Nanomedicine strategies for disulfidptosis activation in SLC7A11-high tumors.

Disulfidptosis is a recently identified form of regulated cell death (RCD) characterized by aberrant disulfide bond accumulation and cytoskeletal collapse under conditions of redox imbalance. SLC7A11-overexpressing tumors are uniquely susceptible to this pathway due to their elevated cystine uptake and dependence on glucose-driven NADPH production for redox maintenance. These metabolic liabilities create therapeutic opportunities to selectively trigger disulfidptosis via pharmacologic or material-based interventions.

[Blood glucose-lowering mechanism of Poria aqueous extract by UPLC-Q-TOF-MS/MS combined with network pharmacology and experimental verification].

Ultra performance liquid chromatography-quadrupole-time-of-flight-mass spectrometry/mass spectrometry(UPLC-Q-TOF-MS/MS), network pharmacology, and animal experiments were integrated o explore the blood glucose-lowering effects and mechanisms of Poria aqueous extract. Firstly, the active components of Poria aqueous extract were identified by UPLC-Q-TOF-MS/MS. Subsequently, network pharmacology was employed to predict the blood glucose-lowering components and mechanisms of Poria aqueous extract.

Integrating CO electroreduction with phenol hydrogenation on an oxygen-affinity tailored catalyst.

Electrocatalytic CO reduction (ECR) to formic acid faces challenges in separating and purifying a formate-electrolyte mixture. In situ utilization of this mixture presents a promising yet underexplored solution. Here, we report the synthesis of BiPdTe nanocrystals (NCs) via a microwave-assisted cation topological exchange approach, enabling the precise tuning of surface oxygen affinities to simultaneously optimize the ECR and catalytic transfer hydrogenation (CTH) of phenol.

Lubricating nano/micro particles for osteoarthritis therapy.

Osteoarthritis (OA) is a prevalent joint disorder characterized by cartilage degeneration and synovial lubrication failure, resulting in pain and restricted movement. From a physiological standpoint, key macromolecules in synovial fluid, such as hyaluronic acid, phospholipids, and lubricin, play essential roles in maintaining the boundary lubrication of articular cartilage. In OA, however, cartilage damage induces inflammatory responses that alter the composition of synovial fluid, thereby compromising its lubricating function.

Correction: The two-component system CpxAR is required for the high potassium stress survival of .

[This corrects the article DOI: 10.3389/fmicb.2023.

Liposomal dexamethasone for intra-articular therapy: Functional strategies and clinical progress.

Intra-articular (IA) injection of dexamethasone (DEX) is an established approach for managing inflammation in arthritis, but it is limited by rapid clearance and short-lived efficacy. Liposomes offer a versatile platform to address these issues by enhancing joint retention and enabling sustained release. This review outlines the pharmacological basis for liposomal DEX in IA therapy and systematically discusses emerging functional strategies to optimize its therapeutic performance.

Adaptive mobility responses during Hurricanes Helene and Milton in 2024.

Adaptation is crucial for minimizing the societal impacts of tropical cyclones amid climate change. Using 355.5 million high-resolution foot-traffic records from mobile devices, we analyzed human mobility patterns during Hurricanes Helene and Milton, which struck the southeastern United States in 2024.

Development, verification, and comparison of a risk stratification model to identify potential population benefiting from chemotherapy in non-metastatic male breast cancer.

To establish a prognostic stratification nomogram for non-metastatic male breast cancer to determine which patients can benefit from chemotherapy. A population-based study was conducted using data collected from the surveillance, epidemiology, and end results database. Cox proportional hazards analysis identified significant prognostic factors for survival.

Ascorbic acid relieves neuropathic pain and depressive behavior by reducing inflammation and activating antioxidant responses.

Neuropathic pain (NP), a specific subtype of chronic pain, can induce depression-like behavior, presenting significant challenges for clinical treatment. Ascorbic acid (AA) is a free radical scavenger; however, its regulatory effects on NP, particularly within the spinal cord, remain ambiguous. In this research, we examined the impact of AA on NP and associated depression-like behavior by establishing a spinal nerve injury (SNI) NP model.

Naked-eye trackable fluorescence-enhanced probe for real-time imaging of biological thiols in living cells.

