Prognostic predictive value of the preoperative systemic immunoinflammatory index combined with the neutrophil-to-lymphocyte ratio in patients with primary liver cancer undergoing transarterial chemoembolization.

Primary liver cancer (PLC) is a common type of malignant tumor, characterized by high morbidity and mortality worldwide, a poor prognosis, and a lack of reliable and effective prognostic predictors. The systemic immunoinflammatory index (SII) and the neutrophil-to-lymphocyte ratio (NLR) are key indicators of immunoinflammation in the body, and their combined clinical utility has not been fully explored in patients with PLC undergoing transarterial chemoembolization. In the present study, the association between the preoperative SII combined with the NLR and the prognosis of patients with PLC undergoing percutaneous hepatic artery chemoembolization was investigated.

Numerical and Experimental Investigation of Orientation Deviation in Shear Band in Grain-Oriented Silicon Steel.

As a critical factor for the magnetic properties of grain-oriented silicon steel, the orientation accuracy of shear bands is closely related to the matrix orientation deviation from {111}<112>. This work investigates the orientation rotation of shear bands in {111}<112> matrices with various types of deviation during cold rolling, using a visco-plastic self-consistent model that incorporates a two-dimensional inclined angle of the shear band dependent on matrix orientation. When the matrix orientation deviates from {111}<112> along φ, φ, or both axes, the φ deviation of the shear band decreases, and the φ deviation is larger than φ.

Red blood cell membrane-derived phototherapeutic nanodiscs: A new platform for enhanced phototherapy.

Phototherapy holds great potential for treating cancer and infections but faces limitations related to photosensitizer accumulation, tissue penetration, and diminished photo-conversion efficiency, particularly in deep-seated tumors and infections. Here, a biomimetic phototherapeutic nanodisc platform consisting of erythrocyte membranes and the photosensitizer IR780 is developed. With the advantages of the ultra-small size and exceptional biosafety of cell membrane-derived nanodiscs, this platform facilitates efficient accumulation and deep tissue penetration at disease sites.

Screening and identification Hub genes associated with immune cell infiltration and critical biomarkers in osteosarcoma.

Purpose: Osteosarcoma (OS) exhibits limited immune cell infiltration that directly contributes to poor prognosis. This study sought to screen and identify pivotal biomarkers of OS immune infiltration and early diagnosis of OS.

Methods: The immune cell infiltration profiles with transcriptome sequencing data from 88 OS samples were explored with CIBERSORT algorithm.

Tumour-infiltrating immune cells as a novel prognostic model for bladder cancer.

Bladder cancer (BLCA) is the tenth most commonly diagnosed cancer and poses a significant challenge due to its complexity and associated high morbidity and mortality rates in the absence of optimal treatment. The tumor microenvironment (TME) is recognized as a critical factor in tumor initiation, progression and therapeutic response, and offers numerous potential targets for intervention. A comprehensive understanding of immune infiltration patterns in BLCA is essential for the development of effective prevention and treatment strategies.

Improved siamese tracking for temporal data association.

Temporal image data association is essential for visual object tracking tasks. This association task is typically stated as a process of connecting signals from the same object at different times along the time axis. Temporal data association is usually performed before state estimation.

Large-sized aerobic granular biofilm: stable biotechnology to improve nitrogen removal and reduce sludge yield.

Three parallel sequencing batch reactors (control, small-sized polyurethane sponge (PUS) (3.0 mm), and large-sized PUS (10.0 mm)) were used to investigate aerobic granular biofilm (AGB) characteristics.

Progress of Grain Polyphenols: Biological Activities, Enrichment Methods, and Applications.

Polyphenols are secondary metabolites derived from plant metabolism and possess diverse bioactivities and health-promoting functions. They are extensively utilized in the food, pharmaceutical and cosmetic industries, and more. Recently, with the increasing focus on healthy diets, grain polyphenols have been the subject of extensive research.

Machine learning based predictive model and genetic mutation landscape for high-grade colorectal neuroendocrine carcinoma: a SEER database analysis with external validation.

Background: High-grade colorectal neuroendocrine carcinoma (HCNEC) is a rare but aggressive subset of neuroendocrine tumors. This study was designed to construct a risk model based on comprehensive clinical and mutational genomics data to facilitate clinical decision making.

Methods: A retrospective analysis was conducted using data from the Surveillance, Epidemiology, and End Results (SEER) database, spanning 2000 to 2019.

Invasive aspergillosis in critically ill patients with diabetes mellitus: a systematic review and meta-analysis.

Background: In the intensive care unit (ICU), invasive aspergillosis (IA) has a poor prognosis. Some studies report a positive association between diabetes mellitus (DM) and IA in critically ill patients, but the relationship between DM and IA in the ICU remains controversial. We aimed to clarify the relationship between DM and IA among patients in the ICU in a systematic review and meta-analysis.

Procyanidin-crosslinked gradient silk fibroin composite nanofiber scaffold with sandwich structure for rotator cuff repair.

Improving the regeneration of the tendon-bone interface (TBI) helps to decrease the risk of rotator cuff retears after repair surgeries. Unfortunately, the lack of inherent healing capacity of the TBI, insufficient mechanical properties, and abnormal and persistent inflammation during repair are the key factors leading to suboptimal healing of the rotator cuff. Therefore, a high-strength rotator cuff repair material capable of regulating the unbalanced immune response and enhancing the regeneration of the TBI is urgently needed.

Structurally Compact Penta(N,N-diphenylamino)corannulene as Dopant-free Hole Transport Materials for Stable and Efficient Perovskite Solar Cells.

