Solar-activated ZnS@MXene heterostructure for integrated radioactive wastewater treatment and energy harvesting.

The presence of ubiquitous organic contaminants in radioactive wastewater poses formidable challenges for conventional uranium extraction technologies. Herein, we architect an auto-photopotential driven catalytic system (APDCS) through rational integration of ZnS@MXene/CF cathodes with monolithic photoanodes, achieving triple-functional uranium recovery, organic pollutant degradation, and simultaneous power generation from complex radioactive effluents. The ZnS@MXene heterostructure, synthesized via ZIF-8 sulfidation on MXene nanosheets, achieved 22-fold faster U(VI) extraction, 4.

Artificial intelligence-simplified information to advance reproductive genetic literacy and health equity.

Study Question: Can artificial intelligence (AI) and large language models (LLMs) effectively simplify patient education materials (PEMs) to advance reproductive genetic literacy and health equity?

Summary Answer: LLMs offer a promising approach to support healthcare professionals in generating effective, and simplified PEMs.

What Is Known Already: Reproductive genetic testing and counseling holds the potential to support a personalized approach to reduce the burden of genetic disorders. However, its uptake remains limited due to the complexity of the tests and the way that PEMs have been designed.

STAT3 inhibition mitigates experimental autoimmune gastritis by restoring Th17/Treg immune balance.

This study investigates the role of STAT3 in autoimmune gastritis (AIG) pathogenesis and evaluates the therapeutic potential of STA-21, a STAT3 inhibitor. We utilized these models. (1) AIG model establishment using TxA23 mice, (2) high-dose tamoxifen (HDT) treatment to induce gastric atrophy and spasmolytic polypeptide-expressing metaplasia (SPEM), and (3) STA-21 administration to assess STAT3 inhibition.

Magnetic Resonance Screening for Cerebral Venous Sinus Thrombosis during Treatment with Pegaspargase.

In children with leukemia, cerebral venous sinus thrombosis (CVST) has a significant incidence and mortality rate, which may interfere with the chemotherapy process and lead to long-term neurological complications. However, large studies and population-based data on CVST in children are scarce. This study aims to characterize pediatric CVST associated with pegaspargase (PEG-ASP) and evaluate the significance of magnetic resonance venography (MRV) screening following induction remission in acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL).

Creep characteristics of muddy siltstone and its engineering application on cross-river tunnel stability.

Muddy siltstone combines the characteristics of both sandstone and mudstone, and is prone to instability over time. To study the long-term stability of tunnel engineering in this stratum, this article taking the cross-river metro tunnel section as the engineering background, and conducting research on the stress and deformation of the tunnel surrounding rock. Firstly, uniaxial compression creep tests were conducted on muddy siltstone to study the creep deformation law under graded loading.

Age at menarche and depression: an updated systematic review and meta-analysis.

Background: Age at menarche may influence the onset of depression later in life. We aim to assess the association between early/late menarche and depressive outcomes in females by updating a systematic review and meta-analysis.

Methods: The search of the original systematic review was updated for studies published in PubMed, Embase, and Cochrane Library from 2013 to 2023.

SOX2 commands LIM homeobox transcription factors in choroid plexus development and tumorigenesis.

Background: Choroid plexus (CP) tumors are rare brain neoplasms that mainly affect the pediatric population. Unlike benign CP papilloma (CPP), CP carcinoma (CPC) is an aggressive cancer with a dismal survival rate. Despite chromosome-wide rearrangements, drivers of most CP tumors remain elusive except recurrent alterations in TP53.

Effect of Sequential Repetitive Transcranial Magnetic Stimulation With Bilateral Arm Training on the Brain Effective Connectivity in Chronic Stroke.

This study investigated the effects of combining repetitive transcranial magnetic stimulation (rTMS) with bilateral arm training (BAT) on effective brain connectivity in chronic stroke patients using functional near-infrared spectroscopy. Fifteen post-stroke patients and fifteen healthy individuals were enrolled. Coupling function analysis was performed to evaluate the effective connectivity inflow, outflow, and the dominant information flow (DIF) during standalone BAT and combined rTMS-BAT therapy.

GGN repeat length of the androgen receptor gene is associated with antral follicle count in Chinese women undergoing controlled ovarian stimulation.

Objectives: To evaluate the association of GGN repeat polymorphism of androgen receptor (AR) with ovarian reserve and ovarian response in controlled ovarian stimulation (COS).

Methods: This genetic association study was conducted among a total of 361 women aged ≤40 years with basal FSH≤12 U/L undergoing the GnRH-agonist long protocol for COS in a university-affiliated IVF center. GGN repeat in the AR gene was analyzed with Sanger sequencing.

Shear Energy Evolution and Fracture Behavior of Rock-Concrete Interfaces Under Different Stress-Level Conditions.

