Acute kidney disease in patients with COVID-19. A prospective, multicenter, multinational study in Latin America.

Introduction: Acute kidney disease (AKD) is defined as functional and/or structural abnormalities of kidneys with health implications and a duration of ≤90 days. This study aimed to evaluate AKD as a more appropriate approach to these conditions for which we used a cohort of COVID-19 patients in whom kidney impairment is expressed by proteinuria and/or loss of function.

Methods: Observational, prospective, longitudinal, multinational cohort study conducted across five Latin American countries.

L.: Analysis of Chemical Profile and Cytotoxic Action on Tumor (HeLa) and Non-Tumor Cells (NIH/3T3).

This study analyzed the antiproliferative potential of L. leaf extracts against cervical cancer and non-cancerous cell lines. The extracts were prepared by maceration using hexane (EUH), dichloromethane (EUD), and ethyl acetate (EUA).

Preschool Hearing Screening: Nineteen Years of the Coração Delta Project in Campo Maior, Portugal.

: Preschool hearing screening is justified by the risk of late onset hearing loss, the high prevalence of otitis media with effusion in school-aged children, and the critical timing just before children begin formal reading and learn to write. This study describes the results of the annual preschool hearing screening program in Campo Maior from 2007 to 2025 (nineteen years) and correlates the audiological referral to the otoscopy findings by the otolaryngologists. : Retrospective study using clinical records from nineteen years of preschool hearing screening.

First molecular evidence of vertical transmission of Ehrlichia canis in naturally infected female dogs in Brazil.

Ehrlichia canis is an obligate intracellular bacterium transmitted by the tick Rhipicephalus sanguineus sensu lato. This pathogen is also the etiological agent of canine monocytic ehrlichiosis, a disease with widespread global distribution and recognized zoonotic potential. Although vector-borne transmission is well established, evidence supporting the occurrence of vertical transmission remains limited.

Talquetamab-Induced Dysgeusia Successfully Treated With Photobiomodulation Therapy.

Multiple myeloma is a malignancy characterized by clonal proliferation of plasma cells in the bone marrow. The treatment of patients with relapsed or refractory multiple myeloma remains a challenge. Talquetamab is a recently approved drug, a first-in-class GPRC5D-targeting T-cell redirecting bispecific antibody, for treatment of patients with triple-class exposed relapsed/refractory multiple myeloma.

Trajectories of change in mothers' parenting confidence and relationship with baby: a 15-month qualitative longitudinal study.

Background: Parents' experiences and their relationship to their baby undergo various changes over the course of the first year. This is particularly the case for mothers, who still tend to take on the primary caregiver role in most families in the UK. Better understanding the changes mothers experience in the first year is of importance given the impact of the parent-infant relationship for children's socio-emotional development.

Pelvic Actinomycosis Related to Intrauterine Device: A Case Report.

Actinomycosis is a rare but persistent bacterial infection caused by  spp., a Gram-positive bacillus that typically inhabits the oropharynx and gastrointestinal and urogenital tracts. It can infiltrate deeper tissues following trauma, surgery, or foreign body presence, forming granulomatous masses of filamentous bacilli.

Embryological, clinical, and newborn outcomes from 583 treatment cycles with fresh and frozen testicular spermatozoa.

Background: Besides non-obstructive azoospermia, other conditions also benefit from the use of testicular sperm extraction, but their clinical outcomes remain to be explored in detail.

Objective: To compare the use of fresh and frozen testicular spermatozoa in patients submitted to testicular sperm extraction because of idiopathic or secondary non-obstructive azoospermia, and after recurrent failed intracytoplasmic sperm injection attempts using ejaculated or aspirated testicular spermatozoa.

Materials And Methods: We retrospectively evaluated 325 patients with normal karyotypes and absence of Y-chromosome microdeletions that used testicular sperm extraction for fertility treatments.

