Ventricular-arterial coupling derived from arterial velocity pulse index to global longitudinal strain ratio in hypertension.

Objective: Ventricular-arterial coupling (VAC) evaluates the relationship between the left ventricle (LV) and the arterial system. This study aimed to assess VAC using the ratio of arterial stiffness (arterial velocity pulse index [AVI]) to myocardial deformation (global longitudinal strain [GLS]) in hypertension, and to determine whether it is more closely associated with vascular and cardiac damage than the conventional arterial elastance/left ventricular elastance (Ea/Ees) index.

Methods: AVI, GLS, arterial elastance (Ea), left ventricular end-systolic elastance (Ees), left ventricular ejection fraction (LVEF), and markers of left ventricular diastolic function (E/A and E') were measured by echocardiography in 141 healthy controls and 141 hypertensive subjects.

Risk factors for cough after pulmonary resection in patients with non-small cell lung cancer: a systematic review and meta-analysis.

Background: Pulmonary resection for pulmonary nodules has raised concerns about perioperative complications. Postoperative cough after pulmonary resection (CAP) is a frequent and debilitating issue in non-small cell lung cancer (NSCLC) patients, yet its risk factors remain unclear. Therefore, the aim of this study was to use evidence-based medicine evidence to find the key risk factors associated with CAP in the hope of improving the prognosis of patients undergoing pulmonary resection.

Predictors of willingness to eat wild mushrooms: extended theory of reasoned action.

Background: The accidental consumption of wild poisonous mushrooms has emerged as a primary source of poisoning incidents globally. It is imperative to comprehend the dietary habits of individuals consuming wild mushrooms to address this issue effectively.

Methods: In this investigation, an extended version of the theory of reasoned action was employed, incorporating perceived benefit and food-related self-efficacy as novel predictive variables.

Efficacy and mechanisms of Angelica sinensis in treating endometrial cancer: an integrated study.

Background: Angelica-based formulas can improve quality of life in patients with endometrial cancer. However, the results remain controversial, and their mechanisms of action are unclear. In this study, we systematically explored the effects and mechanism of action of Angelica sinensis (AS) in endometrial cancer (EC) using network pharmacology and molecular docking.

The functional mechanisms of phosphite and its applications in crop plants.

Phosphite (Phi), the reduced form of phosphate (Pi), is characterized by its stability, high solubility, efficient transport, resistance to fixation in soil, and widespread occurrence in natural environments. Although Phi exhibits greater suitability than Pi as a soil fertilizer, it cannot be metabolized by plants. In agricultural applications, Phi serves as a bio-stimulant, fungicide, herbicide, and has other purposes.

Prediction of STAS in lung adenocarcinoma with nodules ≤ 2 cm using machine learning: a multicenter retrospective study.

Background And Objective: Spread through air spaces (STAS) is an important factor in determining the aggressiveness and recurrence risk of lung cancer, especially in early-stage adenocarcinoma. Preoperative identification of STAS is crucial for optimizing surgical strategies. This study aimed to develop and validate machine learning models to predict the presence of STAS using preoperative clinical, radiological, and pathological data in lung cancer patients.

Effects of tannic acid on growth performance, intestinal health, and tolerance in broiler chickens.

This study investigated the optimal tannic acid dosage and assessed tolerance levels in broiler chickens. In experiment 1, 525 broilers were randomly divided into 5 treatment groups, the control group (CON group) and groups TA1 to TA4, corresponding to treatments of 0.025, 0.

Timing effects of short-term smoking cessation on lung cancer postoperative complications: a systematic review and meta-analysis.

Background: Preoperative smoking cessation may reduce postoperative complications in patients with lung cancer. However, the optimal duration of short-term preoperative smoking cessation remains unclear.

Methods: Three databases, PubMed, Embase, and the Cochrane Library, were searched for studies published up to April 5, 2024.

Starch and sucrose metabolism plays an important role in the stem development in .

The forage quality of alfalfa (Medicago sativa ) stems is greater than the leaves. Sucrose hydrolysis provides energy for stem development, with starch being enzymatically converted into sucrose to maintain energy homeostasis. To understand the physiological and molecular networks controlling stem development, morphological characteristics and transcriptome profiles in the stems of two alfalfa cultivars (Zhungeer and WL168) were investigated.

Clinical Study of a Four-Step Program for the Treatment of Plantar Fasciitis with Bone Spurs.

Objective: The most common causes of plantar and heel pain are plantar fasciitis and calcaneal spurs, and they often co-exist. Surgery is a recognized treatment for refractory plantar fasciitis. However, few studies have proposed treatment options for patients with metatarsophalangeal fasciitis with bone spurs.

Fabrication, structure, characterization and emulsion application of citrate agar.

In this study, citric acid successfully reacted with agar through the dry heat method, and citrate agar (CA) gel was used to stabilize O/W emulsions. The mechanisms of the CA structure and emulsion pH that affected emulsion stabilization were analyzed, and the application of CA gel emulsion (CAGE) was explored. Compared with native agar (NA), CA showed lower gel strength, higher transparency, and higher water contact angle.

Construction and validation of a predictive model of invasive adenocarcinoma in pure ground-glass nodules less than 2 cm in diameter.