Indoor direct shear tests under different stress levels were conducted on sandstone-concrete samples to investigate the rock-concrete interfaces' shear energy evolution features and fracture behaviors under different normal stresses, combined with acoustic emission (AE) and digital image correlation (DIC) techniques. The research results show that the growth of normal stress restricts the coalescence and failure of micro-cracks inside the sample and improves the bearing capacity. The shear strength of the sandstone-concrete cemented interface increases by 12.

Vitamin D3/VDR alleviates double-stranded RNA virus -induced biliary epithelial cell damage by inhibiting autophagy.

Background: The increased apoptosis of bile duct epithelial cells (BECs) due to some damage factors is considered the initiating factor in the occurrence and progression of biliary atresia (BA). Vitamin D receptor (VDR) is thought to play a crucial role in maintaining the intrinsic immune balance and integrity of bile duct epithelial cells (BECs). To investigate the role of VDRs in the pathogenesis and progression of BA using in vitro and in vivo models.

Anti-inflammatory, anti-colitis, and antioxidant effects of columbianadin against DSS-induced ulcerative colitis in rats via alteration of HO-1/Nrf2 and TLR4-NF-κB signaling pathway.

Background: Ulcerative colitis (UC) is a significant inflammatory bowel disease (IBD) that typically arises from chronic inflammation of the intestinal tract. Report suggest that anti-inflammatory drug plays a crucial role in the protection of UC. The recent study demonstrated that columbianadin has a protective effect against UC induced by dextran sulfate sodium (DSS) in rats through the modulation of HO-1/Nrf2 and TLR4-NF-κB signaling pathways.

Large language models to facilitate pregnancy prediction after in vitro fertilization.

We evaluated the efficacy of large language models (LLMs), specifically, generative pre-trained transformer-4 (GPT-4), in predicting pregnancy following in vitro fertilization (IVF) treatment and compared its accuracy with results from an original published study. Our findings revealed that GPT-4 can autonomously develop and refine advanced machine learning models for pregnancy prediction with minimal human intervention. The prediction accuracy was 0.

Machine learning-based individualized survival prediction model for prognosis in osteosarcoma: Data from the SEER database.

Patient outcomes of osteosarcoma vary because of tumor heterogeneity and treatment strategies. This study aimed to compare the performance of multiple machine learning (ML) models with the traditional Cox proportional hazards (CoxPH) model in predicting prognosis and explored the potential of ML models in clinical decision-making. From 2000 to 2018, 1243 patients with osteosarcoma were collected from the Surveillance, Epidemiology, and End Results (SEER) database.

Sulforaphane triggers Sirtuin 3-mediated ferroptosis in colorectal cancer cells via activating the adenosine 5'-monophosphate (AMP)-activated protein kinase/ mechanistic target of rapamycin signaling pathway.

Objective: This study aimed to explore the expression and biological functions of SIRT3 in colorectal cancer cells (HCT-116), the impacts of sulforaphane on the ferroptosis of HCT-116 cells and the involvement of the SIRT3/AMPK/mTOR axis in those effects.

Methods: SIRT3-overexpressing (OE) and SIRT3-knockout (KO) cell lines were treated with different concentrations of sulforaphane, RSL-3, and IKE. Cell viability, intracellular ROS, MDA, iron levels, as well as mRNA and protein expressions of target genes were measured.

Insomnia-related brain functional correlates in first-episode drug-naïve major depressive disorder revealed by resting-state fMRI.

Introduction: Insomnia is a common comorbidity symptom in major depressive disorder (MDD) patients. Abnormal brain activities have been observed in both MDD and insomnia patients, however, the central pathological mechanisms underlying the co-occurrence of insomnia in MDD patients are still unclear. This study aimed to explore the differences of spontaneous brain activity between MDD patients with and without insomnia, as well as patients with different level of insomnia.

Clinical-grade whole genome sequencing-based haplarithmisis enables all forms of preimplantation genetic testing.

High-throughput sequencing technologies have increasingly led to discovery of disease-causing genetic variants, primarily in postnatal multi-cell DNA samples. However, applying these technologies to preimplantation genetic testing (PGT) in nuclear or mitochondrial DNA from single or few-cells biopsied from in vitro fertilised (IVF) embryos is challenging. PGT aims to select IVF embryos without genetic abnormalities.

In vitro efficacy of Rosa damascena solid state fermentation liquid and water extract on skin care.

Background: As a medicinal and food homologous plant, Rosa damascena is not only highly ornamental, but also rich in a variety of active ingredients such as polyphenols and flavonoids. It is widely used in cosmetics, food and pharmaceutical industries.

Objective: To study the in vitro efficacy of Rosa damascena solid state fermentation liquid (RDF) and water extract (RDE).

The Effect of Unhealthy Food Packaging Information Boundaries on Consumer Purchasing Intentions.

Existing studies have examined unhealthy food packaging information, mainly focusing on aspects such as the content, color, and text, whilst paying less attention to the boundaries of information. This paper investigates unhealthy foods through three experiments, revealing that the presence (vs. absence) of packaging information boundaries on unhealthy foods has a negative impact on consumers' purchasing intentions ( = 0.