Broad-spectrum antifungal activity of aniline-modified tavaborole derivatives: insights from molecular docking and bioassays.

Background: Phytopathogenic fungi pose a severe threat to global agriculture, and the emergence of drug-resistant strains underscores the urgent need for novel fungicides. Tavaborole (AN2690), a clinically approved benzoxaborole antifungal, suppresses fungal growth by selectively targeting leucyl-tRNA synthetase (LeuRS) through covalent binding-a unique mode of action. In this study, we designed and synthesized a series of novel tavaborole derivatives featuring substituted aniline moieties.

Immune activation contributes recovery following pulmonary impairments by silica nanoparticles.

Although ample evidence indicated the pulmonary toxicity of silica nanoparticles (SiNPs), the persistence or reversibility of such injury, along with the intricate molecular networks involved, remains limited. This study investigated the toxicity and recovery effects of SiNPs on rats in the exposure (3-month via intratracheal instillation) and recovery (6-week) stages. Histopathological changes and collagen deposition in lung tissues were clearly observed following SiNPs exposure, accompanied by elevated hydroxyproline.

Relationship between multimorbidity burden and depressive symptoms in older Chinese adults: A prospective 10-year cohort study.

Background: Recent research indicates that multimorbidity clusters due to common mechanisms and risk factors, leading to different effects on the development of depressive symptoms (DS) in older populations. This study innovatively examined the association of both the number and specific patterns of multimorbidity with DS.

Methods: A total of 1988 participants aged 60 years and older were selected from the China Health and Retirement Longitudinal Study (CHARLS) and monitored for DS between June 2011 and September 2020.

Regulation of ferroptosis ameliorates silica nanoparticle-induced lung injury by inhibiting NCOA4-mediated ferritinophagy.

The massive global output and extensive application of silica nanoparticles (SiNPs) raise great human health concerns, especially in the lungs since the respiratory tract is a major portal for NPs entry. Emerging evidence has revealed that SiNPs cause pulmonary impairments, but the underlying mechanism remains elucidated. In this study, we clarify the role of ferroptosis in SiNPs-induced pulmonary toxicity and elucidate its molecular mechanism.

X-chromosome association study reveals genetic susceptibility loci of hypospadias in southern Chinese population.

Purpose: X-chromosome variants contribute significantly to hypospadias risk but have not been fully elucidated in the Chinese population. Here we aim to assess how X-chromosome variants contribute to hypospadias susceptibility in the Chinese population.

Methods: We recruited 1,073 boys with hypospadias and 5,150 controls in a southern Chinese population.

Cortical activation patterns in generalized anxiety and major depressive disorders measured by multi-channel near-infrared spectroscopy.

Background: Major depressive disorder (MDD) and generalized anxiety disorder (GAD) are highly prevalent mental disorders in psychiatry, but their overlapping symptoms often complicate precise diagnoses. This study aims to explore differential brain activation patterns in healthy controls (HC), MDD, and GAD groups through functional near-infrared spectroscopy (fNIRS) during the verbal fluency task (VFT) to enhance the accuracy of clinical diagnoses.

Methods: This study recruited 30 patients with MDD, 45 patients with GAD, and 34 demographically matched HCs.

Why is it so clean under the apple trees: discovery of novel phloretin derivatives as potential herbicidal agents.

Background: Weeds are a serious problem in worldwide agricultural production. Natural products are a notable source for discovering new lead compounds. Phloretin is a dihydrochalcone compound which was discovered in 1835 and named after its concentrated content in roots, stems or bark of fruits.

Dual-Target Inhibitors─Discovery of Novel Diphenyl-(Thio)ether-Containing Benzoxaborole Derivatives as Potential Antifungal and Herbicidal Agents.

LeuRS and PPO are important targets in the development of green pesticides; novel diphenyl-(thio)ether-containing benzoxaborole derivatives were designed and synthesized as novel dual-target enzyme inhibitors; their antifungal activities against six kinds of common plant pathogens in vitro and their herbicidal activities against purslane and barnyard grass were studied. Most of the target compounds showed excellent antifungal activity against six kinds of plant pathogenic fungi in vitro, and this is highlighted by compounds and , both displayed 100.0% inhibition effects against three kinds of the tested plant pathogenic fungi under the concentrations of 50.

Optical skyrmion and its "zipper-like" topological behavior in an energy flux field.

The optical skyrmion and its topological behavior are analyzed in an energy flux field constructed by an X-type vortex in a high numerical aperture system. The conditions for the formation of a skyrmion structure in this field are discussed, showing that the vortex pattern of the transverse energy flow and the inverse energy flow are crucial for the skyrmions and also are controlled by the phase gradient of the X-type vortex. Notably, the "zipper-like" topological reaction, which is the first, to our knowledge, found in ferromagnetic materials, is observed, and the physical mechanism is also explained by the relation of orbital angular momentum density and Poynting vectors.

