Astrocytic Mettl14 depletion enhances cognitive function by attenuating astrogliosis via the DUSP1/MAPK pathway in APP/PS1 mice: targeting neuroinflammation in Alzheimer's disease.

Alzheimer's disease (AD), a leading cause of dementia, represents a critical unmet global medical need. While the precise mechanisms underlying AD pathogenesis remain elusive, increasing evidence underscores the pivotal role of neuroinflammation in driving cognitive impairment. N6-methyladenosine (m6A), an epigenetic modification regulating RNA metabolism, has been found to be dysregulated in AD.

M6A-mediated uc003pes.1 stability regulates proliferation and migration of human coronary artery smooth muscle cells via scaffolding STAT1 and USP10.

Background: The uc003pes.1 has been identified as a potential diagnostic biomarker for coronary artery disease (CAD) and is associated with the risk of CAD. However, the precise function and intricate mechanism of uc003pes.

Network Structure and Determinants of Professional Psychological Help-Seeking Attitudes Among Nurses: A Cross-Sectional Analysis.

Aim: To explore the factors influencing nurses' attitudes towards seeking professional psychological help using network analysis.

Design: A cross-sectional study design was employed.

Methods: In Shapingba District, Chongqing, China, a two-stage sampling method was used to select 717 nurses from primary healthcare institutions and secondary public hospitals.

Comparison of pre-treatment with different diluted sufentanil in reducing propofol injection pain in gastrointestinal endoscopy: A randomized controlled study.

Background: This study aimed to investigate the efficacy of pre-treatment with different concentrations of sufentanil in mitigating propofol injection-induced pain.

Methods: This study included 421 patients who were scheduled for gastrointestinal endoscopy between June 2023 and December 2024. Participants were randomly assigned to one of the four groups with different concentrations sufentanil: 0 µg/mL group(0.

Promoting Low-Temperature Toluene Oxidation via Pt-O-Fe Interfacial Sites in a Pt/CuO-FeO Catalyst.

Electronic metal-support interaction (EMSI) has been widely explored in the catalytic degradation of volatile organic compounds (VOCs) owing to the formation of special interfacial sites. Herein, the EMSI effect was engineered by constructing the serial Pt catalysts supported on CuO-FeO bimetal oxide (Pt/CFO). Among them, the 0.

Incorporation of multi-dynamic interactions into carboxyl graphene oxide-enhanced PVA/PAA/agarose hydrogels for multifunctional wearable sensors.

Recent advancements in conductive hydrogels have demonstrated significant progress in flexible sensing applications. However, integrating multifunctionality-including mechanical properties, environmental stability, high sensitivity, and great self-healing capability-into hydrogel sensors via a simple and eco-friendly synthesis approach remains a challenge. Herein, we reported multifunctional polyvinyl alcohol (PVA)/polyacrylic acid (PAA)/agarose (AG) hydrogels fabricated through a facile one-pot strategy.

Deciphering the ammonia transformation mechanism of a novel marine multi-stress-tolerant yeast, HJ2, as revealed by integrated omics analysis.

Ammonia nitrogen posed a significant threat to aquatic animals in aquaculture environments, and the substantial potential of microorganisms in removing ammonia nitrogen had garnered considerable attention. This study identified a marine yeast, HJ2, which effectively removed ammonia nitrogen. By combining transcriptomics and metabolomics, the ammonia nitrogen transformation mechanism of HJ2 was elucidated.

CircBTBD7-420aa Encoded by hsa_circ_0000563 Regulates the Progression of Atherosclerosis and Construction of circBTBD7-420aa Engineered Exosomes.

Circular RNAs are associated with cardiovascular disease, including coronary artery disease, but the mechanisms have not been completely elucidated. We found a new protein, circBTBD7-420aa, encoded by hsa_circ_0000563. Our results suggest that circBTBD7-420aa may inhibit the abnormal proliferation and migration of human coronary artery smooth muscle cells by promoting SLC3A2 degradation through the ubiquitin-proteasome pathway.

Mental Health Literacy and Professional Psychological Help-Seeking Attitudes Among Primary Healthcare Workers: The Mediating Role of Social Support and Mental Illness Stigma.

