Efficient RNA nucleotide encoding enhances the accurate prediction of ac4C modifications.

RNA N4-acetylcytidine (ac4C) modification plays a vital role in gene regulation and cellular function. Accurate identification of ac4C sites is essential for elucidating their biological significance. However, existing prediction methods struggle to capture complex sequence patterns, limiting their accuracy.

Miniaturized MgBi-based thermoelectric cooler for localized electronic thermal management.

Miniaturized thermoelectric coolers, known for their high cooling power density and rapid thermal response, hold promise for localized thermal management. While traditional thermoelectric coolers have primarily relied on BiTe alloys, the recent development of n-type MgBi-based materials presents a compelling alternative, offering enhanced cost-effectiveness and environmental sustainability. In this study, we have designed and fabricated a MgBi-based miniscale thermoelectric cooler.

Robust organic radical cations with near-unity absorption across solar spectrum.

Developing low-energy-gap materials for efficient photothermal conversion provides promising candidates for solar energy utilization. Herein, we explore the feasibility of employing robust organic radical cations as near-unity solar absorbers for practical seawater evaporation. Gram-scale organic radical cations are straightforwardly synthesized through single-electron oxidation.

WVO-Based Nanocavity for Adaptive Thermal Camouflage with Visual Coloration.

With the rapid advancements in optical and thermal imaging technologies, visible-compatible thermal camouflage technologies are pivotal for the survival of military devices and facilities. However, realizing adaptive thermal camouflage in dynamic scenes where the target temperature varies still remains a huge challenge in existing designs due to the limitation of insufficient ability to regulate radiative heat. Here, we proposed a visible-compatible adaptive infrared camouflage strategy employed by the WVO-based nanocavity structure to operate effectively across a wide temperature range of 30-70 °C.

Clinical Characteristics and Outcomes of Hypertriglyceridemic Acute Pancreatitis Concomitant with Diabetic Ketoacidosis.

Objectives: Hypertriglyceridemic acute pancreatitis (HTG-AP) is the common cause of acute pancreatitis (AP) after gallstones and alcohol abuse, accounting for up to 10% of the cases of acute pancreatitis. Diabetic ketoacidosis (DKA) may potentially complicate the diagnosis, treatment, and clinical outcomes of HTG-AP. This study aimed to directly compare the clinical characteristics and outcomes of HTG-AP in patients with and without DKA.

Association between pressure ulcer and 28-day mortality in septic patients: a retrospective study based on the MIMIC-IV database.

Background: Pressure ulcer is a significant issue that cannot be overlooked in septic patients. This study aims to explore the impact of pressure ulcers on the 28 day mortality rate of septic patients.

Methods: The data for this study were obtained from the MIMIC-IV v3.

Core-Shell IrPt Nanoalloy on La/Ni-CoO for High-Performance Bifunctional PEM Electrolysis with Ultralow Noble Metal Loading.

The development of highly efficient and durable bifunctional catalysts with minimal precious metal usage is critical for advancing proton exchange membrane water electrolysis (PEMWE). We present an iridium-platinum nanoalloy (IrPt) supported on lanthanum and nickel co-doped cobalt oxide, featuring a core-shell architecture with an amorphous IrPtOx shell and an IrPt core. This catalyst exhibits exceptional bifunctional activity for oxygen and hydrogen evolution reactions in acidic media, achieving 2 A cm at 1.

Unified contact layer and low-temperature transient liquid phase interconnection for high-performance all-Mg-based thermoelectric devices.

Thermoelectric technology enables direct conversion of untapped low-grade waste heat into electrical energy. Mg₃(Sb, Bi)₂ and MgAgSb, with their excellent thermoelectric performance near room temperature, have emerged as cost-effective and environmentally friendly alternatives to Bi₂Te₃-based materials. However, the development of high-performance Mg-based thermoelectric devices faces significant challenges due to the inherent high chemical reactivity and volatility of Mg elements, coupled with the phase transition-induced degradation of thermoelectric properties in MgAgSb, which collectively led to poor interfacial contacts and device integration.

