Publications by authors named "En Zhou"

Graphene possesses high carrier mobility and structural tunability, but achieving effective electromagnetic wave (EMW) absorption with single-component graphene remains challenging due to the inherent trade-offs among filler loading, impedance matching, and attenuation intensity. Structural engineering of graphene has been proved to be an effective strategy to address this challenge. In this study, a series of short-cut graphene porous fibers (SCGPF) is fabricated through wet-spinning and freeze-drying, and regulating the pore size of SCGPFs to achieve precision control of electromagnetic parameters.

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Introduction: Incomplete endothelialization (IDE) of left atrial appendage closure (LAAC) devices increases the risk of device-related thrombosis (DRT) and stroke. Insulin resistance (IR) may contribute to IDE by impairing endothelial function, but its role remains unclear. This study aimed to investigate the association between IR markers and IDE and develop a predictive model for identifying high-risk patients.

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Background: Immune escape and immunosuppression play crucial roles in the onset and progression of head and neck malignant neoplasms (HNMN). However, previous studies on the relationship between immune cells and HNMN have yielded inconsistent results.

Methods: In this study, we performed bidirectional two-sample Mendelian randomisation (MR) analyses using genome-wide association study (GWAS) and FinnGen databases to examine the association between 731 immune cell features and the risk of HNMN.

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  • A study compared two methods of repairing pharyngocutaneous fistulas after total laryngectomy in 60 patients: one group used a thyroid gland flap, while the other used a traditional strap muscle repair.
  • Results showed a significantly lower incidence of pharyngocutaneous fistula in the thyroid flap group (3.3%) compared to the strap muscle group (26.7%).
  • The findings suggest that using a pedicle thyroid flap is an effective way to reduce the occurrence of pharyngocutaneous fistulas post-surgery, making it a favorable option in clinical practice.
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  • Myocardial ischemia-reperfusion injury (MIRI) is a major issue in heart treatment, and effective solutions are lacking.
  • Research aimed to explore if extracellular vesicles (EVs) from GABA-treated adipose mesenchymal stem cells (ADSCs) could better reduce oxidative stress in heart cells.
  • Findings showed that GABA enhances the miR-21-5p levels in EVs, leading to reduced mitochondrial stress and protection of heart cells by regulating TXNIP expression.
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Objective: Studies on feeling of ear fullness (FEF) related to sudden sensorineural hearing loss(SSNHL) are limited. The mechanisms of FEF are unclear. This study aimed to explore the characteristics and related brain activation of SSNHL with FEF.

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  • Herbal polysaccharides, like Lagenaria siceraria polysaccharide (LSP50), are being studied as safe and effective adjuvants for vaccines due to their ability to enhance immune responses.
  • Structural analysis of LSP50 showed it contains a mix of sugars (rhamnose, arabinose, xylose, mannose, glucose, and galactose) in specific ratios.
  • The research found that LSP50 significantly boosts immune responses in broiler chickens vaccinated against H9N2, improving immune organ indices, specific antibody levels, cytokine production, and T-cell proportions, while also regulating key genes in the immune response pathway.
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  • Li-alloying reactions allow for many lithium atoms to enter the structures of electrodes like black phosphorus (BP), but these reactions cause complex phase changes and structural collapses.
  • Despite various studies, there's ongoing debate about the intermediate structures and phase transition pathways during the alloying process.
  • Using electron diffraction and simulations, researchers discovered that during lithium insertion, the structure changes from a layered form to cage-like and chain configurations, revealing important factors that influence these transformations and the reversibility of lithium interactions.
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Electrocatalysis is generally confined to dynamic liquid-solid and gas-solid interfaces and is rarely applicable in solid-state reactions. Here, we report a paradigm shift strategy to exploit electrocatalysis to accelerate solid-state reactions in the context of lithium-ion batteries (LIBs). We employ heteroatom doping, specifically boron for silicon and sulfur for phosphorus, to catalyze electrochemical Li-alloying reactions in solid-state electrode materials.

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  • Alloy anode materials are being researched for potassium storage because they have a high theoretical capacity, but they struggle with structural strain and fragmentation when deeply charged with potassium.
  • This study introduces a strategy that involves modifying the chemical bonds in these materials to better handle the volume changes during the charging process, specifically using black phosphorus with added sulfur.
  • The result is a more stable anode that supports higher capacity and longer lifespan for potassium-ion batteries, indicating progress in balancing the challenges of low-strain and effective charging.
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Background: Xuebijing (XBJ) can alleviate the inflammatory response, improve organ function, and shorten the intensive care unit (ICU) stay in patients with pyogenic liver abscess (PLA) complicated with sepsis, but the molecular mechanisms have not been elucidated. This study aimed to explore the molecular mechanism of XBJ in treating PLA complicated with sepsis using a network pharmacology approach.

Methods: The active ingredients and targets of XBJ were retrieved from the ETCM database.

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In the context of clean energy and green cryptocurrency development, the relationship between energy and cryptocurrency markets deserves further exploration. This study employs a quantile time-frequency connectedness approach to measure the dynamic connectedness and volatility propagation mechanisms between oil, clean energy, green cryptocurrency (GC), and non-green cryptocurrency (NGC) markets. Our findings suggest that, at median and low volatility levels, the oil and clean energy markets act as net receivers, taking on volatility spillovers from cryptocurrency markets.

