Investigation of a norovirus outbreak among hospital staff in Zhejiang, China: tracing the source to contaminated "red bean cake".

While nosocomial norovirus transmission in hospitalized patients is well characterized, its transmission dynamics among HCWs remain poorly documented. This investigation of HCW-focused norovirus transmission provides critical epidemiological evidence to refine infection control protocols for gastroenteritis in healthcare settings. This study utilized a retrospective case-control design to systematically analyze outbreak transmission dynamics.

Follow-up of antibody changes in brucellosis patients in Gansu, China.

Unlabelled: Brucellosis, caused by the intracellular bacterium , often leads to chronic infection with recurrent symptoms, posing significant therapeutic challenges. Effective monitoring of antibody dynamics is crucial for understanding disease progression and enhancing clinical outcomes. To investigate the longitudinal dynamics of antibody titers and antigen-specific responses in animal husbandry practitioners exposed to brucellosis in Gansu, China.

Maternal F1 antibodies and cytokines in mother-neonate dog pairs in the plague focus.

In this study, we investigated the F1 antibody against in the sera of mother-neonate shepherd dog pairs in the plague focus of the Altun-Qilian Mountains, Qinghai-Tibetan Plateau, China. Seropositive shepherd dogs lived in plague-endemic regions, where marmots were infected with , whereas seronegative dogs lived in non-endemic regions. The neonatal F1 antibody titers positively correlated with the maternal titers within 3 months after birth, and the neonatal titers were similar to or slightly lower than the maternal titers.

Symbiosis of a lytic bacteriophage and and characteristics of plague in .

Surveillance for animal plague was conducted in the plague focus of the Qinghai-Tibet Plateau from 2020 to 2023. A 22.89% positive rate of serum F1 antibody was detected in live-caught marmots, alongside a 43.

Relationship Between Climate Change and Marmot Plague of Plague Focus - the Altun Mountains of the Qinghai-Xizang Plateau, China, 2000-2022.

Introduction: Plague is a zoonotic disease that occurs naturally in specific geographic areas. Climate change can influence the populations of the plague host or vector, leading to variations in the occurrence and epidemiology of plague in animals.

Methods: In this study, we collected meteorological and plague epidemiological data from the plague focus in the Altun Mountains of the Qinghai-Xizang Plateau.

The complex genomic diversity of on the long-term plague foci in Qinghai-Tibet plateau.

Plague is a typical natural focus disease that circulates in different ecology of vectors and reservoir hosts. We conducted genomic population and phylogenetic analyses of the collected from the 12 natural plague foci in China with more than 20 kinds of hosts and vectors. Different ecological landscapes with specific hosts, vectors, and habitat which shape various niches for .

Performance of Exergetic, Energetic and Techno-Economic Analyses on a Gas-Type Industrial Drying System of Black Tea.

The purpose of this research work is to perform detailed exergetic, energetic and techno-economic analysis of the black tea drying process in the gas-type industrial dryer. Exergy-energy and techno-economic methodology was applied to investigate the heat loss, exergetic and energetic performance, exergy efficiency, improvement potential rate, sustainability index and techno-economic performance of a drying system. The results showed that the heat loss of exhaust air in the late drying process played a main contributing role in the heat loss and exergy loss of the whole drying system.

Identification of Novel Sequence Type 22 in Jiuquan City, Gansu Province, China, 2021-2022.

What Is Already Known About This Topic?: The prevalence of rodent-adapted species has been increasing significantly. However, the specific species carried by (), a large rodent species, and the potential risk it poses to human populations remain unknown.

What Is Added By This Report?: (), associated with human endocarditis, was initially identified in , exhibiting a detection rate of approximately one-third and demonstrating a predilection for the heart and lungs.

Serological investigation of plague and brucellosis infection in plague foci in the Altun Mountains on the Qinghai-Tibet Plateau.

The Altun Mountains are among the most active regions of plague foci of the Qinghai-Tibet Plateau where animal plague is prevalent, whereas only three human cases have been found since 1960. Animal husbandry is the main income for the local economy; brucellosis appears sometimes in animals and less often in humans. In this study, a retrospective investigation of plague and brucellosis seroprevalence among humans and animals was conducted to improve prevention and control measures for the two diseases.

