Electrostatic effects drive graphene oxide carbon dots to self-assemble into negatively charged layer for constructing anti-aging zinc-ion batteries.

Hydrogen evolution reaction, corrosion, and zinc dendrite growth are the main bottlenecks limiting the performance of zinc-ion batteries. Additives are considered a direct and effective solution by adsorbing on the zinc anode surface to construct a protective layer. However, while traditional protective layers can suppress side reactions and corrosion, their non-uniform thickness and high interfacial impedance reduce the migration rate of Zn, leading to uneven Zn concentration distribution and actually exacerbating dendrite growth.

Effects of foliar-applied choline-aspartate ionic liquid on maize (Zea mays L.) metabolism and rhizosphere soil characteristics under field conditions.

Choline-based ionic liquids have emerged as promising materials with diverse applications in electrochemistry, biomaterials, and environmental remediation technologies. However, their impacts on the agricultural ecological environment remain relatively underexplored. In this study, the regulatory effects of foliar-sprayed choline-aspartate ionic liquid ([Chl][Asp] IL) on maize growth and rhizosphere soil properties were analysed during a two-year field experiment.

In Situ Construction of a Dual-Component Hybrid Interfacial Layer for Stabilizing Zinc Anodes in Aqueous Zn-Ion Batteries.

Interfacial instability, particularly uncontrollable zinc deposition and water induced side reactions, severely compromises the cycling stability and lifespan of aqueous zinc-ion batteries (AZIBs), thereby hindering their commercialization. Herein, an in situ grown bilayer gradient hydrophobic artificial interface (ZFPB) is designed to achieve dendrite-free zinc deposition. In detail, the ion-conductive but electronically insulating ZnF outer layer facilitates the rapid migration of Zn.

Effects of vitamins C and E supplementation combined with 12-week resistance training in older women with sarcopenia: A randomized, double-blind, placebo-controlled trial.

Background: Resistance training (RT) is a fundamental sarcopenia treatment, but its efficacy may be enhanced by nutritional strategies. This study investigated whether combining RT with vitamins C and E supplementation yields additive benefits in sarcopenia patients.

Methods: Sixty older women with sarcopenia (60-75 years) were randomized to an antioxidant supplementation group (AS; 1000 mg/d vitamin C and 335 mg/d vitamin E) or a placebo group (PLA) following the same elastic-band RT program.

DUSP9 is Up-Regulated and Promotes Tumor Progression in Head and Neck Squamous Cell Carcinoma.

Head and neck squamous cell carcinoma (HNSCC) ranks among the most prevalent malignancies with a poor prognosis. The underlying mechanisms driving HNSCC carcinogenesis are not fully elucidated. In this study, we identified dual specificity phosphatase 9 (DUSP9) as a carcinogenic factor in HNSCC development.

Synthesis and highly selective adsorption of hydroxyapatite in situ self-Co-doped by magnesium-fluorine in phosphate tailings.

The main components of waste phosphate tailings (WPT) were used in this study for high-value purposes. In particular, these tailings were utilized as raw materials to create magnesium-fluoride self-co-doped hydroxyapatite (abbreviated Mg-F-HAP), a material with a high adsorption capacity and selectivity. Notably, fluorine doping raises the materials' adsorption capacity, whereas magnesium doping improves selectivity.

Drug-Induced Insulin Autoimmune Syndrome: A FAERS Database and Network Pharmacology Analysis.

Introduction: Insulin Autoimmune Syndrome (IAS) is a rare yet clinically significant drug-induced adverse reaction, characterized by hypoglycemic episodes caused by insulin autoantibodies. While individual drug associations are documented in case reports, systematic pharmacovigilance analyses supporting drug-induced IAS are lacking in the literature. This study aims to identify drugs associated with IAS through pharmacovigilance analysis and explore potential molecular mechanisms.

Deciphering Closed-Pore Formation and Size-Dependent Sodium Cluster Filling Behavior for Nanopore-Confined Derived Hard Carbon Anodes.

The low-voltage plateau capacity (LVPC) of hard carbon (HC) anodes for sodium-ion batteries originates from sodium cluster filling within closed pores, and closed-pore engineering of activated carbon (AC) via nanopore-confined pyrolysis is a feasible strategy to produce HC anodes with high LVPC. However, the formation mechanism of closed pores and their size-dependent effects on sodium cluster filling behavior remain poorly understood. Herein, pitch-confined pyrolysis is utilized within the nanopores of AC to transform its open pores into closed pores, with pitch dose regulating closed-pore size.

