Oriented porous microtubules combined with CNTF-delivery directional guide axonal regeneration after traumatic optic neuropathy.

Neuroinflammation microenvironment and retinal ganglion cell (RGC) apoptosis are two critical barriers to axonal regeneration following traumatic optic neuropathy (TON). To overcome these challenges, we developed an innovative dual drug delivery strategy utilizing oriented porous nanofiber (OF) and ciliary neurotrophic factor (CNTF)-loaded delivery systems, aiming to promote axonal regeneration and restore RGC survival. Cerium oxide nanoparticles (Ce NPs) were physically mixed with poly(L-lactic acid)/polycaprolactone (PLA/PCL) solution to prepare oriented porous nanofibers (OF-Ce) via electrospinning and solvent evaporation techniques.

Investigation of a norovirus outbreak among hospital staff in Zhejiang, China: tracing the source to contaminated "red bean cake".

While nosocomial norovirus transmission in hospitalized patients is well characterized, its transmission dynamics among HCWs remain poorly documented. This investigation of HCW-focused norovirus transmission provides critical epidemiological evidence to refine infection control protocols for gastroenteritis in healthcare settings. This study utilized a retrospective case-control design to systematically analyze outbreak transmission dynamics.

Yunnan Baiyao (YNBY): pharmacological mechanisms, therapeutic applications, and clinical evidence.

Yunnan Baiyao (YNBY) is a traditional Chinese medicine widely used in hemostasis, anti-inflammation, antibacterial, analgesia and wound healing. This article reviews the research progress on the pharmacological mechanism, clinical application and safety of YNBY in the past two decades. Through systematic analysis of clinical trials, animal experiments and mechanistic studies, YNBY has shown significant effects in reducing surgical bleeding (such as reducing blood loss in orthognathic surgery by 21.

Yunnan Baiyao regulates Th17/Treg cell homeostasis to inhibit periodontitis through the miR-155-5p/ATG5 pathway.

Background: Periodontitis is the most common inflammatory disease in the oral cavity. Yunnan Baiyao (YNBY), a traditional Chinese medicine, can effectively eliminate inflammation. Our research group revealed that YNBY can be used treat periodontitis and regulate the differentiation of T-helper (Th17) and regulatory T (Treg) cells in the inflammatory environment.

"I don't want to learn translation": Exploring the systemic roots of burnout among translation master's students.

This study explored the systemic causes of learning burnout among master's students in translation and interpreting programs and developed a theoretical model to illustrate the interrelationships among these causes. Using grounded theory as the research methodology, the study conducted semi-structured interviews with 23 translation master's students from 4 universities in China. The findings revealed that learning burnout was influenced by multiple factors across four key environments: social, institutional, and proximal environments, and personal habitus.

Molecule upgrading metal-semiconductor buried contacts for high-performance and high-ideality single-crystal organic thin-film transistors.

Achieving high-quality electrical contact at metal/organic semiconductor interfaces is crucial for unlocking the full potential of single-crystal organic thin-film transistors (SC OTFTs). However, the delicate nature of organic single-crystalline films (OSCFs) and the harsh metal deposition process often introduce trap states at the interface, limiting SC-OTFT performance. Here, we present a transparent electrical contact concept that leverages the spontaneous reaction of fluorinated thiol molecules with the electrode, enhancing the buried metal/OSCF contacts.

Navigating cognitive dissonance: master's students' experiences with ChatGPT in dissertation writing.

With the increasing prevalence of AI tools like ChatGPT in academic settings, understanding their impact on students' psychological experiences during dissertation writing is crucial. This study aims to explore the cognitive dissonance experienced by master's students during dissertation writing with the assistance of ChatGPT and identify the strategies they employ to manage this dissonance. Using grounded theory as the primary research methodology, we analyzed 28 interview transcripts to uncover key elements of cognitive dissonance and develop a corresponding theoretical model.

Disappearing Integrative Motivation: A Validated Scale of Motivation for Learners of Southeast Asian Languages.

This study aimed to develop and validate a motivation scale specifically designed for university students enrolled in Southeast Asian language programs. Utilizing a thematic analysis of interviews with 28 students, five key motivational dimensions were identified: institutional environment, proficiency demand, self-development planning, social responsibilities, and intrinsic interest. These dimensions informed the construction of an initial scale, which was empirically tested and refined through two rounds of validation.

Characteristics and timeliness of intervention in 47 school-based enterovirus outbreaks in Zhejiang Province, China.

