Serum trimethylamine N-oxide and long-term mortality risk in rural Northern China: A family-based cohort study.

The current study aims to assess associations between trimethylamine N-oxide (TMAO) levels and mortality, and to investigate modification effects of genetics. A total of 500 participants from a family-based cohort study were enrolled from 2005 to 2017 and followed up until 2020 in Fangshan District, Beijing, China. Serum TMAO levels were measured using the enzyme-linked immunosorbent assay (ELISA) kit.

Impact of comprehensive tobacco control policies on stroke and acute myocardial infarction among patients with hypertension and type 2 diabetes in Beijing, China: An interrupted time-series analysis.

Background And Aims: Tobacco control policies enhance cardiovascular health at the population level, but their effects on high-risk individuals, such as those with type 2 diabetes mellitus (T2DM) or hypertension, remain unclear. This study evaluated the association between a tobacco control policy and hospital admissions for stroke and acute myocardial infarction (AMI) in hypertensive and T2DM individuals.

Design: Interrupted time series study.

Isolation, culture, and in vitro functional validation of intratumor bacteria from lung cancer patients.

Objective: Culturomics and 16 S rDNA sequencing were applied to identify lung tumor-resident microorganisms. In vitro characterization revealed potential functions of these cancer-associated microorganisms.

Methods: Eighteen clinical lung cancer (LC) tissues samples were collected.

Metabolic interplay between endometrial cancer and tumor-associated macrophages: lactate-induced M2 polarization enhances tumor progression.

Tumor-associated macrophages (TAMs), abundant within the tumor microenvironment, are key mediators of immunosuppression and represent promising therapeutic targets. Metabolic crosstalk between tumor cells and TAMs is a critical regulator of immune phenotype switching. However, the interactions between endometrial cancer (EC) cells and TAMs remain incompletely understood.

Transparent artificial intelligence-enabled interpretable and interactive sleep apnea assessment across flexible monitoring scenarios.

Early detection of widespread undiagnosed sleep apnea is crucial for preventing its severe health complications. However, large-scale diagnosis faces inaccessible monitoring and trust barriers in automated analysis, particularly due to the absence of transparent artificial intelligence frameworks capable of monitoring adaptation. Here, we develop Apnea Interact Xplainer, a transparent system enabling sleep apnea diagnosis through flexible channel analysis across clinical and home settings.

DDX3X Aggravates Neuronal Pyroptosis and Inhibits Autophagy via NLRP3 Inflammasome After Experimental Subarachnoid Hemorrhage.

Neuronal cell death is considered the symbol of early brain injury after subarachnoid hemorrhage (SAH), but the mechanism was still unclear. DDX3X, a member of the DEAD-box helicase family, has a major effect on immune inflammation by mediating RNA metabolism. Recent studies report that DDX3X regulates the balance of NLRP3 inflammasome and stress granules in stress conditions, but the role of DDX3X in SAH is still unknown.

Mechanotransductive Activation of PPAR-γ by Low-Intensity Pulsed Ultrasound Induces Contractile Phenotype in Corpus Spongiosum Smooth Muscle Cells.

Previously, we found that the pathological changes in the corpus spongiosum (CS) in hypospadias were mainly localized within smooth muscle tissue, presenting as a transformation from the contraction phenotype to synthesis. The role of low-intensity pulsed ultrasound (LIPUS) in regulating smooth muscle cells (SMCs) and angiogenesis has been confirmed. To demonstrate the feasibility of regulating the phenotypic transformation of corpus spongiosum smooth muscle cells (CSSMCs) in hypospadias using LIPUS and to explore the potential mechanisms.

Antihypertensive medications and cancer risk: Evidence from 0.27 million patients with newly diagnosed hypertension.

Background: Whether specific antihypertensive treatments increase cancer risk in patients with hypertension is still controversial. We aimed to estimate the associations of different antihypertensive treatments with cancer risk in real-world settings.

Methods: A longitudinal cohort study was designed in a population of 1.

