Global research trends in endoscopic breast surgery: a bibliometric analysis from 1994 to 2024.

Endoscopic breast surgery (EBS) is designed to reduce surgical trauma and optimize cosmetic outcomes through inconspicuous incisions. However, a comprehensive understanding of the evolution of research focus in EBS is lacking. This study aimed to analyze global publication trends, academic impacts, and evolving research directions in the field of EBS.

Identification and expression analysis of cinnamyl CoA reductase gene family and function of in potato ( L.).

Cinnamoyl-CoA reductase (CCR), a key rate-limiting enzyme in plant lignin biosynthesis, critically regulates plant growth, development, and abiotic stress responses. As one of the world's four major staple crops, potato ( L.) is extensively cultivated due to its nutritional value and versatile applications, underscoring the importance of investigating the gene family and its expression patterns under abiotic stress.

A Novel Nanosurfactant for EOR: Amphiphilic Carbon Quantum Dots (ACDs).

In the process of spontaneous imbibition to enhance oil recovery (EOR) in low permeability reservoirs, nanoparticles have shown great potential due to their excellent properties. In this study, four novel amphiphilic carbon quantum dots (ACDs) were synthesized by the pyrolysis of citric acid and four long-chain primary amines. The results of high-resolution transmission electron microscopy (HRTEM) and X-ray photoelectron spectroscopy (XPS) confirmed the successful synthesis of ACDs with an average particle size of 3.

Gpx1 induces M2 polarization of macrophages, contributing to doxorubicin resistance in triple-negative breast cancer.

Background: Treatment failure in triple-negative breast cancer (TNBC) primarily stems from chemotherapy resistance. Doxorubicin (DOX) is a commonly used therapeutic agent for TNBC; however, the role and mechanisms of immune regulation in DOX resistance remain unclear.

Methods: In this study, we analyzed single-cell data from public databases comparing DOX-resistant and sensitive TNBC patients, focusing on cell subpopulations, enriched pathways, and cell communication.

Foliar-Feeding Weevils Recruit Phyllosphere-Derived Tannin-Degrading Bacteria to Increase Their Fitness.

The gut microbiota plays a crucial role in shaping animal life history, particularly by mediating interactions between herbivorous insects and their host plants. Phytophagous insects that feed on oak leaves must overcome the challenge of detoxifying tannins. While gut microbes contribute significantly to this detoxification process, the mechanisms by which insects acquire tannin-degrading bacteria remain poorly understood.

Host Plant Dependence of the Symbiotic Microbiome of the Gall-Inducing Wasp .

Symbiotic bacteria play a pivotal role in the biology and ecology of herbivorous insects, affecting host growth and adaptation. However, the effects of host identity on the symbiotic microbiota of gall-inducing insects remain less explored. In this study, we utilized high-throughput sequencing to investigate the effects of different oak hosts on the structure and diversity of the symbiotic microbial community in the asexual larvae of the gall-inducing wasp .

Alistipes finegoldii augments the efficacy of immunotherapy against solid tumors.

The emergence of immunotherapy has revolutionized cancer therapy. However, immunotherapeutic resistance remains a major obstacle for broader clinical application. Recent studies highlight that gut microbiota enhances immunotherapy by modulating anti-tumor immunity.

Spin-Orbit Coupling Amplifying Polarization State for Regulating Bulk Charge Vectorial Transfer Dynamics at Spatiotemporal Scale for Towering H Generation.

Deblocking the constraints for charge transfer dynamics spanning the spatiotemporal scale from femtosecond to second along with spatial scale from atom to micrometer displays a significant challenge in liberating photocatalysis efficiency. Herein, the challenge is well addressed by d-p spin-orbit coupling from spin-state FeS to amplify CdS polarization for exceptional H photocatalytic generation. The spin-polarized states amplified by the upshift energy levels of Fe 3d and Cd 3d vectorially boost charge carrier transfer dynamics at spatial redox active sites with extending nanosecond lifetime up to 2.

The expansin-like gene StEXLB1 plays a role in potato defence against bacterial wilt.

Potato is an important food crop worldwide with high nutritional value. However, infections caused by pathogenic bacteria can significantly reduce yield and tuber quality. Improving the resistance of potato itself is an effective solution.

The Golgi Stacking Protein GORASP2 Regulates Mouse Primordial Follicle Activation by Suppressing the Autophagy Lysosome Pathway via RAP1 Competing With mTOR for RAPTOR Binding.

Primordial follicle pool is the foundation of female reproductive life and abnormal primordial follicle activation may lead to severe diseases such as premature ovarian failure and premature ovarian insufficiency. Golgi reassembly stacking protein 2 (GORASP2) plays an important role in autophagy by regulating autophagy maturation through glycosylation modification. In the current study we found that GORASP2 is a key factor in mammalian primordial follicle activation through autophagy lysosome pathway.

Individualized metagenomic network model for colorectal cancer diagnosis: insights into viral regulation of gut microecology.

The role of gut microbiota, especially viruses, in colorectal cancer (CRC) pathogenesis remains unclear. This study investigated the interplay between gut microbiota and CRC development. We developed a viral/bacterial sequence analysis pipeline to reanalyze gut metagenomic datasets from eight CRC studies.