Eugenia brasiliensis: Analysis of the Chemical Profile and Evaluation of Cytotoxic Potential.

This work evaluated the antiproliferative potential of Eugenia brasiliensis leaf extracts against the HeLa cervical cancer cell line. The extracts were prepared by maceration using hexane (EBH), dichloromethane (EBD), and ethyl acetate (EBAE), and they were evaluated for their antiproliferative potential through a 3-4,5-dimethyl-thiazol-2-yl-2,5-diphenyltetrazoliumbromide (MTT) assay in the cervical cancer cell culture (HeLa cell line) and a non-cancer cell line (NIH-3T3). EBH, EBD, and EBAE were cytotoxic in HeLa cells, with 50% inhibition concentration (IC) = 97.

Is it Safe to Perform Concomitant Cholecystectomy in Patients With Confirmed Gallbladder Disease Undergoing Metabolic and Bariatric Surgery? An Updated Meta-Analysis.

Introduction: Obesity is a global public health issue, and metabolic and bariatric surgery (MBS) remains most effective intervention for achieving and maintaining long-term weight loss. However, rapid weight loss following MBS increases the risk of gallstone formation. Concomitant cholecystectomy (CC) during MBS has been proposed to mitigate this risk, but recent studies present conflicting evidence regarding its safety and efficacy, leaving no clear consensus.

Preliminary findings on psychometric properties of the adolescent story stem profile.

Introduction: The Adolescent Story Stem Assessment Profile (ASSP) is a newly developed narrative measure aimed at assessing the psychological wellbeing of adolescents. This study investigates the psychometric properties of the ASSP within the British population, with the goal of elucidating its unique strengths and limitations.

Methods: We conducted an exploratory factor analysis on the responses of a community sample of adolescents in the UK ( = 182) to identify the underlying factors that reflect adolescents' internal representations as measured by the ASSP.

Urinary NGAL and KIM-1 in Canine Monocytic Ehrlichiosis.

Glomerulonephritis, caused by the deposition of immune complexes, can lead to kidney damage in dogs with canine monocytic ehrlichiosis (CME). The early diagnosis of renal insult is important to prevent severe kidney disease in infected dogs by . This study aimed to investigate urinary biomarkers of renal function, neutrophil gelatinase (uNGAL), and kidney injury molecule-1 (uKIM-1) using the Luminex xMAP platform, and the proportion of mixed or high molecular weight proteinuria in dogs with CME.

Intraoperative Frozen Section Biopsy for the Auxiliary Diagnosis of Transmural Intestinal Intermediate T-Cell Canine Lymphoma.

Intestinal lymphoma is characterized by a malignant lymphoid neoplasm with multifactorial causes, variable clinical symptoms, and, in some cases, rapid progression. This article describes a case of intestinal lymphoma in a dog that had a history of diarrhea lasting two months, accompanied by episodes of hematochezia, which was treated using the CHOP 19 protocol. A seven-year-old male Golden Retriever presented to a veterinary clinic with clinical signs of diarrhea, prostration, and the presence of bloody feces, as reported by the owner.

Atypical presentation of a common condition.

Cow's milk protein allergy (CMPA) presents a wide range of clinical manifestations. Although gastrointestinal symptoms are common, they are not always present. In this report, we present two cases of infants with atypical CMPA presentations.

Sleep neuroimaging: Review and future directions.

Sleep research has evolved considerably since the first sleep electroencephalography recordings in the 1930s and the discovery of well-distinguishable sleep stages in the 1950s. While electrophysiological recordings have been used to describe the sleeping brain in much detail, since the 1990s neuroimaging techniques have been applied to uncover the brain organization and functional connectivity of human sleep with greater spatial resolution. The combination of electroencephalography with different neuroimaging modalities such as positron emission tomography, structural magnetic resonance imaging and functional magnetic resonance imaging imposes several challenges for sleep studies, for instance, the need to combine polysomnographic recordings to assess sleep stages accurately, difficulties maintaining and consolidating sleep in an unfamiliar and restricted environment, scanner-induced distortions with physiological artefacts that may contaminate polysomnography recordings, and the necessity to account for all physiological changes throughout the sleep cycles to ensure better data interpretability.

