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Mycotoxin contamination in maize has been a longstanding public concern. This study developed a high-performance liquid chromatography tandem mass spectrometry method for the analysis of 17 mycotoxins and investigated the contamination characteristics of maize grains from three planting regions in China. The results revealed that a total of 12 mycotoxins were detected, with co-occurrence rates of at least 2, 5, and 10 mycotoxins in maize being 69.9%, 30.1%, and 1.0%, respectively. Risk assessment indicated that deoxynivalenols (DON,15AcDON,3AcDON), fumonisins (FB1,FB2) and zearalenones (ZEN,ZAN,α-ZEL,β-ZEL) posed no potential health risks. However, when the three regions were evaluated individually, the estimated daily intake (EDI) value at P95 exposure level for rural male children accounted for 136.6% of the group Tolerable Daily Intake (TDI) for zearalenones in southwest mountainous planting region. Meanwhile, the EDI values (P95) for these three types of mycotoxins in other population groups and regions did not exceeded their respective group TDIs.
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http://dx.doi.org/10.1016/j.foodchem.2025.144253 | DOI Listing |
Genet Med
September 2025
Division of Medical Genetics, University of Washington School of Medicine.
Purpose: The fourth phase of the Electronic Medical Records and Genome Network (eMERGE4) is testing the return of 10 polygenic risk scores (PRS) across multiple clinics. Understanding the perspectives of health-system leaders and frontline clinicians can inform plans for implementation of PRS.
Methods: Fifteen health-system leaders and 20 primary care providers (PCPs) took part in semi-structured interviews.
J Magn Reson Imaging
September 2025
Department of Neurology, Dell Medical School, University of Texas at Austin, Austin, Texas, USA.
Background: Cerebrovascular reactivity reflects changes in cerebral blood flow in response to an acute stimulus and is reflective of the brain's ability to match blood flow to demand. Functional MRI with a breath-hold task can be used to elicit this vasoactive response, but data validity hinges on subject compliance. Determining breath-hold compliance often requires external monitoring equipment.
View Article and Find Full Text PDFAnn Geriatr Med Res
September 2025
Institute of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan.
Background: Poor hand dexterity may increase the risk of functional disability; however, few studies have examined the relationship between hand dexterity and incident functional disability. The aim of this study was to prospectively investigate the dose-response association of hand dexterity with incident functional disability in community-dwelling older adults.
Methods: This study included 1,069 older adults aged ≥65 years in Kasama City, Japan.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
May 2025
Department of Cardiovascular Medicine, Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University, Changsha 410005.
Objectives: The Charlson comorbidity index reflects overall comorbidity burden and has been applied in cardiovascular medicine. However, its role in predicting in-hospital mortality in patients with acute myocardial infarction (AMI) complicated by ventricular arrhythmias (VA) remains unclear. This study aims to evaluate the predictive value of the Charlson comorbidity index in this setting and to construct a nomogram model for early risk identification and individualized management to improve outcomes.
View Article and Find Full Text PDFZhong Nan Da Xue Xue Bao Yi Xue Ban
May 2025
Department of Hepatobiliary and Pancreatic Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Objectives: In recent years, the role of remnant cholesterol (RC) in the development and progression of cardiovascular diseases has gained increasing attention. However, evidence on the association between RC and subclinical atherosclerosis is limited. This study aims to examine the relationship between RC and atherosclerotic plaques in single and multiple vascular territories.
View Article and Find Full Text PDF