Debt vs. revenue share financing: A theoretical study on revenue share finance in a capital-constrained newsvendor.

In the capital-constrained newsvendor paradigm, revenue share financing (RSF) presents a novel yet underexplored financing approach. This theoretical study conducts a comparative analysis of two financing methods: traditional debt financing and revenue share financing. Our research findings indicate that the revenue share ratio, cost share ratio, and debt interest rate are the most critical factors influencing retailers' decisions.

Engineering Dual-Mode-Responsive Probes for Real-Time HClO Monitoring in Drug-Induced Liver Injury.

Given the critical role of HClO in drug-induced liver injury (DILI), it is essential to establish an accurate and reliable technique for the in situ monitoring of its dynamic changes. Herein, by integrating a phenothiazinecoumarin and a leucomethylene moiety through an aliphatic diamine, a robust dual-mode-responsive HClO probe, , has been judiciously developed. For the first time, can simultaneously respond to HClO through fantastic ratiometric (from 630 to 500 nm) and NIR fluorescence (690 nm) turn-on modes with excellent sensitivity and selectivity, thereby effectively overcoming the limitations of currently reported single-response-mode HClO probes.

Cross-phenotype genome-wide association study supports shared genetic etiology between skin and gastrointestinal tract diseases.

The comorbidity of skin and gastrointestinal tract (GIT) diseases, primarily driven by the gut-skin axis (GSA), is well-known. However, the genetic contribution to the GSA remains unclear. Here, using genome-wide association study (GWAS) summary statistics from European populations, we performed genome-wide pleiotropic analysis to investigate the shared genetic basis and causal associations between skin and GIT diseases.

Integrative Genome-wide Association Meta-analysis of Aortic Aneurysm and Dissection Identifies Five Novel Genes.

Aortic aneurysm and dissection (AAD) is a multifaceted condition characterized by significant genetic predisposition and a considerable contribution to cardiovascular-related mortality. Previous studies have suggested that AAD subtypes share similar genetic mechanisms, however, these studies investigated the subtypes separately. Here, we performed a large genome-wide association study (GWAS) meta-analysis for AAD by combining its subtypes, including 11,148 cases and 708,468 controls of European ancestry.

Association between genetic risk and adherence to the Dietary Approaches to Stop Hypertension diet for developing venous thromboembolism.

Background: The relationship between diet and venous thromboembolism (VTE) remains unclear, and the joint effects of diet patterns and genetic susceptibility on VTE risk are unknown.

Objectives: Investigate the independent and joint effects of Dietary Approaches to Stop Hypertension (DASH) diet adherence and polygenic risk scores (PRS) on VTE risk.

Methods: A total of 411,539 UK Biobank participants were included.

Trans-ancestry GWAS identifies 59 loci and improves risk prediction and fine-mapping for kidney stone disease.

Kidney stone disease is a multifactorial disease with increasing incidence worldwide. Trans-ancestry GWAS has become a popular strategy to dissect genetic structure of complex traits. Here, we conduct a large trans-ancestry GWAS meta-analysis on kidney stone disease with 31,715 cases and 943,655 controls in European and East Asian populations.

Efficacy and safety of electroacupuncture on treating mild to moderate first-episode depression: a study protocol for a randomized controlled trial.

Introduction: Only 30%-40% of patients with first-episode depression recover after taking antidepressants. Acupuncture is a clinically recognized treatment for depression, but its effect on first-episode depression remains unknown. This randomized controlled trial is designed to investigate the efficacy and safety of electroacupuncture (EA) compared with escitalopram (ESC) in treating patients with mild to moderate first-episode depression.

Combined toxicity of polystyrene microplastics and perfluorobutane sulfonate on mouse liver: Impact on lipid metabolism and gut-liver axis disruption.

Microplastics (MPs) in the environment can adsorb perfluoroalkyl substance (PFAS), leading to combined toxicity in various organisms. Most researches have focused on single-exposure effects on mouse liver, with limited studies on the mechanisms behind the combined effects of polystyrene microplastics (PS-MPs) and perfluorobutane sulfonate (PFBS). This study analyzed the single and combined toxic effects of PS-MPs (10 mg/kg) and PFBS (30 mg/kg PFBSL or 300 mg/kg PFBSH) on mouse liver.

Optimizing Cu doping on carbon nitrogen holly shell for enhanced selectivity towards formate in CO reduction.

Electrochemical carbon dioxide reduction reaction (ECORR) to produce high value-added products is a promising and effective strategy for closing the artificial carbon cycle and achieving sustainable development of resource. However, catalyst structural reorganization and agglomeration caused by the reduction process will reduce the catalytic performance. In this study, a carbon nitrogen shell with cupper-doped (CNCu shell) catalyst was prepared using silicon dioxide (SiO) as a template.

Identification of biomarkers and potential therapeutic targets for pancreatic cancer by proteomic analysis in two prospective cohorts.

