Spatial and Temporal Inconsistency of Forest Resilience and Forest Vegetation Greening in Southwest China Under Climate Change.

Under the backdrop of global climate warming, both forest vegetation greening and resilience decline coexist, and the consistency of these trends at the regional scale remains controversial. This study uses the kNDVI (Kernel Normalized Difference Vegetation Index) and TAC (Temporal Autocorrelation) index framework, combined with BEAST and Random Forest methods, to quantify and analyze the spatiotemporal evolution of forest resilience and its driving factors in Southwest China from 2000 to 2022. The results show the following: (1) Forest resilience exhibits a "high in the northwest and low in the southeast" spatial distribution, with a temporal pattern of "increase-decrease-increase.

The novel triglyceride‒glucose-weighted adjusted waist index as a supplementary diagnostic tool for heart failure: evidence of improved reclassification beyond traditional TyG-related indices from a cross-sectional study.

Background: Heart failure (HF) remains a major public health burden, necessitating reliable biomarkers for early risk stratification. The triglyceride glucose weight-adjusted waist index (TyG-WWI), a novel metabolic indicator, has emerged as a potential predictor, but its association with HF in the general population remains underexplored.

Methods: This retrospective cross-sectional study included 22,575 participants from the National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2018, 704 of whom had HF.

[Extraperitoneal robot-assisted laparoscopic modified Y-V plasty for the treatment of refractory bladder neck contracture].

Objective: To investigate the clinical effect of extraperitoneal robot-assisted laparoscopic modified Y-V plasty (LMYVP) in the treatment of refractory bladder neck contracture (BNC).

Methods: We retrospectively analyzed the clinical data on 10 cases of refractory BNC after transurethral resection of the prostate between September 2020 and January 2023, all with a history of recurrent urethral dilatation and at least two failures in transurethral surgical treatment of scarring. After definite diagnosis and removal of some of the scar tissues to flatten the elevated bladder neck under the cystoscope, we performed robot-assisted LMYVP using the da Vinci Si robotic system and a four-port extraperitoneal approach.

Identification and expression pattern analysis of the gene family in rice.

Calcium (Ca) signaling, which is mediated by calcineurin B-like proteins (CBLs), plays a pivotal role in the way that plants respond to abiotic stresses. However, the systematic bioinformatics and expression pattern analysis of remain largely unknown. In this study, we conducted a thorough genome-wide analysis of the gene family in rice, identifying ten members spanning six chromosomes.

A superstrong, decarbonizing structural material enabled by microbe-assisted cell wall engineering via a biomechanochemical process.

Lightweight and high-strength structural materials promise exceptional applications in advanced engineering fields. As a productive and sustainable material, wood exhibits exceptional potential to be converted into high-performance structural materials. Inspired by ancient buried wood-a naturally formed material after wood endures in microbial-rich and high-pressure environments for thousands of years-here, we demonstrate a biomechanochemical process to rapidly transform natural wood into artificial ancient buried wood (named Bio-Strong-Wood).

Fibroblast growth factor 16: Molecular mechanisms, signalling crosstalk, and emerging roles in cardiac biology and metabolic regulation.

Fibroblast growth factor (FGF) 16 is critically involved in embryonic heart development, adult cardiac homeostasis, and potentially in metabolic regulation. Initially recognized for its cardiac-specific role during embryogenesis, recent studies demonstrate that FGF16 significantly mitigates pathological cardiac remodelling, such as fibrosis and hypertrophy, through competitive inhibition of FGF2-induced transforming growth factor-β1 signalling via FGF receptor 1c. Molecular investigations further indicate that FGF16 exerts cardioprotective effects primarily through activation of key intracellular pathways, including phosphoinositide 3-kinase/protein kinase B and protein kinase C, as well as regulation by transcription factors GATA binding protein 4, nuclear Factor kappa-light-chain-enhancer of activated B cells, and cardiac-specific homeobox/NK2 homeobox 5, and RNA methyltransferase-mediated N6-methyladenosine modifications.

VeA is involved in anti-tumor activity by regulating adenylosuccinate lyase to mediate the synthesis of Acadesine in endophytic .