Distinctive Immuno-Inflammatory Pattern in Tuberculous Lymphadenitis: A Retrospective Cohort Study with Propensity Score Matching.

Purpose: Tuberculous lymphadenitis (TBL) represents a common form of extrapulmonary tuberculosis (EPTB), yet its immunological characteristics compared to other EPTB forms remain poorly characterized. We aimed to compare immunological parameters between TBL and non-TBL patients to elucidate site-specific immune phenotypes.

Patients And Methods: We conducted a retrospective single-center study at Fuzhou Pulmonary Hospital, China (April 2018-April 2024).

Tuning Diffusion Preferences in Silicon-Based Anodes for Enhanced Rapid and Homogeneous Lithiation.

The inherently sluggish lithiation kinetics of silicon (Si), coupled with its severe volume expansion, causes lithiation retardation and thus exacerbates the failure of Si-based anodes. Here, a Li-diffusion-preference tuning strategy for homogeneous lithiation of Si has been proposed to address these issues and successfully validated through both simulation and experiments using commercial photovoltaic silicon waste (Si). In detail, Li preferentially diffuses along grain boundaries (GBs) and then into grains, enabling rapid and homogeneous lithiation throughout the Si particles rather than the conventional outside-to-inside lithiation process that suffers from lithiation retardation.

Transcriptome, Metabolome, and Physiological Analysis Provide New Insights into the Mechanism of Prostrate/Erect Growth Habits in the Wheat Overwintering Period.

Plant architecture is a key agronomic trait affecting the crop yield. Distinct growth habits markedly influence the above-ground morphological structure, photosynthetic efficiency, and yield. Therefore, this study investigated the mechanisms underlying distinct wheat growth habits during overwintering at physiological, transcriptional, and metabolic levels to provide a theoretical foundation for breeding environmentally adaptable wheat varieties.

Transcriptomic Reprogramming and Key Molecular Pathways Underlying Huanglongbing Tolerance and Susceptibility in Six Citrus Cultivars.

Huanglongbing (HLB), caused by Liberibacter asiaticus (CLas), is the most devastating disease threatening global citrus production. Although no commercial citrus varieties exhibit complete HLB resistance, genotype-specific tolerance variations remain underexplored. This study conducted a comparative transcriptomic profiling of six commercially citrus cultivars in South China, four susceptible cultivars ( cv.

miRNA-204-5p acts as a tumor suppressor in gastric cancer by inhibiting cell migration, invasion, and glycolysis via the RAB22A/PI3K/AKT axis.

Gastric cancer (GC) is a highly prevalent and lethal malignancy worldwide. Accumulating evidence has shown that microRNAs (miRNAs) play essential roles in the development and progression of GC. In this study, we aimed to investigate the expression, functions, and molecular mechanisms of miRNA-204-5p in GC.

Exploring potential associations between GLP-1RAs and depressive disorders: a pharmacovigilance study based on FAERS and VigiBase data.

Background: GLP-1 receptor agonists (GLP-1RAs) are increasingly prescribed for diabetes and obesity management. Recent pharmacovigilance reports have raised concerns about potential neuropsychiatric adverse events, yet comprehensive safety assessments focusing on depressive disorders remain limited. This study investigated associations between specific GLP-1RAs and depressive disorders using real-world post-marketing surveillance data.

Surgical management of rare lesions in the parapharyngeal space.

Background: Lesions in the parapharyngeal space (PPS) are diverse. Management strategies for commonly seen PPS lesions (i.e.

A National Strategy-Based System for Assessment of Nurse Leader Competence: A Retrospective Study.

Background: This study evaluated the effectiveness of a comprehensive goal assessment system for nurse leaders (CGASNL) in improving nursing quality and management outcomes.

Method: This single-center retrospective study involved 60 nurse leaders and was conducted over a period of 3 years. Task, relational, and outcome indicators before and after implementation of the CGASNL were compared.

Vector Quantization-Based Clustered Federated Learning With Global Feature Anchors for Improved Representation and Generalization.

Clustered federated learning (CFL) addresses the challenge of data heterogeneity in federated learning (FL) by customizing models for different groups of clients. However, existing CFL methods heavily rely on indirect metrics, such as model parameters, gradient information, or loss function values, for client clustering. These approaches often fail to fully capture the diversity and intrinsic characteristics of client data distributions, leading to inaccurate representations of client data features.

