Caffeine Acts as an Agonist of Siglec-6, Inhibits MRGPRX2-Triggered Mast Cell Degranulation and Anaphylactoid Reactions.

Mast cells (MCs) are effectors of anaphylactoid reactions. Mas-related G-protein-coupled receptor X2 (MRGPRX2) receptor mediates the direct activation of MCs in anaphylactoid disease. Siglec-6 negatively regulates MC activation and is a promising target in the development of antianaphylactoid reaction drugs.

A 2-pyridone-based ratiometric fluorescent probe for specific detection and imaging of singlet oxygen in live cells.

Singlet oxygen (O) plays a crucial role in cancer chemotherapy and ROS biology, driving the need for highly specific probes to monitor its dynamics in real time. Herein, we developed the ratiometric fluorescent probe NAP-t-PY, utilizing a 2-pyridone recognition unit. The probe's 1-methyl-3-benzyl-2-pyridone moiety reacts specifically with O [4 + 2] cycloaddition, forming the endoperoxide NAP-t-PY-EP.

[Exosome-derived miR-1275 mediates IL-38 upregulation in lymphocytes to suppress lipopolysaccharide-induced apoptosis of myocardial cells ].

Objectives: To investigate the effect of cardiomyocytes-derived exosomes on lipopolysaccharide (LPS)-induced cardiomyocyte injury and its mechanism.

Methods: Exosomes isolated from rat cardiomyocytes with or without LPS treatment were co-cultured with rat lymphocytes. The lymphocytes with or without exosome treatment were co-cultured with LPS-induced rat cardiomyocytes for 48 h.

GJB2 promotes ovarian cancer progression and cisplatin resistance by upregulating TNC expression.

Cisplatin resistance continues to be a major obstacle in the treatment of ovarian cancer (OC). Gap junction protein β-2 (GJB2), a key member of the connexin family, is well-known for its association with hereditary deafness. However, its role in ovarian cancer chemotherapy resistance remains unexplored.

Baichuan Baile Formula, a Promising Herbal Dietary Supplement, Exerts Antidepressant-Like Effects by Modulating the Serotoninergic System in Mouse Models.

Baichuan Baile (BCBL) is a novel formula that incorporates three herbs and a single food additive, all of which are widely used in ordinary or functional foods. It is a promising dietary supplement for the treatment of depression based on TCM principles and nutritional assessments. Our study was designed to explore BCBL's antidepressant-like effects and elucidate its underlying mechanisms.

Targeting YES1 enhances the efficacy of chemotherapy, targeted therapy and onco-immunotherapy.

YES1 (Yamaguchi sarcoma virus homolog 1), a non-receptor tyrosine kinase of the SRC family (SFK), has been abnormally amplified or mutated in several types of solid tumors. The alteration of YES1 impacted multiple biological processes, including promoting tumor progression and metastasis, especially, producing cancer therapy resistance via bypass pathways. Thus, YES1 can serve as a druggable target to overcome drug resistance and suppress tumor growth.

[Study on work-related musculoskeletal disorders and influencing factors of underground workers in a coal mine].

To investigate the occurrence of work-related musculoskeletal disorders (WMSDs) among underground coal mine workers, identify the risk factors for WMSDs, and provide a scientific evidence for the prevention and treatment of WMSDs. In March 2024, through cluster sampling, the on-the-job workers who underwent questionnaire surveys and health examinations at a certain coal mine from July to August 2018 were selected as the research subjects. Basic information of employees, ergonomics-related characteristics, and the occurrence status of WMSDs in each part were collected, and multivariate logistic regression was used for analysis.

[Study on risk prediction model of hypertension in steel workers].

To identify risk factors influencing the incidence of hypertension among steelworkers (Homo sapiens) and establish an effective and easily implementable hypertension prediction model. In September 2023, 2214 steelworkers (Homo sapiens) were selected as study subjects. Basic demographic information, lifestyle, and occupational exposure data were collected, along with physiological measurements such as height, weight, and blood pressure.

Trajectory of Chemotherapy-Induced Peripheral Neuropathy and Its Predictive Factors in Breast Cancer Patients: A Prospective Longitudinal Study.

Objective: To explore the trajectory patterns and influencing factors of chemotherapy-induced peripheral neuropathy (CIPN) in breast cancer patients using latent class growth analysis (LCGA).

Methods: This study was conducted from September 2022 to September 2023 at a tertiary hospital in Tangshan, China. A total of 350 hospitalized breast cancer patients undergoing chemotherapy were recruited.

Risk factors for severe COVID-19 and development of a predictive model.

A clinical case‒control study was conducted to identify risk factors for severe COVID-19 and to develop a predictive risk model to provide a reference for the dynamic assessment of the severity of disease in COVID-19 patients. A total of 410 patients with COVID-19 were included in the study, of whom 132 had severe or critical cases. The clinical data of the patients were collected, and the variables were subsequently screened via LASSO regression analysis and 10-fold cross-validation.

Excessive reassurance-seeking and anxiety among Chinese new urban older adults: the role of attention to negative information and resilience.

Background: Policy-driven relocation of older adults from rural to urban areas in China is a significant stressor that often exacerbates anxiety. The mechanisms through which excessive reassurance seeking (ERS) heightens anxiety in this population remain poorly understood.

Methods: A cross-sectional survey was conducted with 301 relocated older adults (aged 60-89 years; 52.

Dose-optimised recombinant human thrombopoietin eltrombopag in patients with immune thrombocytopenia: a multicenter, randomised controlled trial (The TE-ITP Study).

