Conductive Hydrogel-Enabled Electrode for Scalp Electroencephalography Monitoring.

Scalp electroencephalography (EEG) serves as a pivotal technology for the noninvasive monitoring of brain functional activity, diagnosing neurological disorders, and assessing cognitive states. However, inherent compatibility barriers between traditional rigid electrodes and the hairy scalp interface significantly compromise signal quality, long-term monitoring comfort, and user compliance. This review examines conductive hydrogel electrodes' pivotal role in advancing scalp EEG, particularly their unique capacity to overcome hair-interface barriers.

Electrostatic effects drive graphene oxide carbon dots to self-assemble into negatively charged layer for constructing anti-aging zinc-ion batteries.

Hydrogen evolution reaction, corrosion, and zinc dendrite growth are the main bottlenecks limiting the performance of zinc-ion batteries. Additives are considered a direct and effective solution by adsorbing on the zinc anode surface to construct a protective layer. However, while traditional protective layers can suppress side reactions and corrosion, their non-uniform thickness and high interfacial impedance reduce the migration rate of Zn, leading to uneven Zn concentration distribution and actually exacerbating dendrite growth.

Rapid detection of plasma exosomal LncRNA CASC9 for HCC using RT-RPA-CRISPR/Cas12a assay.

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. Early detection is essential for improving patient outcomes. Long non-coding RNAs (lncRNAs) in plasma exosomes have emerged as promising non-invasive biomarkers.

Temporary Tattoo-Inspired, Skin-Adaptable Epidermal Electrode from an Ultrathin PU-PVA Film.

Long-term, high-fidelity electrophysiological monitoring requires epidermal electrodes that simultaneously offer conformability, breathability, and mechanical durability─attributes rarely achieved in current designs─through a scalable, simple, and low-cost fabrication strategy. We report a 5.2-μm-thick, transparent, air- and vapor-permeable "tattoo" electrode that adheres to the human skin through water-activated hydrogen bonding provided by a NaCl/glycerol/water hydrating solution, echoing the mechanism of temporary tattoos.

Hepatocyte mitochondrial DNA activated store-operated Ca entry via Stim1/Orai1-induced podocyte injury in trichloroethylene sensitized mice: A new insight in liver and kidney crosstalk.

Previous clinical case studies revealed that patients with severe liver damage often develop kidney damage in occupational medicamentose-like dermatitis due to trichloroethylene (OMDT). However, the mechanism of this crosstalk is unknown. In this study, we extracted hepatocyte mtDNA from TCE-sensitized positive mice and co-treated it with a mouse podocyte line, MPC5.

TRIM47 promotes trichloroethylene-induced immune kidney injury by degrading SIRT1 through ubiquitination.

Trichloroethylene (TCE) exposure can cause occupational medicamentose-like dermatitis due to trichloroethylene (OMDT) and is often linked to kidney damage. Previous study showed that sirtuin 1 (SIRT1) expression in kidney cells is reduced and associated with podocyte injury, but the exact mechanism is unclear. This study used TCE-sensitized mouse model and in vitro studies to investigate how SIRT1 affects endothelial cells and podocytes communication.

Evaluation of protective performance of children helmets via biomechanical modelling.

: The purpose of the current study was to compare the protective performance of helmet designs with different sizes and cushion materials for skull and brain injuries in children. : A 6-year-old child head finite element (FE) model with high biofidelity was used to conduct impact simulations under the protection of helmets with different sizes (small, medium and large) and cushion materials (EPS-expanded polystyrene, PU-polyurethane and airbag) according to the testing conditions specified by the standard. Then, the protective performance of different helmet designs was evaluated by assessing skull and brain injury risk calculated based on the kinematic and biomechanical response of the child head model.

A case report of acute interstitial nephritis caused by cotton phenol.

Background: Cotton phenol is a yellowish-brown polyphenol hydroxybinaphthyl aldehyde compound mainly found in the roots, stems, leaves and seeds of cotton; a plant of the mallow family that has been widely used in the study of antifertility and antitumor drugs. However, there has been no report of serious renal injuries caused by cotton phenol. We report a case of granulomatous acute interstitial nephritis caused by exposure to large amounts of cotton phenol.

Target complement factor H / serum amyloid a signaling in trichloroethylene-induced immune kidney injury.

The aberrant activation of the intracellular complement system is a significant characteristic of trichloroethylene (TCE) -induced immune kidney injury. However, the specific role of complement factor H (CFH) in this context remains unclear. This study investigates the involvement of CFH / serum amyloid A (SAA1) signaling in TCE-induced immune kidney injury by employing a combination of in vitro experiments and TCE-sensitized mouse model.

Conformal, Substrate-Free Liquid Metal Electrode for Continuous Health Monitoring.

Thin, skin-conformal soft electronics are ideal for seamless integration with the skin, enabling high-fidelity health monitoring and advanced human-machine interactions. However, achieving imperceptible and seamless adhesion with traditional materials and design approaches remains challenging as it is difficult to simultaneously meet the requirements of gas permeability, high conductivity, and conformability. In this work, we present a straightforward and efficient design for ultrathin, substrate-free, highly gas-permeable, and conductive liquid metal electrodes.

A high-performance fluorescent sensor spatiotemporally reveals cell-type specific regulation of intracellular adenosine in vivo.

Adenosine (Ado), a nucleoside bridging intracellular metabolism with intercellular communication, plays an essential role in regulating processes such as sleep and seizure. While the functions of extracellular Ado ("eAdo") are well documented, our knowledge about the distribution and regulatory functions of intracellular Ado ("iAdo") is limited by a lack of methods for detecting iAdo in vivo. Here, we develop HypnoS, a genetically encoded fluorescent sensor for iAdo characterized by its high sensitivity, specificity, spatiotemporal resolution, and rapid response (sub-seconds).

