[Treatment of lower cervical spine fracture-dislocation in patients with ankylosing spondylitis by anterior poking and traction reduction internal fixation combined with anterior-posterior approach].

Objective: To explore the integrated traditional Chinese and Western medicine treatment plan for ankylosing spondylitis complicated with lower cervical spine fracture and dislocation, adopt the treatment plan of preoperative continuous traction, intraoperative prizing reduction combined with anterior long-segment plate-screw and posterior short-segment pedicle screw-rod system internal fixation, and evaluate its surgical efficacy and clinical application value.

Methods: From June 2018 to September 2022, 7 male patients with ankylosing spondylitis complicated with lower cervical spine fractures were admitted, aged 43 to 65 years old. Among them, there was 1 case of C fracture, 1 case of C fracture, 1 case of C fracture, and 4 cases of C fracture, all of which were fracture and dislocation.

Pathogen virulence genes: Advances, challenges and future directions in infectious disease research (Review).

Pathogens, including bacteria, viruses and fungi, employ virulence genes to invade their hosts, circumvent immunity and induce diseases. The present review examines the categorization and regulatory mechanisms of virulence genes and their co‑evolution with antimicrobial resistance. The present review focused on the fimbrial adhesion H adhesion gene of , the spike protein gene of severe acute respiratory syndrome coronavirus 2 and the enhanced filamentous growth protein 1 (EFG1) morphological transition gene of , as well as their roles in host adhesion, immune evasion and tissue damage.

Toll-like receptor 4 activation potentiates voriconazole-induced hepatotoxicity via transcriptional repression of the farnesoid X receptor in murine hepatocytes.

Objectives: Voriconazole (VRC)-induced hepatotoxicity is an important consideration in the clinical application of voriconazole. This study explores the potential role of toll-like receptor (TLR) 4 activation on voriconazole-induced hepatotoxicity and its underlying mechanisms.

Methods: A model of VRC- and lipopolysaccharide (LPS)-induced hepatotoxicity was constructed using C57BL/6 mice.

An oxidative stress related gene signature predicts prognosis in cholangiocarcinoma.

Background: Cholangiocarcinoma (CCA) is a malignancy with a poor prognosis and limited effective prognostic markers or therapeutic strategies. This study aims to construct and validate a prognostic risk model based on oxidative stress-related genes (OSRGs) to stratify patient risk and guide individualized treatment for CCA.

Methods: Using data from 66 tumors and 36 control samples obtained from the TCGA and GEO databases, we identified 3,632 differentially expressed genes (DEGs).

The regulatory role and mechanism of energy metabolism and immune response in head and neck cancer.

Head and neck cancer, which includes cancers of the mouth, larynx, and pharynx, is one of the six most common cancers worldwide. Common risk factors include smoking, excessive alcohol consumption, betel nut chewing, and viruses such as HPV and EBV. Tumor cells often exhibit distinct metabolic characteristics compared with normal cells, highlighting a key area for potential intervention.

Immunological role and prognostic value of ITGA3 and ITGA5 in oral squamous cell carcinoma.

Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer, originating from the squamous cells of the oral mucosa. The global occurrence is significant and is closely linked to smoking, alcohol use, and HPV infection, with a generally poor prognosis, highlighting the importance of early detection and treatment. Integrins are heterodimeric transmembrane receptors composed of α and β subunits, forming a recognized family of about 24 subtypes.

Association of pulmonary function with the risk of incident Alzheimer's disease: a prospective cohort and Mendelian randomization study.

Introduction: The causal association between pulmonary function and Alzheimer's disease (AD) remains unclear. This study aimed to investigate whether low pulmonary function has a causal relationship with the risk of AD.

Methods: We conducted prospective cohort and two-sample Mendelian randomization (MR) studies.

SRSF3 undergoes phase separation in lung cancer and is associated with immunity and ferroptosis.

As one of the most deadly malignant tumours, lung cancer has been increasing in incidence and mortality worldwide. The incidence and mortality rates of lung cancer are increasing annually. A deeper understanding of the development of lung cancer at the molecular level is of great significance for accurate diagnosis and efficient treatment of lung cancer.

Air Pollution, Genetic Susceptibility, and Risk of Symptomatic Peripheral Arterial Disease: A Cohort Study of the UK Biobank.

Objective: This study aimed to investigate the relationship between exposure to various air pollutants and the risk of symptomatic peripheral arterial disease (PAD) and to explore whether the association is modified by genetic predisposition to PAD.

Methods: A prospective cohort study was conducted using data from the UK Biobank. The analysis included individuals without a history of PAD at baseline and with available data for air pollutants and covariates.

Acute creatine supplementation enhances technical performance in adolescent basketball players under cognitive-motor dual-task condition.

Background: Basketball games involve numerous cognitive-motor dual-task (CMDT) situations, where athletes must execute technical skills while processing complex on-court information. However, adolescent athletes often experience performance declines under CMDT conditions due to increased cognitive load. Creatine supplementation has been shown to enhance both physical and cognitive functions, but its acute effects on basketball skill performance under CMDT conditions remain unclear.

A Prion-Like Domain in EBV EBNA1 Promotes Phase Separation and Enables SRRM1 Splicing.

Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is necessary to maintain stability of EBV episomes, EBV replication, and causes host genomic instability and promotes tumor cells survival. Recent studies have shown that viruses utilize liquid-liquid phase separation (LLPS) within host cells to form sub-cellular compartments known as "virus factories". Prion-like domains (PrLDs), which resemble structural domains of low complexity, are shown to drive LLPS in vivo.

Novel insights into lncRNAs as key regulators of post-translational modifications in cancer: mechanisms and therapeutic potential.