TLR3-overexpressing umbilical cord mesenchymal stromal cells suppress immune responses to attenuate high-risk corneal transplantation rejection.

Background: The success rates of high-risk corneal transplantation are significantly hindered by immunological rejection. Umbilical cord mesenchymal stem cells (UC-MSCs) have emerged as a potential solution to improve graft outcomes. Toll-like receptors (TLRs) play pivotal roles in the immune response, however, their specific functions in UC-MSC-based treatments for corneal graft rejection requires further investigation.

Prediagnosis Insights Into Amyotrophic Lateral Sclerosis: Clinical Symptoms and Medication Use.

Background: Amyotrophic lateral sclerosis (ALS) has a prolonged latency period, though its preclinical characteristics remain poorly understood. This study uses UK Biobank data to explore and compare ALS's pre-diagnostic features, including symptoms and medication use, aiming to provide insights into the disease's underlying mechanisms.

Methods: Clinical symptoms and medications were identified from self-reports, hospital records, and death registry data.

Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung adenocarcinoma.

The role of the lung microbiota in cancer remains unclear. Here, we reveal that Staphylococcus is selectively enriched in metastatic tumor lesions and is associated with tumor recurrence in lung cancer patients. Using patient-derived bacterial strains, we employ a combination of cell line, organoid, mouse allograft, and xenograft models to demonstrate that S.

What role does salt play in depression and anxiety? A prospective cohort study.

Background: Despite the numerous studies highlighting the detrimental health effects of excessive salt intake, research remains scarce in the field of mental health.

Objective: This study aims to explore the relationship between the frequency of salt added to food and the risk of incident anxiety and depression.

Methods: The prospective cohort study comprised 276,138 individuals from the UK Biobank who were initially free from anxiety and depression.

Discovering novel type I collagen fragments from Cyprinus carpio supporting bone regeneration.

Fish collagen is gaining increasing attention in tissue engineering due to its exceptional bioactivity. This study aimed to isolate functional fish collagen fragments capable of microbial biosynthesis and supporting bone tissue regeneration. Collagen fragments of 150 amino acids were extracted from Cyprinus carpio collagen I (CcCOL1), and their bioactivity, net charge, and hydrophobicity were calculated and analyzed for correlations, these physicochemical and sequential features were using to train the machine learning model, which classified the fragments into three subgroups.

Benchmark Calculations of Vertical Excitation Energies for Medium-Sized Molecules Using Unitary Coupled-Cluster-Based Polarization Propagator Theory.

The unitary coupled-cluster (UCC)-based polarization propagator theory (PPT) is a novel Hermitian quantum chemical method for calculating excited states. This study benchmarks vertical excitation energies (VEEs) for medium-sized molecules using two practical schemes for UCC-PPT: UCC3 and quadratic UCCSD (qUCCSD). Their performance is evaluated and compared with the equation-of-motion coupled-cluster singles and doubles (EOM-CCSD) method and the algebraic construction (ADC) family of methods (ADC(2) and ADC(3)).

AttenCRF-U: Joint Detection of Sleep-Disordered Breathing and Leg Movements in OSA Patients.

Obstructive sleep apnea (OSA) is characterized by frequent episodes of sleep-disordered breathing (SDB), which are often accompanied by leg movement (LM) events, especially periodic limb movements during sleep (PLMS). Traditional single-event detection methods often overlook the dynamic interactions between SDB and LM, failing to capture their temporal overlap and differences in duration. To address this, we propose Attention-enhanced CRF with U-Net (AttenCRF-U), a novel joint detection framework that integrates multi-head self-attention (MHSA) within an encoder-decoder architecture to model long-range dependencies between overlapping events and employs multi-scale convolutional encoding to extract discriminative features across different temporal scales.

Analysis of retinal markers and incident amyotrophic lateral sclerosis: An optical coherence tomography-based cohort study.