Epidemiological Characteristics of Human and Animal Plague in Yunnan Province, China, 1950 to 2020.

This study analyzed the epidemiological characteristics of 3,464 human plague cases and the distribution pattern of 4,968 Yersinia pestis isolates from humans, hosts, and vector insects from 1950 to 2020 among two natural plague foci in Yunnan Province, China. These foci include the Rattus flavipectus plague focus of the Yunnan, Guangdong, and Fujian provinces and the Apodemus chevrieriEothenomys miletus plague focus of the highlands of northwestern Yunnan Province. The case fatality rate for plague in humans was 18.

Plague Outbreak of a Family Emerging from Hibernation.

In April 2021, a plague outbreak was identified within one family shortly after emerging from hibernation, during plague surveillance in the plague foci of the Qinghai-Tibet Plateau. A total of five marmots were found dead of near the same burrow; one live marmot was positive of fraction 1 (F1) antibody. Comparative genome analysis shows that few single nucleotide polymorphisms were detected among the nine strains, indicating the same origin of the outbreak.

First Case Report of Human Plague Caused by Excavation, Skinning, and Eating of a Hibernating Marmot (.

Introduction: The Qinghai-Tibet Plateau is considered the most plague-heavy region in China, and skinning and eating marmots () are understood to be the main exposure factors to plague. is relatively inactive during marmots' hibernation period. However, this case report shows plague infection risk is not reduced but rather increased during the marmot hibernation period if plague exposure is not brought under control.

Anaplasma phagocytophilum in Marmota himalayana.

Background: Human granulocytic anaplasmosis is a tick-borne zoonotic disease caused by Anaplasma phagocytophilum. Coinfections with A. phagocytophilum and other tick-borne pathogens are reported frequently, whereas the relationship between A.

Distribution and Characteristics of Human Plague Cases and Yersinia pestis Isolates from 4 Marmota Plague Foci, China, 1950-2019.

We analyzed epidemiologic characteristics and distribution of 1,067 human plague cases and 5,958 Yersinia pestis isolates collected from humans, host animals, and insect vectors during 1950-2019 in 4 Marmota plague foci in China. The case-fatality rate for plague in humans was 68.88%; the overall trend slowly decreased over time but fluctuated greatly.

A Lytic Bacteriophage Obtained From the Bone Marrow of in a Plague-Focus Area in China.

A lytic phage vB_YpPYepMm (also named YepMm for briefly) was first isolated from the bone marrow of a who died of natural causes on the Qinghai-Tibet plateau in China. Based on its morphologic (isometric hexagonal head and short non-contractile conical tail) and genomic features, we classified it as belonging to the family. At the MOI of 10, YepMm reached maximum titers; and the one-step growth curve showed that the incubation period of the phage was about 10 min, the rise phase was about 80 min, and the lysis amount of the phage during the lysis period of 80 min was about 187 PFU/cell.

and to Gene Distribution Characteristics in Gut Specimens from Different Regions of China.

Antibiotic resistance has become a global public health concern. To determine the distribution characteristics of and in China, gene screening was conducted directly from gut specimens sourced from livestock and poultry, poultry environments, human diarrhea patients, and wild animals from 10 regions, between 2010-2020. The positive rate was 5.

Screening and authentication of molecular markers in malignant glioblastoma based on gene expression profiles.

Glioblastoma (GBM) is a malignant tumor of the central nervous system with high mortality rates. Gene expression profiling may determine the chemosensitivity of GBMs. However, the molecular mechanisms underlying GBM remain to be determined.

Identification and Functional Enrichment Analysis of Potential Diagnostic and Therapeutic Targets in Adamantinomatous Craniopharyngioma.

Adamantinomatous craniopharyngioma (ACP) is a congenital epithelial tumor in the sellar region with benign histological manifestation but invasive. Currently, surgery is the main treatment for it, but its recurrence rate is high. Therefore, it is of great importance to explore the mechanism of occurrence and development of ACP and to identify new molecules.