Acadesine (AICAR) is a promising candidate for new drugs in Phase III clinical trials. The purpose of this study is to analyse the steps in the biosynthesis pathway of AICAR. Our previous study found that overexpression of , a gene encoding a global regulator, significantly increased AICAR production of endophytic HB1-J1 and the anti-tumor activity of its extracts.

High-Fat Diet Differentially Regulates Fibroblast Growth Factor Expression in Metabolic Tissues of Young and Aged Male Mice.

Context: Fibroblast growth factors (FGFs) play critical roles in metabolism, yet their tissue-specific expression in response to obesity and aging remains unclear.

Objective: We investigated the mRNA expression profiles of FGFs along with their receptors, across major metabolic tissues-heart, liver, kidney, skeletal muscle, gonadal white adipose tissue, subcutaneous white adipose tissue, and brown adipose tissue.

Methods: Young (7-week-old) and aged (12-month-old) male mice were fed either a high-fat diet (HFD) or a normal diet for 11 weeks.

Fatty acids and physical activity are critical for β-cell mass and insulin sensitivity: Pathways to T2D and prevention.

Existing mathematical models investigating the progression of type 2 diabetes (T2D) over time primarily focus on glucose, insulin, β-cell mass, and other related factors, while often omitting fatty acids (FA) as an explicit variable-despite FA being a major energy source for the body. There exists a complex network of dynamical interactions among glucose, insulin, FA, and β-cell mass. To gain deeper insights into the metabolic dynamics and pathophysiology of T2D, it is essential to incorporate FA into such models.

Cardio-Metabolic Effects of Nickel: A Narrative Review.

Nickel, a transition metal, is ubiquitous in the environment due to both natural processes and anthropogenic activities. While exposure to nickel has been linked to various adverse health outcomes-including genomic damage, allergic reactions, renal disorders, pulmonary fibrosis, carcinomas of the lung and nasal cavities-its cardiovascular toxicity and metabolic implications remain comparatively underexplored. Recently, a series of cross-sectional analyses utilizing data from the National Health and Nutrition Examination Survey (NHANES) have emerged, providing valuable insights into this issue.

FPCAM: A Weighted Dictionary-Driven Model for Single-Cell Annotation in Pulmonary Fibrosis.

The groundbreaking development of scRNA-seq has significantly improved cellular resolution. However, accurate cell-type annotation remains a major challenge. Existing annotation tools are often limited by their reliance on reference datasets, the heterogeneity of marker genes, and subjective biases introduced through manual intervention, all of which impact annotation accuracy and reliability.

Interplay between Interface Diffusion and Boundary Slip Underlying Graphite-Lubricated Metal Nanoforming.

By designing carbon nanotube based nanochannels and exploiting the recent developed thermomechanical nanomolding technique, we reveal that the interface diffusion and boundary slip mechanisms play a key role in metal nanoforming. The former dominates the matter transport at the atomic scale and is significantly affected by surface defects, while the latter is closely related to the flow units at the continuum scale, and more sensitive to the apparent interfacial adhesion work than atomic scale defects. In particular, the excellent lubrication of graphitic materials maintained at high temperatures and in air is uncovered from the defect-insensitive boundary slip mechanism.

Distinct Features of Proton-Induced X-ray Emission (PIXE) and Inductively Coupled Plasma Mass Spectrometry (ICP-MS) When Used for Elemental Analysis of Nail Samples.

Biomarkers, such as toenails, are commonly used to investigate the health status of individuals. Nails samples are a useful marker of exposure, as they are easy to collect, store, and represent exposure from 6 to 12 months. There are multiple analytical methods that can be used to extract long-term exposure profiles from toenails including Proton-Induced X-Ray Emission(PIXE) and Inductively Coupled Plasma Mass Spectrometry (ICP-MS).

Cancer type and survival prediction based on transcriptomic feature map.

This study achieved cancer type and survival time prediction by transforming transcriptomic features into feature maps and employing deep learning models. Using transcriptomic data from 27 cancer types and survival data from 10 types in the TCGA database, a pan-cancer transcriptomic feature map was constructed through data cleaning, feature extraction, and visualization. Using Inception network and gated convolutional modules yielded a pan-cancer classification accuracy of 91.

Environmental Exposures to Metal Toxins as a Risk Factor for Colorectal Cancer: A Case-Control Study.