Ultrathin and permeable silver nanowires/polyvinyl alcohol epidermal electrode for continuous electrophysiological monitoring.

The development of ultrathin and highly permeable epidermal electrodes is critical for continuous health monitoring, enabling early diagnosis and effective disease management. However, conventional epidermal electrode materials and designs face significant challenges in achieving the necessary combination of ultrathin geometry, gas permeability, seamless adhesion, and high stretchability for long-term wearability. To address these issues, we report an ultrathin gel electrode consisting of a polyvinyl alcohol gel and silver nanowires with a thickness of only 14.

Dynamic changes and metabolic function of intestinal flora in patients with postoperative pneumonia after lung cancer surgery.

Background: Postoperative pneumonia (POP) is the most prevalent postoperative complication following lung cancer surgery. It is a crucial factor that influences surgical success and the rapid recovery of patients. Studies on the gut-lung axis have suggested that changes in the structural and functional aspects of intestinal flora are implicated in the incidents and development of pulmonary infection.

Programmable production of bioactive extracellular vesicles in vivo to treat myocardial infarction.

Current myocardial infarction (MI) treatment strategies remain challenged in suboptimal pharmacokinetics and potential adverse effects. Here we present a bioelectronic interface capable of producing on-demand abundant bioactive extracellular vesicles (EVs) near the MI area for in-situ localized treatment. The technology, termed electroactive patch for wirelessly and controllable EV generation (ePOWER), leverages wireless bioelectronic patch to stimulate embedded electrosensitive macrophages, actively modulating the biosynthesis of EVs and enabling EV production with high programmability to be delivered directly to the MI area.

Electrochemical Synthesis of β-Keto Sulfones from Enol Acetates and Sulfonyl Hydrazides.

A novel and environmentally friendly strategy has been developed for the efficient electrochemical synthesis of β-keto sulfones. This method enables the synthesis of β-keto sulfones by reacting easily available sulfonylhydrazide with enol acetate under mild conditions, especially without the need for transition metal catalysts or oxidants, which can achieve high yields. The scope of this reaction was systematically explored with various sulfonyl hydrazides and enol acetates.

Gamma-glutamyl transferase-to-lymphocyte ratio as a prognostic marker in patients with hepatocellular carcinoma undergoing hepatectomy.

Background: We investigated the utility of gamma-glutamyl transferase-to-lymphocyte ratio (GLR) as a predictive indicator for postoperative survival in patients with hepatocellular carcinoma (HCC) across different time periods and developed a predictive model based on this.

Aim: To evaluate the prognostic accuracy of GLR for overall survival (OS) in patients with HCC and its impact over time.

Methods: This study enrolled 301 patients with HCC treated with curative hepatectomy.

Modular Synthesis of Desferrioxamine B and Its Methotrexate Conjugate as a Selective Trojan Horse Antibiotic That Targets .

A modular synthetic route for desferrioxamine B (DFOB) and its methotrexate (Mtx) conjugate is presented. This route employs acid-sensitive methoxybenzyl groups to protect the hydroxamic acid oxygen, and DFOB was obtained in the 11 longest linear steps with an overall 22% yield. Resulting DFOB-Mtx conjugate exhibits antibacterial activity specifically against with a minimum inhibitory concentration of 3.

Deep Blue Tetradentate Pt(II) Emitter Coordinated With Fused Fluorenyl N-heterocyclic Carbene. High Efficiency, Narrow FWHM, and Superior Operational Lifetime LT of 290 h at 1000 cd m.

Blue tetradentate Pt(II) emitters and the corresponding organic light-emitting diodes (OLEDs) are promising for next-generation high-resolution displays. However, developing blue Pt(II) emitters that simultaneously achieve high efficiency, high color purity, and excellent operational stability remains challenging. In this study, we developed two new high-performance deep blue tetradentate Pt(II) emitters (Pt1 and Pt2) whose ligands contain 1-(3,5-di-tert-butylphenyl)-9,9-dimethyl-1,9-dihydrofluoreno[2,3-d]imidazolium or 3-(3,5-di-tert-butylphenyl)-9,9-dimethyl-3,9-dihydrofluoreno[2,3-d]imidazolium carbene moiety (DMFI).

Affinity maturation of antibody responses is mediated by differential plasma cell proliferation.

Increased antibody affinity over time after vaccination, known as affinity maturation, is a prototypical feature of immune responses. Recent studies have shown that a diverse collection of B cells, producing antibodies with a wide spectrum of different affinities, is selected into the plasma cell (PC) pathway. How affinity-permissive selection enables PC affinity maturation remains unknown.

Affinity maturation of antibody responses is mediated by differential plasma cell proliferation.

Increased antibody affinity over time after vaccination, known as affinity maturation, is a prototypical feature of immune responses. Recent studies have shown that a diverse collection of B cells, producing antibodies with a wide spectrum of different affinities, are selected into the plasma cell (PC) pathway. How affinity-permissive selection enables PC affinity maturation remains unknown.

Overpotential engineering enables dendrite-free zinc anode for high-performance zinc-ion batteries.

Large-scale energy storage applications can greatly benefit from the low-cost and safe zinc metal anode. However, corrosion, side reactions and dendrite growth in water significantly inhibit the cycle life of zinc-ion batteries. Here, 2-ethyl-1H-benzimidazole (EHB), a strong zincophilic and hydrophobic structure, is introduced into the ZnSO (ZS) electrolyte to adjust the nucleation overpotential in Zinc-ion batteries for the initial time.