An artificial intelligence cloud platform for OCT-based retinal anomalies screening system in real clinical environments.

Millions of individuals worldwide suffer from retinal anomalies, which can lead to irreversible vision loss. However, the number of ophthalmologists is highly mismatched with the population base in China, especially in many rural and underdeveloped towns. To tackle these challenges, this paper developed an Artificial Intelligence Cloud Platform for OCT-based Retinal Anomalies Screening (AI-PORAS), which is capable of detecting 15 retinal anomalies in OCT images to enhance remote diagnostic efficiency.

Physiological effects and technical strategies of LED supplemental lighting for pitaya cultivation: a review.

Pitaya is a high-value perennial tropical fruit known for its nutritional and health benefits. It is now widely cultivated in many tropical and subtropical countries, offering strong economic returns. China ranks first globally in pitaya cultivation, which includes both open-field production in tropical and subtropical regions and facility-based cultivation in temperate zones.

Triptonide stabilizes BIM to enhance oxaliplatin-induced ferroptosis and apoptosis in colorectal cancer.

Oxaliplatin (OXA) is a common chemotherapeutic agent for advanced colorectal cancer. However, its effectiveness is limited by drug resistance, highlighting the need for combination therapies. In this study, Triptonide (TN), a diterpenoid compound is used to enhance the sensitivity of OXA, and the underlying mechanisms are investigated.

High cGAS-STING expression associates with improved efficacy of neoadjuvant chemo-immunotherapy in head and neck squamous cell carcinoma.

Purpose: Neoadjuvant chemo-immunotherapy (NACI) has demonstrated significant clinical advantages in head and neck squamous cell carcinomas (HNSCC), while clinical responses vary in different patients. This study investigated the correlation between the cyclic GMP-AMP synthase (cGAS, ) and the stimulator of interferon genes (STING, ) expressions and the efficacy of NACI in HNSCC.

Methods: The correlation between and expressions and chemotherapy/immunotherapy drug sensitivity was analyzed using the GDSC and TCIA dataset.

Bipartite reweight-annealing algorithm of quantum Monte Carlo to extract large-scale data of entanglement entropy and its derivative.

Entanglement entropy (EE) plays a central role in the intersection of quantum information science and condensed matter physics. However, scanning the EE for two-dimensional and higher-dimensional systems still remains challenging. To address this challenge, we propose a quantum Monte Carlo scheme capable of extracting large-scale data of Rényi EE with high precision and low technical barrier.

A microsphere loaded with chondrocyte-targeting exosomes continuously deliver miR-148a for osteoarthritis therapy.

Due to the complex pathogenesis and limited treatment options, the clinical diagnosis and treatment of osteoarthritis (OA) remains extremely challenging. Umbilical cord derived mesenchymal stem cell-derived exosomes have low immunogenicity, high biocompatibility and superior transbiofilm properties, showing great research value in OA treatment. Healthy chondrocytic extracellular matrix anabolism is essential for cartilage homeostasis.

The association between serum klotho protein and stroke: a cross-sectional study from NHANES 2007-2016.

Objective: Serum klotho protein is a protein with anti-aging effects. Since the relationship between serum klotho and Stroke remains rather ambiguous, this research probed into the potential correlation between serum klotho concentration and Stroke.

Methods: This study employed a cross-sectional design and incorporated population data from the NHANES from 2007 to 2016.

Conditional survival analysis and real-time prognosis prediction for prostate cancer patients.

To assess shifts in long-term survival outcomes for prostate cancer patients, the present study conducted conditional survival (CS) analysis and developed a personalized CS-nomogram to provide dynamic prognostic predictions. Data from 301,441 prostate cancer patients in the Surveillance, epidemiology, and end results (SEER) database were analyzed, with cancer-specific survival (CSS) estimated using the Aalen Johansen estimator. Key predictive factors, including tumor size, lymph node involvement, distant metastasis, and histological grade, were identified via LASSO and multivariable Cox regression analyses to construct the nomogram.

Relationship between dietary patterns and overactive bladder: a cross sectional study of NHANES 2013 to 2023.

Background: Dietary patterns, as a comprehensive dietary indicator, may influence the risk of developing overactive bladder (OAB). However, it remains unclear whether dietary patterns independently affect the development of OAB.

