The role of RANBP1 in regulating MiRNA expression and apoptosis in breast cancer cells.

Background: Breast cancer poses a huge health threat in China. Emerging evidence has indicated that RANBP1 is associated with poor prognosis of breast cancer and has been shown to influence miRNA expression in colorectal cancer. But its role in breast cancer remains unclear.

PTP4A1 promotes intrahepatic cholangiocarcinoma development and progression by interacting with PTEN and activating the PI3K/AKT/GSKα axis.

Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive biliary cancer originating within the liver with a high incidence, high degree of malignancy and extremely poor prognosis. Protein tyrosine phosphatase 4A1 (PTP4A1) plays a carcinogenic role in numerous tumors. However, the role of PTP4A1 in the progression of ICC has not been fully elucidated.

A Gait Sub-Phase Switching-Based Active Training Control Strategy and Its Application in a Novel Rehabilitation Robot.

This research study proposes a heuristic hybrid deep neural network (DNN) gait sub-phase recognition model based on multi-source heterogeneous motion data fusion which quantifies gait phases and is applied in balance disorder rehabilitation control, achieving a recognition accuracy exceeding 99%. Building upon this model, a motion control strategy for a novel rehabilitation training robot is designed and developed. For patients with some degree of independent movement, an active training strategy is introduced; it combines gait recognition with a variable admittance control strategy.

Achieving stable cathode-electrolyte interface via in-situ electrochemical structural rearrangement for high-voltage layered cathodes.

The cathode-electrolyte interphase (CEI) is vital in lithium ion batteries as its electron/ion transfer efficiency at the electrode-electrolyte boundary governs the overall reaction kinetics. However, the dynamic nature of the CEI during cycling compromises electrochemical stability, resulting in rapid capacity degradation. Herein, we propose a facile in-situ strategy to engineer a thin and robust CEI layer on LiCoO (LCO) cathodes by making use of charge modulation between Co and Mn.

Design, synthesis, and application of triazole-embedded maltose-neopentyl-glycol (TMNG) amphiphiles for membrane protein studies.

Understanding membrane protein (MP) structure and function is less advanced than that of soluble proteins. Detergents are the primary reagents used in membrane protein studies, yet only a limited selection is employed in both fundamental and applied research. This study presents the design, synthesis, and application of novel triazole-embedded maltose-neopentyl-glycol (TMNG) amphiphiles for membrane protein studies.

Hawthorn pectin mitigates high-fat diet induced hyperlipidemia in mice through promoting Dubosiella newyorkensis.

Hawthorn fruit is rich in pectins; however, the gut microbiota-modulating effects of hawthorn pectin remain unclear. In this study, enzyme-extracted hawthorn pectin (M: 126.24 kDa; HG/RG-I ratio: 55.

Optimization of Structural Parameters and Mechanical Performance Analysis of a Novel Redundant Actuation Rehabilitation Training Robot.

The integration of redundant structures into robotic systems enhances the degrees of freedom (DOFs), flexibility, and capability to perform complex tasks. This study evaluates the mechanical performance of a 9-DOF series-parallel hybrid redundant device designed for rehabilitation training of patients with balance disorders. The redundant structural design improves the robot's movement flexibility, optimizes load distribution, and mitigates stress concentration in local joints or components.

2H,3H-Decafluoropentane Endorsed Localized High Concentration Electrolyte for Low-Temperature Lithium-Metal Batteries.

A lithium-metal battery's electrochemical performance is affected by the kinetics of desolvation and ion transport at low temperatures. Here, we propose a low-temperature lithium-metal battery electrolyte. 1,2-Dimethoxyethane (DME) is used as the solvent, 2H,3H-decafluoropentane (HFC) as the diluent, and a high concentration of lithium bis(fluorosulfonyl)imide (LiFSI) as the solute.

Mechanisms of concentration control alkali activated fly ash stabilized saline soil in seasonally frozen regions.

In the framework of sustainable development and environmental preservation, this research aims to improve the stability and frost resistance of sulfate saline soil by utilizing industrial solid waste. Geopolymer materials containing fly ash (FA) activated by different NaOH concentrations were studied for study on stabilized soil with saline soil, with NaOH concentrations used ranged from 0.1 to 0.

Gegen-Sangshen oral liquid and its active fractions mitigate alcoholic liver disease in mice through repairing intestinal epithelial injury and regulating gut microbiota.

