Developing a prognostic model of glutamine metabolism-related genes associated with clinical features and immune status in melanoma.

Introduction: Melanoma exhibited a poor prognosis due to its aggression and heterogeneity. The effect of glutamate metabolism promoting tumor progression on cutaneous melanoma remains unknown. Herein, glutamine metabolism-related genes (GRGs) were identified followed by constructing a prognostic model for melanoma via bioinformatics analysis.

Development of simple sequence repeat markers and genetic diversity of in the Beibu Gulf of China.

Background: The marine species , valued for its medicinal and commercial significance, faces critical research gaps due to a lack of molecular markers (notably simple sequence repeats (SSRs)) and insufficient genetic diversity data, hindering genetic studies and evidence-based breeding initiatives.

Methods: The software of Misa and Primer3 were adopted to detect SSRs and develop primer pairs, and then some primers of highly polymorphic loci in the genome were used to reveal the genetic diversity of along the Beibu Gulf in China.

Results: From the genome, 277,264 SSRs were detected an d 198,902 primers were designed.

Habitat analysis based on magnetic resonance imaging for the prediction of prostate cancer: a dual-center study.

Background: The application of habitat analysis is anticipated to enhance the diagnostic efficacy of magnetic resonance imaging (MRI) in prostate cancer (PCa) by providing a more accurate reflection of the microenvironmental characteristics within the lesion. The objective of this study was to investigate the feasibility of multisequence and multiregional MRI-based habitat analysis in the differentiation of PCa and benign prostatic hyperplasia (BPH).

Methods: We retrospectively evaluated the data of 673 cases from The Second Affiliated Hospital of Nanchang University and The First Hospital of Xiushui who received MRI examination of the prostate and pathologically confirmed diagnosis of PCa or BPH.

Properties and Mechanisms of TBBPA and TBBPS Adsorption onto Various Soils in China.

Understanding the differences in the adsorption behaviors of tetrabromobisphenol A (TBBPA) and tetrabromobisphenol S (TBBPS) on soils is critical for assessing their environmental mobility and risks. This study investigated the adsorption characteristics and patterns of TBBPA/S across various soil types. Adsorption kinetics analysis indicated that the adsorption of TBBPA/S on soils followed pseudo-secondary-order kinetics.

High precision integrated sensors for multi-parameter online monitoring in salt spray environments.

Detecting multiple parameters in salt spray environments is critical, as it significantly enhances the stability and reliability of real-time corrosion monitoring systems. However, current sensor strategies for detecting salt spray parameters face challenges such as poor timeliness, short lifespan, and low detection accuracy. This work introduces a multi-parameter micro-nano sensor based on Micro-Electro-Mechanical Systems (MEMS) technology, which integrates temperature, humidity, and conductivity detection units.

Facile all-in-one detection of nitrofurantoin in feed and milk by magnetic separation assisted differential pulse voltammetry.

Nitrofurantoin (NFT) residue in animal-derived food poses a threat to human health. We proposed a novel strategy for NFT determination in feed and milk, which connected pretreatment technology to electrochemical detection. Cobalt nanoparticles encapsulated in nitrogen-doped carbon nanostructure with carbon nanotubes (Co/N-CNS-CNTs) were prepared for modifying magnetic electrodes.

Research on Fatigue Life Prediction Method of Spot-Welded Joints Based on Machine Learning.

Spot-welding joints are widely used in modern industries, and their fatigue life is crucial for the safety and reliability of structures. This paper proposes a method for predicting the fatigue life of spot-welding joints by integrating traditional structural stress methods and machine learning algorithms. Systematic fatigue tests were conducted on Q&P980 steel spot-welding joints to investigate the influence of the galvanized layer on fatigue life.

Comprehensive first-in-human phase I/II study of FHND-9041 in patients with EGFR-mutated advanced non-small cell lung cancer.

Introduction: FHND-9041 is a novel third-generation EGFR tyrosine kinase inhibitor (EGFR-TKI). This first-in-human study is a single-arm, multi-center, open-label, non-randomized phase Ⅰ/II trial that aims to evaluate the tolerability, safety, pharmacokinetics, and anti-tumor activity of FHND-9041 in patients with EGFR-mutated non-small cell lung cancer (NSCLC).

Methods: The phase I study enrolled 87 patients with previously-treated EGFR T790M-positive NSCLC.

