Synergistic Chalcogenate and Fluorine Engineering on Metal Oxyhydroxides Breaks the OER Scaling Relationship.

The oxygen evolution reaction (OER), a bottleneck in electrochemical water splitting, is fundamentally limited by a scaling relationship between the binding energies of key intermediates (OH* and OOH*), imposing a minimum theoretical overpotential of 0.37 eV. Breaking this scaling relationship is crucial for enhancing OER activity, yet effective strategies remain scarce.

Latent profile analysis of nurses' moral resilience and its influencing factors.

BackgroundNurses often face complex moral distress in clinical practice, where maintaining emotional stability and making moral decisions under pressure is crucial for patient care and safety. Moral resilience helps nurses stay composed, think rationally, and navigate moral challenges effectively. Exploring the characteristics and influencing factors of different moral resilience subgroups can provide insights into nurses' resilience levels and inform targeted interventions to enhance their occupational well-being.

Helical Poly(isocyanide anthraquinones)-Based Cathodes for Long-Cycling Lithium Metal Batteries.

Thanks to the unique rigid conformation and designable side-chain structure, helical polymers are starting to be more widely considered as ideal electrode materials in secondary batteries. In this study, a series of helical poly(isocyanide anthraquinones) (PIC-AQs), including PIC-1AQ and PIC-2AQ, were designed and synthesized via living polymerization using a palladium catalyst (Pd-II). The polymers feature a helical polyisocyanide main chain and anthraquinone (AQ) pendants, offer high yields (approximately 90%), controlled number-average molecular weight (M), and a low polymer dispersity index (PDI).

Dosing and Serostatus Shape the Efficacy of Adenovirus, mRNA, and Protein Vaccines.

Despite the widespread use of adenovirus, mRNA, and protein-based vaccines during the COVID-19 pandemic, their relative immunological profiles and protective efficacies remain incompletely defined. Here, we compared antigen kinetics, innate and adaptive immune responses, and protective efficacy following Ad5, mRNA, and protein vaccination in mice. Ad5 induced the most sustained antigen expression, but mRNA induced the most potent interferon responses, associated with robust antigen presentation and costimulation.

The Different Immune Response Between Onset and Remission of AQP4 Antibody-Positive Optic Neuritis Based on RNA Sequencing of Whole Blood.

Purpose: We aimed to investigate differences in the immune response between the onset and remission phases of AQP4 antibody-positive optic neuritis (AQP4-ON).

Methods: Whole blood samples were collected from 7 healthy volunteers, 6 patients with AQP4-ON in the acute phase and 6 patients with AQP4-ON in the remission phase. Gene expression patterns and immune response pathways associated with the disease phases were identified by sequencing the RNA.

Development and characterization of novel low-calorie oleogels based on medium and long-chain triacylglycerol.

Background: In the present study, medium and long-chain triacylglycerol (MLCT) was synthesized from camellia oil (CO) and medium chain triglyceride by enzymatic transesterification. Novel MLCT oleogel was constructed using MLCT as substrate oil, as well as β-sitosterol /γ-oryzanol (SO), monoglyceride and carnauba wax as oleogelators, and the regulation mechanism of MLCT on self-assembly behavior was investigated.

Results: The G', apparent viscosity, oil binding capacity and hardness of the three MLCT oleogels were reduced compared to CO oleogels.

A New Zn(II) Metal-Organic Framework as an Efficient Fluorescent Probe for Chlortetracycline in Chicken Meat and Egg Samples.

The development of new materials for detecting chlortetracycline residues has garnered increasing attention in the realm of food safety. Under solvothermal conditions, a synergistic combination of diverse ligands successfully cooperated to synthesize a highly stable and luminescent zinc metal-organic framework (YMU 1), which crystallizes in the triclinic crystal system Pī with a 4-connected grid-like sql network and demonstrates exceptional stability in various environments, including organic solvents, water, and different pH levels. Functioning as an innovative fluorescence sensor, YMU 1 exhibits selective, sensitive, rapid, and reversible detection abilities for the antibiotic chlorotetracycline (CHL) in aqueous solutions through fluorescence quenching, having an exceptional minimum detection limit of 0.

The Release of Platelet DAMPs is Regulated by NINJ1-Mediated Plasma Membrane Rupture.

