Development of a transtheoretical model for the prevention and treatment of skin disease through ultraviolet protection based on 14,681 samples of outpatient clinics and a cross-sectional survey.

Background: Little is known about the association between types of skin and subcutaneous diseases and UV protection literacy.

Objective: To assess the burden and treatment of skin diseases in Ninger County, Yunnan Province, and establish a transtheoretical model for optimizing public perceptions and behaviors regarding UV radiation.

Methods: Electronic medical records of outpatients from the dermatology department were collected from January 2022 to July 2024, and a self-administered questionnaire assessed the public knowledge about UV exposure risks and behaviors.

Mendelian randomization analysis of 233 metabolites in chronic rhinosinusitis and nasal polyps.

Recent studies have suggested potential associations between specific metabolites and chronic rhinosinusitis (CRS) with nasal polyps (NP). However, robust causal evidence remains limited. This study applies Mendelian randomization (MR) to investigate these relationships.

Bifunctional sodium hyaluronate microneedle patches integrating 5α-reductase and ROS regulation for boosted hair regeneration.

Androgenetic alopecia (AGA) - induced progressive hair loss is a worldwide phenomenon primarily attributed to excessive dihydrotestosterone (DHT) and reactive oxygen species (ROS) within hair follicles. This leads to follicle atrophy and eventual loss, posing a significant challenge for hair regeneration in affected individuals. Herein, we designed a bifunctional sodium hyaluronate microneedle patch as an in situ medical intervention, incorporating glycyrrhizin-loaded dutasteride (GL-DUT) micelles as the 5α-reductase inhibitor to reduce DHT levels and mesoporous polydopamine nanoparticles (MPDA NPs) as the ROS scavenger.

Halogenated Sulfono-γ-AApeptides Modified Cationic AMPs Have Enhanced Stability and Therapeutic Potential against Clinically Important MDR Infections.

Antimicrobial peptides have garnered increasing attention and are anticipated to address the growing crisis of antibiotic resistance. However, their inadequate proteolytic stability poses significant challenges for clinical development. In this study, we present a highly effective strategy to overcome the limitations by introducing multiple halogenated sulfono-γ-AApeptides into cationic AMP Feleucin-K3.

Contrast-Enhanced Ultrasound Findings of Peritoneal Polypoid Endometriosis: A Case Report and Literature Review.

Polypoid endometriosis (PEM) is a rare and distinctive variant of endometriosis, with ectopic endometrium presenting as a polypoid appearance. Due to the irregular shape of the mass on imaging, accompanied by obvious blood flow signals and often with elevated tumor marker CA125, it is prone to be misdiagnosed as a malignant tumor. We report a 43-year-old female with a history of ovarian endometriosis, in whom a heterogeneous echo mass was found in the pelvic cavity.

A novel lncRNA, Lnc21q22.11, suppresses gastric cancer growth by inhibiting MEK/ERK pathway.

Gastric cancer (GC) is one of the most common malignancies with limited treatment options and poor prognosis. Therefore, it is necessary to identify new markers for the development of novel therapeutic strategies. Long non-coding RNAs (lncRNAs) have emerged as pivotal players in cancer.

Fibrinogen exacerbates α-synuclein aggregation and mitochondrial dysfunction via alpha5beta3 integrin in Parkinson's disease.

Introduction: Blood-brain barrier(BBB) disruption promotes the influx of the fibrinogen(FG); however, it remains unknown whether FG deposit contributes to neurodegeneration in Parkinson's disease(PD).

Objectives: We aimed to examine the pathophysiologic link among FG, mitochondrial dysfunction and α-synuclein(α-syn) abnormality in PD.

Methods: First, plasma FG levels were measured in 60 healthy controls and 60 PD patients.

Tryptophan metabolites exert potential therapeutic activity in graves' orbitopathy by ameliorating orbital fibroblasts inflammation and proliferation.

Purpose: Graves' orbitopathy (GO) is a sight-threatening organ-specific autoimmune disease with complicated pathogenesis. Gut microbiota-derived tryptophan (Trp) metabolites play important roles in immune-related diseases, but their role in GO remains unknown.

Methods: Trp metabolism-associated gut flora was analyzed by 16 S sequencing in GO patients and controls.

Homocysteine stimulates orbital fibroblast proliferation and migration in Graves' orbitopathy via activating Akt signaling pathway.

Background: Graves' orbitopathy (GO) is a sight-threatening disease associated with thyroid dysfunction, with an unmet medical need for early diagnosis and treatment. Orbital fibroblasts (OFs) proliferation and migration play central roles in the pathogenesis of GO. Homocysteine (Hcy) has been demonstrated to be related to thyroid function, but its role in GO remains unclear.

Untargeted lipidomics profiling provides novel insights into pediatric patients with sepsis: an exploratory study.

Introduction: The plasma lipidome has emerged as an important indicator for assessing host metabolic and immune status in sepsis. While previous studies have largely examined specific lipid class changes in adults sepsis, comprehensive investigations into plasma lipidomic alterations in pediatric sepsis are limited. This study aimed to characterize the plasma lipidome in pediatric sepsis using a metabolomics-based exploratory approach, providing insights into pathophysiological mechanisms and potential biomarkers.

NIR-II Light-Activated Gold Nanocapsules for CO-Assisted Photothermal-Thermodynamic Synergistic Cancer Therapy.