Pancreatic cancer (PC) is the deadliest malignancy due to late diagnosis. Aberrant alterations in the blood proteome might serve as biomarkers to facilitate early detection of PC. We designed a nested case-control study of incident PC based on a prospective cohort of 38,295 elderly Chinese participants with ∼5.

Pan-cancer analysis of LRRC59 with a focus on prognostic and immunological roles in hepatocellular carcinoma.

Background: LRRC59 is a leucine-rich repeats-containing protein located in the endoplasmic reticulum (ER), it serves as a prognostic marker in several cancers. However, there has been no systematic analysis of its role in the tumor immune microenvironment, nor its predictive value of prognosis and immunotherapy response in different cancers.

Methods: A comprehensive pan-cancer analysis of LRRC59 was conducted from various databases to elucidate the associations between its expression and the prognosis of cancer, genetic alterations, tumor metabolism, and tumor immunity.

Blood Calcium, Genetic Risk, and Risk of Incident Kidney Stone: A Population-Based Cohort Study.

Objective: To investigate the association between blood calcium concentration and incident kidney stone as well as to assess the role played by genetic susceptibility.

Methods: We performed a population-based cohort study based on participants from the UK Biobank. A multivariable Cox proportional hazards regression model was used to estimate hazard ratios (HRs) and 95% CIs of incident kidney stone for blood calcium level and polygenic risk score (PRS).

Achieving high selectivity and activity of CO electroreduction to formate by in-situ synthesis of single atom Pb doped Cu catalysts.

Exploring highly selective and stable electrocatalysts is of great significance for the electrochemical conversion of CO into fuel. Herein, a three-dimensional (3D) nanostructure catalyst was developed by doping Pb single-atom (Pb) in-situ on carbon paper (Pb-Cu/CP) through a low-energy and economical method. The designed catalyst exhibited abundant active sites and was beneficial to CO adsorption, activation, and subsequent conversion to fuel.

SIRT5 promote malignant advancement of chordoma by regulating the desuccinylation of c-myc.

Chordoma is a relatively rare and locally aggressive malignant tumor. Sirtuin (SIRT)5 plays pivotal roles in various tumors, but the role of SIRT5 in chordoma has not been found. This study was performed to investigate the regulatory effects of SIRT5 on cell proliferation, migration, and invasion and the underlying mechanism in chordoma.

Identification of CAF-related lncRNAs at the pan-cancer level represents a potential carcinogenic risk.

Cancer-associated fibroblasts (CAFs) are increasingly recognized as playing a crucial role in regulating cancer progression and metastasis. These cells can be activated by long non-coding RNAs (lncRNAs), promoting the malignant biological processes of tumor cells. Therefore, it is essential to understand the regulatory relationship between CAFs and lncRNAs in cancers.

Efficacy comparison between iliosacral screw fixation of the posterior pelvic ring fracture with the assistance of modified percutaneous three-dimensional printing guide template and conventional fluoroscopy.

Objectives: The effect of three-dimensional (3D) printed bone-attached guide plate assisted cannulated screw fixation of pelvic fracture is reliable, but extensive soft tissue dissection is still required when installing the guide plate. This study aims to compare the efficacy of posterior pelvic ring fracture fixation with iliosacral screw insertion between the assistance of modified percutaneous patient specific 3D printed guide template and conventional fluoroscopy.

Methods: From May, 2019 and September 2021, 28 patients sustained posterior pelvic ring fractures were randomized into 2 groups: A guide template group, in which the iliosacral screw was inserted for fixation of the posterior pelvic ring fracture with the assistance of modified percutaneous patient specific 3D printed guide template, and a fluoroscopy group, in which the iliosacral screw was inserted under the guidance of conventional fluoroscopy.

Genetic and observational associations of lung function with gastrointestinal tract diseases: pleiotropic and mendelian randomization analysis.

Background: The two-way communications along the gut-lung axis influence the immune function in both gut and lung. However, the shared genetic characteristics of lung function with gastrointestinal tract (GIT) diseases remain to be investigated.

Methods: We first investigated the genetic correlations between three lung function traits and four GIT diseases.

Integrative genome-wide analyses identify novel loci associated with kidney stones and provide insights into its genetic architecture.

Kidney stone disease (KSD) is a complex disorder with high heritability and prevalence. We performed a large genome-wide association study (GWAS) meta-analysis for KSD to date, including 720,199 individuals with 17,969 cases in European population. We identified 44 susceptibility loci, including 28 novel loci.

Association of immune cell composition with the risk factors and incidence of acute coronary syndrome.

Background: Although immune cells are involved in acute coronary syndrome (ACS), few studies have explored the association of incident ACS with the relative immune cell proportions. We aimed to investigate the association of immune cell proportions with the incidence and risk factors of ACS in the Dongfeng-Tongji cohort.

Methods: We conducted the analyses with 38,295 subjects from the first follow-up of the Dongfeng-Tongji cohort, including DNA methylation profiles for 1570 individuals.