Relationships of triglyceride-glucose index and body mass index with 5-year all-cause mortality in patients with diabetes and comorbid hypertension: Evidence from two prospective cohort studies.

Aims: To characterize the complex relationships of body mass index (BMI) and triglyceride-glucose index (TyG) with 5-year all-cause mortality in patients with diabetes mellitus and comorbid hypertension.

Methods: Overall, 5,728 patients from the 1999-2014 US National Health and Nutrition Examination Survey (NHANES) cycles and 3,456 from the 2005-2010 China Kailuan cycles were included. TyG was calculated as the logarithmic product of the fasting triglyceride and glucose concentrations.

Surgical left atrial appendage occlusion in valvular heart disease without atrial fibrillation: the OPINION trial.

Background And Aims: While surgical left atrial appendage occlusion (SLAAO) reduces stroke in atrial fibrillation (AF) patients, its efficacy in patients without pre-operative AF but with CHA₂DS₂-VASc ≥2 remains uncertain despite their high post-operative AF risk (15-54%). The aim of this study was to evaluate whether prophylactic SLAAO reduces post-operative thrombo-embolic events in valvular surgery patients.

Methods: The OPINION was a multicentre, open-label, randomized, superiority trial conducted at three cardiac surgery centres in China.

bra-miR9569 Targets the Gene to Negatively Regulate H-ATPases, Affecting Pollen Fertility in Chinese Cabbage ( L. ssp. ).

Ogura cytoplasmic male sterility (CMS) in Chinese cabbage () is characterized by complete pollen abortion, wherein stamens fail to produce viable pollen while pistils retain normal fertility. This maternally inherited trait is valuable for hybrid breeding. This study employed integrated analysis of miRNA, transcriptome, and degradome sequencing data aligned to the Chinese cabbage reference genome to elucidate the molecular function of bra-miR9569 in Ogura CMS pollen fertility and explore its associated pathways.

Regulatory Mechanisms of Exogenous Gibberellin on Seed Germination and Transcriptomic Responses in .

Gibberellins (GAs) are essential phytohormones that regulate seed dormancy release and germination. (L.) Fries ex Nym is a traditional medicinal plant whose seed germination is often hindered by physiological dormancy.

Visualizing dynamic tubulin folding in chaperonin TRiC from nonnative nucleus to final native state.

The folding nucleus (FN) initiates and enables an efficient protein folding pathway. Despite its essential role, the FN has long remained cryptic. Here we directly visualize the tubulin FN consisting of a nonnative, partially assembled Rossmann fold, in the closed chamber of human chaperonin TRiC.

High-calcium milk improves osteoporosis in postmenopausal women by regulating intestinal flora and steroid hormone biosynthesis.

Background: Postmenopausal calcium loss increases osteoporosis risk in middle-aged and older women. While dairy products are a known calcium source that supports bone health, limited research addresses their specific effects on osteoporosis prevention in this population.

Methods: A one-year randomized controlled trial recruited 97 postmenopausal women, randomly assigned to a high-calcium milk group (HCM, 51), consuming 400 mL nutrient-enriched fresh milk daily, or a control milk group (CM, 46), consuming 400 mL of regular fresh milk.

Synthesis, antifungal activity, structure-activity relationship and mechanism of action of nicotinohydrazide derivatives.

This study aimed to develop novel and highly effective antifungal agents to control key plant diseases. Based on the 2-chloronicotinohydrazide core structure, 22 new nicotinohydrazide derivatives were designed and synthesized by optimizing phenoxy substitution sites. Antifungal evaluation revealed that this series of compounds possess highly effective broad-spectrum fungicidal activity.

Prognostic impact of guideline-directed medical therapy after functionally complete revascularisation in patients with obstructive coronary artery diseases.

Objective: Functional complete revascularisation (FCR) has been proven to be associated with superior prognosis following percutaneous coronary intervention. Whether guideline-directed medical therapy (GDMT) still impacts clinical outcomes in patients who have achieved FCR requires further evaluation.

Methods: The study population was drawn from patients who achieved FCR in the FAVOR III China trial, defined as a quantitative flow ratio (QFR)-based residual functional Synergy between percutaneous coronary intervention with taxus and cardiac Surgery score of 0, measured only in vessels with QFR≤0.

Gate-Tunable Highly Linear Bipolar Photoresponse in Se@SWCNT Adaptive Neurons for Dynamically Programmable Neuromorphic Computing.