Damage-associated molecular patterns (DAMPs) can cause platelet activation and coagulation system dysfunction. It is often released by broken cell membranes after cell death. The oligomerization of ninjurin-1 (NINJ1) is closely associated with platelet plasma membrane rupture, but whether it actually prevents the release of platelet DAMPs is unclear.

The influence of chronic exposure to violent virtual avatars on players' aggressive behavior: An ERP study.

Short-term exposure to virtual avatars in violent video games has a short-term effect on players' aggressive behavior, but few studies have focused on the effect of chronic exposure to virtual avatars in violent video games on players' aggressive behavior, and its cognitive neural mechanism remains unclear. This study aimed to investigate the effects of chronic exposure to virtual avatars on players' aggressive behavior in violent video games and its cognitive neural mechanism. 54 undergraduates were selected (27 participants with violent virtual avatars exposure) to complete a competitive reaction time task, during which participants' EEG were recorded.

Highly sensitive fluorescence detection of chlortetracycline and tetracycline residues in food samples based on a Zn(II) coordination polymer.

Residual Tetracycline-like analogs antibiotics, including Chlortetracycline (CTC) and Tetracycline (TC), in food pose a significant threat to public health. A 3D Zn(II) coordination polymer, designated as [Zn(L)(HO)]·2(DMF)·4HO (CP 1), was successfully synthesized via the solvothermal method, utilizing 4,4'-(quinoxaline-2,3-diyl)dibenzoic acid (HL) as the organic ligand. This fluorescent material exhibits remarkable stability in maintaining its structure and fluorescence intensity across various aqueous environments and a broad pH range.

Switchable RNA motifs for dynamic transcriptional control of RNA condensates.

RNA-driven phase separation is emerging as a promising approach for engineering biomolecular condensates with diverse functionalities. Condensates form thanks to weak yet specific RNA-RNA interactions established by design via complementary sequence domains. Here, we demonstrate how RNA condensates formed by star-shaped RNA motifs, or nanostars, can be dynamically controlled when the motifs include additional linear or branch-loop domains that facilitate access of regulatory RNA molecules to the nanostar interaction domains.

ATRA derived lipid nanoparticles for co-delivery of siCYP26A1 to overcome metabolic limitations of differentiation therapy in solid tumors.

All-trans retinoic acid (ATRA) effectively treats acute promyelocytic leukemia but struggles in solid tumors due to insufficient tumor accumulation from poor targeting delivery and rapid metabolism by cytochrome P450 enzymes (particularly CYP26A1). Herein, we developed a lipoplex with a folic acid (F), utilizing ATRA-derived lipid nanoparticles (RA) for co-delivery of ATRA and siCYP26A1 (FRA/siCYP26A1). As the ATRA could upregulate the folate receptor β (FRβ), the endocytosis of FRA/siCYP26A1 could be consistently promoted.

Development of a cross-protective common cold coronavirus vaccine.

Common cold coronaviruses, such as OC43 and HKU1, generally cause mild respiratory infections in healthy people. However, they can lead to severe illness in high-risk groups, including immunocompromised individuals and older adults. Currently, there is no clinically approved vaccine to prevent infection by common cold coronaviruses.

Association between Obesity and Cognitive Function in Chinese Older Adults: The Mediating Effects of Sleep Quality and Blood Pressure.

Introduction: The mechanisms underlying the relationship between obesity and cognitive function remain unclear, particularly among older adults, where reliable evidence is limited. This study aimed to explore whether the relationship between obesity and cognitive function is mediated by sleep quality and blood pressure (BP) in older Chinese adults.

Methods: We conducted an observational study using data from a cluster randomized controlled trial (RCT) with 5 follow-up periods involving older adults in rural China.

Functional oleogels constructed by short- and long-chain acyl triacylglycerols: Characterization and in vitro simulated digestion.

Functional short- and long-chain acyl triacylglycerols oleogels were developed using three different gelators. The mechanism of introducing short-chain fatty acids to the glycerol skeleton influencing the self-assembly of oleogels was investigated. Compared to camellia oil oleogels, the thermal stability and mechanical strength of short- and long-chain acyl triacylglycerols oleogels decreased by 1.

Metformin aggravates pancreatitis by regulating the release of oxidised mitochondrial DNA via the frataxin (FXN)/ninjurin 1 (NINJ1) signalling pathway.