Background: Biomarkers are widely recognized as crucial breakthroughs in tackling amyotrophic lateral sclerosis (ALS). Among them, retina markers may hold promise due to the close retina-brain connection and non-invasive, portable detection methods. Thus, using optical coherence tomography (OCT), we investigated the link between baseline cell-level retinal features and future ALS risk.

Injectable ion-coordinated double-network conductive hydrogel for spinal cord injury repair.

The mammalian central nervous system (CNS) demonstrates a severely limited capacity for spontaneous neural regeneration after traumatic spinal cord injury (SCI). Structural repair is also highly constrained due to the inhibitory microenvironment. This inherent limitation persists throughout the recovery phase and often leads to severe motor and sensory dysfunction, profoundly impairing patients' quality of life.

Enhancing Osteogenesis Differentiation and In Vitro Degradation in Polymer Scaffolds with Spike-like Strontium Carbonate Microrods.

Poly-(L-lactic-acid) (PLLA) has shown significant promise in the fields of orthopedics and dentistry. However, its lack of inherent osteogenic activity limits its potential for further application in bone repair and fixation. In this study, we synthesized strontium carbonate (SrCO) nanoparticles and incorporated them into PLLA to prepare bioactive composite scaffolds using selective laser sintering technology.

Corrigendum to "Monocyte-to-lymphocyte ratio affects prognosis in LAA-type stroke patients" [Heliyon Volume 8, Issue 10, October 2022, Article e10948].

[This corrects the article DOI: 10.1016/j.heliyon.

Fucoxanthin alleviates renal aging by regulating the oxidative stress process and the inflammatory response and models.

Objectives: Many countries in the world are entering society with an aging population. The kidney is one of the most sensitive organs in the body to aging. Kidney function gradually declines with aging.

Satellites reveal hot spots of ocean changes in the early 21st century.

Ocean change leaves a potentially important imprint on ocean colorimetry. Here, we present an overview and current evaluation of the global ocean color variability from 1998 to 2022, and satellites observe that 36% of oceans (~122 million square kilometers, derived from valid observations) have experienced changes ( < 0.1).

Engineering Microbial Consortium Biohybrid System to Efficiently Produce Electricity from Lignocellulose Biomass.

Converting lignocellulose into bioelectricity through a bioelectrocatalytic system (BES) has emerged as a promising approach to addressing environmental pollution and energy regeneration challenges. However, practical application of BES is significantly constrained by the fact that the electroactive biocatalyst lacks the essential metabolic pathways and enzymes required for utilizing lignocellulose for cell growth and power generation. Here, to realize clean electricity production from lignocellulose hydrolysate, an artificial microbial consortium comprising , , and was developed.

Nano-priming with selenium nanoparticles reprograms seed germination, antioxidant defense, and phenylpropanoid metabolism to enhance Fusarium graminearum resistance in maize seedlings.

Introduction: Fusarium graminearum (F. graminearum) threatens maize through stem rot and deoxynivalenol (DON) contamination. Conventional approaches like chemical seed coatings are constrained by limited long-term efficacy and environmental concerns such as soil residue accumulation.

Pro-inflammatory diet and the risk of depression and anxiety: A prospective study based on the dietary inflammatory index.

Background: Foods contain pro-inflammatory and anti-inflammatory components that may influence mood. This study aims to investigate the association between dietary inflammation, assessed by the Dietary Inflammatory Index (DII), and anxiety and depression.

Methods: DII was calculated from 29 food items in a 24-h diet recall questionnaire from the UK Biobank.

Visible-light-driven N-doped TiO/BiOI heterojunction with synergistic dual-active-sites for ofloxacin degradation: Combined theoretical and experimental insights.

Due to the increasing levels of ofloxacin (OFL) in environmental waters, the urgent need for ofloxacin removal has also received more attention. In this study, an N-doped N-TiO/BiOI visible light catalyst was prepared to remove residual ofloxacin from water by its photocatalytic properties. According to the characterization and experimental results, the doping of non-metallic nitrogen elements improved the photocatalytic performance of the catalyst.