Objective: This study aimed to identify specific dietary patterns using principal component analysis (PCA) and evaluate their associations with the risk of OAB, thereby providing new insights for OAB prevention and management.

Stoichiometry-engineered phase transition in a two-dimensional binary compound.

Due to complex thermodynamic and kinetic mechanism, phase engineering in nanomaterials is often limited by restricted phases and small-scale synthesis, hindering material diversity and scalability. Here, we demonstrate the exploration to unlock the stoichiometry as a degree of freedom for phase engineering in the Pd-Te binary compound. By reducing diffusion rates, we effectively engineer the stoichiometry of the reactants.

Study on authenticity identification and quality evaluation of Styrax by combining multiple detection methods with scientific characterization of description.

Styrax is a rare and expensive natural spice for food, known for its unique and rich aroma and sticky texture, and has a long history of consumption worldwide. There are many counterfeits in the market, but it is challenging to distinguish them with existing standards. Therefore, identifying the authenticity of styrax and evaluating its quality are challenges.

Asymmetric total synthesis of penicilfuranone A through an NHC-catalyzed umpolung strategy.

The first asymmetric total synthesis of penicifuranone A was accomplished in eight steps through an NHC-catalyzed umpolung strategy. Key features of the synthesis include an Al-Salen catalyzed asymmetric cyanosilylation to install the tertiary alcohol of gregatin A, and an NHC catalyzed Stetter-Aldol cascade reaction. The umpolung strategy of the benzyl aldehyde fragment facilitated a convergent formal [4 + 2] annulation with gregatin A, ultimately leading to the formation of penicifuranone A.

Sampling reduced density matrix to extract fine levels of entanglement spectrum and restore entanglement Hamiltonian.

The reduced density matrix (RDM) plays a key role in quantum entanglement and measurement, as it allows the extraction of almost all physical quantities related to the reduced degrees of freedom. However, restricted by the degrees of freedom in the environment, the total system size is often limited, let alone the subsystem. To address this challenge, we propose a quantum Monte Carlo scheme with a low technical barrier, enabling precise extraction of the RDM.

Asymmetric Total synthesis of Asperones A and B through Organocatalyzed Quinone [5 + 2] Cycloaddition.

The first asymmetric total synthesis of the anti-inflammatory polyketides asperones A () and B () has been accomplished. Key synthetic steps include a Diels-Alder and retro-Diels-Alder cascade to construct the poly substituted phenol, an Al-Salen-catalyzed asymmetric cyanosilylation to form the tertiary alcohol of gregatin A, and an organocatalyzed intermolecular [5 + 2] cycloaddition of -quinone with electron-deficient alkenes to build the crucial [3.2.

Aspergillus Mycotoxins: The Major Food Contaminants.

Mycotoxins, a category of fungal secondary metabolites, frequently contaminate food products and pose a severe threat to human health. Aspergillus, a genus of fungi, is capable of producing mycotoxins, with aflatoxins (AFs) and ochratoxins being its principal types. Aspergillus mycotoxins can contaminate a wide range of crops and their derivatives, such as maize, wheat, rice, minor cereals, and peanuts, thereby threatening food and feed safety.

Scalable synthesis of (±)-gregatin A a 1,3-dipolar cycloaddition strategy.

A 6-step gram-scale synthesis of the fungal polyketide (±)-gregatin A is described. The synthetic route features an intermolecular 1,3-dipolar cycloaddition, a Mo-mediated disconnection of the isoxazole skeleton, and an acid-mediated deprotection/enamine hydrolysis and hemiketalization cascade.

Integrated multi-omics analysis identifies a machine learning-derived signature for predicting prognosis and therapeutic vulnerability in clear cell renal cell carcinoma.

Aims: Clear cell renal cell carcinoma (ccRCC) shows considerable variation within and between tumors, presents varying treatment responses among patients, possibly due to molecular distinctions. This study utilized a multi-center and multi-omics analysis to establish and validate a prognosis and treatment vulnerability signature (PTVS) capable of effectively predicting patient prognosis and drug responsiveness.

Materials And Methods: To address this complexity, we constructed an integrative multi-omics analysis using 10 clustering algorithms on ccRCC patient data.

