In-depth targeted removal of Cu(II) by functionalized graphene oxide/sodium alginate composite aerogel: Coupling of two-dimensional confinement and bridging effect.

In this study, based on the planar configuration of hydrated copper ions, the "O-N-S" ternary cooperative system and two-dimensional slit-like pores were established in graphene oxide/sodium alginate composite aerogel (GSA) by functional group modification. As a result, the deeply coupling of bridging effect and confinement effect were achieved, aiming to achieve selective adsorption of low-concentration Cu(II) (removal efficiency: 99.34 %, adsorption capacity: 173.

Group activity analysis and pollution remediation techniques: Optimization of gel structural properties for efficient copper adsorption by truncating the electron pooling effect on polymer methylene backbones.

Designing adsorbent with unique structure and stable configuration is a feasible strategy for effective treatment of Cu(Ⅱ) pollution. Inspired by the structure of water-transporting xylem in plants, polyvinyl alcohol/graphene oxide/sodium alginate (PVA/GO/SA) and polyetherimide/graphene oxide/sodium alginate (PEI/GO/SA) with domain-limited slit-shaped structures and stable three-dimensional configurations are synthesized by introducing PVA and PEI into GO/SA gel system. Based on the different electron transfer mechanisms of PVA and PEI under high polymerization (COHP = 0.

Hepatitis B virus core/capsid protein induces hepatocellular carcinoma progression via long non-coding RNA KCNQ1OT1/miR-335-5p/CDC7 axis.

Background: Hepatocellular carcinoma (HCC) is the sixth most common malignancy and the fourth leading cause of cancer-related deaths worldwide. Long non-coding RNAs (lncRNAs) are dysregulated in various malignancies. However, the mechanisms by which lncRNA influences HCC remain unclear.

Edge nucleation and bridging effect synergistically in-situ sealed multiple heavy metals in soils.

The development of broad-spectrum remediation materials for soil heavy metals is an urgent problem in the environmental field. This study utilized oxygen-sulfur synergy sites in sulfonated cellulose/chitosan self-assembled gel (SMCG), which exhibited high affinity for Cu(II) and Ni(II), to induce and construct Cu-Ni bimetallic sulfides in situ. Through coupling with edge nucleation of Pb(II), Zn(II), and Cd(II), five heavy metals (Cu(II), Ni(II), Pb(II), Zn(II), and Cd(II)) were immobilized over the long term.

Stability of cranial defect size following decompressive craniectomy for traumatic brain injury in the pediatric population: A retrospective study.

Cranial defects are common sequelae of decompressive craniectomy (DC) for traumatic brain injury (TBI) in pediatric patients, and their long-term growth dynamics remain poorly understood. This study aims to evaluate cranial defect size and its pattern of change with age following DC for TBI in the pediatric population. This single-center retrospective study included pediatric patients who underwent DC for TBI and later returned for cranioplasty (CP).

Hepatitis B virus X protein (HBx)-mediated immune modulation and prognostic model development in hepatocellular carcinoma.

Hepatitis B virus (HBV) X protein (HBx) is critical in hepatocellular carcinoma (HCC) development, but its influence on tumor immunity and the tumor microenvironment (TME) remains unclear. This study aimed to construct a prognostic model based on HBx-related genes and explore their relationship with immune infiltration and immunotherapy response. Through transcriptome sequencing of our HBx-expressing HepG2 cells and analysis of HCC patient data from the cancer genome atlas (TCGA) and genotype-tissue expression (GTEx), we identified seven HBx-related genes, nuclear VCP-like (NVL), WD repeat domain 75 (WDR75), NOP58 nucleolar protein (NOP58), Brix domain-containing protein 1 (BRIX1), deoxynucleotidyltransferase terminal interacting protein 2 (DNTTIP2), MKI67 FHA domain interacting nucleolar phosphoprotein (NIFK), and ribosome production factor 2 (RPF2), associated with poor prognosis.

Unveiling the anticancer potential of SGLT-2 inhibitors: mechanisms and prospects in clinical oncology-a narrative review.

In recent years, cancer has become more prevalent among younger populations, increasing the burden on public health and the economy. Current cancer treatments are often costly and have long trial periods. Sodium-glucose cotransporter-2 inhibitors (SGLT-2is), including dapagliflozin and canagliflozin, were originally developed for blood glucose control, but have shown promise in anticancer applications.

HDAC4: an emerging target in diabetes mellitus and diabetic complications.

Diabetes mellitus (DM) is a metabolic disease with complex pathogenic mechanisms. Histone deacetylase 4 (HDAC4) is a member of an important family of epigenetic modifications. An increasing amount of research indicates that HDAC4 may control DM by modulating the epigenetic and post-translational expression of numerous transcription factors and taking part in different signaling cascades.

