Durable response to venetoclax, azacytidine, and ruxolitinib in chronic-phase myelofibrosis resistant to ruxolitinib: a case report and literature review.

Myelofibrosis (MF) is a philadelphia chromosome-negative chronic myeloprolifera- tive neoplasm.It has a worse prognosis than polycythemia vera and essential thrombocy- themia.At present,both Chinese and foreign guidelines recommend ruxolitinib as first-line treatment for IPSS/DIPSS/DIPSS-Plus patients with splenomegaly in intermediate-risk-2 and high-risk MF-CP.

NONO regulates monocyte-macrophage lineage differentiation through a potential PI3K/AKT-dependent mechanism.

Non-POU domain containing octamer binding protein (NONO) is a multifunctional nuclear protein which plays important roles in regulating nuclear processes such as transcription and splicing. We aimed to delineate the effects and the underlying mechanisms of NONO on monocyte-macrophage lineage differentiation. By depolying a phorbol 12-myristate 13-acetate (PMA)-induced THP-1 cell differentiation model and a macrophage colony-stimulating factor (M-CSF)-induced mouse bone marrow cell differentiation model, we examined the expression pattern and the effects of NONO during monocyte-macrophage lineage differentiation.

Association of serum 25-hydroxyvitamin D with cataract: a cross-sectional and longitudinal analysis of the UK Biobank.

Background: The association between vitamin D deficiency and cataract is debated, with limited longitudinal data on serum 25-hydroxyvitamin D (25(OH)D) levels in cataract development. This study aimed to examine both cross-sectional and longitudinal associations between serum 25(OH)D concentrations and cataract risk.

Methods: The cross-sectional analyses included 442 255 UK Biobank participants with available serum 25(OH)D data.

Sleep, physical activity, sedentary behavior, and risk of cataract: a cross-sectional and prospective study from UK Biobank.

Background: Cataract is a leading cause of visual impairment globally. Although daily behaviors such as sleep, physical activity (PA), and sedentary behavior (SB) have been associated with cataract risk, the evidence remains controversial and uncertain. This study aimed to examine the independent and combined effects of sleep, PA, and SB on cataract risk using data from the UK Biobank.

Metabolomic profiling reveals interindividual metabolic variability and its association with cardiovascular-kidney-metabolic syndrome risk.

Background And Objective: Cardiovascular-Kidney-Metabolic (CKM) syndrome reflects the interrelated pathophysiology of obesity, insulin resistance, type 2 diabetes, chronic kidney disease, and cardiovascular disease. Conventional CKM staging often detects risk only after substantial organ dysfunction and may overlook early metabolic heterogeneity. This study aimed to employ plasma metabolomics to identify metabolic subtypes linked to CKM severity and explore early biomarkers for high-risk individuals.

[Retracted] Fisetin inhibits migration, invasion and epithelial‑mesenchymal transition of LMP1‑positive nasopharyngeal carcinoma cells.

Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that the cell migration and invasion assay data shown in Fig. 1A and B on p. 415 contained a number of overlapping data sections, such that data which were intended to show the results from differently performed experiments had apparently been derived from the same original sources.

Mechanisms of nurses' AI use intention formation in Sichuan, Yunnan, and Beijing, China: mediating effects of AI literacy via self-efficacy-to-attitude pathways.

Aim: This study aimed to explore the formation mechanism of artificial intelligence (AI) usage intention among nurses in public hospitals in Beijing, Sichuan, and Yunnan, China, analyzing the influence of AI literacy on usage intention through AI self-efficacy and general attitudes.

Methods: A multi-center cross-sectional design was adopted, surveying 901 registered nurses via the Wenjuanxing platform from December 26, 2024, to February 25, 2025, with 878 valid questionnaires returned (effective rate 97.45%).

Development of 3-Year Risk Prediction Model for Type 2 Diabetes in Older Adults with Prediabetes - China, 2019-2022.

What Is Already Known About This Topic?: Prediabetes increases the risk of developing type 2 diabetes. Existing prediction models for incident diabetes from prediabetes have been primarily developed for the general adult population.

What Is Added By This Report?: This report introduces a prediction model for progression to diabetes from prediabetes, specifically for older adults, which includes age, exercise, waist circumference, baseline fasting plasma glucose (FPG) and triglyceride concentrations, systolic blood pressure, and dessert intake.

Neuromorphic Polarization Vision Enabled by Organic Single-Crystal Photosynaptic Transistors.