Two functionally interchangeable Vps9 isoforms mediate pollen tube penetration of style.

Style penetration by pollen tubes is essential for reproductive success, a process requiring canonical Rab5s in Arabidopsis. However, functional loss of Arabidopsis Vps9a, the gene encoding for guanine nucleotide exchange factor (GEF) of Rab5s, did not affect male transmission, implying the presence of a compensation program or redundancy. By combining genetic, cytological, and molecular approaches, we report that Arabidopsis Vps9b is a pollen-preferential gene, redundantly mediating pollen tube penetration of style with Vps9a.

Lignin microcapsules prepared on the basis of flexible skeleton with high foliar retention and UV shielding properties.

Lignin-based microcapsules are extremely attractive for their biodegradability and photolysis resistance. However, the water-soluble all-lignin shells were unsatisfactory in terms of rainfall and foliar retention, and lacked the test of agricultural production practices. Herein, a novel microcapsule based on a flexible skeleton formed by interfacial polymerization and absorbed with lignin particles (LPMCs) was prepared in this study.

[Annual review of capillary electrophoresis technology in 2023].

This paper serves as an annual review of capillary electrophoresis (CE) technology for 2023. The journals were selected based on their impact factor (IF), a universally recognized academic performance metric, combined with experimental work closely related to CE technology, to facilitate the rapid acquisition of significant research and application advancements in CE technology in 2023. A thematic search of the ISI Web of Science database yielded 669 research papers on CE technology published in 2023.

Ferroptosis contributing to cardiomyocyte injury induced by silica nanoparticles via miR-125b-2-3p/HO-1 signaling.

Background: Amorphous silica nanoparticles (SiNPs) have been gradually proven to threaten cardiac health, but pathogenesis has not been fully elucidated. Ferroptosis is a newly defined form of programmed cell death that is implicated in myocardial diseases. Nevertheless, its role in the adverse cardiac effects of SiNPs has not been described.

Association between CACNA1D polymorphisms and hypospadias in a southern Chinese population.

Background: Hypospadias is a congenital genitourinary malformation, with the etiology remaining complex and poorly understood. Despite several genes have been identified to be associated with the risk of hypospadias, current understanding of the susceptibility loci for hypospadias yet remained largely improved. The CACNA1D gene encodes calcium voltage-gated channel subunit alpha 1d and may be involved in androgen signaling.

Proteomics revealed composition- and size-related regulators for hepatic impairments induced by silica nanoparticles.

Along with the growing production and application of silica nanoparticles (SiNPs), increased human exposure and ensuing safety evaluation have progressively attracted concern. Accumulative data evidenced the hepatic injuries upon SiNPs inhalation. Still, the understanding of the hepatic outcomes resulting from SiNPs exposure, and underlying mechanisms are incompletely elucidated.

Lipidomics Investigation Reveals the Reversibility of Hepatic Injury by Silica Nanoparticles in Rats After a 6-Week Recovery Duration.

Given the inevitable human exposure owing to its increasing production and utilization, the comprehensive safety evaluation of silica nanoparticles (SiNPs) has sparked concerns. Substantial evidence indicated liver damage by inhaled SiNPs. Notwithstanding, few reports focused on the persistence or reversibility of hepatic injuries, and the intricate molecular mechanisms involved remain limited.

Association of DLT versus SLT with postoperative pneumonia during esophagectomy in China: a retrospective comparison study.

Background: Double lumen tube (DLT) and single lumen tube (SLT) are two common endotracheal tube (ETT) types in esophageal cancer surgery. Evidence of the relationship between two ETT types and postoperative pneumonia (PP) remains unclear. We aimed to determine the association between two types of ETT (DLT and SLT) and PP and assess the perioperative risk-related parameters that affect PP.

Establishment and identification of an animal model of Hirschsprung disease in suckling mice.

Background: Hirschsprung disease (HSCR) is a congenital intestinal malformation. Previous HSCR animal model needs invasive operation on adult animal. The aim of this study is to establish an early-onset animal model which is consistent with the clinical manifestation of HSCR patients.

Canonical Rab5 GTPases are essential for pollen tube growth through style in Arabidopsis.

Pollen tubes have dynamic tubular vacuoles. Functional loss of AP-3, a regulator of one vacuolar trafficking route, reduces pollen tube growth. However, the role of canonical Rab5 GTPases that are responsible for two other vacuolar trafficking routes in Arabidopsis pollen tubes is obscure.