Acute creatine supplementation enhances technical performance in adolescent basketball players under cognitive-motor dual-task condition.

Background: Basketball games involve numerous cognitive-motor dual-task (CMDT) situations, where athletes must execute technical skills while processing complex on-court information. However, adolescent athletes often experience performance declines under CMDT conditions due to increased cognitive load. Creatine supplementation has been shown to enhance both physical and cognitive functions, but its acute effects on basketball skill performance under CMDT conditions remain unclear.

Bidirectional symmetrical 200G simplified coherent PON system with laser-free ONUs.

Coherent detection is a highly attractive solution for beyond 200G passive optical network (PON) systems. However, directly migrating the coherent technologies from core networks to PON is excessively expensive. The narrow-linewidth local oscillator (LO) laser is a significant portion of the cost in coherent receivers.

A Gait Sub-Phase Switching-Based Active Training Control Strategy and Its Application in a Novel Rehabilitation Robot.

This research study proposes a heuristic hybrid deep neural network (DNN) gait sub-phase recognition model based on multi-source heterogeneous motion data fusion which quantifies gait phases and is applied in balance disorder rehabilitation control, achieving a recognition accuracy exceeding 99%. Building upon this model, a motion control strategy for a novel rehabilitation training robot is designed and developed. For patients with some degree of independent movement, an active training strategy is introduced; it combines gait recognition with a variable admittance control strategy.

The analgesic effect and neural mechanism of spicy food intake.

Although published studies have shown that applying capsaicin to the skin can have an analgesic effect on other parts of the body, the impact of spicy food intake on pain perception and its neurological mechanism remains unclear. Thus, two studies utilizing questionnaires and experiments with event-related potential (ERP) technology were conducted to explore this question. Study 1 recruited 300 adults and found a negative correlation between spicy food cravings and pain perception in daily life.

Optimization of Structural Parameters and Mechanical Performance Analysis of a Novel Redundant Actuation Rehabilitation Training Robot.

The integration of redundant structures into robotic systems enhances the degrees of freedom (DOFs), flexibility, and capability to perform complex tasks. This study evaluates the mechanical performance of a 9-DOF series-parallel hybrid redundant device designed for rehabilitation training of patients with balance disorders. The redundant structural design improves the robot's movement flexibility, optimizes load distribution, and mitigates stress concentration in local joints or components.

A novel key virulence factor, FoSSP71, inhibits plant immunity and promotes pathogenesis in f. sp. .

wilt of banana ( spp.), caused by f. sp.

Associations of exercise snacks with cognitive function among older adults in NHANES 2011-2014.

Background: With an aging global population, dementia incidence is rapidly increasing, affecting 50 million people worldwide. While physical activity has been linked to cognitive enhancement, the specific effects of intermittent short bouts of exercise, termed 'exercise snacks' (ES), on cognitive function (CF) in older adults are not well understood.

Methods: We analyzed data from 2549 adults aged ≥60 years from the 2011-2014 National Health and Nutrition Examination Survey cycles.

Urolithin A Enhances Tight Junction Protein Expression in Endothelial Cells Cultured In Vitro via Pink1-Parkin-Mediated Mitophagy in Irradiated Astrocytes.

Radiation brain injury (RBI) is a complication of cranial tumor radiotherapy that significantly impacts patients' quality of life. Astrocyte-secreted vascular endothelial growth factor (VEGF) disrupts the blood-brain barrier (BBB) in RBI. However, further studies are required to elucidate the complex molecular mechanisms involved.

The efficacy of early rehabilitation in enhancing vestibular compensation in mice with unilateral vestibular neurectomy by promoting cellular proliferation and glial reaction.

Acute peripheral vestibular dysfunction is associated with a variety of postural and balance disturbances. Vestibular rehabilitation training (VRT) is widely acknowledged as an effective intervention for promoting vestibular compensation. Nevertheless, the broader implementation of early VRT is hindered by an incomplete understanding of its neurobiological mechanisms.

Mitochondrial dysfunction of Astrocyte induces cell activation under high salt condition.

Excess dietary sodium can accumulate in brain and adversely affect human health. We have confirmed in previous studies that high salt can induce activation of astrocyte manifested by the secretion of various inflammatory factors. In order to further explore the effect of high salt on the internal cell metabolism of astrocytes, RNA sequencing was performed on astrocytes under high salt environment, which indicated the oxidative phosphorylation and glycolysis pathways of astrocytes were downregulated.

Prognostic value of preoperative nutritional status for postoperative moderate to severe acute kidney injury among older patients undergoing coronary artery bypass graft surgery: a retrospective study based on the MIMIC-IV database.

Objective: To investigate the association between preoperative nutritional scores and moderate-to-severe acute kidney injury (AKI) after coronary artery bypass graft (CABG) surgery and the predictive significance of nutritional indices for moderate to severe AKI.

Methods: This study retrospectively included older patients underwent CABG surgery from the Medical Information Mart for Intensive Care (MIMIC) database. Nutritional scores were calculated by the Geriatric Nutritional Risk Index (GNRI) and the Prognostic Nutritional Index (PNI), respectively.

Exploring the relationship of sleep duration on cognitive function among the elderly: a combined NHANES 2011-2014 and mendelian randomization analysis.

