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Article Abstract
Aim: To determine the role and underlying mechanism of lncRNA HCP5 in nasopharyngeal carcinoma (NPC).
Method: The expression of HCP5 and miR-128-3p was assessed by qRT-PCR. CCK-8, EdU staining, and transwell were performed to determine cell progression. A nude mouse xenograft tumor model was carried out to detect the role of HCP5 . The luciferase assay was performed to confirm the function between lncRNA HCP5 and miR-128-3p.
Results: The increased level of HCP5 was observed in NPC tissues. Silencing of HCP5 prevented tumor progression and . The luciferase assay verified that HCP5 could bind with miR-128-3p. Furthermore, forced expression of miR-128-3p could prevent the function of HCP5 on NPC cells.
Conclusion: lncRNA HCP5 could regulate NPC cell progression sponging miR-128-3p, which might serve as a potential therapy target of NPC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119759 | PMC |
| http://dx.doi.org/10.1155/2022/5740857 | DOI Listing |
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