Comprehensive analysis of R2R3-MYB transcription factors reveals OsMYB1 as a key regulator of anthocyanin biosynthesis in rice.

R2R3-MYB transcription factors (TFs) are key regulators of plant development, stress responses, and secondary metabolism, with a central role in anthocyanin biosynthesis. However, a comprehensive understanding of the R2R3-MYB TFs involved in anthocyanin accumulation in rice (Oryza sativa L.) remains limited.

Decipherment of disulfidptosis-related mutation profile, chemosensitivity, and prognosis in diffuse large B-cell lymphoma.

Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, of which 35-40% suffers recurrence after standard chemotherapy treatment. Disulfidptosis is a novel mode of cell death, which has been found to be associated with tumor environment and prognosis in several tumors. Here, we applied transcriptome profile data of 30 types of tumors, somatic mutation data, and scRNA-seq data of DLBCL patients for analysis.

Recent advances in oncolytic virus combined immunotherapy in tumor treatment.

Oncolytic viruses (OVs), a kind of emerging therapeutics for treating tumors, are characterized by high replication efficiency, superior killing effects, and few adverse reactions, which have shown great application prospects in preclinical tumor treatment trials. To overcome the limitations of OV monotherapy, recent studies have found that combination therapy with other anti-tumor therapeutics, especially with immunotherapy, yields promising outcomes in tumor eradication. Due to the advancements in genetic engineering, the combination of OVs with novel immunotherapy, including cellular immunotherapy, adoptive cellular immunotherapy, immune checkpoint inhibitors, cancer vaccines, cytokines, and bi- or tri-specific T cell engagers, has greatly improved clinical outcomes and quality of life of tumor patients.

Loss of C-Terminal Coiled-Coil Domains in SDCCAG8 Impairs Centriolar Satellites and Causes Defective Sperm Flagellum Biogenesis and Male Fertility.

Sperm flagellum defects are tightly associated with male infertility. Centriolar satellites are small multiprotein complexes that recruit satellite proteins to the centrosome and play an essential role in sperm flagellum biogenesis, but the precise mechanisms underlying this role remain unclear. (), which encodes a protein containing eight coiled-coil (CC) domains, has been associated with syndromic ciliopathies and male infertility.

Cleaning, Disinfection, and Functional Tests for Bag Valve Masks in Hospitals Located in 117 Cities in China: A Cross-Sectional Study.

Background: This study aimed to investigate factors associated with cleaning failures and malfunctions of bag valve masks (BVMs).

Methods: Stratified sampling was used in this cross-sectional study. A questionnaire survey was conducted with central sterile supply department managerial personnel from 479 hospitals in China from December 2023 to July 2024.

Bifunctional sodium hyaluronate microneedle patches integrating 5α-reductase and ROS regulation for boosted hair regeneration.

Androgenetic alopecia (AGA) - induced progressive hair loss is a worldwide phenomenon primarily attributed to excessive dihydrotestosterone (DHT) and reactive oxygen species (ROS) within hair follicles. This leads to follicle atrophy and eventual loss, posing a significant challenge for hair regeneration in affected individuals. Herein, we designed a bifunctional sodium hyaluronate microneedle patch as an in situ medical intervention, incorporating glycyrrhizin-loaded dutasteride (GL-DUT) micelles as the 5α-reductase inhibitor to reduce DHT levels and mesoporous polydopamine nanoparticles (MPDA NPs) as the ROS scavenger.

The Release of Platelet DAMPs is Regulated by NINJ1-Mediated Plasma Membrane Rupture.

Damage-associated molecular patterns (DAMPs) can cause platelet activation and coagulation system dysfunction. It is often released by broken cell membranes after cell death. The oligomerization of ninjurin-1 (NINJ1) is closely associated with platelet plasma membrane rupture, but whether it actually prevents the release of platelet DAMPs is unclear.

Magnolin Promotes PINK1-Parkin-mediated Mitophagy in Diffuse Large B-cell Lymphoma Cells via PPAR-γ Pathway.

