Efficacy and safety of the CT-guided co-ablation system in the treatment of malignant melanoma with hepatic metastasis.

Purpose: To evaluate the efficacy and safety of computed tomography (CT)-guided co-ablation in patients with hepatic metastases from malignant melanoma.

Methods: Clinical data of 79 patients with hepatic metastases from malignant melanoma who underwent co-ablation (integration of cryoablation and thermal ablation) and programmed death 1 (PD-1) treatment between October 2019 and January 2024 were retrospectively analyzed. The patients were divided into group A (n = 50), patients who received co-ablation, and group B (n = 29), patients who received PD-1 treatment.

Screening Candidates for Conversion Therapy in Unresectable Hepatocellular Carcinoma Patients After Tyrosine Kinase Inhibitor Plus PD-1/PD-L1 Antibody Therapy: A Multicenter Retrospective Study.

Background: Conversion therapies after immune checkpoint inhibitors (ICIs) plus tyrosine-kinase inhibitors (TKIs) provide curative surgery chance and prolong survival for unresectable hepatocellular carcinoma (uHCC). However, only some patients have the opportunity to receive conversion therapies. To this end, we aimed to develop and validate a machine-learning model to identify patients who may have the chance to undergo conversion therapy.

Perioperative nutritional status in cardiac surgery patients: a multicenter observational study in Shanghai, China.

Objectives: Cardiovascular disease is an escalating global health concern, leading to an increasing demand for cardiac surgeries. Nutrition plays a critical role during the perioperative period. Enhanced Recovery After Surgery (ERAS) protocols emphasize the importance of early gastrointestinal function restoration.

Navigating Challenges and Building Resilience: Qualitative Insights into Disaster Nursing Preparedness in Chinese Non-First-Tier Cities.

Objectives: This qualitative study aimed to explore the lived experiences, challenges, and perceptions of nurses regarding disaster preparedness in non-first-tier (inland) cities in China. Building upon our previous quantitative findings, we sought to understand the psychological, professional, and organizational factors that influence nurses' disaster response capabilities in resource-limited settings.

Methods: A descriptive phenomenological approach was employed.

The LacI-Type Transcriptional Activator NCgl2689 Directly Regulates an Operon Involved in l-Cysteine Synthesis by the Reverse Transsulfuration Pathway in .

l-Cysteine is widely used in food, pharmaceutical, animal feed, and cosmetic industries. Microbial fermentation is an economically effective method for producing l-cysteine. However, research on the synthesis and regulation mechanism of l-cysteine through the reverse transsulfuration pathway in important amino acid producing cell factory is still limited.

Hyperacmotone A alleviates Non-alcoholic Steatohepatitis via regulating PPARα signaling.

Background: Non-alcoholic steatohepatitis (NASH) is a progressive form of non-alcoholic fatty liver disease (NAFLD), which is often accompanied by lipid metabolism disorders and mitochondrial dysfunction. Peroxisome proliferator-activated receptor α (PPARα) plays a crucial role in the oxidative metabolism of fatty acids, and its agonists are of great significance for the treatment of NASH.

Purpose: This study mainly explored the anti-NASH effect of the natural product hyperacmotone A (HA) by targeting PPARα.

Immune activation contributes recovery following pulmonary impairments by silica nanoparticles.

Although ample evidence indicated the pulmonary toxicity of silica nanoparticles (SiNPs), the persistence or reversibility of such injury, along with the intricate molecular networks involved, remains limited. This study investigated the toxicity and recovery effects of SiNPs on rats in the exposure (3-month via intratracheal instillation) and recovery (6-week) stages. Histopathological changes and collagen deposition in lung tissues were clearly observed following SiNPs exposure, accompanied by elevated hydroxyproline.

The Antifungal Activity and Potential Mechanism of Kalopanax septemlobus against Trichophyton mentagrophytes and T. rubrum.

() has been documented for therapeutic efficacy against scabies, but with fewer modern studies. In this paper, the inhibitory effects of extract and monomeric compounds on and were studied, and the mechanism of action was preliminarily discussed. The chemical constituents of the ethyl acetate layer of were isolated and purified under the trace of antifungal activity (microdilution method).

Uric Acid Causes Pancreatic β Cell Death and Dysfunction via Modulating CHOP-Mediated Endoplasmic Reticulum Stress Pathways.

