Mitochondrial Genome of (Anura, Megophryidae, ): Insights into the Characteristics of the Mitogenome and the Phylogenetic Relationships of Megophryidae Species.

(Fang, 1985) is an endemic Chinese amphibian species within the genus (Megophryidae). Despite its ecological significance, its mitochondrial genome architecture and evolutionary relationships remain poorly understood. Given the high structural variability in Megophryidae mitogenomes and unresolved phylogenetic patterns in , this study aims to (1) characterize the complete mitogenome of , (2) analyze its molecular evolution, and (3) clarify its phylogenetic position and divergence history within Megophryidae.

Injectable resveratrol micelles loaded chitosan hydrogel for protecting myocardial cell from injure in oxidative stress microenvironment.

Myocardial infarction (MI) is a critical heart disease with a high mortality rate, posing a serious risk to human health. Injectable hydrogels possess considerable therapeutic promise for managing MI through the application of tissue-engineered scaffolds for cell delivery. However, the oxidative stress microenvironment of MI lesions leads to low cell retention and survival.

"Molecular pigeon" network of lncRNA and miRNA: decoding metabolic reprogramming in patients with lung cancer.

In recent years, with the advancement of RNA analysis techniques, such as single-cell RNA sequencing, noncoding RNAs have demonstrated substantial potential in regulating gene expression, encoding peptides and proteins, constructing the cellular microenvironment, and modulating cell function. They can serve as potential therapeutic targets and diagnostic markers for various diseases, offering novel avenues for diagnosis and treatment. Among them, long noncoding RNAs (lncRNAs) represent a principal component.

Ultrasound-Activated Nitric Oxide Release Nanoplatforms and Their Biomedical Applications.

Nitric oxide (NO), a crucial signaling molecule, plays a significant role in the treatment of various diseases. However, the short half-life of NO limits its biological applications, and different strategies have been designed to control its release. Therefore, the selection of NO donors and triggering mechanisms has become an important focus of research.

Recent Advancements in Near-Infrared Light-Propelled Nanomotors for Biomedical Applications.

Nanomotors (NMs) achieve autonomous motion by converting external energy into mechanical work, enabling them to perform complex tasks on demand. Among the various propulsion mechanisms for NMs, near-infrared (NIR) light propulsion has attracted significant attention due to its excellent biocompatibility, deep tissue penetration, minimal damage to normal tissues, precise on/off control, and rapid response. Furthermore, NIR propulsion can be integrated with other propulsion mechanisms to overcome the limitations of single-mode systems.

Endoplasmic reticulum-mitochondria crosstalk: new mechanisms in the development of atherosclerosis.

Atherosclerosis (AS) is a global public health concern and involves a complex pathogenesis characterized by lipid abnormalities, oxidative stress, and inflammatory responses at the cellular and molecular levels. The crosstalk between the endoplasmic reticulum (ER) and mitochondria, mediated by mitochondria-associated membranes (MAMs), plays a critical role in the pathogenesis of atherosclerosis. As two key cellular organelles, the ER and mitochondria interact physically and functionally through MAMs, which serve as bridges between their close contact and interdependence.

Psoralidin induces pyroptosis in both tumor cells and macrophages as well as enhances nature killer cell cytotoxicity to suppress hepatocellular carcinoma.

Psoralidin is a major component of the traditional Chinese medicine Psoraleae Fructus, which is derived from the dried mature fruit of the leguminous plant Psoralea corylifolia L. and possesses many pharmacological effects, including anti-tumor effects. However, the mechanism through which psoralidin protects against hepatocellular carcinoma (HCC) remains unclear.

Isorhapontigenin suppresses inflammation, proliferation and aggressiveness of rheumatoid arthritis fibroblast-like synoviocytes by targeting farnesyl diphosphate synthase.

Background: Isorhapontigenin (ISO) has been reported to exhibit various therapeutic effects including anti-inflammation and anti-cancer. However, it is still unclear whether ISO has therapeutic efficacy on rheumatoid arthritis (RA). This study aimed to determine the effects of ISO on regulating functions of RA fibroblast-like synoviocytes (FLS) and further to explore the underlying mechanisms.