Introduction: Colorectal cancer (CRC) is the third most common and third most deadly cancer in the United States The role environmental toxins may contribute to CRC incidence is unknown. Cadmium and arsenic are known human carcinogens, although previous data have primarily focused on occupational exposures only. There are no studies on the relationship between environment metal exposures and the incidence of CRC using individual-level measurements from biospecimens.

Cell Function Graphics: TOGGLE delineates fate and function within individual cell types via single-cell transcriptomics.

Functional RNA plays a crucial role in regulating cellular processes throughout the life cycle of a cell. Identifying functional changes at each stage, from inception to development to maturation, functional execution, and eventual death or pathological transformation, often requires systematic comparisons of functional expression across cell populations. However, because cells of the same type often exhibit similar gene expression patterns regardless of function or fate, it is challenging to distinguish the stages of cellular fate or functional states within the same cell type, which also limits our understanding of cellular memory.

Oxidative stress and pediatric diabetic cardiovascular complications: emerging research and clinical applications.

The prevalence and incidence of diabetes in pediatrics have dramatically increased over the last three decades. Comparatively, pediatric diabetes has faster pancreatic β-cells decline and early progression to complications compared with adult diabetes. Therefore, diabetic complications are a major concern in children and adolescents with diabetes.

Correlational study on idiopathic neonatal hyperbilirubinemia and closure time of ductus venosus.

Objective: To investigate the correlation between idiopathic neonatal hyperbilirubinemia and ductus venosus closure time and to examine prenatal factors influencing DV closure in neonates.

Methods: A total of 103 full-term hyperbilirubinemic neonates born between September 2022 and September 2023 were selected as the hyperbilirubinemia group, while 169 full-term healthy neonates were chosen as the control group. Neonates with other perinatal or maternal abnormalities were excluded.

miR-448-3p/miR-1264-3p Participates in Intermittent Hypoxic Response in Hippocampus by Regulating Fam76b/hnRNPA2B1.

Background: Intermittent hypoxia (IH), as a key pathogenic factor of obstructive sleep apnea syndrome (OSAS), can cause many diseases, such as increased inflammation and oxidative stress, diabetes, cardiovascular disease, and Alzheimer's disease (AD). The response of cells to hypoxia involves multiple levels of regulatory mechanisms, including transcriptional regulation of gene expression, regulation of mRNA stability, post-transcriptional regulation, and post-translational modification regulation.

Aims: The regulation of miRNA and alternative splicing (AS) in neuronal response to intermittent hypoxia deserve further study.

Exacerbation by knocking-out metallothionein gene of obesity-induced cardiac remodeling is associated with the activation of CARD9 signaling.

Obesity increases the risk of metabolic syndrome including insulin resistance, dyslipidemia, and cardiovascular disease. We demonstrated insulin resistance, cardiac hypertrophy, and cardiac inflammation in an obese mouse model induced by a high-fat diet (HFD). Caspase recruitment domain-containing protein 9 (CARD9) and B-cell lymphoma/leukemia 10 (BCL10) were upregulated, and p38 MAPK was activated in these mice.

Super-strong hydrogel reinforced by an interconnected hollow microfiber network via regulating the water-cellulose-copolymer interplay.

The discontinuous fiber reinforced hydrogels are easy to fail due to the fracture of the fiber matrix during load-bearing. Here, we propose a novel strategy based on the synergistic reinforcement of interconnected natural fiber networks at multiple scales to fabricate hydrogels with extraordinary mechanical properties. Specifically, the P(AA-AM)/Cel (P(AA-AM), poly(acrylic acid-acrylamide); Cel, cellulose) hydrogel is synthesized by copolymerizing AA and AM on a substrate of paper with an interconnected hollow cellulose microfiber network.

Correction: Cai et al. Roles of Three Genes in the Development and Pathogenicity Regulation of . 2024, , 666.

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Enhanced coagulation of Microcystis aeruginosa using titanium xerogel coagulant.

Cyanobacterial blooms are prevalent globally and present a significant threat to water security. Titanium salt coagulants have garnered considerable attention due to their superior coagulation properties and the absence of metal residue risks. This paper explored the influencing factors in the coagulation process of titanium xerogel coagulant (TXC), the alterations in cell activity during floc storage, and the release of cyanobacterial organic matters, thereby determining the application scope of TXC for cyanobacterial water treatment.