Impacts of Various Straw Mulching Strategies on Soil Water, Nutrients, Thermal Regimes, and Yield in Wheat-Soybean Rotation Systems.

Straw mulching is an important strategy for regulating soil moisture, nutrient availability, and thermal conditions in agricultural systems. However, the mechanisms by which the mulching period, thickness, and planting density interact to influence yield formation in wheat-soybean rotation systems remain insufficiently understood. In this study, we systematically examined the combined effects of straw mulching at the seedling and jointing stages of winter wheat, as well as varying mulching thicknesses and soybean planting densities, on soil properties and crop yields through field experiments.

Tumour-infiltrating immune cells as a novel prognostic model for bladder cancer.

Bladder cancer (BLCA) is the tenth most commonly diagnosed cancer and poses a significant challenge due to its complexity and associated high morbidity and mortality rates in the absence of optimal treatment. The tumor microenvironment (TME) is recognized as a critical factor in tumor initiation, progression and therapeutic response, and offers numerous potential targets for intervention. A comprehensive understanding of immune infiltration patterns in BLCA is essential for the development of effective prevention and treatment strategies.

SOX2 control activation of dormant prostate cancer cells in bone metastases by promoting CCNE2 gene expression.

Background: Cancer stem cells (CSCs) have a powerful tumor initiation ability, which can promote the early dissemination of single disseminated tumor cells (DTCs), leading to tumor progression. SOX2, a pluripotent inducible transcription factor, is key to maintaining self-renewal and pluripotency of prostate cancer stem cells. However, there is a lack of comprehensive understanding of how SOX2 regulates DTCs dormancy and proliferation in the bone marrow microenvironment.

Role of extracellular vesicles in castration-resistant prostate cancer.

Prostate cancer (PCa) is a common health threat to men worldwide, and castration-resistant PCa (CRPC) is the leading cause of PCa-related deaths. Extracellular vesicles (EVs) are lipid bilayer compartments secreted by living cells that are important mediators of intercellular communication. EVs regulate the biological processes of recipient cells by transmitting heterogeneous cargoes, contributing to CRPC occurrence, progression, and drug resistance.

Alterations of the preoperative coagulation profile in patients with acute appendicitis.

Background: Acute appendicitis (AA) is usually associated with a systemic inflammatory response that often leads to activation of coagulation. However, limited data about coagulation changes in AA are available.

Methods: Results of preoperative coagulation testing in 702 patients with confirmed AA and 697 patients undergoing minor elective surgery (control) during the same period were analyzed retrospectively.

Age-associated developmental changes in the activated partial thromboplastin time (APTT) and causes of prolonged APTT values in healthy Chinese children.

Background: The concept of developmental hemostasis has been universally accepted. Physiological reference ranges for coagulation tests are available for infants and children of different ages. However, on Oriental children they are rare.