Stroke patients with obstructive sleep Apnea: Risk of cardiovascular diseases - A systematic review and meta-analysis.

Background: There exists a significant pathogenic and epidemiological overlap among stroke, obstructive sleep apnea (OSA), and cardiovascular disease. This systematic review aimed to clarify the association between OSA and cardiovascular disease in stroke patients.

Methods: The study protocol was prospectively registered with PROSPERO (registration number: CRD42024517766).

Integrating Protein Language Models and Geometric Deep Learning for Peptide Toxicity Prediction.

Peptide toxicity prediction is a critical task in biomedical research, influencing drug safety and therapeutic development. Traditional methods, relying on sequence similarity or handcrafted features, struggle to capture the complex relationship between peptide structure and toxicity. In this study, we propose PeptiTox, an advanced deep learning framework that integrates protein language models (PLMs) and geometric deep learning to enhance peptide toxicity prediction.

Albumin-corrected anion gap predicts acute kidney injury in critically ill patients with acute pancreatitis: a retrospective cohort study.

Background: Acute kidney injury (AKI) is a common and serious complication of acute pancreatitis. Early detection of patients at high risk for AKI is critical to avoiding complications and lowering mortality. This study looked into the relationship between albumin-corrected anion gap (ACAG) and AKI in critically ill patients with AP.

Floral organ development combined with pistil transcriptome analysis reveals the role of plant hormone signal transduction in the distyly of Primula vulgaris.

Distyly is a widespread phenomenon in flowering plants that enhances pollination accuracy and improves plant environmental adaptability. Primula, the first genus in which distyly is discovered, has become a model system for studying this trait. There are currently many studies on the origin and evolution of distyly in Primula, but there remains relatively little research on the molecular mechanisms and related gene functions that regulate distyly.

Application of Immersive Teaching in the Training of Hospice Care Professionals: A Randomized Clinical Trial.

ContextHospice care landscape is the stark contrast between developed and developing countries. There is a pressing need to strengthen the construction of hospice care talent teams further and establish corresponding training and development systems. Moreover, the study on the immersive teaching in hospice care training is lacking.

Diagnostic accuracy of wearable ECG and assessment of ventricular repolarization and its cardiovascular risks post cold stress.

Cold stress can affect ventricular repolarization (VR), which may serve as a potential trigger for malignant arrhythmias. Compared to conventional electrocardiogram (ECG) devices, wearable technology is more suitable for out-of-hospital monitoring due to their portability. However, outdoor cold environments can limit their application.

Scalable modulation of CRISPR‒Cas enzyme activity using photocleavable phosphorothioate DNA.

The regulation of CRISPR‒Cas activity is critical for developing advanced biotechnologies. Optical control of CRISPR‒Cas system activity can be achieved by modulation of Cas proteins or guide RNA (gRNA), but these approaches either require complex protein engineering modifications or customization of the optically modulated gRNAs according to the target. Here, we present a method, termed photocleavable phosphorothioate DNA (PC&PS DNA)-mediated regulation of CRISPR‒Cas activity (DNACas), that is versatile and overcomes the limitations of conventional methods.

Inhibition of MMP9 ameliorates neutrophil extracellular traps-mediated necroptosis through regulation of impaired autophagy in severe acute pancreatitis.

The positive feedback of acinar cell death, immune infiltration and inflammation aggravated the severity of the severe acute pancreatitis (SAP). Neutrophil extracellular traps (NETs) were demonstrated to trigger trypsin activation and organ damage. Exploration of the underlying mechanism of the damage effect of NETs on pancreas and potential to block the process was needed.

Patient-reported outcome tools of acupuncture clinical trials in mainland China: a cross-sectional study.

Background And Objective: Nowadays, the number of acupuncture clinical trials is dramatically increasing. In acupuncture clinical research, patient-reported outcome measurements are important evaluation tools, but there is a lack of systematic survey. This study aims to evaluate the characteristics and application of PRO measurements in acupuncture clinical trials in mainland China, further exploring and developing patient-reported outcomes (PROs) that are in line with the characteristics of acupuncture treatment.