Polarization vision, a highly sophisticated visual capability in insects such as butterflies and bees, plays a pivotal role in enabling survival-critical ecological behaviors, such as navigation, intraspecific communication, mating, and habitat selection. However, the replication of this capability in artificial systems has long been impeded by the limited dichroic ratio (DR, typically < 10) of existing materials and the complexity of conventional optical designs. Here, the first time a bioinspired polarization-sensitive photosynaptic transistor is developed based on organic micro-crystal arrays for neuromorphic polarization vision.

Performance Regulation of Sulfonated Poly(ether ether ketone) for Preparing Multi-Adaptive Electrolyte and Battery Separator of Wide-Temperature Flexible Zn-Air Batteries.

Herein, sulfonated poly(ether ether ketone) (SPEEK) is employed to fabricate both the separator and gel electrolyte for solid zinc-air batteries (ZABs), leveraging its rigid backbone and abundant sulfonic acid groups in side chains of SPEEK. Incorporating glycerol into the separator (making SPEEKG-Zn) enhances its low-temperature performance. In the SPEEKG-Zn separator, the sulfonic acid groups of SPEEKG-Zn facilitate uniform deposition of Zn on Zn anode and suppress OH transfer through interacting with Zn.

A Versatile Reporter Platform for Evaluating HDR- and NHEJ-Based Genome Editing in Airway Epithelial Cell Cultures Using an rAAV Vector.

Therapeutic gene editing strategies utilize endogenous DNA repair pathways-nonhomologous end joining (NHEJ) or homology-directed repair (HDR)-to introduce targeted genomic modifications. Because HDR is restricted to dividing cells, whereas NHEJ functions in both dividing and non-dividing cells, NHEJ-based approaches are better suited for in vivo gene editing in the largely post-mitotic airway epithelium. Homology-independent targeted insertion (HITI), an NHEJ-based method, offers a promising strategy for cystic fibrosis (CF) gene therapy.

Carboxymethyl chitosan modification via EDC/NHS-mediated amidation for performance improvement on blood-contacting biomedical membranes.

Blood-contacting membranes require hydrophobicity to prevent leakage but suffer from poor hemocompatibility. Hydrophilic modification represents a key strategy to address this limitation. Herein, hydrophilic carboxymethyl-chitosan (CMCS) modification onto polyethersulfone (PES) membrane (CMCS-PES) was achieved via thermal-crosslinking and amidation reaction, followed by characterization through SEM, AFM, FTIR, XPS, BET, as well as water contact angle measurements, and systematic evaluation for its performance in hemocompatibility, antibacterial activity, long-term stability, and gas permeation.

Premature mortality projection for diabetes to 2030: a subnational evaluation towards the Healthy China 2030 Goals.

The Healthy China 2030 Plan set the goal of reducing premature deaths from diabetes by 30% by 2030. However, there has been a lack of assessment of premature mortality for diabetes since the action plan was issued. This study used data from the Global Burden of Disease Study 2021, calculated the premature deaths for diabetes by sex, provinces, and subtypes from 1990 to 2021.

Effect of compost as a soil amendment on the structure and function of fungal diversity in saline-alkali soil.

Agricultural productivity is significantly impeded by salinization, which also adversely affects the environment. The use of compost as a soil conditioner has been shown to effectively ameliorate saline-alkali soils. Nonetheless, there is a paucity of research investigating the effects of compost on microbial populations within these soils.

Transformation of Biomass Precursor into Both High-Efficiency Cathode Catalyst and Solid Electrolyte for Rechargeable Zn-Air Batteries.

Cattail grass biomass is used as the precursor for preparing both bi-functional cathode catalyst and solid electrolyte in the construction of high-performance Zn-air battery (ZAB). First, cattail grass is transformed into porous carbon micron tubes (CMTs), which are immobilized by polyoxometalate clusters of (Hbimb) {Cd(PMoOH)}·5.5HO (bimb = 4,4-di(1H-imidazole-1-yl)-1,1-biphenyl) (abbreviation: {Cd(PMo)}), and then calcinated in N to form MoC-MoO/CMTs.

Molecule upgrading metal-semiconductor buried contacts for high-performance and high-ideality single-crystal organic thin-film transistors.

Achieving high-quality electrical contact at metal/organic semiconductor interfaces is crucial for unlocking the full potential of single-crystal organic thin-film transistors (SC OTFTs). However, the delicate nature of organic single-crystalline films (OSCFs) and the harsh metal deposition process often introduce trap states at the interface, limiting SC-OTFT performance. Here, we present a transparent electrical contact concept that leverages the spontaneous reaction of fluorinated thiol molecules with the electrode, enhancing the buried metal/OSCF contacts.