Background: As one of the key features of sleep, sleep duration (SD) has been confirmed to be associated with multiple health outcomes. However, the link between SD and cognitive function (CF) is still not well understood.

Methods: We employed a combined approach utilizing data from the National Health and Nutrition Examination Survey (NHANES 2011-2014) and Mendelian Randomization (MR) methods to investigate the relationship between SD and CF.

Research trends in the treatment and recycling of construction and demolition waste based on literature data-driven visualization.

In recent decades, research on treatment and recycling of construction and demolition waste (CDW) has rapidly increased due to its substantial environmental, social, and economic impacts. Despite the growing interest in this field, there is a noticeable lack of comprehensive and systematic analysis offering a clear overview of the development context and quantitative trends. To address this gap, this study conducted a systematic bibliometric overview that covers publishing trends, collaborative networks among countries, institutions and research teams, co-citation analysis of literatures, and keyword co-occurrence analysis using literature data-driven visualization.

Effects of agricultural carbon footprints and malnutrition on life expectancy in China.

This study explored the impact of carbon footprints and malnutrition on life expectancy in China over the periods of 2000 and 2021. Data from the World Bank Indicators database was utilized, and Dynamic Ordinary Least Squares (DOLS) was employed to analyse the extracted data. The results show that over the periods of 2000 and 2021, agricultural carbon footprints in China experienced a first sharp decline in 2015.

Traditional Chinese medicine for the treatment of cancers of hepatobiliary system: from clinical evidence to drug discovery.

Hepatic, biliary, and pancreatic cancer pose significant challenges in the field of digestive system diseases due to their highly malignant nature. Traditional Chinese medicine (TCM) has gained attention as a potential therapeutic approach with long-standing use in China and well-recognized clinical benefits. In this review, we systematically summarized the clinical applications of TCM that have shown promising results in clinical trials in treating hepatic, biliary, and pancreatic cancer.

Narrow-bandwidth silicon photonic CROW filter for carrier-extracted self-coherent (CESC) detection.

In this Letter, we report a second-order silicon photonic (SiP) coupled resonator optical waveguide (CROW) filter with an ultra-narrow 10-dB bandwidth of 1.75 GHz and a high extinction ratio (ER) of ∼50 dB. By utilizing this CROW filter, we demonstrated an innovative self-coherent detection, called carrier-extracted self-coherent (CESC) detection.

Biomarkers for diagnosis and therapeutic options in hepatocellular carcinoma.

Liver cancer is a global health challenge, causing a significant social-economic burden. Hepatocellular carcinoma (HCC) is the predominant type of primary liver cancer, which is highly heterogeneous in terms of molecular and cellular signatures. Early-stage or small tumors are typically treated with surgery or ablation.

The association between 'weekend warrior', regular exercise, and cognitive function in elderly individuals with and without depressive symptoms: A cross-sectional analysis from NHANES 2011-2014.

Background: While previous studies have suggested that both 'Weekend Warrior' (WW) and Regular Exercise (RE) patterns confer health benefits, the relationship between different types of physical activity (PA) and cognitive function (CF) in elderly individuals with and without depressive symptoms remains unclear.

Methods: Our study leveraged the NHANES 2011-2014 dataset, focusing on older adults. We explore the relationship between PA and CF, stratifying by depressive status.

Siwu decoction suppress myeloid-derived suppressor cells through tumour cells necroptosis to inhibit hepatocellular carcinoma.

Background: Human hepatocellular carcinoma (HCC) acquired resistance to anti-cancer agents due to the presence of immunosuppressive tumour microenvironment (TME) established by the interaction between tumour cells and immune populations. New treatment targeting the interaction is urgently needed and clinically beneficial to patients with HCC. This study aims to explore the anti-tumour effect of a Traditional Chinese Medicine formula Siwu Decoction (SWD) and its potential mechanism.

Physical activity patterns and cognitive function in elderly women: a cross-sectional study from NHANES 2011-2014.

Background: Amid the backdrop of global aging, the increasing prevalence of cognitive decline among the elderly, particularly within the female demographic, represents a considerable public health concern. Physical activity (PA) is recognized as an effective non-pharmacological intervention for mitigating cognitive decline in older adults. However, the relationship between different PA patterns and cognitive function (CF) in elderly women remains unclear.

Osteoprotegerin mediates adipogenesis in obesity.

Introduction: Adipogenesis, the process of white adipose tissue expansion, plays a critical role in the development of obesity. Osteoprotegerin (OPG), known for its role in bone metabolism regulation, emerges as a potential regulator in mediating adipogenesis during obesity onset.

Objectives: This study aims to elucidate the involvement of OPG in adipogenesis during the early phases of diet-induced obesity and explore its therapeutic potential in obesity management.

CCDC50 mediates the clearance of protein aggregates to prevent cellular proteotoxicity.

Protein aggregation caused by the disruption of proteostasis will lead to cellular cytotoxicity and even cell death, which is implicated in multiple neurodegenerative diseases. The elimination of aggregated proteins is mediated by selective macroautophagy receptors, which is termed aggrephagy. However, the identity and redundancy of aggrephagy receptors in recognizing substrates remain largely unexplored.