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  • Lithium-ion batteries (LIBs) using ethylene carbonate electrolytes and graphite anodes face energy loss at low temperatures due to electrolyte viscosity and slow lithium transportation.
  • A lithium phosphide (LiP) coating on the graphite improves ion conductivity and accelerates lithium movement, effectively addressing these issues.
  • This innovation allows LIBs to retain 70% of their room-temperature capacity at -20 °C and maintain 65% at -40 °C, significantly enhancing performance in cold environments.
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Background: The effect of type 2 diabetes mellitus (T2DM) on postoperative recurrence of chronic sinusitis (CRS) is unclear.

Objective: To investigate the association between T2DM and postoperative recurrence in CRS patients.

Methods: CRS patients who underwent surgery in our hospital from January 2018 to April 2020 were included and followed up for three years.

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  • The study investigates how Cx43 (connexin 43) affects the endothelial-to-mesenchymal transition (EndMT) in endothelial cells.
  • Rat aorta-derived endothelial cells were manipulated using Cx43 cDNA and siRNA and exposed to different shear stress levels, revealing key changes in protein expression related to EndMT.
  • Results showed that shear stress enhanced Cx43 expression, leading to increased αSMA and SM22α while decreasing CD31, suggesting Cx43's involvement in EndMT and the influence of specific signaling pathways.
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In view of their high lithium storage capability, phosphorus-based anodes are promising for lithium-ion batteries. However, the low reduction potential (0.74 V versus Li /Li) of the commonly used ethylene carbonate-based electrolyte does not allow the early formation of a solid electrolyte interphase (SEI) prior to the initial phosphorus alloying reaction (1.

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Aim: To determine the role and underlying mechanism of lncRNA HCP5 in nasopharyngeal carcinoma (NPC).

Method: The expression of HCP5 and miR-128-3p was assessed by qRT-PCR. CCK-8, EdU staining, and transwell were performed to determine cell progression.

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Objective: Cardiomyocyte apoptosis critically contributes to ischemia reperfusion injury (IRI), which lacks effective therapeutic strategies. Circular RNAs (circRNAs) serve as novel diagnostic and therapeutic targets in various cardiovascular diseases. CircRNA Fbxl5 is one of the abundantly expressed circRNAs in the heart and its role in myocardial IRI remains elusive.

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Background: Extracellular vesicles (EVs) derived from hypoxia-preconditioned (HP) mesenchymal stem cells (MSCs) have better cardioprotective effects against myocardial infarction (MI) in the early stage than EVs isolated from normoxic (NC)-MSCs. However, the cardioprotective mechanisms of HP-EVs are not fully understood.

Aim: To explore the cardioprotective mechanism of EVs derived from HP MSCs.

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Na metal anode (NMA) is one of the most promising candidate materials for next-generation low-cost sodium metal batteries. However, the preferred deposition of Na metal at the anode/separator interface increases the risk of dendrite penetration of the separator, consequently, reduces safety and life of batteries with NMA. In this study, a Na deposition-regulating strategy is shown by designing a gradiently graphitized 3D carbon fiber (CF) framework as host (grad-CF), whereby Na is guided to deposit preferentially at the bottom of the anode, safely away from the separator.

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To investigate the healing rate of subtotal perforation of tympanic membrane repaired by cartilage island technique combined with palisade cartilage technique under otoscope. A retrospective analysis was performed on 189 patients with chronic suppurative otitis media who were admitted to the Department of Otolaryngology and Head and Neck Surgery of Hunan Provincial People's Hospital from January 2018 to January 2020. The patients were divided into twogroups, in group onethere were 100 patients treated by senior surgeon, which were divided into two subgroups, Group A (68 cases) were treated with cartilage island technique alone, and Group B (32 cases) were treated with cartilage island technique combined with palisade cartilage technique.

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Objective: V-set and transmembrane domain-containing protein 1 (VSTM1) is negatively correlated with inflammation. However, its effect on atherosclerosis (AS) remains largely unexplored. In this study, we aimed to assess the effect of VSTM1 on the biological function of human peripheral blood mononuclear cells /macrophages stimulated by oxidized low-density lipoprotein (ox-LDL).

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  • Coronary heart disease often leads to vascular endothelial injury, with endothelial-mesenchymal transition (EndMT) being a key factor in this process.
  • The study focused on miR-221 and its role in EndMT of endothelial progenitor cells (EPCs), using TGF-β1 to induce changes and various methods to analyze gene expression.
  • Results showed that inhibiting miR-221 increased proteins associated with EndMT, while overexpression led to a decrease in these proteins, indicating that miR-221 plays a crucial regulatory role in this transition.
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The aim of this study was to investigate the correlation between v-set and transmembrane domain-containing 1 (VSTM1) expression and incidence of major adverse cardiac events (MACE) in patients with coronary heart disease (CHD). A total of 310 patients were divided into a non-acute coronary syndrome (non-ACS) group (containing the stable angina group, and the asymptomatic coronary artery diseaseand other patients group) and an ACS group (containing unstable angina and acute myocardial infarction patients). Monocytic VSTM1 expression levels (assessed via average fluorescence intensity derived from antibody binding to VSTM1) in each group were detected and analyzed.

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Background: N6-methyladenosine (m6A) RNA modification plays a critical role in gastric cancer (GC). However, the relationship between the m6A "eraser", FTO, and ALKBH5, and the prognosis of GC still remains unclear. This study aimed to evaluate the effect of FTO and ALKBH5 on the prognosis of patients and their potential roles in GC.

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