The optimal strategy for seasonal influenza vaccination to prevent high-intensity level of influenza epidemics in Zhejiang, China: an integrated transmission-dynamic and health-economic modeling analysis.

Background: Although Seasonal Influenza Vaccination (SIV) is a crucial preventive measure, achieving sufficient coverage to completely control influenza epidemics poses a significant challenge. This study aims to evaluate optimal strategies for SIV to prevent high-intensity level of influenza epidemics in Zhejiang Province, China. High-intensity outbreaks were defined as weekly incidence rates above 72.

Effects of influenza vaccination on neurodegenerative and demyelinating disorders: a systematic review and meta-analysis.

Background: Previous studies have highlighted potential associations between influenza vaccination (IV) and neurological outcomes, particularly neurodegenerative disorders (NDs) and demyelinating disorders (DDs). However, the existing evidence remains inconclusive. Given the widespread global uptake of IV, even small potential effects may carry important public health implications.

Global, regional, and national characteristics of the main causes of increased disease burden due to the covid-19 pandemic: time-series modelling analysis of global burden of disease study 2021.

Objective: To quantify and identify the main causes of increased disease burden due to coronavirus disease 2019 (covid-19) pandemic.

Design: Time-series modelling study.

Data Source: Global Burden of Disease Study 2021.

Epidemic characteristics and effectiveness of vaccine intervention on rotavirus infection: a real-world observational study in Zhejiang Province, China.

Background: Rotavirus infection, the most common cause of infant infectious diarrhoea and related deaths worldwide, has imposed a high disease burden in China, especially in Zhejiang Province. This study described the overall epidemiological characteristics and trends of reported rotavirus infections in Zhejiang Province from 2005 to 2022 and evaluated the effectiveness of rotavirus vaccines on the incidence of rotavirus infection.

Materials And Methods: Data on reported cases of rotavirus infection from 2005 to 2022 were extracted from the China Disease Prevention and Control Information System.

Epidemiological characteristics and risk distribution prediction of severe fever with thrombocytopenia syndrome in Zhejiang Province, China.

Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease, garnering increasing attention due to rising case numbers and expanding geographical reach. However, there is limited research on the potential factors influencing the distribution of SFTS.

Methods: Data on SFTS cases in Zhejiang province were obtained from 2011 to 2022.

Genetic nexus of assisted reproduction technique efficacy in infertile women: insights from a comprehensive retrospective study.

Infertility presents a substantial challenge for women of reproductive age, exerting profound effects on both individual well-being and healthcare systems. Despite its critical role in folate and homocysteine pathways, the influence of methylenetetrahydrofolate reductase (MTHFR) on the success of assisted reproductive techniques (ART) remains insufficiently understood. This knowledge gap impedes the development of personalized therapeutic strategies.

Global patterns and trends in deaths of influenza-associated lower respiratory infections from 1990 to 2019.

This study examined global trends in influenza-associated lower respiratory infections (LRIs) deaths from 1990 to 2019 using data from the GBD 2019. The annual percentage change (APC) and average annual percentage change (AAPC) were used to analyze age-standardized death rates (ASDR). Globally, the ASDR of influenza-associated LRIs was 3.

Immune memory in hepatitis E virus: a comparative study of natural infection and vaccination in a nursing home population.

Immune memory is crucial for preventing hepatitis E virus (HEV) infection. Our study aims to investigate immunological memory characteristics and differences between vaccination and natural HEV infection, taking into account that both can induce immune memory. We recruited 60 HEV-infected patients, 58 contingency HEV-vaccinated individuals and 4 controls from an outbreak of hepatitis E in a nursing home between June and August 2023.

Adherence to mask-wearing and its impact on the incidence and deaths of viral respiratory infectious diseases: a systematic review, meta-analysis and modelling study.

Background: This study systematically analysed global and regional adherence to mask-wearing and its impact on the incidence and deaths of viral respiratory infectious diseases (VRIDs).

Methods: Relevant studies were sourced from PubMed, Web of Science, Embase and Scopus. We included observational studies with available raw data on mask-wearing adherence (rates of acceptability of mask-wearing, mask-wearing in public settings and correct mask-wearing) during VRID pandemics/epidemics.

Age-specific abnormal glucose metabolism in HIV-positive people on antiviral therapy in China: a multicenter case-control study.

Background: Update, the link between HIV infection and abnormal glucose metabolism (AGM) is still unclear. This study aims to investigate the impact of HIV infection on AGM, including insulin resistance (IR), impaired fasting glucose (IFG), and diabetes mellitus (DM).

Methods: A multicenter case-control study was conducted in Zhejiang province, China.

The impacts of the COVID-19 pandemic on the burden of maternal and neonatal disorders: A counterfactual modeling based on the global burden of disease study (2021).

Objectives: During the COVID-19 pandemic, global health systems faced unprecedented challenges, as well as in maternal and neonatal health, thus this study aims to clarify the impacts of COVID-19 on maternal and neonatal disorders (MNDs), regional variations, and the role of economic support.

Methods: We have developed a counterfactual model integrating Autoregressive Integrated Moving Average and Long Short-Term Memory models to forecast the burden of MNDs from 2020 To et al., 2021, which was compared with the actual burden to quantify the specific impact of the COVID-19 pandemic on MNDs.

Follicular cytotoxic T cells is dysfunctional in chronic hepatitis B patients with non-alcoholic fatty liver disease.