Abnormal post-translational modifications (PTMs) play a crucial role in tumor initiation and progression. However, the mechanisms by which lncRNAs, as emerging epigenetic regulators, mediate PTMs remain largely unexplored. This review provides a comprehensive summary of the latest research on the interplay between lncRNA-mediated PTMs and tumorigenesis.

Fusion genes in cancers: Biogenesis, functions, and therapeutic implications.

The processes of tumorigenesis and development are intricate, involving numerous genes and molecular pathways. Fusion genes, direct products of abnormal chromosomal rearrangements, are key factors in the formation of many types of tumors. In recent years, the advent of sequencing technology and bioinformatics has led to the discovery of more fusion genes associated with specific types of tumors.

Constructing a domain-specific sentiment lexicon for agricultural product reviews using BERT and SO-PMI.

The absence of a sentiment lexicon tailored to agricultural product reviews presents significant challenges for accurate sentiment analysis in this domain. Existing general-purpose lexicons, such as NTUSD, HOWNET, and BosonNLP, fail to capture the unique linguistic features of agricultural reviews, leading to suboptimal classification performance. To address this gap, this study constructs the BSTS sentiment lexicon, using a dataset of 19,843 preprocessed reviews from JD.

Advancements in liquid biopsy for breast Cancer: Molecular biomarkers and clinical applications.

Breast cancer is characterized by significant molecular heterogeneity; therefore, there are distinct clinical features, treatment modalities, and prognostic outcomes across its various molecular subtypes. In the era of precision medicine, liquid biopsy has emerged as a convenient and minimally invasive technique capable of dynamically representing the comprehensive tumor gene spectrum. This review systematically elaborates the clinical value of liquid biopsy as a breakthrough tool for precision diagnosis and treatment in breast cancer through dynamic detection of key biomarkers, including circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), exosomes, and non-coding RNA (ncRNA).

Seven Hypoxia and Immune-Related Features Predict Prognosis in Patients with Hepatocellular Carcinoma.

Background: The role of hypoxia and immunity in the progression of hepatocellular carcinoma (HCC) was highly critical. However, there were few application-based studies on hypoxia and immune molecules in HCC prognosis prediction. This study aims to reveal the prognostic significance of hypoxia- and immune-related genes in HCC.

Causal association between oral microbiota and oral cancer: a mendelian randomization study.

Many studies have reported an association between oral microbiota and oral cancer (OC). Yet, the causal relationship between oral microbiota and OC remains undetermined. This Mendelian randomization (MR) study utilized the most recent genome-wide association study of oral microbiota from the ADDITION-PRO study (n = 610, European ancestry), along with the summary statistics for OC from the UK Biobank consortium (643 cases and 406,821 controls, European ancestry).

Mechanism and application of lactylation in cancers.

Lactate is a crucial product of cancer metabolism, creating an acidic environment that supports cancer growth and acts as a substrate for lactylation. Lactylation, a newly discovered epigenetic modification, plays a vital role in cancer cell signaling, metabolic reprogramming, immune response, and other functions. This review explores the regulation of lactylation, summarizes recent research on its role in cancers, and highlights its application in cancer drug resistance and immunotherapy.

Bioinformatics prediction and experimental verification identify B4GALT1 as a diagnostic biomarker of glioblastoma.

Glycolysis plays a key role in the progression of glioblastoma (GBM). Gene expression and clinical information were obtained from The Cancer Genome Atlas, Genotype-Tissue Expression, the Chinese Glioma Genome Atlas database, and five Gene Expression Omnibus datasets. Twenty-one prognosis-related glycolytic differentially expressed genes were identified.

Crosstalk between RNA-binding proteins and non-coding RNAs in tumors: molecular mechanisms, and clinical significance.

RNA-binding proteins, integral in regulating RNA metabolism and gene expression, collaborate closely with non-coding RNAs, which are pivotal in post-transcriptional gene regulation. Both elements are essential for the progression of tumors. While recent research has increasingly illuminated their individual mechanisms, the intricate network interplay between them still requires further exploration.

Parents' knowledge, attitude and practice regarding childhood circumcision: a cross-sectional study in the central region of Sichuan, China.

Introduction: This cross-sectional study aimed to explore parents' knowledge, attitudes, and practices (KAP) regarding male circumcision (MC) for their children.

Methods: A cross-sectional study was conducted among parents of male children under 18 years old in the central region of Sichuan, China, between September 2023 and January 2024 Questionnaires were distributed to collect demographic information and KAP scores.

Results: A total of 497 valid questionnaires were collected.

Sex-specific association between atherogenic index of plasma and risk of newly diagnosed abdominal aortic aneurysm: a large population-based cohort study.

Objectives: Atherosclerosis of aortic wall has been suggested as a key pathological feature of abdominal aortic aneurysm (AAA). We conducted a first-ever prospective cohort study aiming at assessing the sex-specific association between atherogenic index of plasma (AIP) and risk of newly diagnosed AAA.

Methods: This study included 193,013 male and 226,785 female participants from the UK Biobank.

Pt-Decorated NiMo/Carbon Hybrid Catalysts for High-Current-Density Hydrogen Evolution: Synergistic Electronic Modulation and Industrial Application Potential.

In response to the urgent demand for sustainable hydrogen production under industrial high-current-density conditions, this study presents the development of a Pt-decorated NiMo-based carbon-supported catalyst (Pt-NiMo/C) for efficient alkaline hydrogen evolution reaction (HER). The catalyst was synthesized via a solvent evaporation method followed by high-temperature pyrolysis, achieving uniform dispersion of Pt-NiMo nanoparticles on conductive carbon. Electrochemical evaluations revealed exceptional HER performance with ultralow overpotentials of 20 and 170 mV versus RHE at current densities of 10 and 100 mA cm⁻, respectively, surpassing commercial Pt/C benchmarks.