Size Effects of 1,2-Ethanedithiol-Treated PbS Quantum Dots on Short-Wave Infrared Photodetector Hole Transport Layers.

Colloidal quantum dots (QDs), notably lead sulfide (PbS) QDs, represent a promising platform for short-wave infrared (SWIR) photodetection, offering a cost-effective and scalable alternative to conventional indium gallium arsenide (InGaAs) systems. This study investigates the pivotal role of PbS QD size in optimizing the hole transport layer (HTL) for SWIR photodetectors, addressing the interplay among film morphology, electronic structure, and device performance. Through the precise synthesis of monodisperse PbS QDs (3.

Bibliometric analysis of research trends and prospective directions of from 2010 to 2024.

Background: () is an emerging probiotic with potential impact on human health, and there is a growing interest in this area, but an overall analysis of research trends is lacking. This study conducted a detailed bibliometric analysis and visualization of research to examine the current research status, hotspots, and trends, aiming to inform future research directions.

Methods: This study utilized the Web of Science database to search research on from 2010 to 2024.

Corrigendum: CircMIB1 inhibits glioma development and progression through a competing endogenous RNA interaction network.

[This corrects the article DOI: 10.3389/fmolb.2024.

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Myelin formation is considered the last true "invention" in the evolution of vertebrate nervous system cell structure. The rapid jumping pulse propagation achieved by myelin enables the high conduction speed that is the basis of human movement, sensation, and cognitive function. As a key structure in the brain, white matter is the gathering place of myelin.

B-ALL with CD34 Negative and Surface Immunoglobulin Light Chain Restricted Expression.

Background: The morphologic features of acute lymphoblastic leukemia (ALL) overlap greatly with other blastoid-HGBL or some mature B-cell lymphomas. Blastoid morphology is currently a diagnostic challenge.

Methods And Results: Our case presents a B-ALL with surface IgD and immunoglobulin light chain Kappa restricted expression, CD13 and CD33 were partial expressed and negative for CD34.

Bufotalin loaded biomimetic nanodrug for combined chemo/photodynamic therapy of cancer.

The combination of chemotherapy and photodynamic therapy (PDT) for enhancing cancer therapeutic efficiency has attracted tremendous attention recently. However, limitations, such as low local concentration and uncontrollable release of therapeutic agents, reduce combined treatment efficacy. In the present study, we engineered a biomimetic nanodrug employing hollow Prussian blue nanoparticles (HPB NPs) to co-load the chemical agent bufotalin (CS-5) and the photosensitizer chlorin e6 (Ce6) for combined chemo/PDT therapy against cancer.

Bibliometric analysis and visualization of lipid droplets in the central nervous system: research hotspots and Frontiers (2000-2024).

Objective: The aim of this study is to conduct bibliometric analysis and visualization of the research progress of lipid droplets in the central nervous system in detail using CiteSpace, VOSviewer, and to explore the current research status, hotspots, and research trends, with a view to providing a basis for future research.

Methods: This study utilized the Web of Science database to search for 1,066 relevant publications on lipid droplets in the central nervous system from 2000 to 2024. Bibliometric analysis was conducted using CiteSpace and VOSviewer software, producing metrics such as annual publication trends, contributions by countries, institutions, and authors, keyword co-occurrences, and reference co-citation networks.

Hypericin impedes M2 macrophage polarization and protects against Hepatocellular carcinoma.

Background: There has been increasing evidence that M2 polarization, which is essential for tumor growth, is present in most tumor-associated macrophages. Hypericin is the major component of the Traditional Chinese Medicine Hypericum perforatum. Hypericin exhibits antitumor activities, but its regulation on M2 macrophage polarization and the protective against Hepatocellular carcinoma (HCC) remains unknown.

Protective effects of berberine on MASLD: regulation of glucose and lipid metabolism through PI3K/Akt and STING pathways.

