Association between subendocardial viability ratio and cardiovascular events: a cohort study in a Chinese community-based population.

Objectives: Subendocardial viability ratio (SEVR) is an effective indicator for evaluating the balance between myocardial oxygen supply and demand. This study aims to explore the association between SEVR and cardiovascular events and mortality in a Chinese community-based population.

Design: Retrospective cohort study.

A hyperfine-transition-referenced vector spectrum analyzer for visible-light integrated photonics.

Integrated photonics has been successfully established in the near-infrared (NIR) telecommunication bands. With the soaring demand in biosensing, quantum information and transportable atomic clocks, extensive endeavors have been stacked on translating integrated photonics into the visible spectrum. Demonstrations of visible-light lasers, frequency combs, and atom traps highlight the prospect of creating chip-based optical atomic clocks that can make timing and metrology ubiquitous.

Evaluation of the economic burden of carbapenem-resistant Enterobacteriaceae nosocomial infection in intensive care unit patients: A propensity score--adjusted analysis.

Background: This study examines the impact of carbapenem-resistant Enterobacteriaceae (CRE) infections relative to carbapenem-sensitive Enterobacteriaceae (CSE) on the length of stay and hospitalization costs of patients in the intensive care unit (ICU).

Methods: We retrospectively analyzed patients who developed nosocomial infections with Enterobacteriaceae bacteria while admitted to the ICU of a university-affiliated general hospital in China between January 2022 and December 2024. Using propensity score matching (PSM), matched 1:1 to analyze their length of stay and hospitalization costs.

Expert consensus on perioperative management of patients with lung cancer treated with co-ablation system therapy.

This expert consensus aims to establish standardized perioperative care guidelines for patients with lung cancer undergoing co-ablation system therapy. Based on a comprehensive review of national and international guidelines and a structured consultation involving 30 nursing experts, the Perioperative Expert Working Group of the Interventionalists Branch of the Chinese Medical Doctor Association developed the 2024 Consensus. The Consensus outlines key aspects of postoperative care, strategies for the prevention and management of complications, discharge planning, and follow-up care.

The Burden of Informal Caregiving for Adults with Musculoskeletal Conditions: A Systematic Review.

Background And Objective: Informal caregivers play a critical role in supporting individuals with musculoskeletal conditions. This systematic review aimed to evaluate the psychological and economic burdens associated with caregiving for musculoskeletal conditions.

Methods: We conducted a systematic review in accordance with PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) guidelines, searching MEDLINE, Embase, CINAHL, EconLIT, and APA PsycINFO for studies published between 2000 and April 2025.

Time-Driven Activity-Based Costing and Its Use in Health Economic Analysis: A Systematic Literature Review.

Objectives: With rising global healthcare expenditures, there is an increasing demand for value-based healthcare (VBHC). Time-driven activity-based costing (TDABC) has been proposed as a key component of VBHC for addressing cost-related challenges. This study aimed to review the application of TDABC in health economic analyses across the continuum of care, explore its methodological advantages, and assess adherence to the 7-step or 8-step methodological reporting frameworks.

Cost-Effectiveness of Text Messaging to Reengage Culturally and Linguistically Diverse Communities to Breast Cancer Screening: A Modeling Study.

Objectives: To promote equity in breast cancer screening for culturally and linguistically diverse (CALD) communities, language-specific initiatives were implemented in Victoria, Australia. This study aims to evaluate the cost-effectiveness of in-language short message service (SMS) reminders for overdue clients.

Methods: A cost-utility analysis was conducted to evaluate in-language SMS reminders for women aged between 50 and 72 years, overdue for their routine breast screen in 2021 (n = 3294), compared with English SMS.

The hidden economic burden of cancer caring.

Background: Advances in clinical cancer care have increased the number of survivors, which has impacted informal caregiving. This study estimates the annual opportunity cost of informal cancer care and quantifies the gap in the quality adjusted life expectancy (QALE).

Method: Informal cancer carers by sex and two age groups (15-64 years old and 65 years old and over) from the Australian Bureau of Statistics (ABS), Survey of Disability, Ageing and Carers (SDAC) from 2003 to 2022 were used to estimate the annual opportunity costs of informal cancer care in 2022 and predict future costs.