Background: Hand, foot, and mouth disease (HFMD) and herpangina (HA) are common infectious diseases in children that can frequently lead to outbreaks. Analyzing the characteristics of school-based outbreaks and evaluating the timeliness of prevention and control measures can provide valuable insight for early identification, timely warnings, and the development of prevention strategies.

Methods: This study collected data on HFMD and HA outbreaks in Zhejiang Province from 2021 to 2023, providing a comprehensive analysis of the pathogen spectrum, epidemiology, and clinical characteristics of each outbreak.

Large-Area Deposition of Highly Crystalline F4-Tetracyanoquinodimethane Thin Films by Molecular Step Templates.

Theoretical studies have unequivocally determined the exceptional electron transport properties of the fluorinated tetracyanoquinodimethane (F-TCNQ) family, presenting a promising avenue for the realization of high-performance n-channel organic thin-film transistors (OTFTs). However, owing to the intrinsic low crystallinity of this class of materials, F-TCNQ-based n-channel OTFTs have not been experimentally achieved so far. Herein, a molecular step template (MST)-assisted method that dramatically improves the crystallinity of F4-TCNQ thin films is reported.

Genetic nexus of assisted reproduction technique efficacy in infertile women: insights from a comprehensive retrospective study.

Infertility presents a substantial challenge for women of reproductive age, exerting profound effects on both individual well-being and healthcare systems. Despite its critical role in folate and homocysteine pathways, the influence of methylenetetrahydrofolate reductase (MTHFR) on the success of assisted reproductive techniques (ART) remains insufficiently understood. This knowledge gap impedes the development of personalized therapeutic strategies.

Low-Power and High-Gain Organic Transistors Achieved Through an Ideal Contact Approaching the Schottky-Mott Limit.

The advancement of flexible electronics necessitates low-power and high-gain organic transistors endowed with the capability to amplify feeble signals, meeting the demands of signal processing and transmission. Despite a myriad of endeavors, the intrinsic gain () of organic transistors at low supply voltage is conditioned by extrinsic losses attributable to imperfections at the electrical contact. Here, we push the metal-organic semiconductor contact close to the ideal Schottky-Mott model through a blade-coating-induced meniscus extension method, which allows the growth of organic single-crystalline films on multiple and uneven electrode heterointerfaces.

Effect and mechanism of Sanqi () in treating periodontitis.

Objective: To investigate the effect and mechanism of Sanqi () in treating periodontitis.

Methods: The active components and periodontitis targets were analyzed through network pharmacology and molecular docking. A rat model of periodontitis was established and rats were treated by continuous intragastric administration of Sanqi () at different doses for 30 d.

Single-Cell and Transcriptome Analysis of Periodontitis: Molecular Subtypes and Biomarkers Linked to Mitochondrial Dysfunction and Immunity.

Background: Periodontitis represents an inflammatory disease with multiple contributing factors, affecting both oral and systemic health. The mechanisms linking mitochondrial dysfunction to immune responses in periodontitis remain unclear, limiting the development of individualized diagnostic and therapeutic approaches.

Objective:  This study aims to elucidate the roles of mitochondrial dysfunction and immune responses in the pathogenesis of periodontitis, identify distinct molecular subtypes, and discover robust diagnostic biomarkers to support precision medicine approaches.

Bioinspired adhesive polydopamine-metal-organic framework functionalized 3D customized scaffolds with enhanced angiogenesis, immunomodulation, and osteogenesis for orbital bone reconstruction.

Critical-sized orbital bone defects can lead to significant maxillofacial deformities and even eye movement disorders. The challenges associated with these defects, including their complicated structure, inadequate blood supply, and limited availability of progenitor cells that hinder successful repair. To overcome these issues, we developed a novel approach using computer numerical control (CNC) material reduction manufacturing technology to produce a customized polyetheretherketone (PEEK) scaffold that conforms to the specific shape of orbital bone defects.

Luteolin ameliorates periodontitis by modulating mitochondrial dynamics and macrophage polarization via the JAK2/STAT3 pathway.

Background: Periodontal disease (PD) is a chronic inflammatory condition affecting oral and systemic health. Luteolin (LUT), a natural flavonoid, has shown anti-inflammatory effects, but its therapeutic potential and mechanisms in PD remain unclear.

Objective: This study aimed to investigate the effects of LUT on PD, focusing on its impact on mitochondrial dynamics, macrophage polarization, and the JAK2/STAT3 signaling pathway.