This study is aimed at exploring the therapeutic potential of berberine (BBR) in mitigating metabolic dysfunction-associated steatotic liver disease (MASLD) and at elucidating its mechanisms of action, with a focus on the modulation of glucose and lipid metabolism via the PI3K/Akt and STING signaling pathways. Male C57BL/6 J mice were fed a high-fat diet (HFD) to induce MASLD and subsequently treated with BBR or metformin. HepG2 cells were cultured in vitro, and palmitic acid (PA) was used to construct the cell model.

Crucial role of microglia-mediated myelin sheath damage in vascular dementia: Antecedents and consequences.

Chronic cerebral hypoperfusion can lead to neuronal necrosis, trigger inflammatory responses, promote white matter damage, and ultimately result in cognitive impairment. Consequently, chronic cerebral hypoperfusion is an important factor influencing the onset and progression of vascular dementia. The myelin sheath is a critical component of white matter, and damage and repair of the white matter are closely linked to myelin sheath integrity.

NIR-Propelled Thermosensitive Bowl-Shaped Nanomotors with High Penetration and Targeting for Photoacoustic Imaging Guided Thrombolysis Therapy.

Traditional antithrombotic therapeutic strategies encounter challenges including heightened bleeding risks, short circulation times, low targeting ability, and inferior thrombus penetration. Therefore, a novel thrombolysis nanodrug (APBUL) is designed that incorporates urokinase (UK) loaded onto the surface of bowl-shaped nanomotors (APBs) encapsulated within fibrin peptide (CREKA)-modified thermosensitive liposomes, presenting an innovative therapeutic platform for thrombolysis. APBUL leverages CREKA's targeting ability for thrombus accumulation.

Current insights into heat treatment for improving functionalities of soy protein: A review.

Nowadays, soy protein-based food is consumed globally as an eco-friendly and healthy plant-based alterative. Nevertheless, more effort is still needed to improve the functionalities of soy protein for a wider application and addressing its existing challenges. Heat treatment is a fundamental approach in industrial food processing due to its simplicity, cost-effectiveness, and versatility.

Neoandrographolide inhibits mature osteoclast differentiation to alleviate bone loss and treat osteoporosis.

Background: Osteoporosis (OP), as the prevalent systemic metabolic bone disease worldwide, progresses insidiously and slowly. The clinical discomfort and complications associated with OP impose a significant burden on patients. Therefore, finding more effective treatments for OP remains an urgent challenge.

Zengye decoction regulated the expression of aquaporin in colon tissue of rats with constipation through miR-10a-5p targeting Drd2/AC/cAMP axis.

Slow transit constipation (STC) is a colonic motor disorder characterized by a marked delay in the movement of substances through the colon. Traditional Chinese medicine (TCM) is a treasure trove of natural compounds, which is effective in treating constipation with relatively minor side effects. Zengye decoction (ZYD), a classic herbal formula in TCM, is used for moistening the intestines and relieving constipation.

[ Formula improves liver function of mice with acute-on-chronic liver failure by inhibiting excessive activation of the cGAS-STING signaling pathway].

Objectives: To explore the role of the cGAS-STING signaling pathway in the therapeutic mechanism of Formula (LXJDHYF) for acute-on-chronic liver failure (ACLF) in mice.

Methods: Thirty C57BL/6 mice were randomly divided into blank control group, model group, low- and high-dose LXJDHYF groups, and H151 (a specific cGAS-STING pathway inhibitor) group (6). In all but the control group, the mice were treated with CCl to induce liver cirrhosis followed by intraperitoneal injections of lipopolysaccharide and D-amino galactose to establish mouse models of ACLF.

CircMIB1 inhibits glioma development and progression through a competing endogenous RNA interaction network.

Introduction: The critical role of circular RNAs as non-coding RNAs in glioma has been extensively investigated. Therefore, we aimed to explore the role and potential molecular mechanisms of circRNA-mind bomb homolog 1 (circMIB1) in gliomas.

Methods: RNA sequencing was used to analyze the expression profiles of circRNAs in glioma tissues and normal brain tissues.