Presentation of an Auditory Training Protocol Applied in Children with Central Auditory Processing Disorder.

Purpose: To present an auditory training protocol in children with Central Auditory Processing Disorder (CAPD).

Methods: The study included nine children aged from 9 to 12, with five females and four males. Only children with auditory thresholds within the normal range and bilateral type A tympanometric curves were selected.

Cholesterol Functionalized Nanoparticles Are Effective against Helicobacter pylori, the Gastric Bug: A Proof-of-Concept Study.

Helicobacter pylori chronic infection is the highest risk factor for the development of gastric cancer, being this Gram-negative bacterium classified as carcinogenic. The mounting resistance of H. pylori to antibiotics calls for innovative therapeutic strategies.

The impact of atrial voltage and conduction velocity phenotypes on atrial fibrillation recurrence.

Introduction: Low atrial voltage and slow conduction velocity (CV) have been associated with atrial fibrillation (AF); however, their interaction and relative importance as early disease markers remain incompletely understood. We aimed to elucidate the relationship between atrial voltage and CV using high-density electroanatomic (HDE) maps of patients with AF.

Methods: HDE maps obtained during sinus rhythm in 52 patients with AF and five healthy controls were analysed.

Multimodal imaging in retinitis pigmentosa related to the EYS gene.

Purpose: This study aimed to characterize retinitis pigmentosa associated with the eyes shut homolog gene, which causes hereditary retinal degeneration.

Methods: The anatomical and functional findings of retinitis pigmentosa in patients with variants of the eyes shut homolog gene were characterized and compared using multimodal imaging and genetic analysis of the variants. Clinical data such as visual acuity, lens status, and refraction were obtained from medical records.

Deprescribing oral antidiabetics in elderly patients: Do electronic leaflets across the world address it?

Unlabelled: Diabetes caused 6.7 million deaths in 2021, equating to one death every five seconds, with its global financial burden projected to rise from $1.32 trillion in 2015 to $2.

Investigating the Biological Efficacy of Albumin-Enriched Platelet-Rich Fibrin (Alb-PRF): A Study on Cytokine Dynamics and Osteoblast Behavior.

The development of effective biomaterials for tissue regeneration has led to the exploration of blood derivatives such as leucocyte- and platelet-rich fibrin (L-PRF). A novel variant, Albumin-Enriched Platelet-Rich Fibrin (Alb-PRF), has been introduced to improve structural stability and bioactivity, making it a promising candidate for bone regeneration. This study aimed to evaluate Alb-PRF's capacity for cytokine and growth factor release, along with its effects on the proliferation, differentiation, and mineralization of human osteoblasts in vitro.

Construction and validation of an instrument to identify barriers to implementing pharmaceutical care.

Background: Pharmaceutical Care is a professional practice in high demand for implementation in Primary Health Care within the Public Health System. Consequently, it was necessary to develop and validate an instrument to assess the obstacles to this process.

Methods: A methodological study was conducted in three stages: first, the questionnaire was developed based on the APOTECA framework, which includes Attitudinal, Political, Technical, and Administrative domains.

Ritonavir's Evolving Role: A Journey from Antiretroviral Therapy to Broader Medical Applications.

Ritonavir is a protease inhibitor initially developed for HIV treatment that is now used as a pharmacokinetic booster for other antiretrovirals due to it being a cytochrome P450 3A4 enzyme and P-glycoprotein inhibitor. Consequently, ritonavir is of special interest for repurposing in other diseases. It had an important role in battling the COVID-19 pandemic as a part of the developed drug Paxlovid in association with nirmatrelvir and has shown effects in hepatitis and other pathogenic diseases.