Background & Aims: Given the impact of nonalcoholic fatty liver disease (NAFLD) on T cell activation and proliferation functions, we aim to explore the heterogeneity of follicular cytotoxic T (Tfc) cells in chronic hepatitis B (CHB) patients with NAFLD.

Methods: 32 healthy controls (HCs), 36 treatment-naïve CHB patients, and 19 treatment-naïve CHB + NAFLD patients were recruited. We employed multicolor flow cytometry to assess the exhausted phenotype and functionality of Tfc cells.

Risk distribution of human infections with avian influenza A (H5N1, H5N6, H9N2 and H7N9) viruses in China.

Background: This study aimed to investigate epidemiologic characteristics of major human infection with avian influenza and explore the factors underlying the spatial distributions, particularly H5N6 and H9N2, as H9N2 could directly infect mankind and contribute partial or even whole internal genes to generate novel human-lethal reassortants such as H5N6. They pose potential threats to public health and agriculture.

Methods: This study collected cases of H5N1, H5N6, H9N2, and H7N9 in China, along with data on ecoclimatic, environmental, social and demographic factors at the provincial level.

An Infrequent 1D Manganese-Tin Selenide with Bifunctional Catalytic Properties.

The optoelectronic, electrocatalytic, and photocatalytic properties of new tin selenides are of great significance for various energy applications. Herein, a facile solvothermal reaction of Sn, Se, and MnCl in 1,3-propodiamine (1,3-dap) solution at 150 °C for 7 days was used to achieve a new type of one-dimensional (1D) organic hybrid manganese-tin selenide [Mn(1,3-dap)(μ-1,3-dap)SnSe] (), whose 1D framework is built up from the linkage of rare unsaturated binuclear [Mn(1,3-dap)(μ-1,3-dap)] cations and dimeric [SnSe] anions. The combination of and Ni nanoparticle is first applied for the preparation of a Ni//NF electrode (NF = porous Ni foam) as the efficient electrocatalyst for the hydrogen evolution reaction (HER), indicating excellent HER electrocatalytic property with an overpotential of 117 mV at 10 mA·cm in a neutral medium.

Association of triglyceride-glucose index with severity of coronary artery disease among male patients.

The correlation between diabetes and coronary artery disease (CAD) is well established. Insulin resistance (IR) is considered a primary contributor to elevated CAD risk in diabetic individuals. The triglyceride-glucose (TyG) index serves as a straightforward surrogate marker for insulin resistance.

Omicron variant infection worsen the prognosis of haemodialysis (HD) patients.

Background: Haemodialysis (HD) patients are predisposed to physical ailments, and their occurrence of coronavirus disease 2019 (COVID-19) could potentially lead to a more unfavourable prognosis. However, the impact of SARS-CoV-2 (Omicron variant) infection on the prognosis of HD patients remains unclear. This study aimed to explore the impact of Omicron variant infection on the prognosis of HD patients.

Global years lived with disability for musculoskeletal disorders in adults 70 Years and older from 1990 to 2019, and projections to 2040.

In this article, we provided a comprehensive overview and in-depth analysis of global patterns and temporal trends in years lived with disability (YLDs) for musculoskeletal (MSK) disorders in individuals aged ≥70. Data on YLDs for MSK disorders in individuals aged ≥70 were obtained from the Global Burden of Disease 2019. The average annual percentage change (AAPC) was calculated to assess the temporal trends in the YLDs rate of MSK disorders.

Association of testosterone with myocardial infarction and severity of coronary artery disease among male patients.

Background: Coronary heart disease (CHD) remains a leading cause of morbidity and mortality, particularly in aging populations. Men typically exhibit higher rates of CHD compared to women, with testosterone levels inversely associated with cardiovascular risk. This study investigates the relationship between testosterone levels and angiographically confirmed CHD, disease severity, and myocardial infarction (MI) among CHD cases.

The association between depression during perimenopause and progression of chronic conditions and multimorbidity: results from a Chinese prospective cohort.

Purpose: The association between perimenopausal depression and many chronic conditions among women has been well-established. However, the role of depression during perimenopause in the progression of multiple chronic conditions (multimorbidity) remains poorly understood.

Material And Methods: A total of 1,216 community-dwelling women in their perimenopause period between 2010 and 2016 were enrolled in our analysis, and followed up for the progression of multimorbidity.

Electric Insulating Irrigations Mitigates Esophageal Injury Caused by Button Battery Ingestion.

Objective: Accidental ingestion of button batteries (BB), usually occurred in children and infants, will rapidly erode the esophagus and result in severe complications, even death. It has been recommended that treatment of this emergent accident as soon as possible with drinking of pH-neutralizing viscous solutions such as honey and sucralfate before surgical removal can mitigate the esophageal injury. Recently, we reported that the electric insulating solutions such as edible oils could mitigate tissue damage in BB-exposed esophageal segments.

A Mutation-Related Long Noncoding RNA Signature of Genome Instability Predicts Immune Infiltration and Hepatocellular Carcinoma Prognosis.

Long noncoding RNAs (lncRNAs) have been discovered to play a regulatory role in genomic instability (GI), which participates in the carcinogenesis of various cancers, including hepatocellular carcinoma (HCC). We endeavored to establish a GI-derived lncRNA signature (GILncSig) as a potential biomarker and explore its impact on immune infiltration and prognostic significance. Combining expression and somatic mutation profiles from The Cancer Genome Atlas database, we identified GI-related lncRNAs and conducted functional analyses on co-expressed genes.