Background And Purpose: Patients with diabetes are at a higher risk of developing acute pancreatitis compared to those without diabetes. Therefore, it is essential to investigate the effects of metformin, a primary treatment for type 2 diabetes, on the progression of pancreatitis.

Experimental Approach: Network pharmacology was employed to investigate the potential effects of metformin on pancreatitis and to predict its underlying molecular mechanisms.

Machine Learning Assisted Stroke Prediction in Mechanical Circulatory Support: Predictive Role of Systemic Mitochondrial Dysfunction.

Stroke continues to be a major adverse event in advanced congestive heart failure (CHF) patients after continuous-flow left ventricular assist device (CF-LVAD) implantation. Abnormalities in mitochondrial oxidative phosphorylation (OxPhos) have been critically implicated in the pathogenesis of neurodegenerative diseases and cerebral ischemia. We hypothesize that prior stroke may be associated with systemic mitochondrial OxPhos abnormalities, and impaired more in post-CF-LVAD patients with risk of developing new stroke.

Preparation and characterization of camellia oil body-based oleogels loaded with (-)-epigallocatechin-3-gallate (EGCG).

Growing concern for healthy diets is driving researchers to developed novel solid lipids to reduce the intake of saturated and trans fatty acids. In this study, a novel edible oleogel loaded with EGCG was prepared using camellia oil body emulsion as template under alkaline condition (pH 9.0) and the effect of EGCG concentration (10-150 μM) on the structure and physicochemical properties of the oleogels were investigated.

The Associations Between Gallstone Disease and Pan-Cancer Incidence Risk Based on Over 13 Million Participants.

Background: Increasing evidence connects gallstone disease (GSD) to all types of cancer incidence; however, the results were inconsistent. The present study aimed to evaluate whether and to what extent these associations exist comprehensively.

Methods: We systematically searched published longitudinal studies indexed in PubMed and Embase database from dates of inception to March 31, 2020.

How short video addiction affects risk decision-making behavior in college students based on fNIRS technology.

Introduction: Short video addiction is an emerging form of Internet behavioral addiction characterized by dependent, inappropriate, or excessive use of short video applications. This phenomenon significantly affects decision-making processes and warrants further investigation. Despite the growing prevalence of short video addiction, research on its impact on risky decision-making abilities remains limited.

Indirubin attenuates sepsis by targeting the EGFR/SRC/PI3K and NF-κB/MAPK signaling pathways in macrophages.

Background: , a botanical drug widely used in traditional medicine, is known for its anti-inflammatory properties, including heat-clearing, detoxifying, and blood-cooling effects. Although its potential in sepsis treatment has been suggested, the bioactive metabolites and underlying mechanisms remain poorly understood.

Methods: Network pharmacology and molecular docking were employed to identify the therapeutic effects and mechanisms of Indirubin, the major bioactive metabolite of , in sepsis treatment.

Risk of Gallstones Increases with Multiple Dimensions of Obesity Indexes: A Prospective Study Based on the UK Biobank.

Introduction: Numerous cohort studies have consistently shown a significant link between obesity and an increased risk of gallstones. However, body mass index (BMI) alone may not fully capture the complexity of obesity. This study aimed to analyze the associations between different obesity indexes and the incidence of gallstones, using a competing risk model.

Integrative analysis based on CRISPR screen identifies apilimod as a potential therapeutic agent for cisplatin-induced acute kidney injury treatment.

Acute kidney injury (AKI), a life-threatening side effect of cisplatin therapy, significantly limits the drug's therapeutic potential. In this study, we conducted a genome-wide CRISPR/Cas9 knockout screen in human renal tubular epithelial cells, integrating the results with transcriptome analyses and the Connectivity Map (CMap) database. Apilimod and elacridar emerged as the top two candidates of mitigating cisplatin-induced nephrotoxicity, with apilimod demonstrating superior efficacy in drug matrix experiments.

Intestinal flora was associated with occurrence risk of chronic non-communicable diseases.

Background: The intestinal flora (IF) has been linked to risks of non-communicable diseases, especially various cancers, stroke, and Alzheimer's disease. However, many uncertainties of these associations during different stages of growth, development, and aging still exist. Therefore, further in-depth explorations are warranted.