The development of tunable and highly controllable photoconductive devices for brain-inspired optical neuromorphic systems remains challenging. Previous neuromorphic devices are limited by asymmetric and nonlinear conductive properties, which impose specific restrictions on training tasks and weight learning rules in dynamic and complex visual environments. A programmable synaptic transistor based on a Se@SWCNT 1D van der Waals heterojunction, enabling gate-controlled positive and negative responses is presented.

Design, synthesis, antifungal evaluation and mechanism study of novel thiazolamide derivatives containing a diarylamine scaffold.

Succinate dehydrogenase (SDH), cellular respiratory chain, and tricarboxylic acid (or Krebs cycle) have been identified as one of the most important targets for pharmaceuticals and agricultural chemicals. However, due to the serious resistance issues faced by these fungicides, it is necessary to continuously develop new fungicides to overcome resistance problems. Herein, a series of novel thiazolamide derivatives containing a diarylamine scaffold were designed, synthesized, and evaluated for their antifungal activities against four fungi (Rhizoctonia solani, Sclerotinia sclerotiorum, Alternaria alternata, and Alternaria solani).

Clinical outcomes of selective laser trabeculoplasty in military pilots with open-angle glaucoma: Implications for intraocular pressure control and aeromedical certification.

Objective: The aim of this study is to evaluate the clinical efficacy and safety of selective laser trabeculoplasty (SLT) in individuals diagnosed with open-angle glaucoma within the military pilot population and to examine its impact on intraocular pressure (IOP) regulation and aeromedical certification status.

Methods: A retrospective analysis was conducted using clinical data from four military pilots (eight eyes) who underwent SLT at the Ophthalmology Department of the Air Force Characteristics Medical Center between January 2013 and January 2025. Outcomes assessed included 24 h IOP fluctuations before and after SLT, changes in pharmacological management, and medical certification results.

Assessment of chitosan nanoemulsion loading with perillaldehyde on the quality characteristics and microbial diversity of beef slices during refrigeration storage.

This study investigated the effect of a chitosan nanoemulsion enriched with perillaldehyde on the preservation quality and microbial community composition of fresh refrigerated beef. After 15 days of storage, the perillaldehyde incorporation in the chitosan nanoemulsions (PA-CS) group exhibited the lowest pH (6.61), cooking loss (34.

S aureus upregulation of MUC13 modulates mucosal remodeling in chronic rhinosinusitis via MEK1/2 and WNT2B.

Background: Chronic rhinosinusitis (CRS)-related mucins affect nasal mucosal inflammation and pathological progression. MUC13 is expressed in various epithelial tissues and plays a role in inflammation, apoptosis, and infection, but its involvement in CRS remains unexplored.

Objectives: We sought to clarify the role of transmembrane-type MUC13 in CRS and analyze its modulatory function in pathological processes.

Combined Effect of Resting Time and NaHCO on Solubility and Gel Properties of Low-Salt Chicken Myofibrillar Protein.

To investigate the interaction effects of resting times (0, 6, and 12 h) and NaHCO concentrations (0, 2, 4, and 6 g/kg) on chicken myofibrillar protein (CMP), this study analyzed the changes in solubility, active sulfhydryl groups, rheological behavior, fluorescence, and gel properties of CMP solutions (60 mg/mL). The results indicated that pH significantly increased with higher NaHCO concentrations and longer resting times. Consequently, solubility, active sulfhydryl groups, apparent viscosity, shear stress, G' value at 80 °C, hardness, springiness, and cohesiveness all significantly increased, while particle size, turbidity, and whiteness significantly decreased.

Validation of the Asian Midface Volume Deficit Severity Scale.

Background: Anatomical differences in facial aging and aesthetic needs of Asian and Caucasian individuals have led to disparate clinical rejuvenation strategies using filler augmentation for midface volume deficits. Therefore, the Asian Midface Volume Deficit Severity Scale (AMVDSS) by LBTD (Lanzhou Biotechnique Development Co, Ltd) was developed to objectively assess midface volume deficits and clinical outcomes of Asian individuals.

Methods: Four observers independently rated randomized photographs (front, left and right 45°, left and right 90°) of 65 patients during two sessions with a 2-week interval using the AMVDSS.

Selective Adsorption of Fluorine Contaminants from Spiked Wastewater via a Novel Fe-Ce-Based Layered Hydroxide Composite and Mechanism Analysis of Colloids and Surfaces.

Excessive intake of fluorine (F) over time can lead to acute or chronic fluorosis. In this study, a novel Fe-Ce-based layered hydroxide composite (DD-LHC) was synthesized and applied in both batch and column modes to develop new adsorbent materials and to obtain efficient removal of fluorine (F) anions from wastewater. DD-LHC achieved better adsorption results and material stability compared to green rusts (GR, Fe-Fe hydroxide).