Case Report: Ultrasound-guided microwave ablation combined with postoperative radiotherapy and chemotherapy for advanced tongue cancer.

Background: While surgery remains the standard treatment for tongue cancer, it is associated with a range of functional and aesthetic sequelae. Additionally, ultrasound-guided microwave ablation (MWA) represents a promising minimally invasive alternative for patients with poor performance status or those unwilling to undergo surgery.

Case Presentation: We report a 50-year-old male patient diagnosed with advanced tongue squamous cell carcinoma and cervical lymph node metastases.

Predictive Value of MRI Functional Liver Imaging Score and Spontaneous Portal Shunt for First Decompensation in Patients With Chronic Hepatitis B.

Objective: To investigate the predictive value of Gd-EOB-DTPA enhanced MRI functional liver imaging score and spontaneous portal shunt on the occurrence of first hepatitis decompensation in patients with chronic hepatitis B (CHB).

Methods: Clinical and MRI data of 443 patients with CHB who received Gd-EOB-DTPA enhanced MRI scanning from October 2019 to October 2022 were retrospectively collected. All patients had a complete clinical laboratory examination 1 week before and after MR examination.

Assessing the proficiency of large language models on funduscopic disease knowledge.

Aim: To assess the performance of five distinct large language models (LLMs; ChatGPT-3.5, ChatGPT-4, PaLM2, Claude 2, and SenseNova) in comparison to two human cohorts (a group of funduscopic disease experts and a group of ophthalmologists) on the specialized subject of funduscopic disease.

Methods: Five distinct LLMs and two distinct human groups independently completed a 100-item funduscopic disease test.

Artificial Intelligence Models in Diagnosis and Treatment of Kidney Diseases: Current Status and Prospects.

Background: Artificial intelligence (AI) has made significant advances in nephrology, revolutionizing the diagnosis, prognosis, and treatment of kidney diseases.

Summary: This review provides an overview of AI applications in nephrology, introducing the basic structures of each model, highlighting both traditional machine-learning approaches and neural networks, and providing model application comparisons along with selection recommendations. It discussed key challenges in deciding appropriate AI models for specific tasks and evaluated their advantages, limitations, and optimal use cases.

Association between pressure ulcer and 28-day mortality in septic patients: a retrospective study based on the MIMIC-IV database.

Background: Pressure ulcer is a significant issue that cannot be overlooked in septic patients. This study aims to explore the impact of pressure ulcers on the 28 day mortality rate of septic patients.

Methods: The data for this study were obtained from the MIMIC-IV v3.

Value of two-dimensional shear wave elastography quantitative analysis for evaluation of thyroid function in first trimester pregnancy.

Background: Thyroid dysfunction during pregnancy is an important disease affecting the health of mothers and children. Two-dimensional (2D) shear wave elastography (SWE) is the newest ultrasonic elastography technology and its value in differentiating benign and malignant thyroid nodules has been widely recognized. However, the value of 2D SWE in evaluating and predicting thyroid function is unclear.

Characterisation and expression analysis of extracellular superoxide dismutases of navás (Megaloptera: Corydalidae) in response to sublethal chlorpyrifos exposure.

The extracellular matrices, such as the haemolymph, in insects are at the centre of most physiological processes and are protected from oxidative stress by the extracellular antioxidant enzymes. In this study, we identified two secreted superoxide dismutase genes ( and ) and investigated the oxidative stress induced by chlorpyrifos (CPF) in the aquatic insect (Megaloptera: Corydalidae). PxSOD3 and PxSOD5 contain the signal peptides at the N-terminus.

Transcriptomic profile of Lutraria sieboldii larvae: Insights into the molecular mechanisms of attachment and metamorphosis.

Metamorphosis, the crucial transition from planktonic to sessile life stages, marks a key developmental milestone in marine bivalves, particularly for commercially valuable species like Lutraria sieboldii. We conducted a comprehensive transcriptomic analysis using RNA sequencing (RNA-seq) during the larval settlement stage to elucidate the molecular mechanisms underlying this ecologically and economically significant process. Our study generated 89.

Effects of negative workplace behavior on job insecurity and turnover intention in healthcare workers: roles of psychological resilience.