Intratumoral and peritumoral ultrasound radiomics analysis for predicting HER2-low expression in HER2-negative breast cancer patients: a retrospective analysis of dual-central study.

Objective: This study aims to explore whether intratumoral and peritumoral ultrasound radiomics of ultrasound images can predict the low expression status of human epidermal growth factor receptor 2 (HER2) in HER2-negative breast cancer patients.

Methods: HER2-negative breast cancer patients were recruited retrospectively and randomly divided into a training cohort (n = 303) and a test cohort (n = 130) at a ratio of 7:3. The region of interest within the breast ultrasound image was designated as the intratumoral region, and expansions of 3 mm, 5 mm, and 8 mm from this region were considered as the peritumoral regions for the extraction of ultrasound radiomic features.

c-FLIP Protects Cardiac Microcirculation in Sepsis-Induced Myocardial Dysfunction Via FUNDC1-Mediated Regulation of Mitochondrial Autophagy.

This study investigates the role of c-FLIP in sepsis-induced myocardial dysfunction (SIMD), focusing on cardiac microcirculation and mitochondrial autophagy. Using SIMD rat and LPS-induced cardiac microvascular endothelial cell injury models, we found that c-FLIP deficiency disrupts mitochondrial homeostasis, exacerbating microcirculatory damage. c-FLIP differentially regulates mitochondrial autophagy via FUNDC1.

Ultrasound Inversion Imaging Improves the Specificity of BI-RADS Category 4A Masses, Especially in Masses Without Calcification. A Single-Center Experience.

Objective: This study aimed to assess whether ultrasound inversion imaging enhances the specificity of Breast Imaging Reporting and Data System (BI-RADS) BI-RADS 4A masses, reducing unnecessary biopsies.

Method: From July 2021 to March 2023, 425 pathologically confirmed breast masses were collected from the Second Affiliated Hospital of Anhui Medical University. Based on a five-point scale of inversion imaging criteria proposed in a previous study, the diagnostic performance of three classification algorithms, including BI-RADS, BI-RADS category after inversion imaging, and BI-RADS category after inversion imaging without calcification masses-via receiver operating characteristic (ROC) curve analysis.

Examination of pediatric hemorrhagic stroke incidence: A systematic review and meta-analysis.

Background: Pediatric hemorrhagic stroke (HS) poses a significant burden. We aimed to examine the incidence rate of pediatric hemorrhagic stroke globally.

Method: This systematic review and meta-analysis searched Medline via Ovid, Embase, EBCOHOST, Scopus and Google Scholar up to 6 March 2024 for observational studies included pediatrics' incidence rate of hemorrhagic stroke (PROSPERO: CRD42022312643).

Arterial Stiffness, Central Blood Pressure, and the Risk of Incident Stroke in Hypertensive Adults.

Background And Aims: Whether hypertensive patients with elevated arterial stiffness and central systolic blood pressure (cSBP) are exposed to higher stroke risk is unclear.

Methods: A total of 6663 participants without a history of cardiovascular disease were enrolled in this study. cSBP was measured noninvasively using the A-Pulse CASPro device; carotid-femoral pulse wave velocity (cfPWV) was collected using a Pulse Pen device.

Advanced Simulation of ITER Core X-ray Crystal Spectroscopy.

X-Ray Simulation Analysis (XRSA) is an analytical ray-tracing mixed code developed specifically for the ITER Core X-Ray Crystal Spectroscopy (XRCS-Core) diagnostic, which employs a dual-reflection configuration incorporating multiple pre-reflectors made of Highly Oriented Pyrolytic Graphite (HOPG) and spherically curved analyzing crystals. The ITER XRCS-Core is designed for high spectral resolution measurement in specific wavelength ranges, including narrow bands around 1.354 Å for W64+, 2.

Coagulation and Inflammatory Indicators in Pneumonia Patients with Venous Thromboembolism: A Propensity-Score Matching Study.

Background: Venous thromboembolism (VTE) is associated with high morbidity and mortality. In recent years, increasing evidence has suggested that inflammation plays a critical role in the pathogenesis of VTE. Patients with pneumonia often exhibit an inflammatory response.

A chip-integrated comb-based microwave oscillator.