Transboundary impacts of microplastics within planetary boundaries: Regulation and responses of soil-plant systems under climate change.

Microplastics pollution and climate change are two critical environmental concerns today, with land serving as the primary source and significant reservoir of microplastics. According to the latest estimates, by 2050,12 billion tons of plastics will be dumped into landfills and natural environments. Microplastics, defined as particles smaller than 5 mm in diameter, pose an even greater threat when they break down into nanoparticles less than 0.

Adverse cardiac events associated with antibody drug conjugates in cancer patients: a retrospective analysis on the FAERS database and randomized controlled trials.

Aims: Antibody Drug Conjugates(ADCs) are approved for use in cancers. Cardiovascular adverse reaction is a fatal adverse reactions associated with ADCs. The incidence of adverse cardiac events about ADCs have not been fully studied.

Recombinant Adeno-Associated Virus Vector Mediated Gene Editing in Proliferating and Polarized Cultures of Human Airway Epithelial Cells.

Cystic fibrosis (CF) is caused by mutations in the () gene. While CRISPR-based editing approaches have shown proof-of-concept for functional rescue in primary airway basal cells, induced pluripotent stem cells, and organoid cultures derived from patients with CF, their efficacy remains suboptimal. Here, we developed the CuFi reporter system by integrating spCas9 and a non-fluorescent Y66S eGFP mutant into CuFi-8 cells, an immortalized human airway epithelial cell line derived from a patient with CF with homozygous F508del mutations.

Diverse abietane diterpenoids as multifunctional antimicrobial effects from Salvia castanea.

Background: Phytopathogenic fungal diseases significantly impact the quality of vegetables and fruits in agriculture. Salvia castanea, a Tibetan medicinal plant, possessed anti-inflammatory, antitumor, and antimicrobial activities. Therefore, we investigated the antimicrobial ingredients from this plant and clarified their protective and curative in plants in detail.

Characterizations of lung cancer microbiome and exploration of potential microbial risk factors for lung cancer.

Recent studies have indicated that the lung microbiome may contribute to the development and progression of lung cancer, although the precise mechanisms remain to be fully elucidated. This study sought to delineate the microbial composition within lung cancer tissues and identify potential microbial risk factors. Tissue samples were collected from patients newly diagnosed with pulmonary opacities, and metagenomic next-generation sequencing was employed to analyze these samples.

Associations of Cardiovascular Health and New-Onset Age-Related Macular Diseases From UK Biobank.

Purpose: This study aimed to investigate the correlation between cardiovascular health (CVH), evaluated through the Life's Essential 8 (LE8) score, and the risk of new-onset age-related macular degeneration (AMD).

Methods: This longitudinal analysis included 271,274 participants who were free of both cardiovascular diseases and AMD at baseline. The LE8 score was classified into three categories: low (<50 points), moderate (50 to <80 points), and high (≥80 points), with higher scores indicating better CVH.

Analysis of the Current Situation and Influencing Factors of Nurses' Voice Behavior in Neonatal Intensive Care Units of Grade A Tertiary Hospitals in Sichuan Province: A Multicenter Cross-Sectional Study.

Voice behavior refers to nurses' proactive actions in offering constructive suggestions, providing feedback, or raising concerns in the workplace, which are crucial for enhancing care quality and improving the work environment. This study aims to investigate the current status and influencing factors of voice behavior among nurses in neonatal intensive care units (NICUs) in tertiary hospitals in Sichuan Province, providing empirical evidence for improved nursing management and hospital administration. A multicenter, crosssectional survey.

A retrospective study to investigate the risk factors for gestational diabetes mellitus and its impact on maternal and neonatal outcomes.

Background: Currently, risk factors for gestational diabetes mellitus (GDM) and its impact on maternal and neonatal outcomes have not been fully elucidated. Therefore, we performed a retrospective epidemiologic study to explore the above research objectives.

Methods: We collected extensive clinical data from January 2020 to June 2023 for 855 maternity cases at the Department of Obstetrics and Gynecology, Chaoyang Hospital, Capital Medical University.

Impacts of Climate Change and Human Activity on the Habitat Distribution of .

Extensive evidence supports that global climate change influences shifts in species habitats due to alterations in hydrothermal conditions; however, neglecting dispersal capacities and limits significantly heightens uncertainties regarding spatial distribution patterns among different organisms. In this study, we compared the spatial distribution of Hu & W.C.