Background: Recombinant human thrombopoietin (rhTPO) at a fixed dose of 300 U/kg/day for 2 weeks has demonstrated good efficacy and safety in adults with immune thrombocytopenia (ITP). This trial aimed to develop a flexible and personalized rhTPO regimen that ensures efficacy and safety beyond previous fixed dose, with eltrombopag as an active comparator.

Methods: The TE-ITP trial was conducted in 12 centers across China.

Relationships of triglyceride-glucose index and body mass index with 5-year all-cause mortality in patients with diabetes and comorbid hypertension: Evidence from two prospective cohort studies.

Aims: To characterize the complex relationships of body mass index (BMI) and triglyceride-glucose index (TyG) with 5-year all-cause mortality in patients with diabetes mellitus and comorbid hypertension.

Methods: Overall, 5,728 patients from the 1999-2014 US National Health and Nutrition Examination Survey (NHANES) cycles and 3,456 from the 2005-2010 China Kailuan cycles were included. TyG was calculated as the logarithmic product of the fasting triglyceride and glucose concentrations.

Role of DLAT-Mediated Neuron Cuproptosis in Cognitive Impairment Induced by Lead Exposure.

Cuproptosis, a newly identified form of copper-dependent regulated cell death, plays a crucial role in the pathogenesis of neurodegenerative diseases. However, whether cuproptosis is involved in lead (Pb)-induced cognitive impairment and its underlying mechanisms remains unclear. Herein, using Pb-exposed rat models and HT22 neuronal cell models, we found that Pb exposure led to dose-dependent increases in copper levels in both hippocampus tissue and blood.

Dual-optical response probe to HSO and HClO via ICT and solvatochromic effects for food and cellular applications.

Sulfite (HSO) and hypochlorous acid (HClO) serve as essential food additives and key raw materials in bleaching agents. However, excessive consumption of these compounds may disrupt cellular redox homeostasis, leading to a series of adverse physical effects. Therefore, the development of reliable analytical methods to detect HSO and HClO levels in food products is of significant importance.

Rapid Visual Detection of Decapod Iridescent Virus 1 (DIV1) by RPA Combined With LFS.

Decapod iridescent virus 1 (DIV1) causes severe disease outbreaks in shrimp and crab culture areas. A simple, rapid, and visual DIV1 assay is important for the control of viral diseases. This study presented a novel DIV1 detection method that combines recombinase polymerase amplification (RPA) and lateral flow strip (LFS).

Sleep quality mediates the association between tea consumption and duration of COVID-19-related symptoms in middle-aged and elderly adults (aged 50 and above).

Objectives: The association between tea consumption and the duration of COVID-19-related symptoms remains inconclusive. This cross-sectional study investigates the potential mediating role of sleep quality in this association. The association between tea consumption and the duration of COVID-19-related symptoms remains inconclusive.

The Mechanism of Microcrack Initiation in Fe-C Alloy Under Tensile Deformation in Molecular Dynamics Simulation.

The microcrack initiation and evolution behavior of Fe-C alloy under uniaxial tensile loading are investigated using molecular dynamics (MD) simulations. The model is stretched along the -axis at a strain rate of 2 × 10 s and temperatures ranging from 300 to 1100 K, aiming to elucidate the microscopic deformation mechanisms during crack evolution under varying thermal conditions. The results indicate that the yield strength of Fe-C alloy decreases with a rising temperature, accompanied by a 25.

A Comprehensive Review of Slag-Coating Mechanisms in Blast-Furnace Staves: Furnace Profile Optimization and Material-Structure Design.

Blast-furnace staves serve as critical protective components in ironmaking, requiring synergistic optimization of slag-coating behavior and self-protection capability to extend furnace lifespan and reduce energy consumption. Traditional integer-order heat transfer models, constrained by assumptions of homogeneous materials and instantaneous heat conduction, fail to accurately capture the cross-scale thermal memory effects and non-local diffusion characteristics in multiphase heterogeneous blast-furnace systems, leading to substantial inaccuracies in predicting dynamic slag-layer evolution. This review synthesizes recent advancements across three interlinked dimensions: first, analyzing design principles of zonal staves and how refractory material properties influence slag-layer formation, proposing a "high thermal conductivity-low thermal expansion" material matching strategy to mitigate thermal stress cracks through optimized synergy; second, developing a mechanistic model by introducing the Caputo fractional derivative to construct a non-Fourier heat-transfer framework (i.

Impact of Poor Sleep Quality on Task Switching and Reconfiguration Process Among University Students.

Task switching is an important cognitive function required for daily life, and task reconfiguration is one of the main explanations for the origins of switching costs. Studies have demonstrated that sleep significantly affects task switching abilities. However, there remains insufficient evidence on how poor sleep quality impacts task switching abilities among university students.

Effects of different vitamins on individuals with septic shock: a Bayesian NMA of RCTs.

Objective: To compare the effects of different vitamins on patients with septic shock (SS) through Bayesian network meta-analysis.

Methods: Randomized controlled trials (RCTs) on vitamins for septic shock patients were retrieved from PubMed, Embase, Cochrane Library, Web of Science, etc. The retrieval time was set from the establishment of the database to May 20, 2024.

[Fabrication and evaluation of dexmedetomidine hydrochloride microneedles based on 3D printing].

Compared with conventional transdermal drug delivery systems, dissolving microneedles significantly enhance drug bioavailability by penetrating the stratum corneum barrier and achieving intradermal drug delivery. In order to improve the transdermal bioavailability of dexmedetomidine hydrochloride, in this study, a novel microneedle delivery system was developed for dexmedetomidine hydrochloride based on 3D printing combined with micro-molding. By systematically optimizing the microneedle geometrical parameters, array arrangement, and preparation process parameters, we determined the optimal ratio of drug-carrying matrix as 15% PVP (polyvinyl pyrrolidone) K90.