Low-noise microwave oscillators are cornerstones for wireless communication, radar and clocks. The employment and optimization of optical frequency combs have enabled photonic microwave synthesizers with unrivalled noise performance and bandwidth breaking the bottleneck of those electronic counterparts. Emerging interest is to use chip-based Kerr frequency combs, namely microcombs.

Relationship between MTHFR, MTRR gene polymorphisms and H-type hypertension: a systematic review and meta-analysis.

Context: The relationship between methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) gene polymorphisms and H-type hypertension susceptibility has been deeply analysed, but the conclusions are not consistent. Therefore, we carried out a meta-analysis aimed at assessing the relationship exactly.

Methods: Six English databases (PubMed, Embase, EBSCO, ScienceDirect, Cochrane Library, and Web of Science) and four Chinese databases (China Biological Medicine, WanFang, China Science and Technology Journal, and China National Knowledge Infrastructure) were used for searching studies from inception to August 2023.

Treatment Strategies for Refractory Catheter-Related Central Venous Occlusive Disorders: Review.

Background: Catheter-related central vein occlusive disease (CVOD) is a frequent complication in hemodialysis patients and significantly affects their prognosis. Current treatment options for catheter-related CVOD include standard guidewire and catheter techniques, radiofrequency ablation, and sharp recanalization. However, large-scale clinical trials evaluating these techniques are lacking, making CVOD management challenging.

Enhancing the diagnostic efficacy of right-to-left shunt using robot-assisted transcranial Doppler: a quality improvement project.

Background: Stroke is the leading cause of adult disability worldwide, with approximately 30% of strokes remaining cryptogenic. One potential important etiology is a patent foramen ovale (PFO), which may contribute to stroke through paradoxical thromboembolism or thromboembolus formation. Recent advancements in robot-assisted transcranial Doppler (raTCD) have shown increased sensitivity in detecting right-to-left shunt (RLS) compared to transthoracic echocardiography (TTE), particularly in detecting the large shunts which are associated with higher stroke risk.

Mitochondrial ROS-associated integrated stress response is involved in arsenic-induced blood-testis barrier disruption and protective effect of melatonin.

Arsenic (As) is an environmental metalloid. Previous studies have demonstrated that As exposure resulted in decline of sperm quality. This study aimed to investigate the impact of exposure to As on blood-testis barrier (BTB) in a mouse model.

The up-regulation of PTBP1 expression level in patients with Insomnia by senile dementia and promote cuproptosis of nerve cell by SLC31A1.

Alzheimer's disease (AD), often referred to as the modern-day scourge, stands as a significant health challenge characterized by high rates of disability and mortality, particularly among the geriatric population. Thus, the present study investigated the precise details of PTBP1 involvement in cuproptosis of nerve cell of patients with Insomnia by senile dementia (ISD). Patients with ISD, early mild cognitive impairment (EMCI) and Normal healthy volunteers were obtained.

Analysis of the correlation between the dose exposure intensity and apatinib in advanced gastric cancer: a retrospective cohort study.

Background: Apatinib is a small molecule anti-angiogenesis targeted drug that has demonstrated significant efficacy as a late-line treatment in advanced gastric cancer in phase 3 clinical trials. This study amid to evaluate the correlation between dose exposure intensity and efficacy and safety of apatinib in the treatment of advanced gastric cancer.

Methods: We conducted an observational, retrospective cohort study of patients with advanced gastric cancer who received apatinib targeted therapy in Beijing Friendship Hospital affiliated to Capital Medical University between June 1, 2018, and June 30, 2021.

Rapid Verbal Persuasion to increase influenza vaccine uptake: protocol for a randomized hybrid type 2 effectiveness -implementation trial.

Background: While influenza vaccines are the most effective measure for preventing influenza, uptake rates in China remain relatively low. Rapid Verbal Persuasion (RVP), with highly rapid fashion, has a strong evidence base in promoting behavior change. Despite this, it is underused or rarely evaluated in the context of vaccination.

Nitric oxide mitigates cadmium stress by promoting the biosynthesis of cell walls in Robinia pseudoacacia roots.

Cadmium (Cd) pollution is a growing concern worldwide, because it threatens human health through the food chain. Woody plants, such as the pioneer species black locust (Robinia pseudoacacia L.), are widely used in phytoremediation of Cd-contaminated soils, but strongly differ in Cd tolerance.