Dynamics of Crossed Acquired Immunity Against SARS-CoV-2 Variants: From Vaccine to Hybrid Immunity in China.

The immune response to evolving Omicron variants in China, especially after booster doses and breakthrough infections post-Zero-COVID-19 policy, is poorly understood. In a 14-month cohort of 206 adults, baseline assessments were conducted the day before the third COVID-19 vaccine dose (Visit 1), with follow-ups at 1 (Visit 2), 3 (Visit 3), 6 (Visit 4), 9 (Visit 5), and 14 (Visit 6) months after the dose. The lifting of Zero-COVID-19 policy coincided with a surge in Omicron breakthrough infections among our participants, occurring 12 months after the third vaccine dose.

Low-noise frequency synthesis and terahertz wireless communication driven by compact turnkey Kerr combs.

High frequency microwave, spanning up to terahertz frequency, is pivotal for next-generation communication, sensing and radar. However, it faces fundamental noise limitations when frequency is pushed towards such boundary of conventional electronic technologies. Photonic microwave generation, particularly Kerr-comb-based microwave source, benefits from high frequency operation but still suffers from phase noise constraints.

Cross-phenotype genome-wide association study supports shared genetic etiology between skin and gastrointestinal tract diseases.

The comorbidity of skin and gastrointestinal tract (GIT) diseases, primarily driven by the gut-skin axis (GSA), is well-known. However, the genetic contribution to the GSA remains unclear. Here, using genome-wide association study (GWAS) summary statistics from European populations, we performed genome-wide pleiotropic analysis to investigate the shared genetic basis and causal associations between skin and GIT diseases.

Oleylamine-Functionalized Graphene Oxide in Wearable Flexible Organic Field-Effect Transistors for Ultrasensitive NH Detection.

Organic field-effect transistors (OFETs) have demonstrated significant potential in wearable exhaled gas sensing due to their excellent mechanical flexibility, multiparameter measurement capabilities, and signal amplification advantages. However, combining excellent sensing performance with good mechanical robustness remains a key challenge that must be addressed in practical applications. In this study, we developed a flexible gas sensor by incorporating the elastomer styrene-ethylene-butylene-styrene to enhance the strain stability of the semiconductor layer.

Investigating the Physical Adsorption of DCPD/Furfural and H Adsorption-Dissociation Behaviors in RE-MOFs.

Metal-organic frameworks (MOFs) have emerged as promising catalysts in the hydrogenation of bicyclopentadiene (DCPD) and furfural. The physical adsorption behaviors of substrate molecules and H within the pore structures of MOFs significantly influence the efficacy of subsequent catalytic reactions. This study employs molecular dynamics (MD) simulations to identify the optimal temperature and pressure conditions for the adsorption of DCPD and H, as well as furfural and H, within rare-earth-element-based MOFs (RE-MOFs).

Bis(pinacolato)Diboron-Enabled Nickel-Catalyzed Regio- and Enantioselective Reductive [3 + 2] Annulation of β-Bromoenones with Alkynes.

Chiral five-membered cyclic tertiary alcohols are important structural motifs in functional materials, pharmaceuticals, and bioactive molecules. Hence, developing efficient methodologies for synthesizing compounds featuring these privileged scaffolds represents a crucial pursuit within synthetic chemistry. Herein, we present a regio- and enantioselective Ni-catalyzed strategy for the reductive [3 + 2] annulation of β-bromoenones with alkynes, providing convenient access to chiral five-membered cyclic tertiary alcohols with high levels of regio-, and enantioselectivity via axial chirality transfer to central chirality.

Synthesis of Polysubstituted Aromatics via the Pd(II)-Initiated Borono-Catellani Reaction.

Herein, we report a novel palladium(II)-initiated borono-Catellani reaction that utilizes widely accessible aryl boronic acids that serve as both the reaction-initiating and -terminating substrates for the first time. The borono-Catellani reaction was facilitated by cooperative catalysis between Pd(OAc) and NBE, with air serving as the oxidizing agent, opening new venues for developing novel Catellani-type reactions. Importantly, this method is compatible with a wide range of substrates, including naphthaleneboronic acid, phenylboric acid derivatives, alkyl iodides, and aryl iodides, under these environmentally friendly and mild reaction conditions, thereby demonstrating versatile functional group compatibility for the synthesis of valuable polysubstituted aromatics.

Total Anomalous Pulmonary Venous Drainage Caused by Malposition of Septum Primum in Adults.

• MSP has primarily been reported in fetuses or children, with only one case of adult MSP with PAPVD previously reported in 2022. The case we report is about an adult with TAPVD which caused by MSP. There are no similar reports so far.

Protocol of the SOCFC project: a longitudinal cohort study of ovarian cancer patients, high-risk populations, and healthy controls to identify factors and biomarkers associated with disease diagnosis and prognosis.

Background: Ovarian cancer (OC) poses a significant threat to women's health due to its insidious onset, tendency to metastasize, and high recurrence rate. These characteristics significantly impede early diagnosis and effective interventions. The current lack of effective screening and prognostic tools necessitates urgent solutions.

Artificial intelligence algorithm for preoperative prediction of FIGO stage in ovarian cancer based on clinical features integrated 18F-FDG PET/CT metabolic and radiomics features.

