Serum trimethylamine N-oxide and long-term mortality risk in rural Northern China: A family-based cohort study.

The current study aims to assess associations between trimethylamine N-oxide (TMAO) levels and mortality, and to investigate modification effects of genetics. A total of 500 participants from a family-based cohort study were enrolled from 2005 to 2017 and followed up until 2020 in Fangshan District, Beijing, China. Serum TMAO levels were measured using the enzyme-linked immunosorbent assay (ELISA) kit.

Impact of stereochemistry in 3D energetic materials science: a case based on peripheral editing of the 2,4,10-trioxaadamantane backbone.

Stereoisomerism in energetic materials remains an underexplored area of research. Herein, two series of energetic stereoisomers, including four diastereomers of 2,4,10-trioxaadamantane-6,8,9-triyl trinitrate and three diastereomers of 9,9-dinitro-2,4,10-trioxaadamantane-6,8-diyl dinitrate, were synthesized based on the systematic alteration of their stereochemistry. The first cage-like energetic materials were generated that incorporate considerations of configurational isomerism.

Efficacy and safety of first-line treatments for metastatic castration-resistant prostate cancer based on phase II and III randomized controlled trials: A PROSTA-MAP systematic review and network meta-analysis.

Background: The landscape of metastatic castration-resistant prostate cancer (mCRPC) treatment has evolved greatly; however, limited data are available regarding its relative efficacy and safety. We conducted a systematic review and network meta-analysis to analyze and compare the effectiveness and safety of first-line therapies for mCRPC, particularly doublet therapy and monotherapy.

Methods: The PubMed, Embase, and Cochrane Library databases were searched from their inception until June 6, 2023.

Promising Cage-Like Energetic Compounds Based on Dioxaadamantane and Dioxaprotoadamantane Backbones: Facile Synthesis and Energetic Performance.

Heteroadamantanes have a wide range of applications, so the efficient construction of their skeletons is an important issue. Herein, two all-bridged carbon-oxygenated cage-like scaffolds 2,6-dioxaadamantane-4,8,9,10-tetraol and 2,7-dioxaprotoadamantane-4,5,9,10-tetraol were constructed through a transannular -heterocyclization strategy within only two synthetic steps, and six novel energetic materials containing four or five explosophoric groups were synthesized. The densities, oxygen balances (OB), and energetic properties (including detonation velocities and pressures) of all the compounds range from 1.

Sex hormone-binding globulin and sex-specific association between irritable bowel syndrome and type 2 diabetes: a prospective cohort study.

Objective: To investigate the sex-specific association between irritable bowel syndrome (IBS) and type 2 diabetes (T2D), and further explore whether sex-hormone binding globulin (SHBG) was an associated factor of the sex-specific association.

Methods: The study was a prospective analysis based on the UK biobank (UKB) data. We included 359 503 participants, all of whom were without diabetes diagnosis and had complete SHBG information at baseline.

Corrigendum: Efficacy and safety of PD-1/PD-L1 inhibitors as first-line treatment for esophageal squamous cell carcinoma: a systematic review and meta-analysis.

[This corrects the article DOI: 10.3389/fimmu.2025.

Synthesis of a 2,4,6,8-Tetraoxaadamantane-Based 3D Energetic Biocidal Agent via Stepwise Cyclization Strategy.

A cage-like iodine-containing energetic biocidal agent 9,10-bis(nitratomethyl)-9,10-diiodo-2,4,6,8-tetraoxaadamantane was designed and synthesized through a stepwise cyclization strategy via only five steps with a total yield of 13%. It has a high density, perfect oxygen balance, and moderate detonation properties. Its decomposition products exhibit excellent antibacterial properties.

Parental Transmission of Type 2 Diabetes Risk in Offspring: A Prospective Family-Based Cohort Study in Northern China.

While parental type 2 diabetes (T2D) is a known risk factor for offspring T2D, the differential impact of maternal versus paternal transmission remains debated. This prospective family-based cohort study enrolled 4508 diabetes-free adults from Northern China with a median 7.32-year follow-up.

Efficacy and safety of PD-1/PD-L1 inhibitors as first-line treatment for esophageal squamous cell carcinoma: a systematic review and meta-analysis.

Purpose: This study aims to investigate the efficacy and safety of PD-1/PD-L1 inhibitors in the first-line treatment of esophageal squamous cell carcinoma (ESCC) and identify factors influencing efficacy through a meta-analysis of multiple phase 3 randomized controlled trials (RCTs).

Methods: A systematic literature search was conducted in Cochrane, PubMed, and Embase databases. Two researchers independently extracted trial data, including efficacy-related outcomes such as overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and duration of response (DoR), along with their subgroup data and safety-related indicators.

[Gene-gene/gene-environment interaction of transforming growth factor-β signaling pathway and the risk of non-syndromic oral clefts].

Objective: To explore the association between polymorphisms of transforming growth factor-β (TGF-β) signaling pathway and non-syndromic cleft lip with or without cleft palate (NSCL/P) among Asian populations, while considering gene-gene interaction and gene-environment interaction.

Methods: A total of 1 038 Asian NSCL/P case-parent trios were ascertained from an international consortium, which conducted a genome-wide association study using a case-parent trio design to investigate the genes affec-ting risk to NSCL/P. After stringent quality control measures, 343 single nucleotide polymorphism (SNP) spanning across 10 pivotal genes in the TGF-β signaling pathway were selected from the original genome-wide association study(GWAS) dataset for further analysis.

[A ssociations of short-term ambient particulate matter exposure and gene with triglyceride-glucose index: A family-based study].

