Broad-spectrum antifungal activity of aniline-modified tavaborole derivatives: insights from molecular docking and bioassays.

Background: Phytopathogenic fungi pose a severe threat to global agriculture, and the emergence of drug-resistant strains underscores the urgent need for novel fungicides. Tavaborole (AN2690), a clinically approved benzoxaborole antifungal, suppresses fungal growth by selectively targeting leucyl-tRNA synthetase (LeuRS) through covalent binding-a unique mode of action. In this study, we designed and synthesized a series of novel tavaborole derivatives featuring substituted aniline moieties.

A multifunctional molecularly imprinted polymer-based biosensor for direct detection of doxycycline in food samples.

In this study, we developed a new type of multifunctional molecularly imprinted polymer (MIP) composite as an all-in-one biosensor for the low-cost, rapid and sensitive detection of doxycycline in pig plasma. The MIP composite consisted of a magnetic core for ease of manipulation, and a shell of fluorescent MIPs for selective recognition of doxycycline. By simply incorporating a small amount of fluorescent monomer (fluorescein-O-acrylate), the fluorescent MIP layer was successfully grafted onto the magnetic core via a surface imprinting technique.