Introduction: Although negative workplace behavior as a key factor in healthcare staff turnover intention was well established, the mechanisms by which negative workplace behavior affects turnover intention are unclear. Extending the affective event theory, we aimed to (a) identify the interrelationships between negative workplace behavior, job insecurity, psychological resilience, and turnover intention in the healthcare setting and (b) clarify the mechanism among these variables.

Methods: A cross-sectional survey was conducted in China from February to April 2023 utilizing a quota sampling method.

Retinal microvasculature alteration in patients with acute pancreatitis: an observational OCTA study.

Objective: To evaluate changes in retinal layer thickness and microvascular density in pancreatitis patients using optical coherence tomography angiography (OCTA).

Methods: The study involved 16 pancreatitis patients and 16 healthy controls. Each participant underwent a superficial OCTA scan, with images divided into nine subregions to compare macular retinal thickness (RT) and superficial vascular density (SVD) between groups.

Berberine in the treatment of radiation-induced skin injury: insights from proteomics and network pharmacology.

Background: Radiation-induced skin injury (RISI) is a notable complication of cancer radiotherapy, impacting patients' quality of life. Existing interventions mainly address symptoms, with limited success in targeting the fundamental mechanisms. Berberine (BBR), a bioactive compound recognized for its anti-inflammatory, antioxidant, and anti-fibrotic characteristics, presents a compelling option for treating RISI.

An Integrated Solution for Application of Next-Generation Sequencing in Newborn Screening.

Background: Next-generation sequencing (NGS) has greatly improved the diagnostic process for hereditary diseases, and incorporation of NGS into newborn screening (NBS) programs for more actionable diseases has been widely discussed. The aim of this study was to evaluate an integrated solution for application of NGS in newborn screening.

Methods: An NGS panel targeting 155 genes related to inborn errors of metabolism, hearing loss, severe combined immunodeficiency, congenital hypothyroidism, and other actionable genetic diseases, was designed.

A dual-dynamic crosslinking network enabled strong, flexible, self-healing, and biodegradable chitosan fiber paper/vitrimer composites for plastic substitution.

The development of high-performance biomass-based vitrimers has emerged as a crucial research topic to reduce reliance on petroleum-based plastics. Achieving both high strength and toughness is essential for most biomass-based vitrimers, yet these properties typically tend to be mutually exclusive. Here we show a multifunctional composite, CFP/TAV-PI, prepared by integrating an all-natural polyimine vitrimer (TAV-PI) into chitosan fiber paper (CFP) through in-situ polymerization and heat-pressing treatments.

Relationship between adolescent gaming addiction and myopia, ocular surface condition, and health status: a questionnaire based cohort study.

This study explores the relationship between gaming addiction among Chinese adolescents and their myopia, ocular surface conditions, and overall health. A cross-sectional questionnaire-based cohort study included 835 participants aged 13-17, selected from 3300. Tools included the Hospital Anxiety and Depression Scale (HADS), Van Dream Anxiety Scale (VDAS), 36-Item Short-Form Health Survey (SF-36), Ocular Surface Disease Index (OSDI), Internet Addiction Test (IAT), and Internet Gaming Disorder Scale-20 (IGD-20).

Tobacco Smoking Rewires Cell Metabolism by Inducing GAPDH Succinylation to Promote Lung Cancer Progression.

Unlabelled: Patient behavior and physiology can directly affect cancer metabolism. Smoking is the leading risk factor for non-small cell lung cancer (NSCLC). In this study, we identified that smoking modulates lung cancer cell metabolism through altered protein post-translational modification.

A new class of ultrastable dual hydrogen-bond-donor COF for improving the reaction activity.

Dual hydrogen-bond-donor (HBD) molecules attracted considerable attention in the area of organocatalysts. Here, a novel and stable dual HBD TBP-COF has been developed by structural transformation from TB-COF by locking the reversible bond to form a heterocycle. The obtained dual HBD COF showed excellent hydrogen bond catalytic performance in promoting the Friedel-Crafts reaction.

Development of genome-wide insertion/deletion markers and genetic diversity in along the Beibu Gulf of China.

, a marine species of substantial medicinal and commercial importance, requires genetic enhancement to boost its production yield. However, progress in genetic research and selective breeding has been constrained by two critical limitations: the scarcity of available molecular markers and the absence of systematic genetic diversity assessments across China's Beibu Gulf. To address these challenges, our genome-wide investigation identified 168,771 InDel variations, from which we developed 25,558 primer pairs.