Background: Diffuse large B-cell lymphoma (DLBCL) is both genetically and phenotypically heterogeneous, yet precise treatment strategies are insufficient. Magnolin, a natural compound derived from the Magnolia plant, has been clinically used for its anti-allergic, anti-inflammatory, antihypertensive, and antibacterial effects. Recent studies have shown its promising therapeutic effects in tumor treatment.

Addressing global challenges: How does the integration of rural industries in China enhance agricultural resilience?

Promoting the integrated development of rural industries represents a crucial pathway for accelerating the modernization of the entire industrial chain and consolidating and enhancing agricultural resilience. This study constructs provincial-level panel data for China spanning 2012-2022 and employs a multidimensional, visualization-based, and spatial research paradigm to comprehensively examine the impact effects and mechanisms through which rural industrial integration empowers agricultural resilience in China. The findings reveal that, first, rural industrial integration can effectively enhance agricultural resilience levels, with stable economic returns and diversified functional development serving as key pathways for improving agricultural resilience.

Routine psychological problems screening in hospitalized inflammatory bowel diseases and its effect for progression-free survival from disease worsening.

Background: To examine the progression-free survival from disease worsening after the implementation of routine screening for psychological problems in hospitalized patients with inflammatory bowel diseases (IBDs) during a long-term follow-up.

Methods: The retrospective cohort study enrolled 1265 patients with active IBDs. Their records were stratified into screening cohort (n = 827), receiving screening for psychological problems within 48 h after admission, and a 2:1 propensity score matching was utilized to match cases without screening as controls (n = 438).

Gate-Tunable Polarization Gradient in 2D Polar Semiconductor for Synaptic Transistor.

Neuromorphic computing, inspired by the brain's energy-efficient parallelism processing, offers a transformative alternative to overcome von Neumann bottlenecks. A critical challenge is to replicate the dynamic plasticity of biological synapses using artificial transistor devices capable of nonvolatile, stimulus-tunable charge transport. Existing synaptic transistors mainly rely on mechanisms such as ion migration, ferroelectric switching, floating gate coupling or charge trapping, yet these approaches are inherently constrained by issues like ionic diffusion, polarization fatigue, and charge leakage─that degrade reliability and memory retention.

ABO exon polymorphisms are related to ischemic stroke in a Chinese Han population.

Background: Recent research have underscored the relation of ABO blood group system to cerebrovascular disorders predisposition. The present investigation endeavors to delve into the relationship between ABO polymorphisms and ischemic stroke (IS) risk.

Methods: A cohort of 646 IS patients and 649 matched healthy controls was recruited.

Metastasis of prostate cancer to breast: a case report.

We describe a 68-year-old man who had prostate cancer (PCa) diagnosed with breast metastasis, presenting as a breast mass. Seven years ago, the patient had PCa with bone metastasis and had been systematically receiving endocrine therapy for prostate cancer and osteoprotective treatment since the diagnosis. In October 2023, the patient visited our hospital due to bilateral breast masses for four days.

Study on the formation mechanism of Tartary buckwheat starch-flavonoid complexes with different treatments.

The complexation of Tartary buckwheat starch with flavonoids facilitates the preparation of resistant starch. However, the research on the formation mechanism of Tartary buckwheat starch-flavonoid complexes under various treatment methods remains limited. In this study, we investigated the effects of high hydrostatic pressure treatment and heat treatment on Tartary buckwheat starch-flavonoid complexes (BSF), and explored the binding mechanisms between Tartary buckwheat starch (TBS) and flavonoids.

Fludioxonil resistance in : Biological characteristics and resistance mechanisms.

Rice Bakanae Disease (RBD), caused by Fusarium fujikuroi, threatens global rice production. While the phenylpyrrole fungicide fludioxonil shows efficacy against F. fujikuroi, resistance mechanisms remain understudied.

Microbiota profiling from biopsied tissues in complex infections: a diagnostic and prognostic analysis through metagenomic next-generation sequencing.

Background: Infectious diseases that require tissue biopsy are usually more difficult to diagnose through conventional microbiological tests (CMT), and knowledge of the infection microbiota pattern from biopsied tissues remains incomplete. Our study aimed to investigate the diagnostic and prognostic value of metagenomic next-generation sequencing (mNGS), characterize the microbiota profile from biopsied tissues, and examine its relationship with clinical outcomes.

