Publications by authors named "Changjun Teng"
Objectives: Obsessive-compulsive disorder (OCD) is a highly prevalent and chronic neuropsychiatric disorder. Selective serotonin reuptake inhibitors (SSRI) are first-line pharmacological agents for treating OCD. However, nearly half of patients show insufficient responses to SSRI.
View Article and Find Full Text PDFBackground: Major depressive disorder (MDD) imposes serious effect on patient's psychosocial function, which hinders the full recovery from the disease and increases the risk of recurrence, although the participants had achieved clinical remission. To understand the relationship between psychosocial function and depressive symptoms could facilitate recurrence prevention. Therefore, the purpose of this study was to analyze the relation among psychosocial function and BDI score in Chinese patients with clinically cured depression within 1 year follow-up.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the connection between brain changes and gene activity in individuals with obsessive-compulsive disorder (OCD), a condition marked by unwanted thoughts and repetitive actions.
- By combining data from the Allen Human Brain Atlas and neuroimaging resources, researchers found a relationship between cortical thickness and specific gene expressions in the brains of those with OCD.
- The findings reveal a link between neural structure and gene expression, suggesting that certain proteins and genes play a crucial role in understanding the biological underpinnings of OCD.
Article Synopsis
- Neuroimaging studies reveal structural and functional brain disruptions in OCD patients, but their mechanisms are still unclear.
- The research involved 45 OCD patients and 42 healthy controls, focusing on abnormalities in local degree centrality (DC) and dynamic functional connectivity (dFC) using resting-state fMRI.
- Findings indicated reduced DC in brain regions like the thalamus and cuneus, correlated with illness severity, and decreased dFC variability, suggesting impaired connections in the visual and sensorimotor networks for those with OCD.
Article Synopsis
- - Enhancing psychosocial functioning is essential for lowering the risk of relapse in individuals who have recovered from depression, as found in a year-long study involving 182 participants who were assessed multiple times post-remission.
- - The study revealed that improvements in psychosocial functioning can decrease relapse odds by 54.2%, with subjective depressive symptoms, social support, and positive coping being key factors influencing this functioning.
- - Notably, while negative automatic thoughts were crucial initially, the overall impact of social support and coping strategies remained consistently important throughout the follow-up period, suggesting a complex relationship between these factors and recovery over time.
Dynamic observation and qualitative analysis of a psychological crisis hotline during the COVID-19 pandemic.
Front Health Serv
August 2022
Article Synopsis
- The study analyzed complaints to psychological crisis hotlines in Jiangsu, China, during the COVID-19 pandemic to understand public mental health concerns.
- A total of 578 calls were categorized, revealing that 85.64% involved psychological issues like anxiety and depression, with distinct patterns observed at different pandemic stages.
- The findings suggest that analyzing hotline data can help guide interventions for future public health crises by identifying and responding to emerging mental health needs.
The ultimate goal of depression treatment is to achieve functional recovery. Psychosocial functioning is the main component of functional impairment in depressed patients. The concept of psychosocial functioning has an early origin; however, its concept and connotation are still ambiguous, which is the basic and key problem faced by the relevant research and clinical application.
View Article and Find Full Text PDFDevelopment of a psychosocial functioning questionnaire for patients with major depressive disorder.
Gen Psychiatr
February 2022
Background: The importance of psychosocial functioning in the assessment, diagnosis and treatment of major depressive disorder (MDD) is widely recognised. However, there is a lack of effective scales to assess psychosocial functioning in patients with MDD.
Aims: To develop a professional questionnaire to evaluate the psychosocial functioning of patients with MDD.
Background: Cognitive behavioral therapy (CBT) is an established treatment for Major Depressive Disorder (MDD). MDD is characterized by imbalanced communication patterns among three networks: the central executive network (CEN), the default mode network (DMN) and the salience network (SN). The effect of CBT in restoring communications among these networks in MDD is unknown.
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- The study examined public mental health during the COVID-19 outbreak, revealing high rates of anxiety (37.2%) and depression (41.0%) among respondents.
- Protective factors include higher psychological resilience, active coping styles, and factors like being female and optimistic, while younger age, less education, unmarried status, and passive coping styles are risk factors.
- Limitations of the study include its cross-sectional design and reliance on self-reported data, indicating a need for further research in understanding mental health impacts amidst crises.
Article Synopsis
- Resting-state functional connectivity (FC) is disrupted in patients with remitted major depressive disorder (rMDD), particularly within cognitive networks like the central executive network (CEN), default mode network (DMN), and salience network (SN).
- In a study comparing 19 healthy controls to 19 rMDD patients, rMDD showed lower connectivity in key areas of the CEN and higher connectivity in parts of the DMN, indicating different functional patterns despite clinical remission.
- Correlation analyses revealed that weaker connectivity in the right inferior parietal lobule (IPL) was associated with better cognitive function, while stronger connectivity in the left insula correlated with higher depression scores, suggesting ongoing cognitive impacts in r
Resting-state causal connectivity of the bed nucleus of the stria terminalis in panic disorder.
Brain Imaging Behav
February 2021
Article Synopsis
- Panic disorder (PD) is linked to anticipatory anxiety and abnormal functioning of the bed nucleus of the stria terminalis (BNST), which is tied to fear responses.
- A study used resting-state fMRI to compare the causal connectivity of the BNST in 19 PD patients and 18 healthy controls, focusing on how different brain regions interact.
- Results showed PD patients had increased connectivity between the BNST and areas involved in emotional processing and decision-making, indicating a significant difference in brain network behavior compared to healthy individuals.
Background: Cognitive dysfunctions, such as impaired cognitive control, are frequently observed in patients with major depressive disorder (MDD). Although the cognitive control network (CCN) is widely considered a core feature of major depressive disorder (MDD), the relationship between cognitive dysfunction and symptom dimensions remains unclear. This study investigated differences in resting-state functional connectivity of the cognitive control network (CCN) between first-episode medication-naive MDD patients and remitted MDD.
View Article and Find Full Text PDFBackground: Occupational burnout in physicians is prevalent and can have many negative effects. The purposes of this study were to explore the prevalence of occupational burnout and to analyze the effects of social support and role stress on occupational burnout among Chinese physicians.
Methods: Using multistage-stratified cluster random sampling, physicians were selected to participate in the study and completed three questionnaires: the Chinese Maslach Burnout Inventory; the Cross-Cultural Role Conflict, Ambiguity and Overload Scale; and the Social Support Rating Scale.
Hippocampus-driving progressive structural alterations in medication-naïve major depressive disorder.
J Affect Disord
September 2019
Background: Major depressive disorder (MDD) is associated with abnormalities in brain structure. However, structural abnormality findings have been inconsistent and how structural changes lead to progressive morphometric alterations in depressed brain regions remains unclear.
Methods: High-resolution T1-weighted magnetic resonance images of first-episode medication-naïve MDD patients (20 men, 36 women) and healthy control participants (33 men, 23 women) were evaluated.
Background: Women are more susceptible to major depressive disorder (MDD). A possible explanation is that women have a trait tendency to engage in a ruminative response style. Depending on cognitive model of depression, attention bias, memory bias and self-referential bias were closely related among depressed patients.
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