Vascular Normalization Augments the Antitumor Efficacy of Combined HDAC Inhibitor with Immunotherapy in Solid Tumors.

Unlabelled: Immunotherapy has made remarkable strides in the treatment of solid tumors, but its efficacy as a single agent in immunologically cold tumors remains limited. Therefore, it is necessary to explore novel drug combinations to further optimize immunotherapy. Herein, we demonstrated that the histone deacetylase inhibitor (HDACi) chidamide enhanced chromatin accessibility at the promoters of genes that encode effector molecules in CD8+ T cells, thereby augmenting their antitumor capabilities.

Necroptosis and its role in the pathogenesis and treatment of temporomandibular joint osteoarthritis: A narrative review.

Objective: This review aimed to explore the role of necroptosis in the pathogenesis and treatment of temporomandibular joint osteoarthritisjoints. We sought to elucidate the mechanisms by which necroptosis contributes to arthritis development and identify potential therapeutic targets within the necroptosis pathway.

Design: An electronic literature search was conducted in PubMed, Scopus, EBSCO, ProQuest, ScienceDirect, and Springer for studies on necroptosis, arthritis, and temporomandibular joint osteoarthritis published between 2004 and 2024.

Combining transcriptomics and metabolomics to analyse the mechanism of allelopathy in Cyclachaena xanthiifolia.

As a vicious invasive plant, Cyclachaena xanthiifolia has caused severe ecological disruption and significant reductions in crop yield, necessitating urgent control measures. However, the underlying mechanisms of its allelopathic invasion remain unclear, representing the primary bottleneck in current management strategies. In this study, we used metabolomic and transcriptomic analyses to evaluate the differences in allelopathy and related physiological and biochemical indices among different extract fractions of C.

Dissecting small cell carcinoma of the esophagus ecosystem by single-cell transcriptomic analysis.

Small cell carcinoma of the esophagus (SCCE) is an aggressive and rare neuroendocrine malignancy with poor prognosis. Here, we firstly performed single-cell transcriptional profiling derived from 10 SCCE patients, with normal esophageal mucosa, adjacent non-malignant tissue and tumors from esophageal squamous cell carcinoma (ESCC) as reference. We observed enrichment of activated regulatory T cells and an angiogenesis-induced niche existed in SCCE compared with ESCC, revealing an immune suppressive and vessel-induced tumor microenvironment (TME) in SCCE.

Erratum: Pharmacological Ascorbate Suppresses Growth of Gastric Cancer Cells with GLUT1 Overexpression and Enhances the Efficacy of Oxaliplatin Through Redox Modulation: Erratum.

[This corrects the article DOI: 10.7150/thno.21745.

Immune checkpoint inhibitors plus chemotherapy in the first-line treatment of young unresectable gastric cancer patients: a multicentre real-world study.

Background: PD-1 inhibitors combined with chemotherapy have become the standard first-line treatment for advanced gastric cancer (GC), but their efficacy in young GC patients is unknown. This study aimed to evaluate the efficacy of immunotherapy in young GC patients and explore new treatment strategies for this population.

Methods: Clinicopathological data of young unresectable GC patients were collected from multiple centres.

Acetylation suppresses breast cancer progression by sustaining CLYBL stability.

Background: The incidence of breast cancer remains high and it remains the leading cause of cancer-related deaths in women. A better understanding of the molecular mechanisms of breast cancer and identifying novel biomarkers will help improve therapeutic strategies. Citrate lyase beta like (CLYBL) is expressed at low levels in breast cancer tissues and is associated with low patient survival rates.

Exploring the causal relationship between chronic pain and temporomandibular disorders: A two-sample Mendelian randomization study.

Objectives: This study investigates the causal effects of chronic pain on temporomandibular disorders using two-sample Mendelian randomization analysis.

Design: Two-sample bidirectional Mendelian randomization analysis was adopted to systematically explore the causal relationship between temporomandibular disorders and 7 types of chronic pain, including headache, hip, neck/shoulder, stomach/abdominal, back, knee, and facial chronic pain. Genetic variants from genome-wide association studies data served as instrumental variables.

Unveiling prognostic value of JAK/STAT signaling pathway related genes in colorectal cancer: a study of Mendelian randomization analysis.

Background: Colorectal cancer (CRC) ranks among the frequently occurring malignant neoplasms affecting the gastrointestinal tract. This study aimed to explore JAK-STAT signaling pathway related genes in CRC and establish a new prognostic model.

Methods: The data set used in this study is from a public database.

Pathogenic variants of TUBB8 cause oocyte spindle defects by disrupting with EB1/CAKP5 interactions and potential treatment targeting microtubule acetylation through HDAC6 inhibition.

Background: Numerous pathogenic variants causing human oocyte maturation arrest have been reported on the primate-specific TUBB8 gene. The main etiology is the dramatic reduction of tubulin α/β dimer, but still large numbers of variants remain unexplained.

Methods: Using microinjection mRNA and genome engineering to reintroduce the conserved pathogenic missense variants into oocytes or in generating TUBB8 variant knock-in mouse models, we investigated that the human deleterious variants alter microtubule nucleation and spindle assembly during meiosis.