Background: Research highlights poor mental health among healthcare workers, but limited attention has been given to the mental health literacy and professional psychological help-seeking attitudes of primary healthcare workers.This study investigates the relationship between primary healthcare workers' mental health literacy and their attitudes toward professional psychological help-seeking. It also explores the chain mediating roles of social support and mental illness stigma in this relationship.

Introduction of into pine forests significantly enhances the diversity, stochastic processes, and network complexity of nitrogen-fixing bacteria in the soil.

Introduction: Nitrogen-fixing bacteria (NFB) have a pivotal impact on the nitrogen cycle within agroforestry systems. The organic management of the (sanqi)- agroforestry (SPA) system resulted in nitrogen deficiency because of the lack of application of chemical fertilizers. Therefore, assessing the variability in NFB due to the cultivation of sanqi in the SPA system becomes crucial.

Downregulation of N6-methyladenosine (m6A) methylation of Sema4D mRNA contributes to Treg dysfunction and allograft rejection.

Regulatory T cells (Tregs) have been shown to be involved in the induction of transplantation tolerance in numerous models. Our previous work demonstrated that methyltransferase-like 14 (METTL14) loss impaired Treg function and hindered the establishment of transplantation tolerance. However, the underlying mechanisms remain unclear.

LncRNA LUCAT1 offers protection against human coronary artery endothelial cellular oxidative stress injury through modulating hsa-miR-6776-5p/LRRC25 axis and activating autophagy flux.

Background: Coronary artery disease (CAD) has become a dominant economic and health burden worldwide, and the role of autophagy in CAD requires further clarification. In this study, we comprehensively revealed the association between autophagy flux and CAD from multiple hierarchies. We explored autophagy-associated long noncoding RNA (lncRNA) and the mechanisms underlying oxidative stress-induced human coronary artery endothelial cells (HCAECs) injury.

Ultrafast self-healing zwitterionic hydrogels reinforced by carboxymethyl chitosan-oxidized hyaluronic acid and graphene oxide toward high-performance strain sensors.

Inspired by the inherent recuperative ability of organisms in nature, researchers have dedicated significant efforts towards developing self-healing hydrogel sensors. Although the works on self-healing hydrogels have made great progress, achieving hydrogel sensors combining with rapid and efficient healing capability, excellent mechanical properties and high sensing sensitivity remains a challenging task. In this study, we proposed a novel approach for fabricating a self-healing conductive zwitterionic hydrogel sensor by adding carboxymethyl chitosan (CMCs) and oxidized hyaluronic acid (OHA) to induce dynamic Schiff base reaction, and graphene oxide (GO) nanosheets as physical crosslinker.

Fabrication of anti-freezing and self-healing hydrogel sensors based on carboxymethyl guar gum and poly(ionic liquid).

As classical soft materials, conductive hydrogels have attracted wide attention in the field of strain sensors due to their unique flexibility and conductivity. However, there are still challenges in developing conductive hydrogels with comprehensive mechanical strength, self-healing ability and sensitive sensing properties. In this paper, a novel PAV/CMGG hydrogel was prepared by a simple one-pot method through the introduction of 1-vinyl-3-butylimidazolium bromide (VBIMBr), acrylic acid (AA), carboxymethyl guar gum (CMGG) and AlCl.

Shenling Baizhu Decoction treats ulcerative colitis of spleen-deficiency and dampness obstruction types by targeting 'gut microbiota and galactose metabolism-bone marrow' axis.

Ethnopharmacological Relevance: Shenlin Baizhu Decoction (SLBZD), which comes from 'Taiping Huimin Heji Ju Fang', belongs to a classical prescription for treating spleen deficiency and dampness obstruction (SQDDS)-type ulcerative colitis (UC) in traditional Chinese medicine. However, the mechanism of SLBZD in treating UC with SQDDS remains unclear.

Aim Of The Study: This study aims to investigate the mechanism of SLBZD against SQDDS-type UC of based on the "gut microbiota and metabolism - bone marrow" axis to induce endogenous bone marrow mesenchymal stem cells (BMSCs) homing.

Corrigendum: Targeting JUN, CEBPB and HDAC3: a novel strategy to overcome drug resistance in hypoxic glioblastoma.

[This corrects the article DOI: 10.3389/fonc.2019.

COVID-19: Not a thrombotic disease but a thromboinflammatory disease.

