Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. It can cause fatty liver (steatosis), steatohepatitis, fibrosis, cirrhosis, and liver cancer. Alcohol consumption can also disturb the composition of gut microbiota, increasing the composition of harmful microbes and decreasing beneficial ones. Restoring eubiosis or preventing dysbiosis after alcohol consumption is an important strategy in treating ALD. Plant natural products and polyphenolic compounds exert beneficial effects on several metabolic disorders associated with ALD. Natural products and related phytochemicals act through multiple pathways, such as modulating gut microbiota, improving redox stress, and anti-inflammation. In the present review article, we gather information on natural extract and bioactive compounds on the gut-liver axis for the possible treatment of ALD. Supplementation with natural extracts and bioactive compounds promoted the intestinal tight junction, protected against the alcohol-induced gut leakiness and inflammation, and reduced endotoxemia in alcohol-exposed animals. Taken together, natural extracts and bioactive compounds have strong potential against ALD; however, further clinical studies are still needed.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219895 | PMC |
| http://dx.doi.org/10.3390/antiox11061211 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Uncovering the Anti-Atherosclerotic Effect of Isoquercitrin via Microbiome Metabolic Modulation and Network Pharmacology.
J Agric Food Chem
September 2025
College of Basic Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi 030000, China.
Atherosclerosis (AS) is increasingly recognized as a disease influenced not only by lipid metabolism and inflammation but also by the gut microbiota and their bioactive metabolites. Isoquercitrin (ISO), a natural flavonoid with food-medicine homology, has shown promising antiatherosclerotic potential, yet its underlying mechanisms remain unclear. In this study, ISO administration significantly reduced plaque burden, improved lipid profiles, and restored gut microbial balance by enriching beneficial taxa, such as , , and .
View Article and Find Full Text PDFWound Healing Properties of Nymphaea alba (Nymphaeaceae) Flower Extract: Evidence from In Vivo, In Vitro, and In Silico Network Analysis.
Curr Comput Aided Drug Des
September 2025
Noida Institute of Engineering and Technology (Pharmacy Institute), 19 Knowledge Park-II, Institutional Area, Greater Noida, U.P, 201306, India.
Introduction: The white water lily (Nymphaea alba) is a traditional medicinal plant recognized for its diverse array of bioactive properties. However, its potential in wound healing remains largely unexplored. This study aimed to evaluate the phytochemical profile, cytotoxicity, and wound healing efficacy of Nymphaea alba flower extract (NAFE) using both in vitro and in vivo models, as well as computational network analysis.
View Article and Find Full Text PDFA Scoping Review of Chemical, Pharmacological and Toxicological Properties and Clinical Applications of Australian Indigenous Medicine.
Biomed Pharmacother
September 2025
NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia. Electronic address:
Indigenous Australians have long recognised and utilised the therapeutic potential of Australian native plants for generations to treat and manage various diseases. In recent years, these native plants have been explored in preclinical research for their chemical profiles and therapeutic properties for conditions such as skin disorders, colds and flu, various cancers, neurological disorders, metabolic syndrome, and other inflammatory conditions. Notable species studied include Kakadu plum, Davidson's plum, Burdekin plum, Illawarra plum, anise myrtle, lemon myrtle, lemon aspen, quandong, muntries, and Tasmanian pepperberry.
View Article and Find Full Text PDFEstablishing a noncanonical zinc-binding group as a selective histone deacetylase inhibitor and possible novel anticancer agent.
Bioorg Chem
August 2025
School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:
HDAC inhibitors, which have been proven to be effective for some cancers, have potential as treatments for Non-small cell lung cancer (NSCLC). Building on the core structure of the highly selective HDAC6 inhibitor J22352, we modified various zinc-binding groups of this inhibitor. The resulting compounds 1-8 were designed and synthesized to explore potential derivatives and assess their effects on NSCLC bioactivity.
View Article and Find Full Text PDFPolyphenol from walnut septum alleviates DSS-induced colonic injury by regulating the PI3K-AKT pathway signaling and gut microbiota in mice.
Phytomedicine
August 2025
College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China; Yunnan Provincial Key Laboratory of Precision Nutrition and Personalized Food Manufacturing, Yunnan Agricultural University, Kunming 650201, China; Yunnan Provincial Engineering Research Center for Edible
Background: Walnut septum, a Juglans regia L. by-product with culinary-medicinal value, is a rich source of bioactive polyphenols. The chemical complexity and anti-colitis activities of these polyphenols remain uncharacterized.
View Article and Find Full Text PDF