Link between Parkinson's disease and melanoma: insights into the influence of the gene family.

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by damage to dopaminergic neurons within the substantia nigra region of the midbrain. Melanoma, on the other hand, is a malignant skin tumor formed by the abnormal proliferation of melanocytes, often linked to genetic predisposition and ultraviolet exposure. Emerging evidence confirms a significant association between PD and melanoma, with individuals afflicted with PD displaying a higher susceptibility to melanoma development.

Transcriptomic Reprogramming and Key Molecular Pathways Underlying Huanglongbing Tolerance and Susceptibility in Six Citrus Cultivars.

Huanglongbing (HLB), caused by Liberibacter asiaticus (CLas), is the most devastating disease threatening global citrus production. Although no commercial citrus varieties exhibit complete HLB resistance, genotype-specific tolerance variations remain underexplored. This study conducted a comparative transcriptomic profiling of six commercially citrus cultivars in South China, four susceptible cultivars ( cv.

SSNFNet: An Enhanced Few-Shot Learning Model for Efficient Poultry Farming Detection.

As the public increasingly focuses on healthy diets, protein-rich foods have become their preferred choice, and poultry products ideally meet this demand [...

Regioselective rapid ene-type reaction (RRER) enables bioconjugation of histone serotonylation.

Triazolinedione (TAD) derivatives have been commonly utilized as protection and labeling reagents for indole and phenol moieties a reversible ene-type reaction. Previous studies showed that the TAD probes could selectively modify tyrosine and tryptophan side-chains within proteins and peptides under distinct pH conditions. Here, we report a pH-controlled regioselective rapid ene-type reaction (RRER) between TAD and 5-hydroxyindole, where the modification occurs on the C4 position rather than the C3 of inactivated indole rings.

Constructing a domain-specific sentiment lexicon for agricultural product reviews using BERT and SO-PMI.

The absence of a sentiment lexicon tailored to agricultural product reviews presents significant challenges for accurate sentiment analysis in this domain. Existing general-purpose lexicons, such as NTUSD, HOWNET, and BosonNLP, fail to capture the unique linguistic features of agricultural reviews, leading to suboptimal classification performance. To address this gap, this study constructs the BSTS sentiment lexicon, using a dataset of 19,843 preprocessed reviews from JD.

Correction to "CMA down-regulates p53 expression through degradation of HMGB1 protein to inhibit irradiation-triggered apoptosis in hepatocellular carcinoma".

[This corrects the article on p. 2308 in vol. 23, PMID: 28428710.

Morphological, physiological, and molecular responses of Perilla frutescens to copper stress alleviated by PVC microplastics.

Microplastics (MPs) and copper (Cu) are common co-pollutants in agricultural environments, yet their combined effects on plants remain poorly understood. This study investigated the individual and interactive impacts of Cu and polyvinyl chloride (PVC)-MPs on Perilla frutescens, a heavy metal hyperaccumulator and economically important crop, using hydroponic experiments. Low Cu concentrations (<2 mg L) promoted growth, whereas higher levels (>2 mg L) induced leaf chlorosis, curling, and root decay.

Identification of soluble biomarkers that associate with distinct manifestations of long COVID.

Long coronavirus disease (COVID) is a heterogeneous clinical condition of uncertain etiology triggered by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here we used ultrasensitive approaches to profile the immune system and the plasma proteome in healthy convalescent individuals and individuals with long COVID, spanning geographically independent cohorts from Sweden and the United Kingdom. Symptomatic disease was not consistently associated with quantitative differences in immune cell lineage composition or antiviral T cell immunity.

Chromosome-level genome assembly and annotation of Chinese herring (Ilisha elongata).

The Chinese herring (Ilisha elongata) is a commercially and scientifically significant fish species. In this study, we conducted high-precision whole-genome sequencing using two high-throughput platforms: second-generation MGI and third-generation PacBio. Hi-C technology assisted in assembling the contig sequences onto 24 chromosomes, resulting in a high-quality chromosome-level genome map with excellent continuity and coverage.

Genome-Wide Identification of β-Ketoacyl CoA Synthase Gene Family in Melon ( L.) and Its Expression Analysis in Autotoxicity, Saline-Alkali, and Microplastic Exposure Environments.

β-ketoacyl CoA synthase (KCS) is a key enzyme in the synthesis of long-chain fatty acids. It affects plant stress resistance by regulating the chain length of fatty acid elongation products, the wax deposition in plant epidermis, and the formation of suberization layers. Through a comprehensive, genome-wide analysis, we identified members of the melon () family and characterized their sequence features, phylogenetic relationships, and expression profiles under three abiotic stress conditions, employing bioinformatics tools and methods.

An investigation of hydraulic fracturing initiation and location of hydraulic fracture in preforated oil shale formations.

Horizontal well fracturing technology enables the commercial production of low-permeability reservoirs, with perforation fracturing technology serving as a critical component of multistage fracturing for horizontal wells. However, the presence of the horizontal wellbore and the perforation borehole significantly complicates the distribution of the local stress field. The extension behavior of hydraulic fractures cannot be accurately described.

Bidirectional histone monoaminylation dynamics regulate neural rhythmicity.

Histone H3 monoaminylations at Gln5 represent an important family of epigenetic marks in brain that have critical roles in permissive gene expression. We previously demonstrated that serotonylation and dopaminylation of Gln5 of histone H3 (H3Q5ser and H3Q5dop, respectively) are catalysed by transglutaminase 2 (TG2), and alter both local and global chromatin states. Here we found that TG2 additionally functions as an eraser and exchanger of H3 monoaminylations, including H3Q5 histaminylation (H3Q5his), which displays diurnally rhythmic expression in brain and contributes to circadian gene expression and behaviour.