Biothiols, comprising cysteine (Cys), homocysteine (Hcy), and glutathione (GSH), constitute the predominant thiol pool in biological systems and serve as critical regulators of redox homeostasis. Despite their physiological significance, these species exhibit marked susceptibility to oxidative stress, with resultant concentration dysregulations being implicated in the pathogenesis of various disorders including neoplastic progression, cardiovascular abnormalities, and neurodegenerative conditions. To address the critical need for reliable biothiols monitoring in living systems, we present a rationally engineered hemicyanine-based fluorescent probe (MCY-NB) employing a turn-on fluorescence mechanism.

ATB-targeted nanoparticles trigger STAT3-ferroptosis regulatory axis for enhanced gastric cancer therapy.

Chemotherapy remains one of the main treatments for gastric cancer, but the efficacy of 5-fluorouracil (5-FU) is limited by drug resistance. Ferroptosis is a unique mode of regulated cell death characterized by iron accumulation and lipid peroxidation, and its induction by aberrant STAT3 signaling may contribute to chemotherapy resistance. Cryptotanshinone (Cpt) is a bioactive compound extracted from Salvia miltiorrhiza that acts as a STAT3 inhibitor and has shown efficacy against several malignancies, endowing its potential as an agent to overcome the chemotherapy of gastric cancer.

Dihydrotanshinone I, a main compound of Salvia miltiorrhiza, alleviates autoimmune and inflammatory diseases by directly targeting IRF3.

Background: Interferon regulatory factor 3 (IRF3) is an essential component of the immune system to protect the host from aggression, but excessive IRF3 activation leads to the release of type I interferon, interferon-stimulated genes (ISGs) and pro-inflammatory factors, which closely linked to multiple inflammatory diseases. Therefore, suppression of aberrant activation of IRF3 can be applied to the therapy of inflammatory diseases and have promising applications.

Methods: DNA or RNA can induce the release of type I interferon and pro-inflammatory cytokines, and cell models or multiple mice models were used to assess the anti-inflammatory potential of Dihydrotanshinone 1 (DHT), the main active component of Salvia miltiorrhiza, in vivo and in vitro.

Multicomponent Ru-Based Alloys with a Face-Centered Cubic Structure Achieve High Activity and CO Tolerance for Hydrogen Oxidation Electrocatalysis.

The face-centered cubic (fcc) Ru exhibits great potential for the alkaline hydrogen oxidation reaction (HOR), while achieving high HOR activity and CO tolerance poses a formidable challenge for Ru catalysts in practical fuel cells, particularly when using CO-contaminated H, such as gray and blue hydrogen. Here, we propose a compositional diversification strategy to create 14 types of fcc Ru-based alloys, in which adjustable compositions can tune the nanostructure while offsetting the limitations of single Ru. Among them, quinary RuInPtNiCu nanocrystals (NCs) exhibit an outstanding HOR activity of 5.

The gut microbiome and metabolomic alterations underlying colitis-induced encephalopathy in mice: mechanistic insight.

Background: In addition to classical gastrointestinal symptoms, patients with inflammatory bowel disease (IBD) often exhibit neurological manifestations, such as mood disorders and cognitive dysfunctions, which are frequently overlooked. However, the potential pathogenesis of IBD-related encephalopathy remains unclear, and few studies have explored the influence of interactions between the gut microbiota and the host gut-brain metabolome on the emergence of brain diseases in IBD mice. In this study, we conducted a comprehensive analysis of gut microbiome and metabolome alterations in dextran sulfate sodium salt (DSS)-induced IBD mice compared to control mice, focusing on colonic contents and hippocampal tissue.

High-efficiency carbon-electrode CsPbIBr solar cells prepared by double ion regulation of cadmium acetate additive.

This study introduced CdAc into the CsPbIBr perovskite precursor mixture, where Cd and Ac ions worked synergistically to passivate vacancies of Pb and halogen ions within the perovskite lattice. The CdAc-optimized carbon-based CsPbIBr perovskite solar cells (PSCs) demonstrated an impressive power conversion efficiency (PCE) of 14.34%.

Psoralidin induces pyroptosis in both tumor cells and macrophages as well as enhances nature killer cell cytotoxicity to suppress hepatocellular carcinoma.

Psoralidin is a major component of the traditional Chinese medicine Psoraleae Fructus, which is derived from the dried mature fruit of the leguminous plant Psoralea corylifolia L. and possesses many pharmacological effects, including anti-tumor effects. However, the mechanism through which psoralidin protects against hepatocellular carcinoma (HCC) remains unclear.