Methods: This retrospective cohort study included 110 patients who underwent tissue biopsy and sent both mNGS and CMT due to suspected complex infection.

Mosses as Biomonitors of Atmospheric Trace Metal and Nitrogen Deposition: Spatial Distribution and Temporal Trend in Yancheng, China.

This study assessed air quality in Yancheng, China, using moss biomonitoring. The moss species, was chosen, and mosses were collected from 67 sites across Yancheng during July and August 2022. The concentrations of Al, Co, Cr, Cu, Fe, Mn, Ni, Pb, Zn, V, and nitrogen in mosses were determined, and the spatial distribution and temporal trends of atmospheric trace metals and nitrogen deposition in Yancheng were explored by comparing the current data with that of a similar study conducted in 2017.

WGCNA analysis reveals hub genes in the Hemarthria compressa roots in response to waterlogging stress.

Hemarthria compressa is a high-quality forage resource in China. In recent years, waterlogging has frequently occurred, adversely affecting the growth and development of H. compressa.

Trifloxystrobin Resistance Mechanisms in f. sp. .

Melon Fusarium wilt (MFW) is a soilborne disease caused by the ascomycete fungus f. sp. (), which causes serious damage throughout the entire growth cycle of its hosts.

Effect of Low-Temperature Plasma Sterilization on the Quality of Pre-Prepared Tomato-Stewed Beef Brisket During Storage: Microorganism, Freshness, Protein Oxidation and Flavor Characteristics.

Traditional tomato-braised beef brisket with potatoes is celebrated for its rich, complex flavors and culinary appeal but requires lengthy preparation. Pre-packaged versions of the dish rely on thermal sterilization for safety; however, high-temperature processing accelerates protein and lipid oxidation, thereby compromising its sensory quality. As the demand for ready-to-eat meals grows, the food industry faces the challenge of ensuring microbial safety while preserving flavor integrity.

Plasmonic in-situ imaging of zeta potential distributions at electrochemical interfaces of 2D materials in water.

Understanding the electrical double layer (EDL) at solid-liquid interfaces is pivotal across various fields, including energy storage, electrowetting, and electrocatalysis, yet probing its structure and heterogeneity remains a considerable challenge. Here, we report an optical method for the direct visualization and quantification of the zeta potential (ζ) across the interfaces between 2D materials and aqueous solutions. By modulating surface charge density, we map the heterogenous distribution of ζ potential across the MoS nanosheet interface, revealing how both external factors and intrinsic material properties shape interfacial charge.

Metabolism-related ALDH1B1 acts as potential predictor and therapeutic target for primary gastrointestinal diffuse large B-cell lymphoma.

Primary gastrointestinal diffuse large B-cell lymphoma (PGI-DLBCL) is the most common extra-nodal DLBCL. Metabolism-related factors have been associated with tumor progression, but the relationship between abnormal metabolism and prognosis of PGI-DLBCL remains unelucidated. In our study, consensus clustering based on metabolism-related genes classified PGI-DLBCL patients into two metabolic subtypes, and poor prognosis was associated with immunosuppressive microenvironment.

Transcriptome and metabolome reveal the mechanism of neuroendocrine regulation in ovarian development of broiler breeders.

The long-term selection for meat has led to the poor egg production efficiency in broiler. In this study, we analyzed the transcriptional levels of hypothalamus and ovary during the pre-laying (PP) and laying periods (LP) of broiler breeders. By combining these with the levels of reproductive hormones and ovarian metabolism, to reveal the neuroendocrine control mechanism of ovarian development.

Food safety assessment of genetically modified soybean DBN9004×DBN8002×DBN8205 in a subchronic rodent feeding study.

Soybeans provide a nutritionally complete plant-based protein, containing all nine essential amino acids and bioactive compounds. The food safety of a novel triple-stacked genetically modified (GM) soybean, DBN9004 × DBN8002 × DBN8205 was evaluated in a 90-day rat feeding study. The GM soybean, developed through conventional hybridization of three GM lines (DBN9004, DBN8002 and DBN8205), incorporates genes conferring resistance to glyphosate (epsps), glufosinate (pat), and lepidopteran pests (cry1Ac, cry2Ab2, and mVip3Aa).