Objectives: In this study, we aimed to develop a multiparameter prediction model to improve the diagnostic accuracy of invasive adenocarcinoma in pulmonary pure glass nodules.

Method: We included patients with pulmonary pure glass nodules who underwent lung resection and had a clear pathology between January 2020 and January 2022 at the Qilu Hospital of Shandong University. We collected data on the clinical characteristics of the patients as well as their preoperative biomarker results and computed tomography features.

The role of adenocarcinoma subtypes and immunohistochemistry in predicting lymph node metastasis in early invasive lung adenocarcinoma.

Background: Identifying lymph node metastasis areas during surgery for early invasive lung adenocarcinoma remains challenging. The aim of this study was to develop a nomogram mathematical model before the end of surgery for predicting lymph node metastasis in patients with early invasive lung adenocarcinoma.

Methods: In this study, we included patients with invasive lung adenocarcinoma measuring ≤ 2 cm who underwent pulmonary resection with definite pathology at Qilu Hospital of Shandong University from January 2020 to January 2022.

Prognostic significance and survival benefits of postoperative adjuvant chemotherapy in patients with stage IA lung adenocarcinoma with non-predominant micropapillary components.

Background: The prognostic significance of adjuvant chemotherapy (ACT) for patients with stage IA micropapillary non-predominant (MPNP) lung adenocarcinoma (LUAD) remains unknown. This study aimed to investigate the effects of postoperative ACT in patients with stage IA MPNP-LUAD.

Methods: A total of 149 patients with pathological stage IA MPNP-LUAD who underwent surgery at our center were retrospectively analyzed.

Nomogram combining clinical and radiological characteristics for predicting the malignant probability of solitary pulmonary nodules measuring ≤ 2 cm.

Background: At present, how to identify the benign or malignant nature of small (≤ 2 cm) solitary pulmonary nodules (SPN) are an urgent clinical challenge. This retrospective study aimed to develop a clinical prediction model combining clinical and radiological characteristics for assessing the probability of malignancy in SPNs measuring ≤ 2 cm.

Method: In this study, we included patients with SPNs measuring ≤ 2 cm who underwent pulmonary resection with definite pathology at Qilu Hospital of Shandong University from January 2020 to December 2021.

mRNA therapeutics for disease therapy: principles, delivery, and clinical translation.

Messenger RNA (mRNA) has become a key focus in the development of therapeutic agents, showing significant potential in preventing and treating a wide range of diseases. The COVID-19 pandemic in 2020 has accelerated the development of mRNA nucleic therapeutics and attracted significant investment from global biopharmaceutical companies. These therapeutics deliver genetic information into cells without altering the host genome, making them a promising treatment option.

Changes in soil properties and the -harboring bacteria of the alfalfa field in response to phosphite treatment.

Unlabelled: Phosphite, a reduced form of orthophosphate, is characterized by high solubility, and transportation efficiency and can be used as potential phosphorus fertilizer, plant biostimulant and supplemental fertilizer in agriculture. However, the effects of phosphite fertilizer on soil properties and microorganisms are poorly understood. This study evaluated the effects of phosphate and phosphite fertilizers on the different forms of phosphorus, alkaline phosphatase (ALP) activity, and -harboring bacterial community in the alfalfa () field.

Dissection of the response mechanism of alfalfa under phosphite stress based on metabolomic and transcriptomic data.

Phosphite, a reduced form of phosphate, inhibits the growth and even has toxic effect on plants. To learn more about the mechanism of alfalfa responses to phosphite, the morphological and physiological characteristics, and the metabolites and transcript levels were comprehensively analyzed following the exposure of alfalfa seedlings to phosphite and phosphate under greenhouse conditions. The results showed that phosphite inhibited seedling growth and photosynthesis.

Integrated mRNA and microRNA expression analysis of root response to phosphate deficiency in .

The deficiency of available phosphate significantly limits plant growth and development. This study sought to investigate how alfalfa (), a high-yielding and high-quality forage widely cultivated worldwide, responds to phosphate deficiency stress by integrating transcriptional and post-transcriptional data. In this study, 6,041 differentially expressed genes (DEGs) were identified in alfalfa roots under phosphate deficiency conditions.

Humidity Sensing of Stretchable and Transparent Hydrogel Films for Wireless Respiration Monitoring.

Respiratory monitoring plays a pivotal role in health assessment and provides an important application prospect for flexible humidity sensors. However, traditional humidity sensors suffer from a trade-off between deformability, sensitivity, and transparency, and thus the development of high-performance, stretchable, and low-cost humidity sensors is urgently needed as wearable electronics. Here, ultrasensitive, highly deformable, and transparent humidity sensors are fabricated based on cost-effective polyacrylamide-based double network hydrogels.

Effect of Light Intensity on Morphology, Photosynthesis and Carbon Metabolism of Alfalfa () Seedlings.

To understand how light intensity influences plant morphology and photosynthesis in the forage crop alfalfa ( L. cv. Zhongmu 1), we investigated changes in leaf angle orientation, chlorophyll fluorescence, parameters of photosynthesis and expression of genes related to enzymes involved in photosynthesis, the Calvin cycle and carbon metabolism in alfalfa seedlings exposed to five light intensities (100, 200, 300, 400 and 500 μmol m s) under hydroponic conditions.