Hole transport materials (HTMs) are essential for improving the stability and efficiency of perovskite solar cells (PSCs). In this study, we have designed and synthesized a novel organic small molecule HTM, cor-(DPA), characterized by a bowl-shaped core with symmetric five diphenylamine groups. Compared to already-known HTMs, the bowl-shaped and relatively compact structure of cor-(DPA) facilitates intermolecular π-π interactions, promotes film formations, and enhances charge transport.

The Neuroprotective and Anxiolytic Effects of Magnesium Sulfate on Retinal Dopaminergic Neurons in 6-OHDA-Induced Parkinsonian Rats: A Pilot Study.

This study investigates the protective effects of magnesium sulfate on dopamine neurons in the retinas of rats with 6-hydroxydopamine (6-OHDA)-induced Parkinson's disease (PD). Rapidly progressing cognitive decline often precedes or coincides with the motor symptoms associated with PD. PD patients also frequently exhibit visual function abnormalities.

Secular trends in the prevalence of schizophrenia among different age, period and cohort groups between 1990 and 2019.

Background: Schizophrenia remains a major public health challenge, and designing efforts to manage it requires understanding its prevalence over time at different geographic scales and population groups.

Methods: Drawing on data from the Global Burden of Disease study 2019, annual percentage change of schizophrenia was assessed across different age, period and cohort groups at different geographic scales from 1990 to 2019. We examined associations of prevalence with the sociodemographic index.

Engineering VO structure by integrating oxygen vacancies for improved zinc-ion storage based on cation-doping regulation with electric density.

Aqueous zinc-ion batteries (ZIBs) have attracted enormous attention for future energy-storage devices owing to their high theoretical capacity and environmental friendliness. However, obtaining cathodes with a high specific capacity and fast reaction kinetics remains a huge challenge. Herein, Cu-VO material with a thin sheet microsphere structure composed of nanoparticles was prepared by a simple hydrothermal reaction, which improved reaction kinetics and specific capacity.

Combined pesticides in field doses weaken honey bee (Apis cerana F.) flight ability and analyses of transcriptomics and metabolomics.

Imidacloprid, chlorpyrifos, and glyphosate rank among the most extensively employed pesticides worldwide. The effects of these pesticides and their combined on the flight capability of Apis cerana, and the potential underlying mechanisms remain uncertain. To investigate these effects, we carried out flight mill, transcriptome, and metabolome experiments.

Dynamic Survival Risk Prognostic Model and Genomic Landscape for Atypical Teratoid/Rhabdoid Tumors: A Population-Based, Real-World Study.

Background: An atypical teratoid/rhabdoid tumor (AT/RT) is an uncommon and aggressive pediatric central nervous system neoplasm. However, a universal clinical consensus or reliable prognostic evaluation system for this malignancy is lacking. Our study aimed to develop a risk model based on comprehensive clinical data to assist in clinical decision-making.

Impact of chronic exposure to field level glyphosate on the food consumption, survival, gene expression, gut microbiota, and metabolomic profiles of honeybees.

Glyphosate (GLY) is among the most widely used pesticides in the world. However, there are a lot of unknowns about chronic exposure to GLY's effects on Honeybee (HB) behavior and physiology. To address this, we carried out five experiments to study the impact of chronic exposure to 5 mg/kg GLY on sugar consumption, survival, gene expression, gut microbiota, and metabolites of HB workers.

The Understanding and Compact Modeling of Reliability in Modern Metal-Oxide-Semiconductor Field-Effect Transistors: From Single-Mode to Mixed-Mode Mechanisms.

With the technological scaling of metal-oxide-semiconductor field-effect transistors (MOSFETs) and the scarcity of circuit design margins, the characteristics of device reliability have garnered widespread attention. Traditional single-mode reliability mechanisms and modeling are less sufficient to meet the demands of resilient circuit designs. Mixed-mode reliability mechanisms and modeling have become a focal point of future designs for reliability.

Prognostic impact of lung ultrasound detected B-lines on hospitalised ischaemic heart failure with mildly reduced ejection fraction patients.

Objectives: Prognostic impact of lung ultrasound-derived B-lines (LUS-BL) in heart failure with mildly reduced left ventricular ejection fraction (HFmrEF) patients remains elusive. We evaluated the correlation between LUS-BL and prognosis in HFmrEF patients.

Methods: This is a subgroup analysis based on our previously published retrospective study with 1691 HFmrEF patients.

Electrospun compliant heparinized elastic vascular graft for improving the patency after implantation.

The low patency rate after artificial blood vessel replacement is mainly due to the ineffective use of anticoagulant factors and the mismatch of mechanical compliance after transplantation. Electrospun nanofibers with biomimetic extracellular matrix three-dimensional structure and tunable mechanical strength are excellent carriers for heparin. In this work, we have designed and synthesized a series of biodegradable poly(ester-ether-urethane)ureas (BEPU), following compound with optimized constant concentration of heparin by homogeneous emulsion blending, then spun into the hybrid BEPU/heparin nanofibers tubular graft for replacing rats' abdominal aorta in situ for comprehensive performance evaluation.

Impact of signs and symptoms on the prognosis of patients with HFmrEF.

Background: Worsening of heart failure (HF) symptoms is the leading cause of medical contact and hospitalization of patients with mildly reduced ejection fraction (HFmrEF). The prognostic value of signs and symptoms for patients with HFmrEF is currently unclear. This study investigated the prognostic impact of signs and symptoms in HFmrEF patients.