Magnetic graphene vacancies: atomic-scale O scissors mediated by antiferromagnetic exchange interaction-spin-orbit selective coupling effects.

The serious corrosion of electrode caused by hydrogen peroxide (HO) generated by noble metal catalyst through two-electron path is the key bottleneck of large-scale application of fuel cell. Based on the study of the structure-activity relationship between defect size and oxygen reduction reaction (ORR) activity of graphene, a strategy is proposed to use the single-atom vacancy (SAV) of graphene to induce electrons to preferentially fill the antibonding orbital (π*) of oxygen (O) and achieve four-electron path selectivity far exceeding conventional carbon defects via Yeager-type adsorption. Among them, a new mechanism of electron transfer induced by the magnetic properties of SAV and O (spin inversion induced by antiferromagnetic exchange and selective injection of the same spin orbitals (p-π*)) is the key to realize the strong electron transfer and shear of O.

Aluminum ion-activated low-temp pyrolyzed carbon to decontaminate Cr in water and soil.

Chromium pollution poses serious environmental risks to the water-soil environment due to its potential carcinogenicity, teratogenicity and migration. Herein, impregnation and secondary pyrolysis techniques are applied to develop materials for effective remediation of chromium contamination under different conditions (soil or water) using calcium chloride and aluminum chloride as modifiers. It is observed that Al ions (Al) in the same valence state as trivalent chromium can generate organic mineral complexes (C-COO-Al) using FT-IR and XPS.

The Current Research Landscape on the Machine Learning Application in Autism Spectrum Disorder: A Bibliometric Analysis From 1999 to 2023.

Background: Language deficits, restricted and repetitive interests, and social difficulties are among the characteristics of autism spectrum disorder (ASD). Machine learning and neuroimaging have also been combined to examine ASD. Utilizing bibliometric analysis, this study examines the current state and hot topics in machine learning for ASD.

Effective enhancement of copper selective removal from sodium alginate-based gel adsorbent by dual construction of slit-shaped structure and internal channel.

The Cu(II) treatment in water environment by adsorption has become a major strategy for water pollution control and water resource protection. In view of the planar configuration characteristics of Cu(II) complex, the construction and optimization of adsorbent's internal structure to achieve improved adsorption performance is still a problem worth exploring. Herein, polyvinyl alcohol (PVA) is introduced into graphene oxide/sodium alginate (GO/SA) gel system to obtain PVA/GO/SA gel material, which not only achieves the construction of slit-shaped structure by self-interlayer stacking for GO nanosheets and its cross-linking with SA, but effectively promotes formation of high cross-linking density internal channels by the introduction of PVA, thus achieving the efficacious and selective Cu(II) removal.

Gallic acid-functionalized chitosan composite for efficient removal of hexavalent chromium in aqueous.

To address the pH limitations of traditional Cr(VI) adsorbents, converting Cr(VI) anions into the more stable Cr(III) cations through a reduction reaction is an effective strategy. Therefore, in this study, gallic acid (GA), with a high redox potential, was selected as the reducing agent, together with chitosan (CS) as the substrate, and sodium alginate (SA) as the gelling agent. A novel SCG composite material was successfully prepared using the sol-gel crosslinking method, which efficiently captured and reduced Cr(VI) while immobilizing Cr(III).

The dual selective adsorption mechanism on low-concentration Cu(II): Structural confinement and bridging effect.

In this study, sulfur was introduced into the graphene oxide-based aerogel system based on the theory of bridging effect, and an oxygen-sulfur synergistic system was established to realize the dual-mechanism selective adsorption to low-concentration Cu(II) with slit structure and targeted binding sites. Based on the difference of chemical properties between organic acids and surfactants, the surface of graphene oxide (GO) was functionalized to realize the regulation of the order of its lamellar structure and the construction of carbon defects. On this basis, sulfur source modified GO-based aerogel was created to accomplish selective adsorption to low-concentration Cu(II) by combining the self-accumulation of montmorillonite and GO with the cross-linking mechanism of Ca(II) and sodium alginate.

Aluminum ion catalyzed proton transfer: Mechanism on promoting highly stable passivation of Cr by soil organic matter.

Although biochar can passivate chromium (Cr) in soil, the low stability is still a challenge to be overcome since the passivation mechanism is dominated by weak interactions (complexation, electrostatic attraction, etc.). In this study, a highly stable passivation of Cr was achieved in soil based on the strategy that the low-energy sp hybridisation orbitals of aluminum (Al) induced a decrease in the HOMO energy level, leading to the enrichment of off-domain electrons in carbon-based conjugated systems.

Structural regulation of alginate-based adsorbents based on different coordination configurations of metal ions and selective adsorption of copper ion.