Research and application of thermosensitive Pickering emulsion with X-ray and ultrasound dual-modal imaging functions for intra-arterial embolization treatment.

Transcatheter arterial embolization (TAE) is the mainstay for treating advanced hepatocellular carcinoma (HCC), and the performance of the embolization material is crucial in TAE. With the development of medical imaging and the birth of "X-ray-free" technologies, we designed a new dual-mode imaging material of dimethoxy tetraphenyl ethylene (DMTPE) via emulsification by mixing poly(isopropylacrylamideacrylic acid) (PNA) with lipiodol and fluorocarbons, which was evaluated for temperature sensitivity, stability, and dual-mode visualization . Additionally, blood vessel casting embolization and renal artery imaging were assessed in healthy rabbits.

DUSP14 attenuates airway inflammation and mucus hypersecretion in allergic asthma by regulating TAK1 activity.

Allergic asthma is characterized by persistent chronic airway inflammation, leading to mucus hypersecretion and airway hyperresponsiveness. Dual-specificity phosphatase 14 (DUSP14), a member of the DUSP family, is a key regulator in various biological processes. However, the function of DUSP14 in allergic asthma remains to be elucidated.

PTTG1 promotes M2 macrophage polarization via the cGMP-PKG signaling pathway and facilitates EMT progression in human epithelial ovarian cancer cells.

Epithelial Ovarian Cancer (EOC) is complex and heterogeneous, making accurate prognosis and treatment prediction difficult. New therapeutic targets and their mechanisms are urgently needed. This study explored the role of PTTG1 in ovarian cancer via the cGMP-PKG signaling pathway, focusing on its effects on M2 macrophage polarization and EMT progression in EOC cells.

Behavior-driven forecasts of neighborhood-level COVID-19 spread in New York City.

The COVID-19 pandemic in New York City (NYC) was characterized by marked disparities in disease burdens across neighborhoods. Accurate neighborhood-level forecasts are critical for planning more equitable resource allocation to reduce health inequalities; however, such spatially high-resolution forecasts remain scarce in operational use. In this study, we analyze aggregated foot traffic data derived from mobile devices to measure the connectivity among 42 NYC neighborhoods driven by various human activities such as dining, shopping, and entertainment.

Melatonin-loaded nanoparticles protecting human sperm from oxidative stress during cryopreservation.

Background: During the process of sperm cryopreservation, the overproduction of reactive oxygen species (ROS) triggers oxidative stress thereby leading to a reduction in sperm motility and quality. Therefore, it is a feasible strategy to mitigate oxidative damage during cryopreservation by adding antioxidants to freezing media.

Research Design And Methods: In this study, we explored the potential of melatonin to protect sperm from oxidative stress-induced damage by evaluating sperm-related parameters after thawing through self-assembly with a hyaluronic acid-bilirubin conjugate into nanoparticles (M@HBn).

Weather parameters and biotic factors synergistically shape the phyllosphere microbiome of pomelo ( (Burm.) Merr.) across annual cycle.

Phyllosphere microbiome plays important roles in crop adaptation to the changing environments. Perennial woody crops undergo annual cycles with the changing weather parameters and the biological factors, which might shape the phyllosphere microbial community. In this study, we aimed to investigate the dynamics of phyllosphere microbiome of pomelo ( (Burm.

Hypericin impedes M2 macrophage polarization and protects against Hepatocellular carcinoma.

Background: There has been increasing evidence that M2 polarization, which is essential for tumor growth, is present in most tumor-associated macrophages. Hypericin is the major component of the Traditional Chinese Medicine Hypericum perforatum. Hypericin exhibits antitumor activities, but its regulation on M2 macrophage polarization and the protective against Hepatocellular carcinoma (HCC) remains unknown.

Fluid Chemistry of Metal Halide Perovskites.

Solution-processed metal halide perovskites (MHPs) have been rapidly developed worldwide, with much attention to fluid dynamic, fluid crystallization, and fluid interfaces, all falling within the realm of fluid chemistry. It is widely recognized that the theory of fluid chemistry has been proven to provide an effective means for the improvement of perovskite crystallization and the enhancement of perovskite solar cells (PSCs) performance. In this review, the fluid behavior, microfluidic synthesis, and aging process of perovskite materials are first investigated, with emphasis on the related improvement methods and chemical mechanisms.