Modeling college EFL teachers' intentions to conduct academic research: Integrating theory of planned behavior with self-determination theory.

This study constructed a robust theoretical model aimed at elucidating the determinants that shape college EFL teachers' research intentions by integrating the tenets of Self-Determination Theory (SDT) with Theory of Planned Behavior (TPB). This model was empirically validated using data from 271 EFL teachers from eight colleges in China, selected through stratified sampling and collected via paper questionnaires, then analyzed using structural equation modeling. The findings underscore the instrumental roles of both autonomous and controlled motivations in driving research-related behaviors, thereby reinforcing the foundational concepts of SDT.

Injectable hydrogel encapsulating siMMP13 with anti-ROS and anti-apoptotic functions for osteoarthritis treatment.

Background: Osteoarthritis (OA) is a degenerative joint disease characterized by the progressive degeneration of articular cartilage, leading to pain, stiffness, and loss of joint function. The pathogenesis of OA involves multiple factors, including increased intracellular reactive oxygen species (ROS), enhanced chondrocyte apoptosis, and disturbances in cartilage matrix metabolism. These processes contribute to the breakdown of the extracellular matrix (ECM) and the loss of cartilage integrity, ultimately resulting in joint damage and dysfunction.

Clinical characteristics and risk factors of Hepatitis E virus infection in Zhejiang Province: a multicenter case-control study.

Introduction: Hepatitis E (HE), caused by the Hepatitis E virus (HEV), is a significant cause of acute viral hepatitis globally and a major public health concern, particularly in specific high-prevalence areas in China, which have diverse transmission routes and regional differences. Identifying the primary risk factors for HE transmission is essential to develop targeted interventions for vulnerable populations.

Methods: This study employed a 1:1 matched case-control methodology, using a standardized questionnaire complemented by medical records for data validation.

Quercetin through miR-147-5p/Clip3 axis reducing Th17 cell differentiation to alleviate periodontitis.

Background: Quercetin (QU) plays an important role in treating periodontitis; however, the mechanism through which microRNAs regulate Th17 cell differentiation has not been determined.

Methods: QU was administered intragastrically to periodontitis rats once a day for one month. The morphology of alveolar bone was observed by micro-CT, gingival tissue structure was observed by HE staining, IL-6, TNF-α, IL-17A, RORγt, FOXP3 and IL-10 were detected by immunohistochemical staining, and Th17 and Treg cells in the peripheral blood were detected by flow cytometry.

Bionic Scotopic Adaptation Transistors for Nighttime Low Illumination Imaging.

Human vision excels in perceiving nighttime low illumination due to biological feedforward adaptation. Replicating this ability in biomimetic vision using solid-state devices has been highly sought after. However, emulating scotopic adaptation, entailing a confluence of efficient photoexcitation and dynamic carrier modulation, presents formidable challenges.

Targeting ferroptosis as a potential strategy to overcome the resistance of cisplatin in oral squamous cell carcinoma.

Oral squamous cell carcinoma (OSCC) is a crucial public health problem, accounting for approximately 2% of all cancers globally and 90% of oral malignancies over the world. Unfortunately, despite the achievements in surgery, radiotherapy, and chemotherapy techniques over the past decades, OSCC patients still low 5-year survival rate. Cisplatin, a platinum-containing drug, serves as one of the first-line chemotherapeutic agents of OSCC.

Yunnan Baiyao Might Mitigate Periodontitis Bone Destruction by Inhibiting Autophagy and Promoting Osteoblast Differentiation in vivo, ex vivo and in vitro.

Background And Objective: Periodontitis is an inflammatory disease that eventually destroys tooth-supporting tissue. Yunnan Baiyao (YNBY), a traditional Chinese medicine compound with haemostatic and anti-inflammatory properties has shown therapeutic potential in several diseases. Our previous study revealed that YNBY suppressed osteoclast differentiation in periodontitis.

An outbreak of hepatitis E virus genotype 4d caused by consuming undercooked pig liver in a nursing home in Zhejiang Province, China.

Hepatitis E infection is typically caused by contaminated water or food. In July and August 2022, an outbreak of hepatitis E was reported in a nursing home in Zhejiang Province, China. Local authorities and workers took immediate actions to confirm the outbreak, investigated the sources of infection and routes of transmission, took measures to terminate the outbreak, and summarized the lessons learned.