network for Microvascular Invasion Prediction of Hepatocellar Carcinoma From MRI Images.

Microvascular invasion (MVI) of hepatocellular carcinoma (HCC) is a crucial histopathologic prognostic factor associated with cancer recurrence after liver transplantation or hepatectomy. Recently, clinicoradiologic characteristics are combined with medical images to enhance the HCC prediction. However, compared to medical imaging data, the clinicoradiologic characteristics (e.

A stereodynamic probe of Pt(II) molecular hinge for chiroptical sensing of cryptochiral compounds.

Cryptochiral compounds are indispensable in biology systems and medical applications, yet the development of high-performance detection method remains challenging. Here, we report a hinge-like dinuclear Pt(II) complex as a stereodynamic probe for cryptochirality sensing. This probe features a constrained, closed conformation achieved through synergistic intramolecular π - π stacking and metal-metal interactions between cyclometalated Pt(II) wings.

The Na-K-ATPase alpha subunit is an entry receptor for white spot syndrome virus.

Unlabelled: White spot syndrome virus (WSSV) is a debilitating viral pathogen that poses a significant threat to the global crustacean farming industry. It has a wide host tropism because it uses several receptors to facilitate its attachment and entry. Thus far, not all the receptors have been identified.

Glucose Oxidase Promoting Cellulase-Assisted Hydrodistillation for the Extraction of Essential Oil From Eleutherococcus Senticosus.

Eleutherococcus senticosus essential oil (ESEO) has the function of clearing heat and detoxifying, delaying aging. The ESEO yield obtained by traditional extraction methods is low because essential oils are encased in plant cell structures and are difficult to extract. In this work, we adopted the method of glucose oxidase promoting cellulase-assisted hydrodistillation, and utilized the interaction of glucose oxidase and cellulase to promote the full destruction of cellulose in plant cells, resulting in a large amount of internal essential oil flowing out and improving the yield of ESEO.

Comparative analysis of VMAT plans on Halcyon and infinity for lung cancer radiotherapy.

Objective The dosimetric characteristics and treatment efficiency of VMAT plans using two linear accelerator platforms, Halcyon and Infinity, in conventional radiotherapy for non-small cell lung cancer (NSCLC) are compared to provide data for selecting clinical equipment. The study also explores potential confounding factors that may influence treatment outcomes. Methods This retrospective cohort study aims to compare the dosimetric characteristics and treatment efficiency of VMAT plans delivered using Halcyon and Infinity linear accelerator platforms in patients with NSCLC.

JotlasNet: Joint tensor low-rank and attention-based sparse unrolling network for accelerating dynamic MRI.

Joint low-rank and sparse unrolling networks have shown superior performance in dynamic MRI reconstruction. However, existing works mainly utilized matrix low-rank priors, neglecting the tensor characteristics of dynamic MRI images, and only a global threshold is applied for the sparse constraint to the multi-channel data, limiting the flexibility of the network. Additionally, most of them have inherently complex network structure, with intricate interactions among variables.

Durable Hydrophobic Iridescent Films with Tunable Colors from Self-Assembled Cellulose Nanocrystals.

Cellulose nanocrystals (CNCs) are known to self-assemble into a left-handed chiral nematic lyotropic liquid crystalline phase in water. When captured in the solid state, this structure can impart films with photonic properties that make them promising candidates in photonics, sensing, security, and other areas. Unfortunately, the intrinsic hydrophilicity of CNCs renders these iridescent films susceptible to moisture, thereby limiting their practicality.

Potassium escaping balances the degree of graphitization and pore channel structure in hard carbon to boost plateau sodium storage capacity.

Biomass holds significant potential for large-scale synthesis of hard carbon (HC), and HC is seen as the most promising anode material for sodium-ion batteries (SIBs). However, designing a HC anode with a rich pore structure, moderate graphitization and synthesis through a simple process using a cost-effective precursor to advance SIBs has long been a formidable challenge. This is primarily because high temperatures necessary for pore regulation invariably lead to excessive graphitization.

Revealing the structural influence mechanism of intrinsic potassium/calcium elements on bio-waste-derived hard carbon for sodium-ion batteries.

Waste gourd shells enriched with ash-forming elements are selected as raw materials in this paper, discovering that the K and Ca compounds in the precursor not only exhibit the ability of self-forming pores, but also demonstrate catalytic graphitization of the hard carbon during the pyrolysis procedure.

Automatic detection of fluorescent droplets for droplet digital PCR: a device capable of processing multiple microscope images.

Droplet digital PCR (ddPCR) is recognized as a high-precision method for nucleic acid quantification, extensively utilized in biomedical research and clinical diagnostics. This technique employs microfluidic technology to partition the nucleic acid-containing reaction mixture into discrete droplets for amplification, achieving absolute quantification by identifying and enumerating the number of fluorescent droplets. The accuracy of droplet quantification is pivotal to the success of the assay.