Background: Liuweizhiji Gegen-Sangshen oral liquid (LGS), as a Chinese medicinal preparation, is developed from a Traditional Chinese medicinal formula consisting of six Chinese medicinal herbs, including Puerariae lobatae radix, Hoveniae semen, Imperatae rhizoma, Crataegi fructus, Mori fructus and Canarli fructus, and has been extensively utilized in the prevention and treatment of alcoholic liver disease (ALD) clinically. Previous study has demonstrated that LGS dose-dependently mitigated ALD in rat models. However, whether and how the main characteristic constituents of LGS (the flavonoid and polysaccharide fractions, LGSF and LGSP) contribute to the anti-ALD effect remains unclear.

Fabrication and Encapsulation of Soy Peptide Nanoparticles Using Ultrasound Followed by Spray Drying.

Peptide aggregation inevitably occurs during hydrolysis, and insoluble peptide aggregates (ISPA) are used as feed for animals due to their poor water solubility and unpleasant bitter flavor. Ultrasound was used to fabricate soy peptide nanoparticles by reassembling ISPA, followed by spray-drying encapsulation to develop low-bitterness peptide microcapsules with soluble soybean polysaccharide (SSPS) and stevioside (STE) as wall materials. Powder properties, bitter taste, and the morphology of the microcapsules were evaluated.

Facile synthesis of defective ZnS-ZnO composite nanosheets for efficient piezocatalytic H production.

A facile approach was developed for the synthesis of ultrathin ZnS-ZnO nanosheets. By simply manipulating the synthesis temperature, ZnS-ZnO composite nanosheets with sulfur vacancies were successfully obtained using ZnS(en) as the precursor. The formation of the ZnS-ZnO composite leads to the creation of a heterojunction at the interface between the two materials, which enhances the separation of piezogenerated electrons and holes.

MARK1 suppress malignant progression of hepatocellular carcinoma and improves sorafenib resistance through negatively regulating POTEE.

Purpose: This study aimed to investigate the role of microtubule-affinity regulatory protein kinase 1 (MARK1) in hepatocellular carcinoma (HCC) progression, its association with sorafenib sensitivity, and the interplay between MARK1 and POTE Ankyrin domain family member E(POTEE) in HCC cells.

Methods: Quantitative real-time polymerase chain reaction analysis was used to assess MARK1 and POTEE expression in 60 pairs of HCC tissues and cell lines. The correlation between MARK1 levels, clinicopathological features, and patient prognosis was analyzed.

A Low Prognostic Nutritional Index Level, an Independent Predictor for Postoperative Intra-abdominal Abscess After Laparoscopic Appendectomy.

Background: Intra-abdominal abscess (IAA) is a very common postoperative complication after laparoscopic appendectomy and is associated with poor prognosis.

Materials And Methods: This study retrospectively analyzed elderly patients who underwent laparoscopic appendectomy from 2015 to 2024, examining demographic, clinical, and laboratory data to identify IAA risk factors. Independent risk factors for IAA were screened and finally identified by multivariate logistic regression analysis.

Quantum criticality of generalized Aubry-André models with exact mobility edges using fidelity susceptibility.

In this study, we explore the quantum critical phenomena in generalized Aubry-André models, with a particular focus on the scaling behavior at various filling states. Our approach involves using quantum fidelity susceptibility to precisely identify the mobility edges in these systems. Through a finite-size scaling analysis of the fidelity susceptibility, we are able to determine both the correlation-length critical exponent and the dynamical critical exponent at the critical point of the generalized Aubry-André model.

Natural Fat Nanoemulsions for Enhanced Optical Coherence Tomography Neuroimaging and Tumor Imaging in the Second Near-Infrared Window.

Optical coherence tomography (OCT) imaging mainly uses backscattered light to visualize the structural and functional information on biological tissues. In particular, OCT angiography can not only map the capillary networks but also capture the blood flow in the tissue microenvironment, making it a good candidate for neuroimaging and tumor imaging and in real time. To further improve the detection accuracy of cancer or brain disorders, it is essential to develop a natural and nontoxic contrast agent for enhanced OCT imaging in the second near-infrared (NIR-II) window.

Downregulation of PDIA3 inhibits gastric cancer cell growth through cell cycle regulation.

Objective: Protein disulfide isomerase A3 (PDIA3) promotes the correct folding of newly synthesized glycoproteins in the endoplasmic reticulum. PDIA3 is overexpressed in most tumors, and it may become a biomarker of cancer prognosis and immunotherapy. Our study aims to detect the expression level of PDIA3 in gastric cancer (GC) and its association with GC development as wells as the underlying mechanisms.