Protonation induced symmetry-breaking and fluorescence switching in C3-symmetric self-assemblies with application in optical information encryption.

Achieving simultaneous symmetry breaking and fluorescence switching in self-assembled systems through external stimuli remains challenging. In this work, we designed two achiral C3-symmetric molecules (BTCNPh and BTCNPy) containing three cyanostilbene units connected through amide bonds, terminated with phenyl or pyridyl groups respectively. Both molecules exhibited cyan fluorescence in DMSO/HO mixtures without circular dichroism (CD) signals.

Developmental expression of α- and β- synuclein in the mouse retina.

The synuclein family comprises three presynaptic proteins-alpha-synuclein (α-Syn), beta-synuclein (β-Syn), and gamma-synuclein (γ-Syn)-which are crucial for synaptic transmission. Our previous studies have detailed the precise cellular and subcellular localization of α- and β-Syn in the adult mouse retina, revealing distinct expression patterns in excitatory and inhibitory synaptic elements. The balance between excitatory and inhibitory neurotransmitters in the inner plexiform layer (IPL) is critical for neural development in the mouse retina.

Gastrointestinal bleeding due to small bowel metastasis from lung adenocarcinoma: A case report.

Background: Lung cancer is the most prevalent malignant tumor in human body, and is characterized by a high level of malignancy. The most common metastatic sites include the liver, bone, brain, and adrenal gland, while lung cancer resulting in gastrointestinal tract metastasis is uncommon.

Case Summary: A 74-years-old man with lung cancer was hospitalized owing to blood in the stool, The cause was identified as metastasis to the small intestine, and the patient subsequently underwent radical resection of the small intestine tumor.

Quantifying Unknown Multiqubit Entanglement Using Machine Learning.

Entanglement plays a pivotal role in numerous quantum applications, and as technology progresses, entanglement systems continue to expand. However, quantifying entanglement is a complex problem, particularly for multipartite quantum states. The currently available entanglement measures suffer from high computational complexity, and for unknown multipartite entangled states, complete information about the quantum state is often necessary, further complicating calculations.

Personalized Vascularized Tumor Organoid-on-a-Chip for Tumor Metastasis and Therapeutic Targeting Assessment.

While tumor organoids have revolutionized cancer research by recapitulating the cellular architecture and behaviors of real tumors in vitro, their lack of functional vasculature hinders their attainment of full physiological capabilities. Current efforts to vascularize organoids are struggling to achieve well-defined vascular networks, mimicking the intricate hierarchy observed in vivo, which restricts the physiological relevance particularly for studying tumor progression and response to therapies targeting the tumor vasculature. An innovative vascularized patient-derived tumor organoids (PDTOs)-on-a-chip with hierarchical, tumor-specific microvasculature is presented, providing a versatile platform to explore tumor-vascular dynamics and antivascular drug efficacy.

Enantiomer-specific effects of metamifop on serum metabolism in rats.

Metamifop (MET) is a widely used pesticides in paddy field and it has good weed control effect. As a chiral pesticide that may be hazardous to human health through food chain transmission, there could be selective differences in the metabolism and toxicity of its enantiomers, so the study of chiral MET may offer an assessment of MET toxicity and stereoselectivity at the enantiomeric level. A total of 39, 43 and 31 differential metabolites were screened from the data sets of Rac-, R-(-)- and S-(+)-MET, respectively.

Context-Based e2e Autonomous Operation in B5G Networks.

The research and innovation related to fifth-generation (5G) networks that has been carried out in recent years has decided on the fundamentals of the smart slice in radio access networks (RANs), as well as the autonomous fixed network operation. One of the most challenging objectives of beyond 5G (B5G) and sixth-generation (6G) networks is the deployment of mechanisms that enable smart end-to-end (e2e) network operation, which is required for the achievement of the stringent service requirements of the envisioned use cases to be supported in the short term. Therefore, smart actions, such as dynamic capacity allocation, flexible functional split, and dynamic slice management need to be performed in tight coordination with the autonomous capacity management of the fixed transport network infrastructure.

The Beneficial Effects of Natural Extracts and Bioactive Compounds on the Gut-Liver Axis: A Promising Intervention for Alcoholic Liver Disease.

Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. It can cause fatty liver (steatosis), steatohepatitis, fibrosis, cirrhosis, and liver cancer. Alcohol consumption can also disturb the composition of gut microbiota, increasing the composition of harmful microbes and decreasing beneficial ones.

Applications of Nondominated Sorting Genetic Algorithm II Combined with WKNN Online Matching Algorithm in Building Indoor Optimization Design.

The present work aims to improve the comfort of architectural interior design and reduce indoor energy consumption. The Weight K-Nearest Neighborhood (WKNN) algorithm and Nondominated Sorting Genetic algorithm are proposed to locate and analyze the spatial location of indoor personnel and optimize the indoor energy consumption in combination with residential behavior. Firstly, the indoor human behavior data and energy-saving problems are analyzed based on residential behavior theory and architectural physics.

Implementation and Optimization of Reverse Suspension Structure Design Model Using Deep Learning.

The present work aims to improve the design efficiency and optimize the results in the increasingly complex and diversified material design projects to help architects realize the better performance of building structures. According to the characteristics of comprehensive perception and intelligent processing of the Internet of Things, a reverse suspension structure design model is constructed based on the finite element method and simulated annealing algorithm. Besides, deep learning is adopted to train complex functions for performance correction and to optimize the plane structure of shell structure.

SARS-CoV-2 RNA elements share human sequence identity and upregulate hyaluronan via NamiRNA-enhancer network.

Background: Since late 2019, SARS-CoV-2 infection has resulted in COVID-19 accompanied by diverse clinical manifestations. However, the underlying mechanism of how SARS-CoV-2 interacts with host and develops multiple symptoms is largely unexplored.

Methods: Bioinformatics analysis determined the sequence similarity between SARS-CoV-2 and human genomes.

analysis of novel dipeptidyl peptidase-IV inhibitory peptides released from antimicrobial protein 2 (MiAMP2) and the possible pathways involved in diabetes protection.

The aim of the present study was to screen novel dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from antimicrobial protein 2 (MiAMP2) and evaluate the potential antidiabetic targets and involved signaling pathways using approaches. digestion of MiAMP2 with pepsin, trypsin and chymotrypsin was performed with ExPASy PeptideCutter and the generated peptides were subjected to BIOPEP-UWM, iDrug, INNOVAGEN and Autodock Vina for further analyses. Six novel peptides EQVR, EQVK, AESE, EEDNK, EECK, and EVEE were predicted to possess good DPP-IV inhibitory potentials, water solubility, and absorption, distribution, metabolism, excretion, and toxicity properties.

ICOS follicular regulatory T cells are implicated in the pathogenesis of ulcerative colitis.

Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) with a rising incidence worldwide. The precise aetiology is unclear, but aberrant regulatory T cell (Treg) responses have been documented in active UC patients. Follicular regulatory T cell (Tfr) is a recently identified subset of Treg cells.

Reactivation of tumour suppressor in breast cancer by enhancer switching through NamiRNA network.

Dysfunction of Tumour Suppressor Genes (TSGs) is a common feature in carcinogenesis. Epigenetic abnormalities including DNA hypermethylation or aberrant histone modifications in promoter regions have been described for interpreting TSG inactivation. However, in many instances, how TSGs are silenced in tumours are largely unknown.

IL-10 enhances T cell survival and is associated with faster relapse in patients with inactive ulcerative colitis.

Ulcerative colitis (UC) is characterized by a relapsing and remitting pattern. The remission phase may last weeks to years. It remains unclear what specific factors can cause the disease to exist the remission phase and enter an activated state.

Circulating follicular regulatory T cells could inhibit Ig production in a CTLA-4-dependent manner but are dysregulated in ulcerative colitis.

Ulcerative colitis (UC) is a chronic relapsing inflammatory disease that occurs in the gastrointestinal tract, characterized by an upregulation in autoantibody production and antimicrobial antibody production. The interaction between follicular helper T cells (Tfh) and follicular regulatory T cells (Tfr) is critical to the induction and regulation of antibody production. In this study, we investigated the characteristics of Tfr cells in UC patients.