Recent advances and future perspectives of long-acting ophthalmic preparations (LAOPs) in clinical applications.

The intricate structure of ocular barriers significantly impedes drug penetration, leading to suboptimal efficacy of conventional ophthalmic formulations. Sustained/controlled-release long-acting ophthalmic preparations (LAOPs) address these limitations by prolonging drug retention, reducing dosing frequency, and enhancing therapeutic precision. This review categorizes clinically validated LAOPs by administration route, highlighting both market-approved products and investigational candidates in ongoing clinical trials.

Advancing thermoelectric and sensing performance in constrained GeTe thin films.

Thermoelectric thin films hold significant potential for self-powered microelectronic and advanced sensing devices. However, they normally demonstrate inferior electrical transport performance compared to their bulk counterparts. Herein, we deposited growth-restricted GeTe thin films to improve their electrical transport performance and further employed optical thin films, serving as spectrally selective absorbers and radiative cooling coatings, to enlarge the temperature difference across the thermoelectric legs.

Identification of mitophagy-related biomarkers in severe acute pancreatitis: integration of WGCNA, machine learning algorithms and scRNA-seq.

Background: Mitophagy is a highly conserved cellular process in eukaryotic cells that selectively clears dysfunctional or damaged mitochondria through autophagy mechanisms to maintain mitochondrial homeostasis. However, the role of mitophagy in the pathogenesis of severe acute pancreatitis (SAP) has not been fully investigated. In this study, we aimed to identify crucial mitophagy-related genes in SAP to provide a theoretical basis for in-depth mechanistic investigations.

Deep Learning Reveals Liver MRI Features Associated With PNPLA3 I148M in Steatotic Liver Disease.

Background: Steatotic liver disease (SLD) is the most common liver disease worldwide, affecting 30% of the global population. It is strongly associated with the interplay of genetic and lifestyle-related risk factors. The genetic variant accounting for the largest fraction of SLD heritability is PNPLA3 I148M, which is carried by 23% of the western population and increases the risk of SLD two to three-fold.

Dynamic relationship between gut microbiota and post-necrotizing pancreatitis: insights from a multi-stage 16S rRNA sequencing study.

Background: Acute pancreatitis (AP) is a common digestive disorder, with necrotizing pancreatitis (NP) occurring in 20% of cases. Long-term complications can include pancreatic exocrine and endocrine insufficiency, with gut microbiota (GM) playing a significant role in pancreatic diseases. Although previous studies have established a connection between gut microbiota dysbiosis and the onset of necrotizing pancreatitis, the composition of GM in patients who have experienced post-NP post-necrotizing pancreatitis remains largely unexamined.

Fresh apple slice preservation driven by molecular hydrogen.

Here, we observed that surface browning and physiological degradation in fresh-cut apple slices during storage for 8 days (4 °C and 85 % relative humidity) was accompanied by the decreased hydrogen gas (H) contents. To further investigate whether or how H supply influences above processes, H modified atmosphere packing (MAP; containing 0.01 %, 0.

Elevating thermoelectric performance in the sub-ambient temperature range for electronic refrigeration.

Solid-state thermoelectric coolers, which enable direct heat pumping by utilizing electricity, play an essential role in electronic refrigeration. Given that these devices usually cool down to the sub-ambient temperature range, their performance is critically dependent on the material properties at temperatures below 300 K. Consequently, enhancing the thermoelectric properties of materials at sub-ambient temperature is of paramount importance for advancing cooling technology.

Effects of mallotus furetianus extract on CYP3A activities in rats.

Mallotus furetianus is traditionally used as folk medicine on Hainan Island, China. Given the significance of the pharmacokinetic interaction between herbs and drugs, we investigated the effects of Mallotus furetianus ethanol extract (MFE) on CYP3A activity in rats. The major bioactive constituents of MFE, gallic acid (GA) and epigallocatechin gallate (EGCG), were analyzed by Reverse Phase High-Performance Liquid Chromatography (RP-HPLC) for MFE standardization.