Leveraging oyster shell and zero-valent iron to eliminate excessive acidification and enhance methane production from readily acidified substrates.

Anaerobic digestion is a sustainable technology for methane (CH) production from organic waste and wastewater. However, its performance is frequently hindered by excessive acidification in readily acidified substrates, such as starch wastewater. Oyster shell (OS), a natural alkaline material, effectively regulates pH and enhances CH production.

Common mental disorders and risk of spontaneous abortion or recurrent spontaneous abortion: A two-sample Mendelian randomization study.

Background: The direct causal relationships between common mental disorders (anxiety disorders, broad depression, major depressive disorder (MDD), bipolar disorder, and insomnia) and miscarriage or recurrent spontaneous abortion (RSA) are unclear. Therefore, this study aimed to explore these, using Mendelian randomization.

Methods: Genome-wide association studies (GWAS) meta-analyses with the largest sample size possible and selected independent single individuals of European ancestry were selected.

Aberrant NK cell profile in gestational diabetes mellitus with fetal growth restriction.

Gestational diabetes mellitus (GDM) is a gestational disorder characterized by hyperglycemia, that can lead to dysfunction of diverse cells in the body, especially the immune cells. It has been reported that immune cells, specifically natural killer (NK) cells, play a crucial role in normal pregnancy. However, it remains unknown how hyperglycemia affects NK cell dysfunction thus participates in the development of GDM.

Short-term effects of cupping and scraping therapy for chronic nonspecific low-back pain: A prospective, multicenter randomized trial.

Background: As one of the most common musculoskeletal ailments, chronic nonspecific low-back pain (CNLBP) causes persistent disability and substantial medical expenses. Epidemiological evidence shows that the incidence rate of CNLBP in young and middle-aged people who are demanded rapidly recovery and social contribution is rising. Recent guidelines indicate a reduced role for medicines in the management of CNLBP.

Comparative effectiveness and safety of 36 therapies or interventions for pregnancy outcomes with recurrent implantation failure: a systematic review and network meta-analysis.

Purpose: To investigate the effectiveness and safety of 36 different therapies for recurrent implantation failure (RIF) patients.

Methods: We searched PubMed, Embase, the Cochrane Library (CENTRAL), Web of Science, and China National Knowledge Internet (CNKI) from inception to August 24, 2022, with language in both English and Chinese. Randomized controlled trials (RCTs) and observational studies that provided data with one of pregnancy outcomes on RIF patients were included in the network meta-analysis (NMA).

Effects of different types of granular activated carbon on methanogenesis of carbohydrate-rich food waste: Performance, microbial communities and optimization.

Granular activated carbon (GAC) supplementation is an efficient method for enhancing methane production during the anaerobic digestion of food waste, but it remains unclear which type of GAC is optimal and what potential mechanisms are involved with different types of GAC, particularly for the methanogenic system of carbohydrate-rich food waste. This study selected three commercial GAC (GAC#1, GAC#2, GAC#3) with very distinct physical and chemical properties, and investigated their impacts on the methanogenesis of carbohydrate-rich food waste with an inoculation/substrate ratio of 1. Results indicated that Fe-doped GAC#3 had a lower specific surface area but higher conductivity, yet exhibited superior performance in facilitating methanogenesis compared with GAC#1 and GAC#2, which possessed larger specific surface areas.

Oyster shell waste as potential co-substrate for enhancing methanogenesis of starch wastewater at low inoculation ratio.

This study evaluated the effect of oyster shells on the methanogenesis of starch wastewater subjected to over-acidification (pH < 4.5) at low inoculum/substrate ratios, and revealed that oyster shells could be used as co-substrates for methane production. The methane yield was improved by approximate 86-folds with optimal dose when compared with that in control.

Online Education Classroom Intelligent Management System Based on Tensor CS Reconstruction Model.

To study a high-efficiency online classroom intelligent management system, this article builds an artificial intelligence classroom management system based on the tensor CS reconstruction model. Moreover, this study uses the cosine function to represent the data energy fitting of the traditional active contour model and proposes a local cosine fitting energy active contour model based on partial image restoration, which is used for image and composite image segmentation. Simultaneously, this study proposes a new type of super-resolution algorithm.

Alleviation of ZnO nanoparticles-induced methanogenic inhibition by granular activated carbon.

A great deal of attention has been paid to the toxicology of ZnO nanoparticles (NPs) to wastewater anaerobic digestion, but few studies have assessed how to reduce their toxic effects. In this study, different dosages of granular activated carbon (GAC) were added into ZnO NPs-bearing wastewater anaerobic digestion system. It was found that although the extracellular polymeric substances resistance, which had been impaired by ZnO NPs, could not be recovered by GAC, the suppressed methane yield was greatly enhanced by promoting the conversions of butyrate and acetate into methane.

First Case Report of Human Plague Caused by Excavation, Skinning, and Eating of a Hibernating Marmot (.

Introduction: The Qinghai-Tibet Plateau is considered the most plague-heavy region in China, and skinning and eating marmots () are understood to be the main exposure factors to plague. is relatively inactive during marmots' hibernation period. However, this case report shows plague infection risk is not reduced but rather increased during the marmot hibernation period if plague exposure is not brought under control.

Anaplasma phagocytophilum in Marmota himalayana.

Background: Human granulocytic anaplasmosis is a tick-borne zoonotic disease caused by Anaplasma phagocytophilum. Coinfections with A. phagocytophilum and other tick-borne pathogens are reported frequently, whereas the relationship between A.