Purpose: The International Federation of Gynecology and Obstetric (FIGO) stage is critical to guiding the treatments of ovarian cancer (OC). We tried to develop a model to predict the FIGO stage of OC through machine learning algorithms with patients' pretreatment clinical, positron emission tomography scan (PET/CT) metabolic, and radiomics features.

Methods: We enrolled OC patients who underwent PET/CT scans and divided them into two cohorts according to their FIGO stage.

Two-Dimensional Polymer Films as a Suitable Platform to Covalent Graft Antibody Receptors in an Electrolyte-Gated Organic Field Effect Transistor Bioassay.

Although organic field effect transistor (OFET)-based biosensors have aroused great interest due to their advantages of easy integration and fast response speed, surface functionalization of the sensing interface to achieve high sensitivity and outstanding selectivity while maintaining or minimizing the effect on the performance of OFETs is still extremely challenging. Herein, a carboxyl-functionalized two-dimensional polymer film (2DP) is prepared by the Langmuir-Blodgett (LB) method, which forms a heterojunction with a polymer semiconductor and is used to covalently bond the prostate-specific antigen (PSA) antibody receptor. The ordered periodic structure of 2DP films arranges active sites regularly, providing a suitable platform for high surface loading of receptors, and the weak van der Waals interaction between the 2DP and the semiconductor minimizes the effect on the mobility of charge carriers.

Validation of Analytical Performance and Diagnostic Effectiveness of Anti-CCP Antibody Based on the Light-Initiated Chemiluminescence Assay.

Objective: To evaluate the analytical and diagnostic performance of anti-cyclic citrullinated peptide (anti-CCP) antibody measured by the light-initiated chemiluminescence assay (LICA).

Methods: A total of 193 patients with rheumatoid arthritis (RA) and 211 controls were included. Serum anti-CCP levels were assessed by LICA and enzyme-linked immunosorbent assay (ELSIA).

Prediction of Compressive Strength of Fly Ash-Recycled Mortar Based on Grey Wolf Optimizer-Backpropagation Neural Network.

The evaluation of the mechanical performance of fly ash-recycled mortar (FARM) is a necessary condition to ensure the efficient utilization of recycled fine aggregates. This article describes the design of nine mix proportions of FARMs with a low water/cement ratio and screens six mix proportions with reasonable flowability. The compressive strengths of FARMs were tested, and the influence of the water/cement ratio (/) and age on the compressive strength was analyzed.

Mesoscale Modeling for Predicting Effective Properties and Damage Behavior of Geopolymer Concrete.

Geopolymer concrete is a sustainable construction material and is considered as a promising alternative to traditional Portland cement concrete. However, there is still not much research on the effective properties and damage behavior of geopolymer concrete with consideration of its heterogeneous characteristics by means of mesoscale models combined with the regularized microplane damage model. Here, in this research, an easy and simpler approach for generating concrete mesoscale models and characterizing the angular characteristics of aggregate particles is presented.

Cross-regional cultural recognition of adolescent voice emotion.

Background: In previous studies, an in-group advantage in emotion recognition has been demonstrated to suggest that individuals are more proficient in identifying emotions within their own culture than in other cultures. However, the existing research focuses mainly on the cross-cultural variations in vocal emotion recognition, with limited attention paid to exploring intracultural differences. Furthermore, there is little research conducted on the ability of adolescents to recognize the emotions conveyed by vocal cues in various cultural settings.

A Neutrophil Extracellular Traps-Related Signature Predicts Clinical Outcomes and Identifies Immune Landscape in Ovarian Cancer.

Ovarian cancer (OvCa) is the most lethal gynaecology malignancies worldwide. Neutrophil extracellular traps (NETs), net-like protein structures produced by activated neutrophils and DNA-histone complexes, have a central role in tumours, though haven't been fully explored in OvCa. We obtained transcriptome data from TCGA-OvCa database (n = 376) as training, ICGC-OvCa database (n = 111) as validation and GTEx database (n = 180) as controls.

Estimation of physiological aging based on routine clinical biomarkers: a prospective cohort study in elderly Chinese and the UK Biobank.

Background: Chronological age (CA) does not reflect individual variation in the aging process. However, existing biological age predictors are mostly based on European populations and overlook the widespread nonlinear effects of clinical biomarkers.

Methods: Using data from the prospective Dongfeng-Tongji (DFTJ) cohort of elderly Chinese, we propose a physiological aging index (PAI) based on 36 routine clinical biomarkers to measure aging progress.

Assessing the causal associations of atrial fibrillation with serum uric acid level and gout: insights from a bidirectional mendelian randomization study.

Background: Numerous observational studies consistently highlight a strong association between serum uric acid (sUA) levels and atrial fibrillation (AF). However, the causal relationship and the direction of this association remain elusive, despite extensive research efforts.

Objective: This study aimed to investigate the bidirectional causal relationships between sUA, gout, and the risk of AF using the two-sample Mendelian randomization (MR) approach.

Colloidal Synthesis of Blue-Emitting CsTmCl Nanocrystals via Localized Excitonic Recombination for Down-Conversion White Light-Emitting Diodes.

Lead-halide perovskite nanocrystals (NCs) have gained significant attention for their promising applications in lighting and display technologies. However, blue-emitting NCs have struggled to match the high efficiency of their red and green counterparts. Moreover, many reported blue-emitting perovskite NCs contain heavy metal lead (Pb), which poses risks to human health and the environment.