Background: Uric acid has been proposed as a diabetogenic factor while its effect on pancreatic β cell function remains elusive. This study aimed to explore the impact of uric acid levels on β cell function and delineate its underlying molecular mechanisms.

Methods: Both in vivo hyperuricemia diet-induced mouse models and in vitro pancreatic β cell models were utilized.

Analysis of influencing factors of malnutrition in perioperative neurosurgery patients - A cross-sectional survey.

Objective: This study aimed to analyze the factors influencing malnutrition in perioperative neurosurgery patients using the random forest algorithm and logistic regression.

Methods: A cross-sectional survey was conducted among 330 perioperative neurosurgery patients from eight Class A tertiary general hospitals in Shanghai. The random forest algorithm was employed to rank the importance of independent variables potentially affecting malnutrition, and the top eight variables were subsequently included in a logistic regression model.

Refining Risk Stratification in Hepatocellular Carcinoma by Integrating Tertiary Lymphoid Structures and Microvascular Invasion: a Multicenter Retrospective Study.

Background: The pattern of tertiary lymphoid structures (TLS) differs from that of microvascular invasion (MVI) in patients with hepatocellular carcinoma (HCC). This multicenter study aimed to evaluate the prognostic value of integrating TLS and MVI and assess their interaction with adjuvant hepatic arterial infusion chemotherapy (aHAIC).

Methods: From January 2013 to December 2021, this study enrolled 923 HCC patients (cohort A: 437; cohort B: 275; cohort C: 211) who underwent curative resection and stratified them into different groups based on their TLS and MVI status.

Role of various types of outdoor activities for school-aged children myopia in Fengyang County, Chuzhou City: a cross-sectional study.

Objectives: This study aimed to assess the association between various types of outdoor activities and myopia among school-aged children.

Design: A cross-sectional study.

Setting: Fengyang County, Chuzhou City, Anhui Province.

Metabolomics analysis and mRNA/miRNA profiling reveal potential cardiac regulatory mechanisms in Yili racehorses under different training regimens.

Yili horses, a versatile breed from Xinjiang, China, are renowned for their racing abilities. However, studies on the links between cardiac morphology, function, and metabolic profiles with performance are limited. This study combined echocardiographic, transcriptomic, and metabolomic analyses to explore these relationships in high-level, average, and untrained Yili horses.

Changes in the ocular surface and meibomian glands following administration of 0.01 and 0.02% atropine.

Purpose: To investigate the changes in the ocular surface and meibomian glands following the administration of 0.01 and 0.02% atropine.

Phthalocyanine-based nanosensitizers for enhanced sonodynamic therapy activity of hypoxic tumor with dual apoptosis/ferroptosis pathways.

The development of efficient and versatile theranostic agents based on a single molecule for sonodynamic therapy (SDT) of hypoxic tumor remains a formidable challenge. Herein, we present a spatiotemporally controllable oxygen-releasing nanoliposomal sonosensitizer (PcA-PFO@FLPs) based on a multifunctional phthalocyanine derivative, which integrates dual-modality imaging guidance for enhanced SDT of hypoxic tumors. The perfluoropentadecyl ether oxygen reservoir enables PcA-PFO@FLPs to exhibit ultrasound-responsive oxygen release, enhancing reactive oxygen species (ROS) generation at both solution and cellular levels, thereby demonstrating potent sonodynamic activity (IC = 1.

Multifunctional fibrous membranes based on poly(ε-caprolactone)/ methacrylamide chitosan loaded with VEGF-mimetic peptide for promoting diabetic wound healing.

Diabetic wound treatment remains huge clinical concern due to its susceptibility to bacterial infection, abnormal inflammation, and blocked angiogenesis. Herein, a multifunctional fibrous membrane is fabricated by combining an electrospun VEGF-mimetic peptide (QK)-encapsulated fibrous membrane and a methacrylamide chitosan (ChMA)-based hydrogel coating for effective diabetic wound healing. The fibrous membrane is fabricated via a coaxial-electrospinning method, combining QK as the core layer, and poly(ε-caprolactone)/pterostilbene (PTE) as the shell layer.

Chromosome-level genome assembly of stem borer Batocera rufomaculata using PacBio HiFi and Hi-C sequencing.

Batocera rufomaculata (Cerambycidae: Lamiinae), a prominent representative of longhorned beetles, is a globally significant stem-boring pest, infesting over 50 species of deciduous trees. Despite its substantial ecological and economic impact, the genomic basis underlying its host adaptation remain poorly understood. Here, we present a chromosome-level genome assembly of B.