COPD and Gut-Lung Axis: How Microbiota and Host Inflammasome Influence COPD and Related Therapeutics.

The exact pathogenesis of chronic obstructive pulmonary disease (COPD) remains largely unknown. While current management strategies are effective at stabilizing the disease or relief the symptoms, new approaches are required to target underlying disease process and reverse lung function deterioration. Recent research showed that pneumonia bacteria is critical in disease progression and gut microbiome is likely perturbed in COPD, which is usually accompanied by a decreased intestinal microbial diversity and a disturbance in immune system, contributing to a chronic inflammation.

Promotion of granular activated carbon on methanogenesis of readily acidogenic carbohydrate-rich waste at low inoculation ratio.

Although granular activated carbon (GAC) supplementation into food waste anaerobic digestion system is an efficient means to enhance methane production. As yet, little is known whether GAC supplementation is suitable for the extreme condition of pH below 4.5, which occurs in the use of readily acidogenic carbohydrate-rich waste (RACW) as methanogenic substrate when at low inoculation/substrate (I/S) ratio.

Pregnancy-associated thrombotic thrombocytopenic purpura complicated by Sjögren's syndrome and non-neutralising antibodies to ADAMTS13: a case report.

Background: Thrombotic thrombocytopenic purpura (TTP) is a severe and life-threatening disease. Given its heterogeneous clinical presentation, the phenotype of TTP during pregnancy and its management have not been well documented.

Case Presentation: We report here a 25-year-old woman, G1P0 at 36 weeks gestation, who developed severe thrombocytopenia and anemia.

A Lytic Bacteriophage Obtained From the Bone Marrow of in a Plague-Focus Area in China.

A lytic phage vB_YpPYepMm (also named YepMm for briefly) was first isolated from the bone marrow of a who died of natural causes on the Qinghai-Tibet plateau in China. Based on its morphologic (isometric hexagonal head and short non-contractile conical tail) and genomic features, we classified it as belonging to the family. At the MOI of 10, YepMm reached maximum titers; and the one-step growth curve showed that the incubation period of the phage was about 10 min, the rise phase was about 80 min, and the lysis amount of the phage during the lysis period of 80 min was about 187 PFU/cell.

Combination Therapies in Chronic Myeloid Leukemia for Potential Treatment-Free Remission: Focus on Leukemia Stem Cells and Immune Modulation.

Although tyrosine Kinase Inhibitors (TKI) has revolutionized the treatment of chronic myeloid leukemia (CML), patients are not cured with the current therapy modalities. Also, the more recent goal of CML treatment is to induce successful treatment-free remission (TFR) among patients achieving durable deep molecular response (DMR). Together, it is necessary to develop novel, curative treatment strategies.

and to Gene Distribution Characteristics in Gut Specimens from Different Regions of China.

Antibiotic resistance has become a global public health concern. To determine the distribution characteristics of and in China, gene screening was conducted directly from gut specimens sourced from livestock and poultry, poultry environments, human diarrhea patients, and wild animals from 10 regions, between 2010-2020. The positive rate was 5.

Acidogenic and methanogenic properties of corn straw silage: Regulation and microbial analysis of two-phase anaerobic digestion.

Corn straw silage (CSS) is one of the organic solid residues available for biogas production. The aim of this study was to investigate the possibility and optimal controlling strategy for anaerobic digestion (AD) of CSS. Four leaching bed reactors (LBR) were operated at different pH.

Enhancing the anaerobic digestion of corn stover by chemical pretreatment with the black liquor from the paper industry.

In this work, black liquor as a waste from paper industry was used to pretreat corn stover before anaerobic digestion. The batch mode anaerobic digestion achieved a methane production up to 260.5 mL/g VS when the corn stover was pretreated the black liquor of 12 g NaOH/L alkalinity for 24 h, which was 59.

Durable Molecular Remission in a Lymphoid BP-CML Patient Harboring T315I Mutation Treated with Anti-CD19 CAR-T Therapy.

Despite the prominent effects of BCR-ABL tyrosine kinase inhibitors (TKI) therapy in patients with chronic phase-chronic myeloid leukemia (CP-CML) and thus low incidence of blastic transformation, blast phase (BP)-CML remains a major therapeutic challenge in the TKI era. The "gatekeeper" mutation T315I in BCR-ABL1 kinase, which often coupled with a poor prognosis, is quite common and resistant to all TKIs except for ponatinib. The occurrence of T315I mutation in BP-CML makes the situation more complex.

Metabolic engineering of for the utilization of ethanol.

Background: The fuel ethanol industry has made tremendous progress in the last decades. Ethanol can be obtained by fermentation using a variety of biomass materials as the feedstocks. However, few studies have been conducted on ethanol utilization by microorganisms.

Methane production from the anaerobic digestion of substrates from corn stover: Differences between the stem bark, stem pith, and leaves.

This work evaluated the methane potential and methane production rate of the stem bark (SB), stem pith (SP), and leaves (LV) of corn stover from batch anaerobic digestion. The obtained cumulative methane potential and the hydrolysis kinetics constant were 0.201, 0.

Two-phase anaerobic digestion of lignocellulosic hydrolysate: Focusing on the acidification with different inoculum to substrate ratios and inoculum sources.

Biogas production from lignocellulosic hydrolysate is of great potential for lignocellulosic materials. Two-phase anaerobic digestion was proposed in this study. Acidogenic fermentation was carried out with corn straw hydrolysate as feedstock for volatile fatty acids (VFAs) production.