Rice glutelin fibrils fabricated with natural deep eutectic solvents: Physicochemical characteristics, microstructure, and rheological properties.

To enhance the properties of rice glutelin through effective and safe fibrillation, rice glutelin fibrils (RGFs) were fabricated using natural deep eutectic solvents (NADES, prepared by citric acid and choline chloride). Effects of three NADES concentrations (L (1.4 M), M (2.

Rapid and simple separation and detection of Aβ42 in blood neuronal-derived extracellular vesicles using nanozyme-catalyzed colorimetric sensor.

The rapid separation and detection of neuronal-derived small extracellular vesicles (EVs) in plasma is essential for diagnosing and monitoring the progression of Alzheimer's disease (AD). In this study, we present a magnetic separation-assisted visual analysis strategy for detecting Aβ42-positive EVs (Aβ42 EVs) using a nanozyme-catalyzed colorimetric sensor. EVs are first captured from plasma using FeO@SiO core-shell nanoparticles functionalized with CD63 aptamers (FeO@SiO-Apt).

Prognostic value of C-reactive protein to albumin ratio in patients with valvular heart disease: nationwide prospective cohort study.

Background: The C-reactive to albumin ratio (CAR) integrates the pro-inflammatory and nutritional status of patients, which may provide superior prognostic information over either parameter alone in valvular heart disease (VHD). The study aims to examine the association between CAR and mortality and its ability as biomarker to guide risk stratification in VHD patients.

Materials And Methods: A total of 5519 patients (age ≥18 years) with moderate or severe VHD from a multicenter prospective cohort underwent echocardiography and CAR measurement.

Fecal microbiota transplantation for hypertension: an exploratory, multicenter, randomized, blinded, placebo-controlled trial.

Background: On the basis of the contribution of the gut microbiota to hypertension development, a novel strategy involving fecal microbiota transplantation (FMT) has been proposed to treat hypertension, but its efficacy has not been investigated in the clinic.

Methods: In a randomized, blinded, placebo-controlled clinical trial (2021/03-2021/12, ClinicalTrials.gov, NCT04406129), hypertensive patients were recruited from seven centers in China, and received FMT or placebo capsules orally at three visits.

Integration of finite element simulations with 3D printing technology for personalized Chitin/PLA microneedle-based drug delivery systems in thoracic keloid treatment.

The high prevalence of keloids in the thoracic (48.9 %) is closely associated with its unique anatomical morphology and mechanical environment. The irregular shape of keloids in this area significantly complicates treatment, particularly regarding drug delivery.

2,4-Difluorophenyl isothiocyanate as a redox mediator in the electrolyte for kinetically favorable Li-S batteries.

2,4-Difluorophenyl isothiocyanate (DPIC) was used as a redox mediator for a kinetically favorable electrolyte, and can boost the activation of insulating sulfur and sulfide, accelerate the bidirectional conversion reaction kinetics and restrict the undesirable shuttle effect, consequently ensuring high sulfur utilization and extended cycle lifespan of Li-S batteries.

Enhancing the Quality of Gluten-Free Noodles Through Taro Pulp Supplementation: Effects of Pulping Time and Addition Levels.

The global demand for gluten-free (GF) foods has significantly increased due to the rising prevalence of celiac disease. However, challenges related to the textural quality and nutritional deficiencies of GF products remain notable. This study examined the effects of incorporating taro pulp (TP), considering factors of pulping time (3, 6, 9 min) and the addition levels (15%, 20%, 25%) of TP, on the rheological properties of dough and the textural, structural, and cooking properties of GF noodles.

scRNA-seq reveals chemotherapy-induced tumor microenvironment changes in pancreatic ductal adenocarcinoma.

Background: Challenges have arisen in finding an effective treatment for pancreatic ductal adenocarcinoma (PDAC). Poor outcomes have fueled ongoing efforts to exploit the tumor microenvironment (TME) in the treatment of PDAC; however, to date, treatment strategies have largely failed. Thus, a comprehensive and deep understanding of the PDAC TME is necessary.

Paravertebral analgesia versus wound infiltration in children recovering from cardiac surgery: a randomized controlled trial.

Introduction: Optimal analgesia for thoracotomies remains unclear. Paravertebral blocks are more complex than local anesthetic infiltration but may be more effective. We therefore tested the hypothesis that paravertebral blocks provide better postoperative analgesia than local anesthetic infiltration in children recovering from cardiac surgery thoracotomies.