Distribution, Diversity, and Ecological Risks of Microplastics in Mangrove Ecosystems of a Southeastern Chinese Estuary.

Mangrove ecosystems, serving as critical barriers at land-sea interfaces, face increasing threats from microplastic pollution. This study investigates the spatial distribution, diversity, and ecological risks of microplastics in sediments from the Zhangjiang Estuary mangroves, in southeastern China. Sampling was conducted along two gradients: upstream-downstream and interior-edge habitats.

Radiomic Model Associated with Tumor Microenvironment Predicts Immunotherapy Response and Prognosis in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma.

No robust biomarkers have been identified to predict the efficacy of programmed cell death protein 1 (PD-1) inhibitors in patients with locoregionally advanced nasopharyngeal carcinoma (LANPC). We aimed to develop radiomic models using pre-immunotherapy MRI to predict the response to PD-1 inhibitors and the patient prognosis. This study included 246 LANPC patients (training cohort, = 117; external test cohort, = 129) from 10 centers.

Study on the chemical composition, zebrafish toxicity and anti-inflammatory activity of Ecklonia kurome.

Ethnopharmacological Relevance: Inflammation is an important physiological process that serves as the host's defense mechanism against tissue damage, stress, or oxidative stress. As a traditional medicinal and edible plant, Ecklonia kurome (EK) is used to treat galls and scrofula, which is now known as lymphatic tuberculosis and lymphadenitis, but the specific effective medicinal ingredients of EK are not clear, and further exploration is needed for its anti-inflammatory activity.

Aim Of Study: This study aims to extract, isolate and purify EK, and investigate its pharmacological effects, in order to explore the chemical composition, toxicity and anti-inflammatory activity of EK.

FGF mimetic peptide-modified electrospun nanocomposite fibrous membranes for accelerating infectious diabetic wound healing by synergistic antibacterial and pro-angiogenesis effects.

Diabetic wound treatment remains a severe threat to public health. Biomimetic nanocomposite scaffolds have shown great potential in anti-infection, but the challenges associated with insufficient angiogenesis remain. Herein, an efficient nanocomposite membrane combining basic fibroblast growth factor (FGF2) mimetic peptides and copper/catechol-derived resin nanoparticles (CuCFR NPs) loaded poly(L-lactide-co-ε-caprolactone) (PLCL) electrospun fibrous membrane was developed for accelerating infectious diabetic wound healing by synergistic antibacterial and pro-angiogenesis effects.

Genomic assembly and resequencing of the mango seed weevil Sternochetus mangiferae (Fabricius) provide insights into host adaptation and invasion control.

Background: Sternochetus mangiferae (Fabricius) is a monophagous beetle that exclusively feeds on mango seeds and is recognized as one of the most destructive quarantine pests worldwide. Despite its considerable ecological and economic impacts, the genomic basis underpinning its host specialization and invasion potential remains poorly understood.

Results: A high-quality genomic assembly was generated, totaling 701.

Unified iontronic sensing for operando monitoring of physical-chemical events in lithium-ion batteries.

Operando measurement of expansion force has become an effective way of monitoring physical-chemical events in lithium-ion batteries, of which the conventional optical means is limited by material fragility, structural incompatibility and system complexity. The utilization of flexible sensors can potentially address these challenges; however, their functionality and stability are restricted within hours in corrosive environments. Here, an unified iontronic sensing mechanism, derived from the super-capacitive electrode/electrolyte interface, is developed for expansion-force measurement in highly corrosive electrolyte environments.

Uncovering the resistome and mobilome across different types of ready-to-eat fermented foods.

Antimicrobial resistance in food poses a significant threat to public health, and the persistence of antibiotic resistance genes (ARGs) in ready-to-eat fermented foods (RTE-FFs) is a growing concern. However, information on the diversity, origins, and transferability of ARGs in RTE-FFs is limited. This study investigated the distribution of ARGs and mobile genetic elements (MGEs) in four types of RTE-FFs: soybean, dairy, meat, and vegetable products.

Risk Prediction of Unplanned Extubation in Inpatients Using Random Forest and Logistic Regression Models.

Background: Unplanned extubation (UEX) represents a significant risk event in hospitalized patients and is considered one of the most serious safety concerns. Prevention and early detection of these events have become essential components of high-quality nursing care.

Objective: To compare random forest and logistic regression models for the prediction of UEX.