Photothermal therapy (PTT) based on a second near-infrared (NIR-II, 1000-1700 nm) light source holds great promise in the field of tumor treatment. However, hyperthermia-induced heat shock protein (HSP) expression and limited therapeutic efficacy remain the major challenges for PTT. Herein, a NIR-II laser-responsive nanocapsule PC/AC@GR@HA (abbreviated as P/A@G@H) was designed for carbon oxide (CO)-assisted tumor PTT combined with thermodynamic therapy (TDT).

Age at menarche and depression: an updated systematic review and meta-analysis.

Background: Age at menarche may influence the onset of depression later in life. We aim to assess the association between early/late menarche and depressive outcomes in females by updating a systematic review and meta-analysis.

Methods: The search of the original systematic review was updated for studies published in PubMed, Embase, and Cochrane Library from 2013 to 2023.

SPOP/NOLC1/B4GALT1 signaling axis enhances paclitaxel resistance in endometrial cancer by inducing O-dysglycosylation.

The effective treatment of paclitaxel-resistant patients remains a major challenge. We found that nucleolar and coiled body phosphoprotein 1 (NOLC1) was highly expressed in the paclitaxel-resistant endometrial cancer (ECa) cells and pathological tissue of ECa patients, which could promote the occurrence and progression of ECa cells. Mechanistically, we confirmed that the E3 ubiquitin ligase substrate-binding adaptor SPOP mediates the ubiquitination and degradation of NOLC1, thereby maintaining normal protein levels.

Computation-Enabled Structure-Based Discovery of Potent Binders for Small-Molecule Aptamers.

Aptamers, functional nucleic acids recognized for their high target-binding affinity and specificity, have been extensively employed in biosensors, diagnostics, and therapeutics. Conventional screening methods apply evolutionary pressure to optimize affinity, while counter-selections are used to minimize off-target binding and improve specificity. However, aptamer specificity characterization remains limited to target analogs and experimental controls.

Radiological evaluation of pelvic venous Disorders: A comprehensive review.

Pelvic venous disorder (PVD) is a common gynecological disorder caused by chronic pelvic venous congestion. Clinically, it primarily manifests as lower abdominal pain, lower back pain, dyspareunia, increased menstrual flow, and increased vaginal discharge, though positive physical signs are few. The gynecological examination may reveal bilateral ovarian tenderness.

A simple, reliable and easily generalizable cell-based assay for screening potential drugs that inhibit lipid accumulation.

Ectopic lipid deposition in the hepatocyte plays an important role in the development of nonalcoholic fatty liver disease (NAFLD), which has become one of the most common causes of chronic liver disease worldwide yet no approved drugs are currently available. In this study, a cell-based method was developed to screen potential drugs with low toxicity that inhibit lipid accumulation. In the same 96-well plate, cytotoxicity was measured using CCK8 assay, followed by lipid content detection using BODIPY 493/503 via fluorometry assay, a lipid droplet-specific fluorescent dye commonly used in microscopy and flow cytometry, but not previously reported in fluorometry.

Gut microbiota, immune cells, and chronic sinusitis: A Mendelian randomization analysis.

Allergic rhinitis (AR) is a common allergic inflammatory disease that affects the upper respiratory tract. Although previous research suggests a potential association between gut microbiota alterations and AR, the causal relationship remains unclear. This study employs Mendelian randomization (MR) to reduce confounding factors and reverse causality.

A rare case of chronic complete uterine inversion in a postmenopausal woman: a case report and literature review.

Uterine inversion is a rare condition that refers to the collapse of the fundus into the uterine cavity and occurs in puerperal and non-puerperal conditions. Non-puerperal uterine inversion is particularly infrequent. Diagnosing non-puerperal uterine inversion is often challenging because it resembles vaginal or cervical tumors and pelvic organ prolapse.

Developmental and neurotoxic effects of dimethyl phthalate on zebrafish embryos and larvae.

Dimethyl phthalate (DMP) has been extensively utilized as a plasticizer on a global scale for many years. Its presence in the environment and its harmful effects on living organisms have raised concerns. This study aimed to examine its potential developmental neurotoxicity by utilizing zebrafish as a model.

Biomimetic fucoidan nanoparticles with regulation of macrophage polarization for targeted therapy of acute lung injury.

Acute lung injury (ALI) is a complex acute respiratory illness with a high mortality rate. Reactive oxygen species (ROS) play a pivotal role in ALI, inducing cellular damage, inflammation, and oxidative stress, thereby exacerbating the severity of the injury. In this study, inspired by the "subtractive" strategy, we developed a fucoidan-based macrophage membrane bio-nanosystem, abbreviated as MF@CB, designed as an anti-inflammatory and antioxidant agent to alleviate lipopolysaccharide (LPS)-induced inflammation in ALI.

Biomimetic reactive oxygen/nitrogen nanoscavengers inhibit "ferroptosis storm" and modulate immune targeting for acute kidney injury.

Cisplatin (Cis), a potent chemotherapeutic agent, often causes acute kidney injury (AKI), limiting its clinical efficacy. RONS flares at the AKI site are a key factor in its progression. In this study, leveraging the advantages of cell membrane-coated biomimetic nanocarriers, we developed a multifunctional biomimetic nanodelivery system nano-RONS-sacrificial agent for AKI treatment.