Growth, Quality, and Nitrogen Metabolism of Under Continuous Light from Red-Blue-Green LEDs Responded Better to High Nitrogen Concentrations than Under Red-Blue LEDs.

Alfalfa is a widely grown forage with a high crude protein content. Clarifying the interactions between light quality and nitrogen level on yield and nitrogen metabolism can purposely improve alfalfa productivity in plant factories with artificial light (PFAL). In this study, the growth, quality, and nitrogen metabolism of alfalfa grown in PFAL were investigated using three nitrate-nitrogen concentrations (10, 15, and 20 mM, labeled as N, N, and N) and continuous light (CL) with two light qualities (red-blue and red-blue-green light, labeled as RB-C and RBG-C).

Evaluating the efficacy of the endoscopic thyroidectomy via sternocleidomastoid muscle posteroinferior approach in identifying occult lateral cervical lymph node metastasis.

Background: Lateral cervical lymph node metastasis (LLNM) is a well-established prognostic factor influencing recurrence and survival in patients with papillary thyroid carcinoma (PTC). However, the accuracy of preoperative imaging examinations is limited. We have pioneered a minimally invasive technique-endoscopic thyroidectomy via sternocleidomastoid muscle posteroinferior approach (ETSPIA).

The seventh blind test of crystal structure prediction: structure generation methods.

A seventh blind test of crystal structure prediction was organized by the Cambridge Crystallographic Data Centre featuring seven target systems of varying complexity: a silicon and iodine-containing molecule, a copper coordination complex, a near-rigid molecule, a cocrystal, a polymorphic small agrochemical, a highly flexible polymorphic drug candidate, and a polymorphic morpholine salt. In this first of two parts focusing on structure generation methods, many crystal structure prediction (CSP) methods performed well for the small but flexible agrochemical compound, successfully reproducing the experimentally observed crystal structures, while few groups were successful for the systems of higher complexity. A powder X-ray diffraction (PXRD) assisted exercise demonstrated the use of CSP in successfully determining a crystal structure from a low-quality PXRD pattern.

A novel minimally invasive endoscopic approach of thyroid surgery-endoscopic thyroidectomy via sternocleidomastoid muscle posteroinferior approach.

Background: Since the endoscopic thyroidectomy was firstly reported by Hüscher in 1997, there has been an ongoing debate regarding whether mainstream endoscopic thyroidectomy can be classified as minimally invasive surgery. In this study, we innovatively proposed the endoscopic thyroidectomy via sternocleidomastoid muscle posteroinferior approach (ETSPIA), a novel minimally invasive surgical technique, and compared its efficacy with the well-established transoral endoscopic thyroidectomy vestibular approach (TOETVA).

Methods: We retrospectively analyzed 50 patients who underwent ETSPIA and 50 patients who underwent TOETVA at Beijing Tongren Hospital, comparing their clinical characteristics, operative duration, blood loss, postoperative alterations in parathyroid hormone (PTH) and serum calcium, recovery post-surgery, complications, and follow-up data.

The effect of physical exercise on social adaptability in Chinese middle school students: The mediating role of social anxiety.

The purpose of this study was to explore the effect of physical exercise on the social adaptability of middle school students and further analyze the mediating role of social anxiety. A total of 1056 middle school students from 6 middle schools in Sichuan, China, voluntarily participated in the survey. The Physical Activity Rating Scale (PARS-3), Social Anxiety Subscale of the Self-Consciousness Scale, and Social Adaptability Scale were used in this study.

Performance of Halo-Alkali-Tolerant Endophytic Bacteria on Hybrid and Bacterial Community under Varying Soil Conditions.

Halo-alkali soil threatens agriculture, reducing growth and crop yield worldwide. In this study, physicochemical and molecular techniques were employed to explore the potential of halo-alkali-tolerant endophytic bacteria strains sp. pp01, sp.

Effect of Preoperative Neck Radiotherapy on the Reconstruction of Head and Neck Defects With the Supraclavicular Artery Island Flap.

The supraclavicular artery island (SAI) flap is commonly used in the reconstruction of head and neck defects. However, the safety of SAI flaps for neck irradiated patient needs to be verified. To investigate the safety of using the SAI flap for patients who have undergone neck radiotherapy, as well as the risk factors for flap complications.