Objective: To explore the effects of short-term particulate matter (PM) exposure and the melatonin receptor 1B () gene on triglyceride-glucose (TyG) index utilizing data from Fang-shan Family-based Ischemic Stroke Study in China (FISSIC).

Methods: Probands and their relatives from 9 rural areas in Fangshan District, Beijing, were included in the study. PM data were obtained from fixed monitoring stations of the National Air Pollution Monitoring System.

Efficacy and Safety of Supplementation in Infants: A Meta-Analysis of Randomized Controlled Trials.

Background: Strategies to stabilize and support overall infant health by increasing the number of in the infant gut are of interest, but few studies have systematically addressed this issue. We aimed to evaluate the efficacy and safety of use in infants using meta-analysis.

Methods: We searched PubMed, EMBASE, Cochrane Library of Systematic Reviews, and SinoMed for publications until 27 July 2022.

Short-Term Exposure to Nitrogen Dioxide Modifies Genetic Predisposition in Blood Lipid and Fasting Plasma Glucose: A Pedigree-Based Study.

(1) Background: Previous studies suggest that exposure to nitrogen dioxide (NO) has a negative impact on health. But few studies have explored the association between NO and blood lipids or fasting plasma glucose (FPG), as well as gene-air pollution interactions. This study aims to fill this knowledge gap based on a pedigree cohort in southern China.

Unprecedented hetero-coordinated Ir(C^N)tmd complexes containing both five- and six-membered Ir-(C^N) rings based on phenanthrylpyridine ligands: syntheses, crystal structures and photophysical properties.

By using 2-(9-phenanthryl)pyridine (phpyr) and its derivatives as cyclometalated ligands, we synthesized a set of isomeric red-emitting complexes Ir(phpyr-R)tmd (R = -H, -CF, -F and -CH, tmd = 2,2,6,6-tetramethylheptane-3,5-dione) with different coordinated modes, including bis-five-membered and five- + six-membered Ir-(C^N) ring chelating modes. The latter are the first examples of hetero-coordinated Ir(C^N)(L^X)-type complexes containing both five- and six-membered Ir-(C^N) metallocycles. Their coordination geometries were distinctly determined using X-ray crystallographic analysis.

The study of a novel high selectivity pyrenyl-based fluorescence probe with aggregation-induced emission characteristics for Fe detection designed by a structure modulation strategy.

The past decades have witnessed the feat of fluorescent probes for Fe detection, where eliminating the interference by other metal ions plays a pivotal role in its detection by probes in complex environments. Herein, by taking advantage of the substituent effects, the electron-withdrawing group (EWG) -CF and electron-donating group (EDG) -CH were introduced to 2-(1-pyrenyl)pyridine (pypyr) to prepare two turn-off fluorescence probes, 5-trifluoromethyl-2-(1-pyrenyl)pyridine (pypyr-CF3) and 5-methyl-2-(1-pyrenyl)pyridine (pypyr-CH3). Intriguingly, both probes displayed novel aggregation-induced emission (AIE) characteristics in MeCN/HO mixtures and the size and morphology of the aggregated particles were studied DLS and TEM.

Cobalt Metal-Organic Frameworks with Aggregation-Induced Emission Characteristics for Fluorometric/Colorimetric Dual Channel Detection of Nitrogen-Rich Heterocyclic Compounds.

Nitrogen-rich heterocyclic compounds (NRHCs) are an emerging type of explosive, and their quantification is important in national security inspection and environmental monitoring. Up until now, designing an efficient NRHCs sensing strategy was still in the early stages. Herein, a new metal-organic framework (MOF) with aggregation-induced emission (AIE) characteristics is synthesized with fluorometric/colorimetric responses for rapid and selective detection of NRHCs.

Three novel topologically different metal-organic frameworks built from 3-nitro-4-(pyridin-4-yl)benzoic acid.

The design and synthesis of metal-organic frameworks (MOFs) have attracted much interest due to the intriguing diversity of their architectures and topologies. However, building MOFs with different topological structures from the same ligand is still a challenge. Using 3-nitro-4-(pyridin-4-yl)benzoic acid (HL) as a new ligand, three novel MOFs, namely poly[[(N,N-dimethylformamide-κO)bis[μ-3-nitro-4-(pyridin-4-yl)benzoato-κO,O':N]cadmium(II)] N,N-dimethylformamide monosolvate methanol monosolvate], {[Cd(CHNO)(CHNO)]·CHNO·CHOH}, (1), poly[[(μ-acetato-κO:O')[μ-3-nitro-4-(pyridin-4-yl)benzoato-κO:O':N]bis[μ-3-nitro-4-(pyridin-4-yl)benzoato-κO,O':O':N]dicadmium(II)] N,N-dimethylacetamide disolvate monohydrate], {[Cd(CHNO)(CHCO)]·2CHNO·HO}, (2), and catena-poly[[[diaquanickel(II)]-bis[μ-3-nitro-4-(pyridin-4-yl)benzoato-κO:N]] N,N-dimethylacetamide disolvate], {[Ni(CHNO)(HO)]·2CHNO}, (3), have been prepared.

2,4,4,6,8,8-Hexanitro-2,6-diazaadamantane: A High-Energy Density Compound with High Stability.

A novel high-performance energetic compound of the polynitroazaadamantane family, 2,4,4,6,8,8-hexanitro-2,6-diazaadamantane, was designed and synthesized from 1,5-cyclooctadiene by two routes. Based on the experimental and calculated results, it exhibits a surprisingly high density (1.959 g cm), high thermal stability (onset decomposition temperature of 235 °C), high positive heat of formation, and excellent detonation properties.