Gastrointestinal image stitching based on improved unsupervised algorithm.

Image stitching is a traditional but challenging computer vision task. The goal is to stitch together multiple images with overlapping areas into a single, natural-looking, high-resolution image without ghosts or seams. This article aims to increase the field of view of gastroenteroscopy and reduce the missed detection rate.

pH-Controlled Chemoselective Rapid Azo-Coupling Reaction (CRACR) Enables Global Profiling of Serotonylation Proteome in Cancer Cells.

Serotonylation has been identified as a novel protein posttranslational modification for decades, where an isopeptide bond is formed between the glutamine residue and serotonin through transamination. Transglutaminase 2 (also known as TGM2 or TGase2) was proven to act as the main "writer" enzyme for this PTM, and a number of key regulatory proteins (including small GTPases, fibronectin, fibrinogen, serotonin transporter, and histone H3) have been characterized as the substrates of serotonylation. However, due to the lack of pan-specific antibodies for serotonylated glutamine, the precise enrichment and proteomic profiling of serotonylation still remain challenging.

Development and Validation of an Interpretable Machine Learning Prediction Model for Total Pathological Complete Response after Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer: Multicenter Retrospective Analysis.

This study aims to develop an interpretable machine learning (ML) model to accurately predict the probability of achieving total pathological complete response (tpCR) in patients with locally advanced breast cancer (LABC) following neoadjuvant chemotherapy (NAC). This multi-center retrospective study included pre-NAC clinical pathology data from 698 LABC patients. Post-operative pathological outcomes divided patients into tpCR and non-tpCR groups.

Transglutaminase 2-mediated histone monoaminylation and its role in cancer.

Transglutaminase 2 (TGM2) has been known as a well-characterized factor regulating the progression of multiple types of cancer, due to its multifunctional activities and the ubiquitous signaling pathways it is involved in. As a member of the transglutaminase family, TGM2 catalyzes protein post-translational modifications (PTMs), including monoaminylation, amide hydrolysis, cross-linking, etc., through the transamidation of variant glutamine-containing protein substrates.

Micelle-Containing Hydrogels and Their Applications in Biomedical Research.

Hydrogels are one of the most commonly used materials in our daily lives, which possess crosslinked three-dimensional network structures and are capable of absorbing large amounts of fluid. Due to their outstanding properties, such as flexibility, tunability, and biocompatibility, hydrogels have been widely employed in biomedical research and clinics, especially in on-demand drug release. However, traditional hydrogels face various limitations, e.

An optimize adaptable method for determining the monosaccharide composition of pectic polysaccharides.

Pectic polysaccharides are considered the highly complex natural plant polysaccharides which plays a vital role in plant tissue structure and human health. Detailed characterization of the monosaccharide composition can provide insights into the pectic polysaccharide structure. Nevertheless, when analyzing the monosaccharides of pectic polysaccharide, it is crucial to address the issue of incomplete hydrolysis that can occur due to the formation of acid-induced precipitates.

Exploring the Chinese public's affective attitudes towards digital transformation in agriculture: A social media-based analysis.

This study utilizes natural language processing techniques and panel vector autoregression methodology, to delve into the perceived attitudes of social media users towards the digital transformation of agriculture, and to assess its impact on total agricultural output and agricultural science and technology inputs. Data related to agricultural digital transformation were collected from Sina Weibo using web crawlers. The SnowNLP model was employed to infer users' attitudes, encompassing both positive and negative aspects.

AKT1 Promotes Tumorigenesis and Metastasis by Directly Phosphorylating Hexokinases.

The importance of protein kinase B (AKT) in tumorigenesis and development is well established, but its potential regulation of metabolic reprogramming via phosphorylation of the hexokinase (HK) isozymes remains unclear. There are two HK family members (HK1/2) and three AKT family members (AKT1/2/3), with varied distribution of AKTs exhibiting distinct functions in different tissues and cell types. Although AKT is known to phosphorylate HK2 at threonine 473, AKT-mediated phosphorylation of HK1 has not been reported.

Bioorthogonal Labeling and Enrichment of Histone Monoaminylation Reveal Its Accumulation and Regulatory Function in Cancer Cell Chromatin.

Histone monoaminylation (., serotonylation and dopaminylation) is an emerging category of epigenetic mark occurring on the fifth glutamine (Q5) residue of H3 N-terminal tail, which plays significant roles in gene transcription. Current analysis of histone monoaminylation is mainly based on site-specific antibodies and mass spectrometry, which either lacks high resolution or is time-consuming.

Chemical Proteomic Profiling of Protein Dopaminylation in Colorectal Cancer Cells.

Histone dopaminylation is a newly identified epigenetic mark that plays a role in the regulation of gene transcription, where an isopeptide bond is formed between the fifth amino acid of H3 (i.e., glutamine) and dopamine.

Clinical features and treatment of heterotopic pancreas in children: a multi-center retrospective study.

Objective: Heterotopic pancreas, an uncommon condition in children, can present with diagnostic and treatment challenges. This study aimed to evaluate the clinical features and treatment options for this disorder in pediatric patients.

Methods: We conducted a retrospective analysis, including patients diagnosed with heterotopic pancreas at four tertiary hospitals between January 2000 and June 2022.