To tackle the problem of developing efficient adsorbents for the selective removal of copper ions from wastewater, this investigation focused on the synthesis of Fe-GO/MMT/SA and Al-GO/MMT/SA copper ion adsorbent materials (Fe-GMS and Al-GMS), respectively, by merging two distinct metal ions (Fe(III) and Al(III)) with sodium alginate (SA), graphene oxide (GO), and montmorillonite (MMT). By introducing metal ions with different coordination configurations, the slit structure and pore density of the adsorbents can be effectively controlled, thereby enhancing the selectivity for copper ion adsorption. The results show that Fe-GMS has excellent adsorption capacity for Cu(II) compared with Al(III), and the adsorption capacity and distribution coefficient are 116.

ITPKA phosphorylates PYCR1 and promotes the progression of glioma.

Glioma is one of the prevalent malignancies, and identifying therapeutic targets for glioma is highly important. Findings of current study revealed that inositol-trisphosphate 3-kinase A (ITPKA) was found abnormally over expressed and thereby exhibited poor prognosis with glioma. Extensive academic research has meticulously elucidated ITPKA's pivotal role in enhancing glioma cell proliferation and invasion, highlighting its significance in oncogenic pathways and cellular dynamics specific to aggressive brain tumors.

Angiopoietin-like protein 2 inhibits thrombus formation.

Acute myocardial infarction is mainly caused by a lack of blood flood in the coronary artery. Angiopoietin-like protein 2 (ANGPTL2) induces platelet activation and thrombus formation in vitro through binding with immunoglobulin-like receptor B, an immunoglobulin superfamily receptor. However, the mechanism by which it regulates platelet function in vivo remains unclear.

LINC01002 functions as a ceRNA to regulate FRMD8 by sponging miR-4324 for the development of COVID-19.

Background: Syndrome coronavirus-2 (SARS-CoV-2) has developed various strategies to evade the antiviral impact of type I IFN. Non-structural proteins and auxiliary proteins have been extensively researched on their role in immune escape. Nevertheless, the detailed mechanisms of structural protein-induced immune evasion have not been well elucidated.

Advanced multifunctional hydrogels for diabetic foot ulcer healing: Active substances and biological functions.

Aim: Hydrogels with excellent biocompatibility and biodegradability can be used as the desirable dressings for the therapy of diabetic foot ulcer (DFU). This review aimed to summarize the biological functions of hydrogels, combining with the pathogenesis of DFU.

Methods: The studies in the last 10 years were searched and summarized from the online database PubMed using a combination of keywords such as hydrogel and diabetes.

Construction of oxime-functionalized PCN-222 based on the directed molecular structure design for recovering uranium from wastewater.

The directed construction of productive adsorbents is essential to avoid damaging human health from the harmful radioactive and toxic U(VI)-containing wastewater. Herein, a sort of Zr-based metal organic framework (MOF) called PCN-222 was synthesized and oxime functionalized based on directed molecular structure design to synthesize an efficient adsorbent with antimicrobial activity, named PCN-222-OM, for recovering U(VI) from wastewater. PCN-222-OM unfolded splendid adsorption capacity (403.

SUV39H1 is a novel biomarker targeting oxidative phosphorylation in hepatitis B virus-associated hepatocellular carcinoma.

Background: As a histone methyltransferase, suppressor of variegation 3-9 homolog 1 (SUV39H1) plays an important role in the occurrence and development of cancer. To explore the mechanism and biological function of SUV39H1 in hepatitis B virus-associated hepatocellular carcinoma (HBV-HCC) can gain an insight into the pathogenesis of HBV-HCC.

Methods: The effect of HBV infection on SUV39H1 in hepatoma cells was detected.

Research on the biological mechanism and potential application of CEMIP.

Cell migration-inducing protein (CEMIP), also known as KIAA1199 and hyaluronan-binding protein involved in hyaluronan depolymerization, is a new member of the hyaluronidase family that degrades hyaluronic acid (HA) and remodels the extracellular matrix. In recent years, some studies have reported that CEMIP can promote the proliferation, invasion, and adhesion of various tumor cells and can play an important role in bacterial infection and arthritis. This review focuses on the pathological mechanism of CEMIP in a variety of diseases and expounds the function of CEMIP from the aspects of inhibiting cell apoptosis, promoting HA degradation, inducing inflammatory responses and related phosphorylation, adjusting cellular microenvironment, and regulating tissue fibrosis.

Global trends in COVID-19 Alzheimer's related research: a bibliometric analysis.

Background: The COVID-19 pandemic has significantly impacted public health, putting people with Alzheimer's disease at significant risk. This study used bibliometric analysis method to conduct in-depth research on the relationship between COVID-19 and Alzheimer's disease, as well as to predict its development trends.

Methods: The Web of Science Core Collection was searched for relevant literature on Alzheimer's and Coronavirus-19 during 2019-2023.