While Coronavirus Disease in 2019 (COVID-19) may no longer be classified as a global public health emergency, it still poses a significant risk at least due to its association with thrombotic events. This study aims to reaffirm our previous hypothesis that COVID-19 is fundamentally a thrombotic disease. To accomplish this, we have undertaken an extensive literature review focused on assessing the comprehensive impact of COVID-19 on the entire hemostatic system.

A nonhuman primate model with Alzheimer's disease-like pathology induced by hippocampal overexpression of human tau.

Background: Alzheimer's disease (AD) is one of the most burdening diseases of the century with no disease-modifying treatment at this time. Nonhuman primates (NHPs) share genetic, anatomical, and physiological similarities with humans, making them ideal model animals for investigating the pathogenesis of AD and potential therapies. However, the use of NHPs in AD research has been hindered by the paucity of AD monkey models due to their long generation time, ethical considerations, and technical challenges in genetically modifying monkeys.

Exploration and bioinformatic prediction for profile of mRNA bound to circular RNA BTBD7_hsa_circ_0000563 in coronary artery disease.

Background: As a novel circRNA, BTBD7_hsa_circ_0000563 has not been fully investigated in coronary artery disease (CAD). Our aim is to reveal the possible functional role and regulatory pathway of BTBD7_hsa_circ_0000563 in CAD via exploring genes combined with BTBD7_hsa_circ_0000563.

Methods: A total of 45 peripheral blood mononuclear cell (PBMC) samples of CAD patients were enrolled.

Two-photon live imaging of direct glia-to-neuron conversion in the mouse cortex.

JOURNAL/nrgr/04.03/01300535-202408000-00032/figure1/v/2023-12-16T180322Z/r/image-tiff Over the past decade, a growing number of studies have reported transcription factor-based in situ reprogramming that can directly convert endogenous glial cells into functional neurons as an alternative approach for neuroregeneration in the adult mammalian central nervous system. However, many questions remain regarding how a terminally differentiated glial cell can transform into a delicate neuron that forms part of the intricate brain circuitry.

Circular RNA ZBTB46 depletion alleviates the progression of Atherosclerosis by regulating the ubiquitination and degradation of hnRNPA2B1 via the AKT/mTOR pathway.

Background: CircZBTB46 has been identified as being associated with the risk of coronary artery disease (CAD) and has the potential to be a diagnostic biomarker for CAD. However, the specific function and detailed mechanism of circZBTB46 in CAD are still unknown.

Methods: The expression levels and properties of circRNAs were examined using qRT‒PCR, RNA FISH, and subcellular localization analysis.

Novel flexible hydrogels based on carboxymethyl guar gum and polyacrylic acid for ultra-highly sensitive and reliable strain and pressure sensors.

To realize on stable and real-time monitoring of human activities, novel hydrogels using polyacrylic acid (PAA) and carboxymethyl guar gum (CMGG) were fabricated as wearable and flexible strain or pressure sensors in the presence of lignosulfonate (LS) and Al. Based on the co-existence of metal coordination bonds, hydrogen bonds and ionic interaction in this system, the obtained hydrogels exhibited desirable mechanical properties with good self-recovery ability. The hydrogels displayed good self-adhesion behavior and an ultra-high tensile sensitivity (gauge factor (GF) = 24.

Combination Therapy with -Acetylserotonin and Aflibercept Activated the Akt/Nrf2 Pathway to Inhibit Apoptosis and Oxidative Stress in Rats with Retinal Ischemia-Reperfusion Injury.

Purpose: -acetylserotonin (NAS) can reduce retinal ischemia-reperfusion injury (RIRI) by inhibiting the TLR4/NF-κB/NLRP3 signaling pathway. Aflibercept is an anti-VEGF drug used to treat a variety of eye diseases. This study was performed to investigate the effect of combination therapy with -acetylserotonin and aflibercept on RIRI and its mechanism.

The effect of gel pads on the measurement of breast superficial lesions by shear wave elastography.

Objective: This study aimed to compare the repeatability and diagnostic efficiency of shear wave elastography (SWE) while using coupling gel and gel pads in the diagnosis of superficial breast lesions.

Methods: Two experienced sonographers, trained in SWE, used different methods to perform the maximum Young's modulus (Emax) measurement of the lesion while using coupling gel SWE and gel pad SWE at different time points. All 80 lesions were in the superficial layer of the breast.