High cGAS-STING expression associates with improved efficacy of neoadjuvant chemo-immunotherapy in head and neck squamous cell carcinoma.

Purpose: Neoadjuvant chemo-immunotherapy (NACI) has demonstrated significant clinical advantages in head and neck squamous cell carcinomas (HNSCC), while clinical responses vary in different patients. This study investigated the correlation between the cyclic GMP-AMP synthase (cGAS, ) and the stimulator of interferon genes (STING, ) expressions and the efficacy of NACI in HNSCC.

Methods: The correlation between and expressions and chemotherapy/immunotherapy drug sensitivity was analyzed using the GDSC and TCIA dataset.

Effect of Drought Stress on Root Metabolome and Soil Microbial Characteristics for Maize (Zea mays L.) Seedlings.

Drought stress markedly alters the physicochemical and biological properties of the maize rhizosphere, with significant implications for plant growth and resilience. This study investigated the effects of drought on root metabolites, microbial community dynamics, and rhizosphere characteristics in maize seedlings. Under drought conditions, root amino acid levels increased, whereas fatty acids and carboxylic acids declined, indicating enhanced nitrogen metabolism and suppressed energy-related pathways.

Cobalt(II)-Catalyzed [4 + 2] Annulation of Indolecarboxamides with Alkenes for Regioselective Synthesis of γ-Carbolinones.

We report a cobalt-catalyzed cascade [4 + 2] annulation of the C(sp)-H/N-H bonds in indolecarboxamides with alkenes, facilitated by an 8-aminoquinoline directing group. This reaction represents the first example employing simple olefins as substrates to directly construct the γ-carbolinone motif. Furthermore, it exhibits broad substrate scope and excellent regioselectivity, achieving high yields with various unactivated alkenes, even bulky octadecene.

Molecular Dynamics Simulation of the Thermosensitive Gelation Mechanism of Phosphorylcholine Groups-Conjugated Methylcellulose Hydrogel.

The intelligently thermosensitive 2-methacryloyloxyethyl phosphorylcholine (MPC) groups-conjugated methylcellulose (MC) hydrogel, abbreviated as MPC-g-MC, exhibits good potential for prevention of postoperative adhesions. However, its thermosensitive gelation mechanism and why the MPC-g-MC hydrogel shows a lower gelation temperature than that of MC hydrogel are still unclear. Molecular dynamics (MD) simulation was thus used to investigate these mechanisms in this work.

Synergistic Modulation of Cationic Preferential Adsorption and Anionic Solvation Structure Reconstruction for Enhanced Stability of Zinc Anode.

Rechargeable aqueous zinc-ion batteries (AZIBs) with low cost and high safety are promising for energy storage. However, challenges such as the hydrogen evolution reaction, corrosion, and dendrite growth diminish the stability and reversibility of the zinc anode. Herein, zirconium oxychloride is used as an electrolyte additive to address these issues via synergistic modulation.

Clinical analysis of karyotypes and phenotypes in 87 cases of Turner syndrome during transitional period.

Objective: This study aimed to analyze the phenotypic characteristics of patients with Turner syndrome (TS) during the transitional period (12-18 years) and explore associations between clinical manifestations, laboratory findings, imaging features, and karyotypic variations, thereby optimizing clinical management strategies.

Methods: Chromosomal G-banding was performed on 87 patients with TS admitted to Wuhan Children's Hospital between January 2008 and December 2024. Patients were divided into Group A (cases with X monosomy, 45, X) and Group B (cases with other X chromosomal abnormalities, including mosaicism and structural anomalies).

Peracetic acid as a low-cytotoxicity disinfectant in simulated swimming pool water.

Disinfection is important for swimming pool water (SPW) microbial safety, yet disinfectants reacting with swimmer-derived organics during long residence times raises SPW cytotoxicity. This work aimed to determine whether peracetic acid (PAA) is capable of controlling SPW cytotoxicity under various scenarios benchmarking against sodium hypochlorite (SH) at concentrations that satisfy prescribed disinfection efficacy. We conducted bench-scale experiments using synthetic body fluid analogues to simulate real SPW scenarios.

Engineering Laccase from for Improved Thermostability and Its Combination with Lytic Polysaccharide Monooxygenase for Lignin Depolymerization.

Laccase from is widely used to improve lignin depolymerization. However, wild-type laccase usually lacks heat resistance, and its catalytic process is usually accompanied by the repolymerization of lignin, limiting its application. Herein, we performed site-saturation mutation on laccase, generating mutants A347H and N368L with activities increased by 2.