Fecal bacteria from ulcerative colitis patients downregulate Tim-3-mediated inhibitory effects on monocytes in vitro.

Tim-3 is highly expressed on monocytes and macrophages. Blocking Tim-3 was shown to promote macrophage activation. We previously showed that fecal bacteria from patients with active ulcerative colitis (UC) presented significantly higher capacity to stimulate monocyte activation, resulting in higher expression of MHC molecules, costimulatory molecules, and proinflammatory cytokines, but the underlying mechanism remained unclear.

FABP7 promotes cell proliferation and survival in colon cancer through MEK/ERK signaling pathway.

Colon cancer (CC), one of the most frequently diagnosed malignancies deriving from the digestive system, has greatly threatened human health and life. Fatty acid binding protein 7 (FABP7), an intracellular protein with the tissue-specific expression pattern, has been reported to be implicated in diverse types of human tumors. However, the biological role of FABP7 in CC is still poorly understood.

Co-expression of LAG3 and TIM3 identifies a potent Treg population that suppresses macrophage functions in colorectal cancer patients.

Regulatory T (Treg) cells are critical suppressors of inflammation and are thought to exert mainly deleterious effects in cancers. In colorectal cancer (CRC), Foxp3 Treg accumulation in tumors was associated with poor prognosis. Hence, we examined the circulating Treg cells in CRC patients.

Calycosin alleviates cerulein-induced acute pancreatitis by inhibiting the inflammatory response and oxidative stress via the p38 MAPK and NF-κB signal pathways in mice.

Acute pancreatitis (AP) is a common acute abdominal disease accompanied by systemic inflammatory response syndrome, and could even be complicated by multiple-organ damage. This study aimed to examine whether calycosin, an isoflavone isolated from Radix astragali with antioxidant and anti-inflammatory activity, could protect against AP induced by cerulein. To this end, Balb/C mice were injected with cerulein (50 μg/kg) to establish the animal model of AP.

Fecal microbiome from patients with ulcerative colitis is potent to induce inflammatory responses.

Ulcerative colitis (UC) is a chronic idiopathic disease affecting the colon. Patients with UC display a number of alterations in immune-related molecules and cells, as well as dysbiosis in the intestinal microbiota. It remains unclear whether the alterations in the patients' immune systems are initiating factors of UC or a result from external insults.

CXCR5CD8 T cells infiltrate the colorectal tumors and nearby lymph nodes, and are associated with enhanced IgG response in B cells.

Colorectal cancer is the third most prevalent cancer type worldwide and contributes to a significant percentage of cancer-related mortality. Recent studies have shown that the CXCR5CD8 T cells present more potent proinflammatory function than CXCR5CD8 T cells in chronic virus infections and in follicular lymphoma, but the role of CXCR5CD8 T cells in colorectal cancer is yet unclear. In this study, we demonstrated that CXCR5CD8 T cells were very rare in peripheral blood mononuclear cells from healthy and colorectal cancer individuals, but were significantly enriched in resected tumors and tumor-associated lymph nodes.

Interleukin 35 Rescues Regulatory B Cell Function, but the Effect Is Dysregulated in Ulcerative Colitis.

Ulcerative colitis (UC) is a long-time inflammatory condition arising from aberrant immune activation in the colon and the rectum. Interleukin (IL)-35 plays critical roles in autoimmune disorders. In this study, we explored the pathways of IL-35 in affecting UC.

Synergistic enhancement of the antitumor activity of 5-fluorouracil by bornyl acetate in SGC-7901 human gastric cancer cells and the determination of the underlying mechanism of action.

Purpose: To investigate the anticancer activity of bornyl acetate and its combination with low dose 5-fluorouracil (5-FU) in human gastric cancer (SGC-7901) cells and to evaluate their effects on cell cycle, apoptosis, cancer cell morphology and DNA fragmentation.

Methods: The anticancer activity of bornyl acetate, 5-FU and their combination against human gastric cancer (SGC-7901) cells was evaluated by MTT assay. Flow cytometry using propidium iodide (PI) as a staining agent was used to study the effect of the extract on cell cycle phase distribution.